{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:35:08Z","timestamp":1791837308142,"version":"4.3.4"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["66354"],"award-info":[{"award-number":["66354"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007054","name":"Meso Scale Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ebiom.2024.105033","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T19:37:52Z","timestamp":1708457872000},"page":"105033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Phenome-wide Mendelian randomization analysis reveals multiple health comorbidities of coeliac disease"],"prefix":"10.1016","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5055-5627","authenticated-orcid":false,"given":"Shuai","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Lebwohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.R.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Leffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna C.","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-2577","authenticated-orcid":false,"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10344","key":"10.1016\/j.ebiom.2024.105033_bib1","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/S0140-6736(22)00794-2","article-title":"Coeliac disease","volume":"399","author":"Catassi","year":"2022","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105033_bib2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.14309\/ajg.0000000000000523","article-title":"Incidence of celiac disease is increasing over time: a systematic review and meta-analysis","volume":"115","author":"King","year":"2020","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105033_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1177\/2050640614561668","article-title":"Screening for celiac disease in the general population and in high-risk groups","volume":"3","author":"Ludvigsson","year":"2015","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.ebiom.2024.105033_bib4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jpeds.2016.02.058","article-title":"Celiac disease and risk of autoimmune disorders: a population-based matched birth cohort study","volume":"174","author":"Canova","year":"2016","journal-title":"J\u00a0Pediatr"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105033_bib5","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.jhep.2015.01.013","article-title":"Increased risk of non-alcoholic fatty liver disease after diagnosis of celiac disease","volume":"62","author":"Reilly","year":"2015","journal-title":"J\u00a0Hepatol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105033_bib6","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.cgh.2021.05.034","article-title":"Cancer risk in 47,241 individuals with celiac disease: a nationwide cohort study","volume":"20","author":"Lebwohl","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105033_bib7","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1572-0241.2001.03616.x","article-title":"Vitamin B12 deficiency in untreated celiac disease","volume":"96","author":"Dahele","year":"2001","journal-title":"Am J Gastroenterol"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105033_bib8","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm0797-797","article-title":"Identification of tissue transglutaminase as the autoantigen of celiac disease","volume":"3","author":"Dieterich","year":"1997","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105033_bib9","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0016-5085(98)70007-1","article-title":"Autoantibodies to tissue transglutaminase as predictors of celiac disease","volume":"115","author":"Dieterich","year":"1998","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105033_bib10","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/gut.50.5.624","article-title":"The first large population based twin study of coeliac disease","volume":"50","author":"Greco","year":"2002","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105033_bib11","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1136\/gutjnl-2016-311713","article-title":"Heritability of non-HLA genetics in coeliac disease: a population-based study in 107 000 twins","volume":"65","author":"Kuja-Halkola","year":"2016","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105033_bib12","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.998","article-title":"Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease","volume":"43","author":"Trynka","year":"2011","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105033_bib13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.169.1.345","article-title":"Evidence for a primary association of celiac disease to a particular HLA-DQ alpha\/beta heterodimer","volume":"169","author":"Sollid","year":"1989","journal-title":"J\u00a0Exp Med"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105033_bib14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nri.2017.143","article-title":"HLA variation and disease","volume":"18","author":"Dendrou","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ebiom.2024.105033_bib15","series-title":"Mendelian randomization: methods for using genetic variants in causal estimation","author":"Burgess","year":"2015"},{"key":"10.1016\/j.ebiom.2024.105033_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103865","article-title":"Health effects of high serum calcium levels: updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies","volume":"76","author":"Yuan","year":"2022","journal-title":"eBioMedicine"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105033_bib17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/gepi.21998","article-title":"Bias due to participant overlap in two-sample Mendelian randomization","volume":"40","author":"Burgess","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105033_bib18","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nrg1489","article-title":"Gene map of the extended human MHC","volume":"5","author":"Horton","year":"2004","journal-title":"Nat Rev Genet"},{"issue":"20","key":"10.1016\/j.ebiom.2024.105033_bib19","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1093\/bioinformatics\/btw373","article-title":"PhenoScanner: a database of human genotype-phenotype associations","volume":"32","author":"Staley","year":"2016","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105033_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"issue":"7726","key":"10.1016\/j.ebiom.2024.105033_bib21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105033_bib22","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/nbt.2749","article-title":"Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data","volume":"31","author":"Denny","year":"2013","journal-title":"Nat