{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:28:52Z","timestamp":1785436132561,"version":"3.56.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NCT00094302"],"award-info":[{"award-number":["NCT00094302"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0205"],"award-info":[{"award-number":["01GI0205"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 01KG0506"],"award-info":[{"award-number":["FKZ 01KG0506"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003385","name":"Georg-August-Universit\u00e4t G\u00f6ttingen","doi-asserted-by":"publisher","award":["NCT00108251"],"award-info":[{"award-number":["NCT00108251"]}],"id":[{"id":"10.13039\/501100003385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.ebiom.2023.104795","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T18:09:39Z","timestamp":1694110179000},"page":"104795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Treatment response to spironolactone in patients with heart failure with preserved ejection fraction: a machine learning-based analysis of two randomized controlled trials"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-6751","authenticated-orcid":false,"given":"Karl-Patrik","family":"Kresoja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-276X","authenticated-orcid":false,"given":"Matthias","family":"Unterhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Wachter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Philipp","family":"Rommel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Besler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Edelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Lurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2023.104795_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCULATIONAHA.114.010637","article-title":"Phenomapping for novel classification of heart failure with preserved ejection fraction","volume":"131","author":"Shah","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.ebiom.2023.104795_bib2","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMoa1313731","article-title":"Spironolactone for heart failure with preserved ejection fraction","volume":"370","author":"Pitt","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ebiom.2023.104795_bib3","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1908655","article-title":"Angiotensin-neprilysin inhibition in heart failure with preserved ejection fraction","volume":"381","author":"Solomon","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ebiom.2023.104795_bib4","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1001\/jama.2021.18463","article-title":"Effect of sacubitril\/valsartan vs standard medical therapies on plasma NT-proBNP concentration and submaximal exercise capacity in patients with heart failure and preserved ejection fraction: the PARALLAX randomized clinical trial","volume":"326","author":"Pieske","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.ebiom.2023.104795_bib5","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ebiom.2023.104795_bib6","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1001\/jama.2013.905","article-title":"Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial","volume":"309","author":"Edelmann","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.ebiom.2023.104795_bib7","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.CIR.0000138680.89536.A9","article-title":"Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure","volume":"110","author":"Mottram","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ebiom.2023.104795_bib8","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0140-6736(21)01638-X","article-title":"Redefining \u03b2-blocker response in heart failure patients with sinus rhythm and atrial fibrillation: a machine learning cluster analysis","volume":"398","author":"Karwath","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2023.104795_bib9","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.jacc.2021.08.018","article-title":"Proteomics-enabled deep learning machine algorithms can enhance prediction of mortality","volume":"78","author":"Unterhuber","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ebiom.2023.104795_bib10","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1016\/j.csbj.2023.05.002","article-title":"Development and validation of a prognostic 15-gene signature for stratifying HER2+\/ER+ breast cancer","volume":"21","author":"Liu","year":"2023","journal-title":"Comput Struct Biotechnol J"},{"key":"10.1016\/j.ebiom.2023.104795_bib11","series-title":"Proceedings of the 22nd ACM SIGKDD international conference on Knowledge discovery and data mining","first-page":"785","article-title":"XGBoost","author":"Chen","year":"2016"},{"key":"10.1016\/j.ebiom.2023.104795_bib12","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1161\/01.CIR.102.15.1788","article-title":"Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler-catheterization study","volume":"102","author":"Ommen","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ebiom.2023.104795_bib13","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1093\/eurheartj\/ehab601","article-title":"Heart failure with preserved ejection fraction: a stepchild no more!","volume":"42","author":"Braunwald","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ebiom.2023.104795_bib14","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1093\/eurheartj\/ehu315","article-title":"Pulmonary capillary wedge pressure during exercise and long-term mortality in patients with suspected heart failure with preserved ejection fraction","volume":"35","author":"Dorfs","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ebiom.2023.104795_bib15","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(15)00723-0","article-title":"Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete follow-up results from the CHAMPION randomised trial","volume":"387","author":"Abraham","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2023.104795_bib16","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1161\/CIRCHEARTFAILURE.113.001229","article-title":"Wireless pulmonary artery pressure monitoring guides management to reduce decompensation in heart failure with preserved ejection fraction","volume":"7","author":"Adamson","year":"2014","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ebiom.2023.104795_bib17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American society of echocardiography and the European association of cardiovascular imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J\u00a0Am Soc Echocardiogr"},{"key":"10.1016\/j.ebiom.2023.104795_bib18","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1186\/s13063-021-05489-x","article-title":"The role of machine learning in clinical research: transforming the future of evidence generation","volume":"22","author":"Weissler","year":"2021","journal-title":"Trials"},{"key":"10.1016\/j.ebiom.2023.104795_bib19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jchf.2019.06.013","article-title":"Machine learning prediction of mortality and hospitalization in heart failure with preserved ejection fraction","volume":"8","author":"Angraal","year":"2020","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ebiom.2023.104795_bib20","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/ejhf.1621","article-title":"Phenomapping of patients with heart failure with preserved ejection fraction using machine learning-based unsupervised cluster analysis","volume":"22","author":"Segar","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ebiom.2023.104795_bib21","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/ejhf.2144","article-title":"Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction","volume":"23","author":"Woolley","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ebiom.2023.104795_bib22","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/520609a","article-title":"Personalized medicine: time for one-person trials","volume":"520","author":"Schork","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2023.104795_bib23","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1056\/NEJMc1612601","article-title":"Spironolactone metabolites in TOPCAT\u2013new insights into regional variation","volume":"376","author":"de Denus","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ebiom.2023.104795_bib24","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDctcs2100007","article-title":"Behind the scenes of TOPCAT \u2014 bending to inform","volume":"1","author":"Pfeffer","year":"2022","journal-title":"NEJM Evidence"},{"key":"10.1016\/j.ebiom.2023.104795_bib25","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.jacc.2016.02.018","article-title":"Extracellular volume fraction for characterization of patients with heart failure and preserved ejection fraction","volume":"67","author":"Rommel","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ebiom.2023.104795_bib26","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s40273-020-00952-0","article-title":"A\u00a0systematic review of medical costs associated with heart failure in the USA (2014-2020)","volume":"38","author":"Urbich","year":"2020","journal-title":"Pharmacoeconomics"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423003614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423003614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:23:27Z","timestamp":1762457007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396423003614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":26,"alternative-id":["S2352396423003614"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104795","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment response to spironolactone in patients with heart failure with preserved ejection fraction: a machine learning-based analysis of two randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104795","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104795"}}