{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:01:58Z","timestamp":1789142518464,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ebiom.2024.105140","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T21:58:31Z","timestamp":1715637511000},"page":"105140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Human antibody signatures towards the Chlamydia trachomatis major outer membrane protein after natural infection and vaccination"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0085-7883","authenticated-orcid":false,"given":"Ida","family":"Rosenkrands","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja W.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Knudsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nida","family":"Dehari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene B\u00e6k","family":"Juel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah M.","family":"Cheeseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin J.","family":"Shattock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Follmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2024.105140_bib1","series-title":"Global health sector strategy on sexually transmitted infections 2016\u20132021","year":"2016"},{"key":"10.1016\/j.ebiom.2024.105140_bib2","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1017\/S0950268818002704","article-title":"Repeated Chlamydia trachomatis infections are associated with lower bacterial loads","volume":"147","author":"Gupta","year":"2018","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.ebiom.2024.105140_bib3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00007435-198707000-00008","article-title":"Effect of prior sexually transmitted disease on the isolation of Chlamydia trachomatis","volume":"14","author":"Katz","year":"1987","journal-title":"Sex Transm Dis"},{"issue":"Suppl 2","key":"10.1016\/j.ebiom.2024.105140_bib4","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1086\/652400","article-title":"Protective immunity to Chlamydia trachomatis genital infection: evidence from human studies","volume":"201","author":"Batteiger","year":"2010","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105140_bib5","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1093\/infdis\/jit094","article-title":"Spontaneous resolution of genital Chlamydia trachomatis infection in women and protection from reinfection","volume":"207","author":"Geisler","year":"2013","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105140_bib6","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/infdis\/173.4.950","article-title":"The epidemiology of Chlamydia trachomatis within a sexually transmitted diseases core group","volume":"173","author":"Brunham","year":"1996","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105140_bib7","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.3389\/fimmu.2018.01981","article-title":"An adaptive Chlamydia trachomatis-specific IFN-gamma-Producing CD4(+) T cell response is associated with protection against Chlamydia reinfection in women","volume":"9","author":"Bakshi","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2024.105140_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13103","article-title":"Anti-chlamydia IgG and IgA are insufficient to prevent endometrial chlamydia infection in women, and increased anti-chlamydia IgG is associated with enhanced risk for incident infection","volume":"81","author":"Darville","year":"2019","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.ebiom.2024.105140_bib9","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1128\/iai.11.4.698-703.1975","article-title":"Neutralization of Chlamydia trachomatis in cell culture","volume":"11","author":"Howard","year":"1975","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1128\/iai.65.1.317-319.1997","article-title":"Chlamydia trachomatis major outer membrane protein variants escape neutralization by both monoclonal antibodies and human immune sera","volume":"65","author":"Lampe","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib11","first-page":"95","author":"Jones","year":"1994"},{"key":"10.1016\/j.ebiom.2024.105140_bib12","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4103\/ijmm.IJMM_17_1","article-title":"Systemic antibody response to Chlamydia Trachomatis infection in patients either infected or reinfected with different Chlamydia serovars","volume":"35","author":"Gupta","year":"2017","journal-title":"Indian J Med Microbiol"},{"key":"10.1016\/j.ebiom.2024.105140_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0258759","article-title":"Human genital antibody-mediated inhibition of Chlamydia trachomatis infection and evidence for ompA genotype-specific neutralization","volume":"16","author":"Ardizzone","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2024.105140_bib14","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1128\/iai.61.4.1365-1370.1993","article-title":"Characterization of a neutralizing monoclonal antibody directed at variable domain I of the major outer membrane protein of Chlamydia trachomatis C-complex serovars","volume":"61","author":"Qu","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib15","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1128\/iai.59.11.4147-4153.1991","article-title":"Functional and structural mapping of Chlamydia trachomatis species-specific major outer membrane protein epitopes by use of neutralizing monoclonal antibodies","volume":"59","author":"Peterson","year":"1991","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1084\/jem.175.1.227","article-title":"Immunogenicity of a chimeric peptide corresponding to T helper and B cell epitopes of the Chlamydia trachomatis major outer membrane protein","volume":"175","author":"Su","year":"1992","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.ebiom.2024.105140_bib17","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1473-3099(19)30279-8","article-title":"Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial","volume":"19","author":"Abraham","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105140_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1057375","article-title":"Multi-component