{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:40:22Z","timestamp":1793313622901,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023280","name":"CSL Seqirus Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006209","name":"Radboudumc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008955","name":"Wilhelmina Children's Hospital University Medical Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009480","name":"Friends of the Sophia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ebiom.2023.104868","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T02:57:33Z","timestamp":1699585053000},"page":"104868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Mycoplasma pneumoniae carriage in children with recurrent respiratory tract infections is associated with a less diverse and altered microbiota"],"prefix":"10.1016","volume":"98","author":[{"given":"Mischa H.","family":"Koenen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben C.A.","family":"de Groot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter A.A.","family":"de Steenhuijsen Piters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Ling J.N.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayleigh","family":"Arp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00efza","family":"Hasrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad C.J.M.","family":"de Bruijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia C.","family":"Estev\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhard","family":"van der Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5317-3202","authenticated-orcid":false,"given":"Jeroen D.","family":"Langereis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Boes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Bogaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie M.C.","family":"van Rossum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy W.J.","family":"Unger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilly M.","family":"Verhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ebiom.2023.104868_bib1","doi-asserted-by":"crossref","first-page":"e362","DOI":"10.1097\/INF.0000000000001304","article-title":"Burden of recurrent respiratory tract infections in children: a prospective cohort study","volume":"35","author":"Toivonen","year":"2016","journal-title":"Pediatr Infect Dis J"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104868_bib2","article-title":"Diagnosis and management of recurrent respiratory tract infections in children: a practical guide","volume":"4","author":"Schaad","year":"2016","journal-title":"Arch Pediatr Infect"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104868_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/thx.2008.112136","article-title":"Early life origins of chronic obstructive pulmonary disease","volume":"65","author":"Svanes","year":"2010","journal-title":"Thorax"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104868_bib4","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/cid\/ciz1059","article-title":"Improved Diagnostics help to identify clinical features and biomarkers that predict Mycoplasma pneumoniae community-acquired pneumonia in children","volume":"71","author":"Meyer Sauteur","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"9","key":"10.1016\/j.ebiom.2023.104868_bib5","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1056\/NEJMoa1405870","article-title":"Community-acquired pneumonia requiring hospitalization among U.S. children","volume":"372","author":"Jain","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"Suppl 1","key":"10.1016\/j.ebiom.2023.104868_bib6","first-page":"S95","article-title":"Things that could be Mycoplasma pneumoniae","volume":"74","author":"de Groot","year":"2017","journal-title":"J\u00a0Infect"},{"issue":"9424","key":"10.1016\/j.ebiom.2023.104868_bib7","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/S0140-6736(04)16357-5","article-title":"Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children","volume":"363","author":"Bogaert","year":"2004","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104868_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001444","article-title":"Carriage of Mycoplasma pneumoniae in the upper respiratory tract of symptomatic and asymptomatic children: an observational study","volume":"10","author":"Spuesens","year":"2013","journal-title":"PLoS Med"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104868_bib9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/infdis\/jiaa062","article-title":"Circulating antibody-secreting cell response during Mycoplasma pneumoniae childhood pneumonia","volume":"222","author":"Meyer Sauteur","year":"2020","journal-title":"J\u00a0Infect Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104868_bib10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/cid\/cir769","article-title":"Fatal outcomes in family transmission of Mycoplasma pneumoniae","volume":"54","author":"Kannan","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104868_bib11","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1086\/318529","article-title":"Results of molecular detection of Mycoplasma pneumoniae among patients with acute respiratory infection and in their household contacts reveals children as human reservoirs","volume":"183","author":"Dorigo-Zetsma","year":"2001","journal-title":"J\u00a0Infect Dis"},{"issue":"9","key":"10.1016\/j.ebiom.2023.104868_bib12","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1086\/592281","article-title":"Community outbreak of Mycoplasma pneumoniae infection: school-based cluster of neurologic disease associated with household transmission of respiratory illness","volume":"198","author":"Walter","year":"2008","journal-title":"J\u00a0Infect Dis"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104868_bib13","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00129-2021","article-title":"Mycoplasma pneumoniae carriage evades induction of protective mucosal antibodies","volume":"59","author":"de Groot","year":"2022","journal-title":"Eur Respir J"},{"issue":"8","key":"10.1016\/j.ebiom.2023.104868_bib14","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1164\/rccm.201212-2277OC","article-title":"Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults","volume":"187","author":"Ferreira","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104868_bib15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/infdis\/jix559","article-title":"The role of B cells in carriage and clearance of Mycoplasma pneumoniae from the respiratory tract of mice","volume":"217","author":"Meyer