Biotechnol"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105033_bib23","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1093\/ije\/dyac036","article-title":"Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation","volume":"51","author":"Yuan","year":"2022","journal-title":"Int J Epidemiol"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105033_bib24","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1136\/annrheumdis-2017-212534","article-title":"MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank","volume":"77","author":"Li","year":"2018","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105033_bib25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41588-022-01286-7","article-title":"Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism","volume":"55","author":"Ghouse","year":"2023","journal-title":"Nat Genet"},{"issue":"7944","key":"10.1016\/j.ebiom.2024.105033_bib26","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.ebiom.2024.105033_bib27","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/bioinformatics\/btu197","article-title":"R\u00a0PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment","volume":"30","author":"Carroll","year":"2014","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105033_bib28","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105033_bib29","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105033_bib30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2024.105033_bib31","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105033_bib32","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12916-019-1380-z","article-title":"Celiac disease: a comprehensive current review","volume":"17","author":"Caio","year":"2019","journal-title":"BMC Med"},{"key":"10.1016\/j.ebiom.2024.105033_bib33","article-title":"Causal relationship between gut microbiota and autoimmune diseases: a two-sample Mendelian randomization study","volume":"12","author":"Xu","year":"2021","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105033_bib34","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41588-020-00763-1","article-title":"Large-scale association analyses identify host factors influencing human gut microbiome composition","volume":"53","author":"Kurilshikov","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2024.105033_bib35","first-page":"1","article-title":"Causal relationships between autoimmune diseases and celiac disease: a Mendelian randomization analysis","author":"Li","year":"2023","journal-title":"Biotechnol Genet Eng Rev"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105033_bib36","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/apt.12973","article-title":"Systematic review with meta-analysis: associations between coeliac disease and type 1 diabetes","volume":"40","author":"Elfstrom","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105033_bib37","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.2337\/dc06-0794","article-title":"Celiac disease and risk of subsequent type 1 diabetes: a general population cohort study of children and adolescents","volume":"29","author":"Ludvigsson","year":"2006","journal-title":"Diabetes Care"},{"issue":"Suppl 1","key":"10.1016\/j.ebiom.2024.105033_bib38","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.2337\/dc18-S012","article-title":"12. Children and adolescents: standards of medical Care in diabetes-2018","volume":"41","author":"American Diabetes","year":"2018","journal-title":"Diabetes Care"},{"issue":"Suppl 27","key":"10.1016\/j.ebiom.2024.105033_bib39","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/pedi.12740","article-title":"ISPAD clinical practice consensus guidelines 2018: other complications and associated conditions in children and adolescents with type 1 diabetes","volume":"19 Suppl 27","author":"Mahmud","year":"2018","journal-title":"Pediatr Diabetes"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105033_bib40","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.humimm.2004.04.004","article-title":"The rare HLA-DQA1\u221703-DQB1\u221702 haplotype confers susceptibility to type 1 diabetes in whites and is preferentially associated with early clinical disease onset in male subjects","volume":"65","author":"van Autreve","year":"2004","journal-title":"Hum Immunol"},{"issue":"Suppl 2","key":"10.1016\/j.ebiom.2024.105033_bib41","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.2337\/dcs15-2007","article-title":"Contrasting the genetic background of type 1 diabetes and celiac disease autoimmunity","volume":"38 Suppl 2","author":"Gutierrez-Achury","year":"2015","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105033_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1365-2796.1999.00403.x","article-title":"High prevalence of undiagnosed coeliac disease in adults: a Swedish population-based study","volume":"245","author":"Ivarsson","year":"1999","journal-title":"J\u00a0Intern Med"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105033_bib43","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/gutjnl-2021-324209","article-title":"Two waves of coeliac disease incidence in Sweden: a nationwide population-based cohort study from 1990 to 2015","volume":"71","author":"Bergman","year":"2021","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105033_bib44","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s00125-014-3223-y","article-title":"Risk of renal disease in patients with both type 1 diabetes and coeliac disease","volume":"57","author":"Mollazadegan","year":"2014","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105033_bib45","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2337\/dc12-0766","article-title":"A\u00a0population-based study of the risk of diabetic retinopathy in patients with type 1 diabetes and celiac disease","volume":"36","author":"Mollazadegan","year":"2013","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105033_bib46","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1177\/2050640619844125","article-title":"European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders","volume":"7","author":"Al-Toma","year":"2019","journal-title":"United European Gastroenterol J"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105033_bib47","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1210\/jc.2008-0798","article-title":"Risk of thyroid disease in individuals with celiac disease","volume":"93","author":"Elfstrom","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105033_bib48","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1089\/thy.2016.0108","article-title":"Prevalence of celiac disease in patients with autoimmune thyroid disease: a meta-analysis","volume":"26","author":"Roy","year":"2016","journal-title":"Thyroid"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105033_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168708","article-title":"Increased incidence of thyroid disease in patients with celiac disease: a systematic