{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:31:55Z","timestamp":1790757115614,"version":"4.1.0"},"reference-count":8,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.ebiom.2024.105059","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T17:14:51Z","timestamp":1710609291000},"page":"105059","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The HHIP gene: from a candidate to an established participant in COPD susceptibility"],"prefix":"10.1016","volume":"102","author":[{"given":"Zakaria","family":"Lahmar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Bergougnoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-5209","authenticated-orcid":false,"given":"Arnaud","family":"Bourdin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2024.105059_bib1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/ng.3752","article-title":"Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis","volume":"49","author":"Hobbs","year":"2017","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2024.105059_bib2","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.3390\/ijms23095265","article-title":"Hedgehog signaling pathway orchestrates human lung branching morphogenesis","volume":"23","author":"Belgacemi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2024.105059_bib3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41580-019-0141-3","article-title":"Cellular crosstalk in the development and regeneration of the respiratory system","volume":"20","author":"Zepp","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ebiom.2024.105059_bib4","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.144575","article-title":"Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice","volume":"6","author":"Yun","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.ebiom.2024.105059_bib5","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/hmg\/ddr569","article-title":"Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP","volume":"21","author":"Zhou","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ebiom.2024.105059_bib6","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1101\/gad.1026303","article-title":"Feedback control of mammalian hedgehog signaling by the hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung","volume":"17","author":"Chuang","year":"2003","journal-title":"Genes Dev"},{"key":"10.1016\/j.ebiom.2024.105059_bib7","doi-asserted-by":"crossref","first-page":"E4681","DOI":"10.1073\/pnas.1602342113","article-title":"Hhip haploinsufficiency sensitizes mice to age-related emphysema","volume":"113","author":"Lao","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2024.105059_bib8","doi-asserted-by":"crossref","first-page":"105026","DOI":"10.1016\/j.ebiom.2024.105026","article-title":"Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells","volume":"101","author":"Guo","year":"2024","journal-title":"eBioMedicine"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642400094X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642400094X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T18:51:25Z","timestamp":1738003885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235239642400094X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":8,"alternative-id":["S235239642400094X"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105059","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The HHIP gene: from a candidate to an established participant in COPD susceptibility","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105059"}}