{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:01:50Z","timestamp":1767211310617,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017415","name":"Peking University First Hospital","doi-asserted-by":"publisher","award":["2022CR59"],"award-info":[{"award-number":["2022CR59"]}],"id":[{"id":"10.13039\/100017415","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.ebiom.2023.104951","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T13:51:03Z","timestamp":1704376263000},"page":"104951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Establishment and validation of a multivariate predictive model for the efficacy of oral rehydration salts in children with postural tachycardia syndrome"],"prefix":"10.1016","volume":"100","author":[{"given":"Bowen","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6990-2203","authenticated-orcid":false,"given":"Yumeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbao","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2023.104951_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113625","article-title":"Risk factors for postural tachycardia syndrome in children and adolescents","volume":"9","author":"Lin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2023.104951_bib2","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2021-054945","article-title":"Pediatric postural orthostatic tachycardia syndrome: where we stand","volume":"150","author":"Boris","year":"2022","journal-title":"Pediatrics"},{"key":"10.1016\/j.ebiom.2023.104951_bib3","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1016\/j.jacc.2010.02.043","article-title":"Cardiac origins of the postural orthostatic tachycardia syndrome","volume":"55","author":"Fu","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ebiom.2023.104951_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.autneu.2021.102828","article-title":"Postural orthostatic tachycardia syndrome (POTS): state of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - part 1","volume":"235","author":"Vernino","year":"2021","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.ebiom.2023.104951_bib5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3389\/fneur.2020.00525","article-title":"Update of individualized treatment strategies for postural orthostatic tachycardia syndrome in children","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Neurol"},{"key":"10.1016\/j.ebiom.2023.104951_bib6","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jacc.2018.11.059","article-title":"Postural orthostatic tachycardia syndrome: JACC focus seminar","volume":"73","author":"Bryarly","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ebiom.2023.104951_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jpeds.2012.01.054","article-title":"Twenty-four-hour urinary sodium excretion and postural orthostatic tachycardia syndrome","volume":"161","author":"Zhang","year":"2012","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.ebiom.2023.104951_bib8","first-page":"25","article-title":"Evaluation of the changes in heart rate during head-up test predicting the efficacy of oral rehydration salts on postural tachycardia syndrome in children","volume":"53","author":"Lin","year":"2015","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.ebiom.2023.104951_bib9","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00246-016-1436-1","article-title":"Body mass index (BMI) is associated with the therapeutic response to oral rehydration solution in children with postural tachycardia syndrome","volume":"37","author":"Li","year":"2016","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.ebiom.2023.104951_bib10","article-title":"Baroreflex sensitivity predicts short-term outcome of postural tachycardia syndrome in children","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2023.104951_bib11","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.scib.2018.09.019","article-title":"Chinese Pediatric Cardiology Society (CPCS) guideline for diagnosis and treatment of syncope in children and adolescents","volume":"63","author":"Wang","year":"2018","journal-title":"Sci Bull"},{"key":"10.1016\/j.ebiom.2023.104951_bib12","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/eurheartj\/ehy037","article-title":"2018 ESC Guidelines for the diagnosis and management of syncope","volume":"39","author":"Brignole","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ebiom.2023.104951_bib13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jpeds.2017.04.034","article-title":"Hemocytometric measures predict the efficacy of oral rehydration for children with postural tachycardia syndrome","volume":"187","author":"Lu","year":"2017","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.ebiom.2023.104951_bib14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jpeds.2019.07.041","article-title":"The benefits of oral rehydration on orthostatic intolerance in children with postural tachycardia syndrome","volume":"214","author":"Medow","year":"2019","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.ebiom.2023.104951_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00420-002-0395-4","article-title":"Diagnostic management of orthostatic intolerance in the workplace","volume":"76","author":"Winker","year":"2003","journal-title":"Int Arch Occup Environ Health"},{"key":"10.1016\/j.ebiom.2023.104951_bib16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.arcped.2020.06.001","article-title":"Short-term efficacy of ORS formulation and propranolol regimen in children with POTS","volume":"27","author":"Yozgat","year":"2020","journal-title":"Arch Pediatr"},{"key":"10.1016\/j.ebiom.2023.104951_bib17","article-title":"Baseline corrected QT interval