{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:29:51Z","timestamp":1793168991515,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010676","name":"Horizon 2020 Societal Challenges","doi-asserted-by":"publisher","award":["815643"],"award-info":[{"award-number":["815643"]}],"id":[{"id":"10.13039\/100010676","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["81564"],"award-info":[{"award-number":["81564"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.ebiom.2023.104832","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:42:52Z","timestamp":1697071372000},"page":"104832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Safety and infectivity of female cercariae in Schistosoma-na\u00efve, healthy participants: a controlled human Schistosoma mansoni infection study"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1335-9402","authenticated-orcid":false,"given":"Jan Pieter R.","family":"Koopman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0448-6055","authenticated-orcid":false,"given":"Emma L.","family":"Houlder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline J.","family":"Janse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Casacuberta-Partal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia A.C.","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen C.","family":"Sijtsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"de Dood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4207-6850","authenticated-orcid":false,"given":"Stan T.","family":"Hilt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arifa","family":"Ozir-Fazalalikhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent P.","family":"Kuiper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert V.T.","family":"Roozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"de Bes-Roeleveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne C.M.","family":"Kruize","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Wammes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermelijn H.","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette","family":"van Lieshout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govert J.","family":"van Dam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge M.","family":"van Amerongen-Westra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Meij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.A.M.","family":"Corstjens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P.","family":"Jochems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"van Diepen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yazdanbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3545-7804","authenticated-orcid":false,"given":"Cornelis H.","family":"Hokke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-2830","authenticated-orcid":false,"given":"Meta","family":"Roestenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2023.104832_bib1","author":"World Health Organization"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104832_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","article-title":"Schistosomiasis","volume":"4","author":"McManus","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104832_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007349","article-title":"Modelling the impact of a Schistosoma mansoni vaccine and mass drug administration to achieve morbidity control and transmission elimination","volume":"13","author":"Kura","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104832_bib4","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.3390\/ijms23042255","article-title":"Vaccines for human schistosomiasis: recent progress, new developments and future prospects","volume":"23","author":"Molehin","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.ebiom.2023.104832_bib5","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1016\/S1473-3099(18)30177-4","article-title":"Experimental infection of human volunteers","volume":"18","author":"Roestenberg","year":"2018","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104832_bib6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41591-020-0759-x","article-title":"A\u00a0controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics","volume":"26","author":"Langenberg","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2023.104832_bib7","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3389\/fimmu.2018.00861","article-title":"Host defense versus immunosuppression: unisexual infection with male or female Schistosoma mansoni differentially impacts the immune response against invading cercariae","volume":"9","author":"Sombetzki","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104832_bib8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/nyas.13942","article-title":"Sm-p80-based schistosomiasis vaccine: double-blind preclinical trial in baboons demonstrates comprehensive prophylactic and parasite transmission-blocking efficacy","volume":"1425","author":"Zhang","year":"2018","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104832_bib9","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/infdis\/jiy275","article-title":"Establishing the production of male Schistosoma mansoni cercariae for a controlled human infection model","volume":"218","author":"Janse","year":"2018","journal-title":"J\u00a0Infect Dis"},{"issue":"14","key":"10.1016\/j.ebiom.2023.104832_bib10","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1017\/S0031182014000626","article-title":"Tools for diagnosis, monitoring and screening of Schistosoma infections utilizing lateral-flow based assays and upconverting phosphor labels","volume":"141","author":"Corstjens","year":"2014","journal-title":"Parasitology"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104832_bib11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0035-9203(89)90506-3","article-title":"Recognition of gut-associated antigens by immunoglobulin M in the indirect fluorescent antibody test for schistosomiasis mansoni","volume":"83","author":"Deelder","year":"1989","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104832_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003959","article-title":"Is PCR the next reference standard for the diagnosis of schistosoma in stool? A comparison with microscopy in Senegal and