review and meta-analysis","volume":"11","author":"Sun","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105033_bib50","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1053\/gast.2002.32416","article-title":"Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure","volume":"122","author":"Kaukinen","year":"2002","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105033_bib51","doi-asserted-by":"crossref","first-page":"820","DOI":"10.14309\/ajg.0000000000002123","article-title":"Prevalence of celiac disease in patients with liver diseases: a systematic review and meta-analyses","volume":"118","author":"Yoosuf","year":"2023","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105033_bib52","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.3899\/jrheum.120493","article-title":"Increased risk of systemic lupus erythematosus in 29,000 patients with biopsy-verified celiac disease","volume":"39","author":"Ludvigsson","year":"2012","journal-title":"J\u00a0Rheumatol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105033_bib53","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/jebm.12355","article-title":"Celiac disease and risk of sarcoidosis: a systematic review and meta-analysis","volume":"12","author":"Wijarnpreecha","year":"2019","journal-title":"J\u00a0Evid Based Med"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105033_bib54","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1093\/rheumatology\/keaa071","article-title":"Association between celiac disease and systemic lupus erythematosus: a Mendelian randomization study","volume":"59","author":"Inamo","year":"2020","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105033_bib55","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s11914-018-0488-y","article-title":"Celiac disease-musculoskeletal manifestations and mechanisms in children to adults","volume":"16","author":"Zylberberg","year":"2018","journal-title":"Curr Osteoporos Rep"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105033_bib56","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/jnci\/djq564","article-title":"Risk of lymphoproliferative malignancy in relation to small intestinal histopathology among patients with celiac disease","volume":"103","author":"Elfstrom","year":"2011","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105033_bib57","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7326\/0003-4819-159-3-201308060-00006","article-title":"Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study","volume":"159","author":"Lebwohl","year":"2013","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105033_bib58","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo definitions for coeliac disease and related terms","volume":"62","author":"Ludvigsson","year":"2013","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105033_bib59","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/gut.2009.195131","article-title":"Classification and management of refractory coeliac disease","volume":"59","author":"Rubio-Tapia","year":"2010","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105033_bib60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1210\/jc.2014-1858","article-title":"Celiac disease and bone fractures: a systematic review and meta-analysis","volume":"100","author":"Heikkila","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105033_bib61","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1053\/j.gastro.2018.04.016","article-title":"Prevalence of celiac disease in patients with iron deficiency anemia-A systematic review with meta-analysis","volume":"155","author":"Mahadev","year":"2018","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105033_bib62","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/bjc.2011.536","article-title":"Risk of prostate cancer in a population-based cohort of men with coeliac disease","volume":"106","author":"Ludvigsson","year":"2012","journal-title":"Br J Cancer"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105033_bib63","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.3109\/00365521.2011.615858","article-title":"Screening for unrecognized coeliac disease in subfertile couples","volume":"46","author":"Hogen Esch","year":"2011","journal-title":"Scand J Gastroenterol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105033_bib64","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/rmb2.12374","article-title":"The prevalence of celiac disease in women with infertility-A systematic review with meta-analysis","volume":"20","author":"Glimberg","year":"2021","journal-title":"Reprod Med Biol"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105033_bib65","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.immuni.2012.06.006","article-title":"Celiac disease: an immunological jigsaw","volume":"36","author":"Meresse","year":"2012","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105033_bib66","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2337\/dc19-1944","article-title":"Screening and treatment outcomes in adults and children with type 1 diabetes and asymptomatic celiac disease: the CD-DIET study","volume":"43","author":"Mahmud","year":"2020","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105033_bib67","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.2337\/dci21-0043","article-title":"The management of type 1 diabetes in adults. A consensus report by the American diabetes association (ADA) and the European association for the study of diabetes (EASD)","volume":"44","author":"Holt","year":"2021","journal-title":"Diabetes Care"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105033_bib68","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1001\/jama.2017.1462","article-title":"Screening for celiac disease: US preventive services task force recommendation statement","volume":"317","author":"Bibbins-Domingo","year":"2017","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105033_bib69","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1053\/gast.1999.0029900297","article-title":"Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP study group for autoimmune disorders in celiac disease","volume":"117","author":"Ventura","year":"1999","journal-title":"Gastroenterology"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424000689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424000689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:27:52Z","timestamp":1762457272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424000689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":69,"alternative-id":["S2352396424000689"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105033","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenome-wide Mendelian randomization analysis reveals multiple health comorbidities of coeliac disease","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105033"}}