Sauteur","year":"2018","journal-title":"J\u00a0Infect Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104868_bib16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/mi.2016.71","article-title":"Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage","volume":"10","author":"Mitsi","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104868_bib17","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1038\/s41467-019-10814-9","article-title":"Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine","volume":"10","author":"de Steenhuijsen Piters","year":"2019","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104868_bib18","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.chom.2015.03.008","article-title":"The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development","volume":"17","author":"Teo","year":"2015","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104868_bib19","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41564-021-01043-2","article-title":"Early-life viral infections are associated with disadvantageous immune and microbiota profiles and recurrent respiratory infections","volume":"7","author":"de Steenhuijsen Piters","year":"2022","journal-title":"Nat Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104868_bib20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1373\/clinchem.2007.075861","article-title":"Coexistence of (partial) immune defects and risk of recurrent respiratory infections","volume":"53","author":"Bossuyt","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.ebiom.2023.104868_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12865-014-0031-6","article-title":"Primary immunodeficiency in infection-prone children in southern Sweden: occurrence, clinical characteristics and immunological findings","volume":"15","author":"Brodszki","year":"2014","journal-title":"BMC Immunol"},{"key":"10.1016\/j.ebiom.2023.104868_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6343818","article-title":"Mycoplasma pneumoniae infections and primary immune deficiencies","volume":"2022","author":"Poddighe","year":"2022","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.ebiom.2023.104868_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41390-023-02725-9","article-title":"Antibody deficiencies in children are associated with prematurity and a family history of infections","author":"Koenen","year":"2023","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ebiom.2023.104868_bib24","series-title":"Evidence-based richtlijn diagnostiek naar onderliggende aandoeningen bij kinderen met recidiverende luchtweginfecties: Erasmus MC, Sophia Kinderziekenhuis, subafdeling kinderinfectieziekten-immunologie","author":"Driessen","year":"2016"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104868_bib25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1399-3038.2007.00688.x","article-title":"History of respiratory infections in the first 12 yr among children from a birth cohort","volume":"19","author":"Gruber","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.ebiom.2023.104868_bib26","series-title":"ESID registry diagnosis criteria","author":"Soresina","year":"2016"},{"issue":"6","key":"10.1016\/j.ebiom.2023.104868_bib27","first-page":"517","volume":"34","author":"Dati","year":"1996","journal-title":"Eur J Clin Chem Clin Biochem"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104868_bib28","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.mimet.2010.06.004","article-title":"Macrolide resistance determination and molecular typing of Mycoplasma pneumoniae by pyrosequencing","volume":"82","author":"Spuesens","year":"2010","journal-title":"J\u00a0Microbiol Methods"},{"key":"10.1016\/j.ebiom.2023.104868_bib29","series-title":"MagMAXTM pathogen RNA\/DNA kit","year":"2018"},{"key":"10.1016\/j.ebiom.2023.104868_bib30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2217\/fmb-2016-0215","article-title":"Simultaneous identification of Haemophilus influenzae and Haemophilus haemolyticus using real-time PCR","volume":"12","author":"Price","year":"2017","journal-title":"Future Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104868_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-96556-5","article-title":"Benchmarking laboratory processes to characterise low-biomass respiratory microbiota","volume":"11","author":"Hasrat","year":"2021","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104868_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032942","article-title":"Deep sequencing analyses of low density microbial communities: working at the boundary of accurate microbiota detection","volume":"7","author":"Biesbroek","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.ebiom.2023.104868_bib33","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"issue":"7505","key":"10.1016\/j.ebiom.2023.104868_bib34","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature13421","article-title":"Persistent gut microbiota immaturity in malnourished Bangladeshi children","volume":"510","author":"Subramanian","year":"2014","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104868_bib35","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.anai.2013.01.022","article-title":"Mycoplasma pneumoniae in children with acute and refractory asthma","volume":"110","author":"Wood","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104868_bib36","first-page":"490","article-title":"Increased total serum immunoglobulin E in children developing Mycoplasma pneumoniae-related extra-pulmonary diseases","volume":"17","author":"Poddighe","year":"2018","journal-title":"Iran J Allergy Asthma Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104868_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.22887","article-title":"Impact of atopy on the severity and extrapulmonary manifestations of childhood Mycoplasma pneumoniae pneumonia","volume":"33","author":"Wang","year":"2019","journal-title":"J\u00a0Clin Lab Anal"},{"key":"10.1016\/j.ebiom.2023.104868_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.783635","article-title":"Increased total serum immunoglobulin E is likely to cause complications of Mycoplasma pneumoniae pneumonia in children","volume":"11","author":"Zhou","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104868_bib39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/cid\/ciy419","article-title":"Mycoplasma pneumoniae among children hospitalized with community-acquired pneumonia","volume":"68","author":"Kutty","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104868_bib40","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12985-022-01914-y","article-title":"Comprehensive virome analysis of