{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:45:19Z","timestamp":1793886319048,"version":"4.8.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1134649\/INV-000247"],"award-info":[{"award-number":["OPP1134649\/INV-000247"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ebiom.2024.105166","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T17:31:33Z","timestamp":1717435893000},"page":"105166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["A microbiota-directed complementary food intervention in 12\u201318-month-old Bangladeshi children improves linear growth"],"prefix":"10.1016","volume":"104","author":[{"given":"Ishita","family":"Mostafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6520-677X","authenticated-orcid":false,"given":"Matthew C.","family":"Hibberd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8561-3417","authenticated-orcid":false,"given":"Steven J.","family":"Hartman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0005-2516","authenticated-orcid":false,"given":"Md Hasan","family":"Hafizur Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Mahfuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-4072","authenticated-orcid":false,"given":"S.M. Tafsir","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Ashorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Barratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahmeed","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8304-3548","authenticated-orcid":false,"given":"Jeffrey I.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2024.105166_bib1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0140-6736(07)61690-0","article-title":"Maternal and child undernutrition study group. maternal and child undernutrition: global and regional exposures and health consequences","volume":"371","author":"Black","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2024.105166_bib3","series-title":"Levels and trends in child malnutrition: UNICEF\/WHO\/World bank group joint child malnutrition estimates: key findings of the 2023 edition","year":"2023"},{"key":"10.1016\/j.ebiom.2024.105166_bib4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/mcn.12231","article-title":"Childhood stunting: a global perspective","volume":"12","author":"de Onis","year":"2016","journal-title":"Matern Child Nutr"},{"key":"10.1016\/j.ebiom.2024.105166_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1368980018002434","article-title":"Prevalence thresholds for wasting, overweight and stunting in children under 5 years","volume":"22","author":"de Onis","year":"2019","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.ebiom.2024.105166_bib6","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1186\/s12889-021-12178-6","article-title":"Factors contributing to the reduction in childhood stunting in Bangladesh: a pooled data analysis from the Bangladesh demographic and health surveys of 2004 and 2017\u201318","volume":"21","author":"Kumar","year":"2021","journal-title":"BMC Public Health"},{"key":"10.1016\/j.ebiom.2024.105166_bib7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0140-6736(07)61692-4","article-title":"For the maternal and child undernutrition group. Maternal and child undernutrition: consequences for adult health and human capital","volume":"371","author":"Victora","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2024.105166_bib8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1740-8709.2011.00349.x","article-title":"Long-term consequences of stunting in early life","volume":"Suppl 3","author":"Dewey","year":"2011","journal-title":"Matern Child Nutr"},{"key":"10.1016\/j.ebiom.2024.105166_bib9","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3390\/nu15051076","article-title":"Effectiveness of dietary management for moderate wasting among children > 6 Months of age-A systematic review and meta-analysis exploring different types, quantities, and durations","volume":"15","author":"Cichon","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.ebiom.2024.105166_bib10","series-title":"Guideline: updates on the management of severe acute malnutrition in infants and children","year":"2013"},{"key":"10.1016\/j.ebiom.2024.105166_bib11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/nutrit\/nuy068","article-title":"Environmental enteric dysfunction and child stunting","volume":"77","author":"Budge","year":"2019","journal-title":"Nutr Rev"},{"issue":"Suppl 1","key":"10.1016\/j.ebiom.2024.105166_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/mcn.12282","article-title":"Reducing stunting by improving maternal, infant and young child nutrition in regions such as South Asia: evidence, challenges and opportunities","volume":"12","author":"Dewey","year":"2016","journal-title":"Matern Child Nutr"},{"key":"10.1016\/j.ebiom.2024.105166_bib13","article-title":"Nutritional interventions for preventing stunting in children (birth to 59 months) living in urban slums in low- and middle-income countries (LMIC)","volume":"6","author":"Goudet","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ebiom.2024.105166_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0230480","article-title":"Concurrently wasted and stunted 6-59 months children admitted to the outpatient therapeutic feeding programme in Karamoja, Uganda: prevalence, characteristics, treatment outcomes and response","volume":"15","author":"Odei Obeng-Amoako","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2024.105166_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/mcn.12817","article-title":"Linear