prime-boost Chlamydia trachomatis vaccination regimes induce antibody and T cell responses and accelerate clearance of infection in a non-human primate model","volume":"13","author":"Lorenzen","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2024.105140_bib19","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/infdis\/jiv137","article-title":"Protection against Chlamydia trachomatis infection and upper genital tract pathological changes by vaccine-promoted neutralizing antibodies directed to the VD4 of the major outer membrane protein","volume":"212","author":"Olsen","year":"2015","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105140_bib20","first-page":"349","article-title":"Detection of antibodies to Chlamydia trachomatis with peptide-based species-specific enzyme immunoassay","volume":"5","author":"Narvanen","year":"1997","journal-title":"Infect Dis Obstet Gynecol"},{"key":"10.1016\/j.ebiom.2024.105140_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/sextrans-2018-053915","article-title":"Prevalence and persistence of Chlamydia trachomatis-specific antibodies after occasional and recurrent infections","volume":"96","author":"Ohman","year":"2019","journal-title":"Sex Transm Infect"},{"key":"10.1016\/j.ebiom.2024.105140_bib22","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1086\/508203","article-title":"Identification of CT521 as a frequent target of Th1 cells in patients with urogenital Chlamydia trachomatis infection","volume":"194","author":"Olsen","year":"2006","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105140_bib23","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1086\/522524","article-title":"Identification of human T cell targets recognized during Chlamydia trachomatis genital infection","volume":"196","author":"Olsen","year":"2007","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105140_bib24","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1128\/IAI.66.8.3618-3625.1998","article-title":"Phylogenetic analysis of the Chlamydia trachomatis major outer membrane protein and examination of potential pathogenic determinants","volume":"66","author":"Stothard","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010768","article-title":"Protection against Chlamydia promoted by a subunit vaccine (CTH1) compared with a primary intranasal infection in a mouse genital challenge model","volume":"5","author":"Olsen","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2024.105140_bib26","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.xphs.2018.02.005","article-title":"Unusual self-assembly of the recombinant Chlamydia trachomatis major outer membrane protein-based fusion antigen CTH522 into protein nanoparticles","volume":"107","author":"Rose","year":"2018","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.ebiom.2024.105140_bib27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/infdis\/168.2.415","article-title":"Workshop on in\u00a0vitro neutralization of Chlamydia trachomatis: summary of proceedings","volume":"168","author":"Byrne","year":"1993","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105140_bib28","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41541-021-00312-9","article-title":"A\u00a0Chlamydia trachomatis VD1-MOMP vaccine elicits cross-neutralizing and protective antibodies against C\/C-related complex serovars","volume":"6","author":"Olsen","year":"2021","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.ebiom.2024.105140_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/105294199277860","article-title":"The international conference on harmonization good clinical practice guideline","volume":"6","author":"Dixon","year":"1999","journal-title":"Qual Assur"},{"key":"10.1016\/j.ebiom.2024.105140_bib30","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/s41467-024-45526-2","article-title":"Immune signature of Chlamydia vaccine CTH522\/CAF\u00ae01 translates from mouse-to-human and induces durable protection in mice","volume":"15","author":"Olsen","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2024.105140_bib31","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1128\/iai.59.10.3811-3814.1991","article-title":"Expression of Fc gamma RIII on HeLa 229 cells: possible effect on in\u00a0vitro neutralization of Chlamydia trachomatis","volume":"59","author":"Su","year":"1991","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/iai.38.2.745-754.1982","article-title":"Neutralization of Chlamydia trachomatis infectivity with antibodies to the major outer membrane protein","volume":"38","author":"Caldwell","year":"1982","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib33","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1016\/j.vaccine.2009.05.008","article-title":"Protection against an intranasal challenge by vaccines formulated with native and recombinant preparations of the Chlamydia trachomatis major outer membrane protein","volume":"27","author":"Sun","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.ebiom.2024.105140_bib34","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1128\/iai.58.5.1450-1455.1990","article-title":"Mapping antigenic sites on the major outer membrane protein of Chlamydia trachomatis with synthetic peptides","volume":"58","author":"Zhong","year":"1990","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib35","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00654-20","article-title":"Antibodies to variable domain 4 linear epitopes of the Chlamydia trachomatis major outer membrane protein are not associated with Chlamydia resolution or reinfection in women","volume":"5","author":"Collar","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.ebiom.2024.105140_bib36","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1128\/IAI.00574-08","article-title":"Protection