Kenya","volume":"9","author":"Meurs","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"11","key":"10.1016\/j.ebiom.2023.104832_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005752","article-title":"mixOmics: an R package for 'omics feature selection and multiple data integration","volume":"13","author":"Rohart","year":"2017","journal-title":"PLoS Comput Biol"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104832_bib14","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1017\/S0031182021001839","article-title":"Excretion patterns of Schistosoma mansoni antigens CCA and CAA by adult male and female worms, using a mouse model and ex\u00a0vivo parasite cultures","volume":"149","author":"Casacuberta-Partal","year":"2022","journal-title":"Parasitology"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104832_bib15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/cid\/ciac820","article-title":"A\u00a0systematic review of human challenge trials, designs, and safety","volume":"76","author":"Adams-Phipps","year":"2022","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104832_bib16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104832_bib17","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1086\/649841","article-title":"Induction of type 2 responses by schistosome worms during prepatent infection","volume":"201","author":"de Oliveira Fraga","year":"2010","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.ebiom.2023.104832_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1010932","article-title":"A\u00a0one-year unisexual Schistosoma mansoni infection causes pathologic organ alterations and persistent non-polarized T cell-mediated inflammation in mice","volume":"13","author":"Sombetzki","year":"2022","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104832_bib19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00436-003-0943-1","article-title":"Preliminary study on sex-related inflammatory reactions in mice infected with Schistosoma mansoni","volume":"91","author":"Boissier","year":"2003","journal-title":"Parasitol Res"},{"issue":"10","key":"10.1016\/j.ebiom.2023.104832_bib20","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1093\/infdis\/jiy714","article-title":"Micro array-assisted analysis of anti-schistosome glycan antibodies elicited by protective vaccination with irradiated cercariae","volume":"219","author":"Yang","year":"2019","journal-title":"J\u00a0Infect Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104832_bib21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1017\/S0022149X00010117","article-title":"Schistosoma mansoni: vitelline gland development in females from single sex infections","volume":"61","author":"Shaw","year":"1987","journal-title":"J\u00a0Helminthol"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104832_bib22","doi-asserted-by":"crossref","first-page":"676","DOI":"10.4269\/ajtmh.2007.77.676","article-title":"T\u00a0regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment","volume":"77","author":"Watanabe","year":"2007","journal-title":"Am J Trop Med Hyg"},{"issue":"8","key":"10.1016\/j.ebiom.2023.104832_bib23","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/eji.200737063","article-title":"Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2","volume":"37","author":"Layland","year":"2007","journal-title":"Eur J Immunol"},{"issue":"8","key":"10.1016\/j.ebiom.2023.104832_bib24","doi-asserted-by":"crossref","first-page":"e1269","DOI":"10.1371\/journal.pntd.0001269","article-title":"CD4(+)CD25(+) regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection","volume":"5","author":"Turner","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104832_bib25","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ijpara.2003.12.003","article-title":"Sex- and stage-related sensitivity of Schistosoma mansoni to in\u00a0vivo and in\u00a0vitro praziquantel treatment","volume":"34","author":"Pica-Mattoccia","year":"2004","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.ebiom.2023.104832_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijpddr.2022.11.002","article-title":"In\u00a0vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice","volume":"20","author":"Wang","year":"2022","journal-title":"Int J Parasitol Drugs Drug Resist"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104832_bib27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3390\/tropicalmed3040125","article-title":"Artemether and praziquantel: origin, mode of action, impact, and suggested application for effective control of human schistosomiasis","volume":"3","author":"Bergquist","year":"2018","journal-title":"Trop Med Infect Dis"},{"key":"10.1016\/j.ebiom.2023.104832_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.914372","article-title":"Pharmacogenetics of praziquantel metabolism: evaluating the cytochrome P450 genes of Zimbabwean patients during a schistosomiasis treatment","volume":"13","author":"Zdesenko","year":"2022","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104832_bib29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00436-020-06968-x","article-title":"Human serum activates the tegument of female schistosomes and supports recovery from Praziquantel","volume":"120","author":"Winkelmann","year":"2021","journal-title":"Parasitol Res"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104832_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011008","article-title":"Limited efficacy of repeated praziquantel treatment in Schistosoma mansoni infections as revealed by highly accurate diagnostics, PCR and UCP-LF CAA (RePST trial)","volume":"16","author":"Hoekstra","year":"2022","journal-title":"PLoS Negl Trop Dis"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423003985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423003985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:29:51Z","timestamp":1762457391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396423003985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":30,"alternative-id":["S2352396423003985"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104832","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and infectivity of female cercariae in Schistosoma-na\u00efve, healthy participants: a controlled human Schistosoma mansoni infection study","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104832","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104832"}}