the viral spectrum in paediatric patients diagnosed with Mycoplasma pneumoniae pneumonia","volume":"19","author":"Guo","year":"2022","journal-title":"Virol J"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104868_bib41","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1136\/ard.53.3.183","article-title":"Mycoplasmas and ureaplasmas in patients with hypogammaglobulinaemia and their role in arthritis: microbiological observations over twenty years","volume":"53","author":"Furr","year":"1994","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ebiom.2023.104868_bib42","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3389\/fimmu.2020.01245","article-title":"Low IgA associated with oropharyngeal microbiota changes and lung disease in primary antibody deficiency","volume":"11","author":"Berbers","year":"2020","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.ebiom.2023.104868_bib43","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/ana.24755","article-title":"Mycoplasma pneumoniae triggering the Guillain-Barre syndrome: a case-control study","volume":"80","author":"Meyer Sauteur","year":"2016","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ebiom.2023.104868_bib44","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fmicb.2016.00023","article-title":"Classification of extrapulmonary manifestations due to Mycoplasma pneumoniae infection on the basis of possible pathogenesis","volume":"7","author":"Narita","year":"2016","journal-title":"Front Microbiol"},{"issue":"12","key":"10.1016\/j.ebiom.2023.104868_bib45","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1164\/rccm.201703-0554OC","article-title":"Maturation of the infant respiratory microbiota, environmental drivers, and health consequences. A prospective cohort study","volume":"196","author":"Bosch","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104868_bib46","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.chom.2020.07.004","article-title":"Early life microbiota and respiratory tract infections","volume":"28","author":"de Steenhuijsen Piters","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104868_bib47","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S2213-2600(18)30449-1","article-title":"Bacterial and viral respiratory tract microbiota and host characteristics in children with lower respiratory tract infections: a matched case-control study","volume":"7","author":"Man","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104868_bib48","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41426-018-0097-y","article-title":"The concordance between upper and lower respiratory microbiota in children with Mycoplasma pneumoniae pneumonia","volume":"7","author":"Dai","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.ebiom.2023.104868_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104189","article-title":"Different nasopharynx and oropharynx microbiota imbalance in children with Mycoplasma pneumoniae or influenza virus infection","volume":"144","author":"Zhou","year":"2020","journal-title":"Microb Pathog"},{"key":"10.1016\/j.ebiom.2023.104868_bib50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijmmb.2022.09.012","article-title":"Species-level respiratory microbiome profiling for etiologic diagnosis of children pneumonia using full length 16S rRNA gene sequencing","volume":"43","author":"Li","year":"2023","journal-title":"Indian J Med Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104868_bib51","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2023.2202272","article-title":"Respiratory microbiota imbalance in children with Mycoplasma pneumoniae pneumonia","volume":"12","author":"Wang","year":"2023","journal-title":"Emerg Microbes Infect"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104868_bib52","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jaci.2015.04.049","article-title":"Practice parameter for the diagnosis and management of primary immunodeficiency","volume":"136","author":"Bonilla","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"11","key":"10.1016\/j.ebiom.2023.104868_bib53","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1002\/ppul.25042","article-title":"Risk factors for atopic diseases and recurrent respiratory tract infections in children","volume":"55","author":"Kansen","year":"2020","journal-title":"Pediatr Pulmonol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104868_bib54","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41390-020-01233-4","article-title":"Risk factors for recurrent respiratory tract infection in preschool-aged children","volume":"90","author":"Zhou","year":"2021","journal-title":"Pediatr Res"},{"issue":"2","key":"10.1016\/j.ebiom.2023.104868_bib55","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00939-2020","article-title":"Microbial and clinical factors are related to recurrence of symptoms after childhood lower respiratory tract infection","volume":"7","author":"de Koff","year":"2021","journal-title":"ERJ Open Res"},{"issue":"3","key":"10.1016\/j.ebiom.2023.104868_bib56","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/QCO.0000000000000826","article-title":"The microbiota in respiratory tract infections: from association to intervention","volume":"35","author":"Koenen","year":"2022","journal-title":"Curr Opin Infect Dis"},{"issue":"11","key":"10.1016\/j.ebiom.2023.104868_bib57","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1164\/rccm.201407-1240OC","article-title":"Early respiratory microbiota composition determines bacterial succession patterns and respiratory health in children","volume":"190","author":"Biesbroek","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"22","key":"10.1016\/j.ebiom.2023.104868_bib58","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1093\/nar\/24.22.4420","article-title":"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae","volume":"24","author":"Himmelreich","year":"1996","journal-title":"Nucleic Acids Res"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423004346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423004346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T14:42:09Z","timestamp":1737384129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396423004346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":58,"alternative-id":["S2352396423004346"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104868","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mycoplasma pneumoniae carriage in children with recurrent respiratory tract infections is associated with a less diverse and altered microbiota","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104868"}}