dispersion is useful to predict effectiveness of metoprolol on pediatric postural tachycardia syndrome","volume":"8","author":"Wang","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.ebiom.2023.104951_bib18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1253\/circj.CJ-10-0514","article-title":"Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome","volume":"75","author":"Chen","year":"2011","journal-title":"Circ J"},{"key":"10.1016\/j.ebiom.2023.104951_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.930994","article-title":"Baroreflex sensitivity predicts therapeutic effects of metoprolol on pediatric postural orthostatic tachycardia syndrome","volume":"9","author":"Cui","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.ebiom.2023.104951_bib20","first-page":"414","article-title":"Hemodynamic changes in standing-up test of children and adolescents with postural tachycardia syndrome","volume":"51","author":"Tao","year":"2019","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.ebiom.2023.104951_bib21","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ejim.2014.03.007","article-title":"P-wave voltage and peaking on electrocardiogram in patients undergoing head-up tilt testing for history of syncope","volume":"25","author":"de Gregorio","year":"2014","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.ebiom.2023.104951_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.121.010435","volume":"15","author":"Chen","year":"2022","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"1","key":"10.1016\/j.ebiom.2023.104951_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"issue":"5","key":"10.1016\/j.ebiom.2023.104951_bib24","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1017\/S1047951112000133","article-title":"The effect of paediatric syncope on health-related quality of life","volume":"22","author":"Anderson","year":"2012","journal-title":"Cardiol Young"},{"key":"10.1016\/j.ebiom.2023.104951_bib25","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1161\/CIRCULATIONAHA.115.016795","article-title":"Evaluating the atrial\u00a0myopathy underlying atrial fibrillation: identifying the arrhythmogenic and thrombogenic substrate","volume":"132","author":"Goldberger","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.ebiom.2023.104951_bib26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2217\/fca.15.22","article-title":"Atrial cardiopathy: a broadened concept of left atrial thromboembolism beyond atrial fibrillation","volume":"11","author":"Kamel","year":"2015","journal-title":"Future Cardiol"},{"key":"10.1016\/j.ebiom.2023.104951_bib27","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/hrt.27.5.748","article-title":"Electrocardiographic P wave and atrial weights and volumes","volume":"27","author":"Gordon","year":"1965","journal-title":"Br Heart J"},{"key":"10.1016\/j.ebiom.2023.104951_bib28","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1540-8167.1994.tb01142.x","article-title":"Effects of acute volume changes on P wave characteristics: correlation with echocardiographic findings in healthy men","volume":"5","author":"Vainer","year":"1994","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.ebiom.2023.104951_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13054-018-2171-1","article-title":"The meaning of blood pressure","volume":"22","author":"Magder","year":"2018","journal-title":"Crit Care"},{"key":"10.1016\/j.ebiom.2023.104951_bib30","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1161\/01.CIR.0000160356.97313.5D","article-title":"Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndrome","volume":"111","author":"Raj","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ebiom.2023.104951_bib31","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1161\/HYPERTENSIONAHA.109.136853","article-title":"Renal impairment of pure autonomic failure","volume":"54","author":"Garland","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.ebiom.2023.104951_bib32","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/hrt.75.2.134","article-title":"Salt supplement increases plasma volume and orthostatic tolerance in patients with unexplained syncope","volume":"75","author":"El-Sayed","year":"1996","journal-title":"Heart"},{"key":"10.1016\/j.ebiom.2023.104951_bib33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/CS20050254","article-title":"Increased plasma angiotensin II in postural tachycardia syndrome (POTS) is related to reduced blood flow and blood volume","volume":"110","author":"Stewart","year":"2006","journal-title":"Clin Sci"},{"key":"10.1016\/j.ebiom.2023.104951_bib34","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.hrthm.2010.11.009","article-title":"Abnormalities of angiotensin regulation in postural tachycardia syndrome","volume":"8","author":"Mustafa","year":"2011","journal-title":"Heart Rhythm"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423005170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396423005170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:29:42Z","timestamp":1762457382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396423005170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":34,"alternative-id":["S2352396423005170"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104951","relation":{},"ISSN":["2352-3964"],"issn-type":[{"type":"print","value":"2352-3964"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Establishment and validation of a multivariate predictive model for the efficacy of oral rehydration salts in children with postural tachycardia syndrome","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2023.104951","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104951"}}