growth faltering and the role of weight attainment: prospective analysis of young children recovering from severe wasting in Niger","volume":"15","author":"Isanaka","year":"2019","journal-title":"Matern Child Nutr"},{"key":"10.1016\/j.ebiom.2024.105166_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/mcn.13246","article-title":"The relationship between wasting and stunting in young children: a systematic review","volume":"18","author":"Thurstans","year":"2022","journal-title":"Matern Child Nutr"},{"key":"10.1016\/j.ebiom.2024.105166_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1740-8709.2004.00004.x","article-title":"Infant weight-for-length is positively associated with subsequent linear growth across four different populations","volume":"1","author":"Dewey","year":"2005","journal-title":"Matern Child Nutr"},{"key":"10.1016\/j.ebiom.2024.105166_bib18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1651-2227.2003.tb00584.x","article-title":"Seasonality of growth and the relationship between weight and height gain in children under three years of age in rural Malawi","volume":"92","author":"Maleta","year":"2003","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.ebiom.2024.105166_bib19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature13421","article-title":"Persistent gut microbiota immaturity in malnourished Bangladeshi children","volume":"510","author":"Subramanian","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2024.105166_bib20","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.chom.2022.04.002","article-title":"Gut microbiome development and childhood undernutrition","volume":"30","author":"Barratt","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ebiom.2024.105166_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau4735","article-title":"A\u00a0sparse covarying unit that describes healthy and impaired human gut microbiota development","volume":"365","author":"Raman","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2024.105166_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad3311","article-title":"Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children","volume":"351","author":"Blanton","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2024.105166_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau4732","article-title":"Effects of microbiota-directed foods in gnotobiotic animals and undernourished children","volume":"365","author":"Gehrig","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2024.105166_bib24","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12889-020-8330-8","article-title":"Proof-of-concept study of the efficacy of a microbiota-directed complementary food formulation (MDCF) for treating moderate acute malnutrition","volume":"20","author":"Mostafa","year":"2020","journal-title":"BMC Public Health"},{"key":"10.1016\/j.ebiom.2024.105166_bib25","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1056\/NEJMoa2023294","article-title":"A\u00a0microbiota-directed food intervention for undernourished children","volume":"384","author":"Chen","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ebiom.2024.105166_bib26","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0140-6736(16)31529-X","article-title":"Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study","volume":"388","author":"Liu","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2024.105166_bib27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41586-023-06838-3","article-title":"Bioactive glycans in a microbiome-directed food for malnourished children","volume":"625","author":"Hibberd","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2024.105166_bib28","doi-asserted-by":"crossref","first-page":"e1309","DOI":"10.1016\/S2214-109X(18)30349-8","article-title":"Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study","volume":"6","author":"Platts-Mills","year":"2018","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.ebiom.2024.105166_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J\u00a0R Stat Soc Series B Stat Methodol"},{"key":"10.1016\/j.ebiom.2024.105166_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128036","article-title":"Inexpensive multiplexed library preparation for megabase-sized genomes","volume":"10","author":"Baym","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2024.105166_bib31","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ebiom.2024.105166_bib32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13059-019-1891-0","article-title":"Improved metagenomic analysis with Kraken 2","volume":"20","author":"Wood","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.ebiom.2024.105166_bib33","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.7717\/peerj-cs.104","article-title":"Bracken: estimating species abundance in metagenomics data","volume":"3","author":"Lu","year":"2017","journal-title":"PeerJ Comput Sci"},{"key":"10.1016\/j.ebiom.2024.105166_bib34","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/bioinformatics\/btz848","article-title":"GTDB-Tk: a toolkit to classify genomes with the genome taxonomy database","volume":"36","author":"Chaumeil","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ebiom.2024.105166_bib35","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/bioinformatics\/btaa687","article-title":"Dream: powerful differential expression analysis for repeated measures