{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:56:28Z","timestamp":1790621788587,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-20-F2II-0003"],"award-info":[{"award-number":["ANR-20-F2II-0003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004571","name":"Minist\u00e8re des Affaires Sociales et de la Sant\u00e9","doi-asserted-by":"publisher","award":["AOM19330"],"award-info":[{"award-number":["AOM19330"]}],"id":[{"id":"10.13039\/501100004571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health & Wellness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.ebiom.2024.105145","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T09:43:27Z","timestamp":1714988607000},"page":"105145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["First-in-man use of a cardiovascular cell-derived secretome in heart failure. Case report"],"prefix":"10.1016","volume":"103","author":[{"given":"Philippe","family":"Menasch\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisa K.","family":"Renault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hag\u00e8ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Puscas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Bellamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Humbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Blons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Granier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Benhamouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4538-6646","authenticated-orcid":false,"given":"Anne","family":"Bacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Churlaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Sabatier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Larghero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2024.105145_bib1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.stem.2013.05.008","article-title":"Cardiac stem cell therapy and the promise of heart regeneration","volume":"12","author":"Garbern","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ebiom.2024.105145_bib2","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1161\/CIRCRESAHA.117.311578","article-title":"Lack of remuscularization following transplantation of human embryonic stem cell-derived cardiovascular progenitor cells in infarct-ed nonhuman primates\u2019","volume":"122","author":"Zhu","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.ebiom.2024.105145_bib3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jacc.2017.11.047","article-title":"Transplantation of human embryonic stem cell-derived cardiovascular progenitors for severe ischemic left ventricular dys-function\u2019","volume":"71","author":"Menasch\u00e9","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ebiom.2024.105145_bib4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.healun.2016.01.013","article-title":"Cardiovascular progenitor\u2013derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure","volume":"35","author":"Kervadec","year":"2016","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.ebiom.2024.105145_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1206279","article-title":"Therapeutic potential of extracellular vesicles derived from cardiac progenitor cells in rodent models of chemotherapy-induced cardiomyopathy","volume":"10","author":"Desgres","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.ebiom.2024.105145_bib6","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/eurheartj\/ehy012","article-title":"Acellular therapeutic approach for heart failure: in\u00a0vitro production of extracellular vesicles from human cardiovascular progenitors","volume":"39","author":"El Harane","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ebiom.2024.105145_bib7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/cvr\/cvaa028","article-title":"Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts","volume":"117","author":"Lima Correa","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ebiom.2024.105145_bib8","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.7150\/thno.62304","article-title":"Extracellular vesicles fail to trigger the generation of new cardiomyocytes in chronically infarcted hearts","volume":"11","author":"Lima Correa","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.ebiom.2024.105145_bib9","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1002\/ejhf.1236","article-title":"Advanced heart failure: a position statement of the heart failure association of the European society of Cardiology","volume":"20","author":"Crespo-Leiro","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ebiom.2024.105145_bib10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3390\/pharmaceutics15020325","article-title":"Small extracellular vesicles as a new class of medicines","volume":"15","author":"Lee","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ebiom.2024.105145_bib11","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s12015-021-10289-6","article-title":"Extracellular vesicles as a cell-free therapy for cardiac repair: a systematic Review and meta-analysis of randomized controlled preclinical trials in animal myocardial infarction models","volume":"18","author":"Khan","year":"2022","journal-title":"Stem Cell Rev Rep"},{"key":"10.1016\/j.ebiom.2024.105145_bib12","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/s41419-022-05034-x","article-title":"Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?","volume":"13","author":"Kou","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ebiom.2024.105145_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41582-022-00736-4","article-title":"Cell-based therapies for neurological disorders \u2014 the bioreactor hypothesis","volume":"19","author":"Savitz","year":"2023","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.ebiom.2024.105145_bib14","doi-asserted-by":"crossref","first-page":"7831","DOI":"10.3390\/ijms22157831","article-title":"Targeting inflammation after myocardial infarction: a therapeutic opportunity for extracellular vesicles?","volume":"22","author":"Viola","year":"2021","journal-title":"IJMS"},{"key":"10.1016\/j.ebiom.2024.105145_bib15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41569-019-0315-x","article-title":"Reappraising the role of inflammation in heart failure","volume":"17","author":"Adamo","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.ebiom.2024.105145_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/sctm.19-0202","article-title":"Trends in mesenchymal stem cell clinical trials 2004-2018: is efficacy optimal in a narrow dose range?\u2019","volume":"9","author":"Kabat","year":"2020","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.ebiom.2024.105145_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh1168","article-title":"The cellular response to extracellular vesicles is dependent on their cell source and dose","volume":"9","author":"Hagey","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.ebiom.2024.105145_bib18","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.tcb.2020.09.009","article-title":"Extracellular vesicle-associated proteins in tissue repair","volume":"30","author":"Roefs","year":"2020","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.ebiom.2024.105145_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax8005","article-title":"Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip","volume":"12","author":"Yadid","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ebiom.2024.105145_bib20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/cells7120273","article-title":"Tangential flow filtration for highly efficient concentration of extracellular vesicles from large volumes of fluid","volume":"7","author":"Busatto","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.ebiom.2024.105145_bib21","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/CIRCRESAHA.116.309782","article-title":"A\u00a0deep proteome analysis identifies the complete secretome as the functional unit of human cardiac progenitor cells","volume":"120","author":"Sharma","year":"2017","journal-title":"Circ Res"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424001804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424001804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T07:44:58Z","timestamp":1738482298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424001804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":21,"alternative-id":["S2352396424001804"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105145","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First-in-man use of a cardiovascular cell-derived secretome in heart failure. Case report","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105145","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105145"}}