of wild-type and severe combined immunodeficiency mice against an intranasal challenge by passive immunization with monoclonal antibodies to the Chlamydia trachomatis mouse pneumonitis major outer membrane protein","volume":"76","author":"Pal","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib37","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.3389\/fimmu.2017.01652","article-title":"Protective effect of vaccine promoted neutralizing antibodies against the intracellular pathogen Chlamydia trachomatis","volume":"8","author":"Olsen","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2024.105140_bib38","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.1073\/pnas.85.11.4000","article-title":"Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes","volume":"85","author":"Baehr","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ebiom.2024.105140_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068934","article-title":"A\u00a03-dimensional trimeric beta-barrel model for Chlamydia MOMP contains conserved and novel elements of Gram-negative bacterial porins","volume":"8","author":"Feher","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2024.105140_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013171","article-title":"Adaptive evolution of the Chlamydia trachomatis dominant antigen reveals distinct evolutionary scenarios for B- and T-cell epitopes: worldwide survey","volume":"5","author":"Nunes","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2024.105140_bib41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2958.1989.tb00176.x","article-title":"The major outer membrane protein of Chlamydia trachomatis: critical binding site and conformation determine the specificity of antibody binding to viable chlamydiae","volume":"3","author":"Conlan","year":"1989","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.ebiom.2024.105140_bib42","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1128\/iai.64.7.2839-2841.1996","article-title":"Species-, serogroup-, and serovar-specific epitopes are juxtaposed in variable sequence region 4 of the major outer membrane proteins of some Chlamydia trachomatis serovars","volume":"64","author":"Batteiger","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib43","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1073\/pnas.0508983103","article-title":"Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigen","volume":"103","author":"Crane","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ebiom.2024.105140_bib44","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/mbo3.186","article-title":"All subtypes of the Pmp adhesin family are implicated in chlamydial virulence and show species-specific function","volume":"3","author":"Becker","year":"2014","journal-title":"Microbiologyopen"},{"key":"10.1016\/j.ebiom.2024.105140_bib45","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1046\/j.1365-2958.2000.02167.x","article-title":"Characterization and functional analysis of PorB, a Chlamydia porin and neutralizing target","volume":"38","author":"Kubo","year":"2000","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.ebiom.2024.105140_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1099\/jmm.0.46801-0","article-title":"Chlamydia trachomatis OmcB protein is a surface-exposed glycosaminoglycan-dependent adhesin","volume":"56","author":"Fadel","year":"2007","journal-title":"J\u00a0Med Microbiol"},{"key":"10.1016\/j.ebiom.2024.105140_bib47","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00246-18","article-title":"Discovery of human-specific immunodominant Chlamydia trachomatis B cell epitopes","volume":"3","author":"Rahman","year":"2018","journal-title":"mSphere"},{"key":"10.1016\/j.ebiom.2024.105140_bib48","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.0019-2805.2001.01354.x","article-title":"Fc receptor regulation of protective immunity against Chlamydia trachomatis","volume":"105","author":"Moore","year":"2002","journal-title":"Immunology"},{"key":"10.1016\/j.ebiom.2024.105140_bib49","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.1128\/IAI.00622-10","article-title":"CD4+ T cells and antibody are required for optimal major outer membrane protein vaccine-induced immunity to Chlamydia muridarum genital infection","volume":"78","author":"Farris","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib50","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1128\/IAI.00749-16","article-title":"IFNgamma is required for optimal antibody-mediated immunity against genital Chlamydia infection","volume":"84","author":"Naglak","year":"2016","journal-title":"Infect Immun"},{"key":"10.1016\/j.ebiom.2024.105140_bib51","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1093\/infdis\/jiw485","article-title":"Identification of Chlamydia trachomatis antigens recognized by T cells from highly exposed women who limit or resist genital tract infection","volume":"214","author":"Russell","year":"2016","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105140_bib52","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/infdis\/jiz087","article-title":"Cervical cytokines associated with Chlamydia trachomatis susceptibility and protection","volume":"220","author":"Poston","year":"2019","journal-title":"J\u00a0Infect Dis"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424001750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424001750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T13:20:04Z","timestamp":1718544004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424001750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":52,"alternative-id":["S2352396424001750"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105140","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human antibody signatures towards the Chlamydia trachomatis major outer membrane protein after natural infection and vaccination","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105140"}}