designs","volume":"37","author":"Hoffman","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ebiom.2024.105166_bib36","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.ebiom.2024.105166_bib37","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.ebiom.2024.105166_bib38","series-title":"Indicators for assessing infant and young child feeding practices: definitions and measurement methods","year":"2021"},{"key":"10.1016\/j.ebiom.2024.105166_bib39","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1128\/AEM.68.10.5186-5190.2002","article-title":"Acetate utilization and butyryl coenzyme A (CoA):acetate-CoA transferase in butyrate-producing bacteria from the human large intestine","volume":"68","author":"Duncan","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.ebiom.2024.105166_bib40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.anaerobe.2016.12.001","article-title":"Blautia massiliensis sp. nov., isolated from a fresh human fecal sample and emended description of the genus Blautia","volume":"43","author":"Durand","year":"2017","journal-title":"Anaerobe"},{"key":"10.1016\/j.ebiom.2024.105166_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1109889","article-title":"Profiling Blautia at high taxonomic resolution reveals correlations with cognitive dysfunction in Chinese children with Down syndrome","volume":"13","author":"Hou","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.ebiom.2024.105166_bib42","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.devcel.2004.10.009","article-title":"Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO","volume":"7","author":"Cole","year":"2004","journal-title":"Dev Cell"},{"key":"10.1016\/j.ebiom.2024.105166_bib43","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1046\/j.1523-1747.2002.01863.x","article-title":"Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis","volume":"119","author":"Takeda","year":"2002","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.ebiom.2024.105166_bib44","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1128\/MCB.25.13.5599-5606.2005","article-title":"Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head","volume":"25","author":"Hankenson","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ebiom.2024.105166_bib45","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.matbio.2017.11.006","article-title":"Thrombospondin-4 in tissue remodeling","volume":"75-76","author":"Stenina-Adognravi","year":"2019","journal-title":"Matrix Biol"},{"key":"10.1016\/j.ebiom.2024.105166_bib46","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1210\/er.2010-0023","article-title":"Evidence for a continuum of genetic, phenotypic, and biochemical abnormalities in children with growth hormone insensitivity","volume":"32","author":"David","year":"2011","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ebiom.2024.105166_bib47","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1056\/NEJMoa1509342","article-title":"Cortical-bone fragility--insights from sFRP4 deficiency in pyle's Disease","volume":"374","author":"Kiper","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ebiom.2024.105166_bib48","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0959-4388(99)00048-3","article-title":"The GDNF family ligands and receptors - implications for neural development","volume":"10","author":"Baloh","year":"2000","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.ebiom.2024.105166_bib49","article-title":"The role of SliTrk5 in central nervous system","volume":"2022","author":"Liu","year":"2022","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.ebiom.2024.105166_bib50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","article-title":"Neurotrophin regulation of neural circuit development and function","volume":"14","author":"Park","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ebiom.2024.105166_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2023.152070","article-title":"Robo2 promotes osteoblast differentiation and mineralization through autophagy and is activated by parathyroid hormone induction","volume":"248","author":"Yuan","year":"2023","journal-title":"Ann Anat"},{"key":"10.1016\/j.ebiom.2024.105166_bib52","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41467-023-36135-6","article-title":"The gut microbiome and early-life growth in a population with high prevalence of stunting","volume":"14","author":"Robertson","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2024.105166_bib53","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/s41564-024-01628-7","article-title":"Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition","volume":"9","author":"Chang","year":"2024","journal-title":"Nat Microbiol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424002019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424002019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:37:28Z","timestamp":1778873848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424002019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":52,"alternative-id":["S2352396424002019"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105166","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.04.29.24306564","asserted-by":"object"}]},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A microbiota-directed complementary food intervention in 12\u201318-month-old Bangladeshi children improves linear growth","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105166"}}