{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:38:07Z","timestamp":1792226287166,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ebiom.2024.105175","type":"journal-article","created":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T01:40:57Z","timestamp":1717206057000},"page":"105175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Impact of insomnia on ovarian cancer risk and survival: a\u00a0Mendelian randomization study"],"prefix":"10.1016","volume":"104","author":[{"given":"Heming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett M.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0574-5071","authenticated-orcid":false,"given":"Rebecca C.","family":"Richmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke L.","family":"Fridley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Redline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley S.","family":"Tworoger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-408X","authenticated-orcid":false,"given":"Xuefeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ebiom.2024.105175_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105175_bib2","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2174\/1389202921999200403151720","article-title":"The association of sleep disorders, obesity and sleep-related hypoxia with cancer","volume":"21","author":"Brzecka","year":"2020","journal-title":"Curr Genom"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105175_bib3","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3390\/cancers14010258","article-title":"Neuropsychiatric disorders and frailty in older adults over the spectrum of cancer: a narrative review","volume":"14","author":"Muzyka","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.ebiom.2024.105175_bib4","article-title":"Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study","volume":"365","author":"Richmond","year":"2019","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105175_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1158\/1940-6207.CAPR-20-0174","article-title":"Sleep characteristics and risk of ovarian cancer among postmenopausal women","volume":"14","author":"Liang","year":"2021","journal-title":"Cancer Prev Res"},{"issue":"3 Suppl 1","key":"10.1016\/j.ebiom.2024.105175_bib6","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/j.amepre.2013.10.032","article-title":"Circadian disruption and fatal ovarian cancer","volume":"46","author":"Carter","year":"2014","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.ebiom.2024.105175_bib7","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jpsychires.2020.11.036","article-title":"Depression and sleep disorders are associated with early mortality in women with breast cancer in the United Kingdom","volume":"143","author":"Bach","year":"2021","journal-title":"J\u00a0Psychiatr Res"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105175_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.canlet.2013.09.040","article-title":"Circadian molecular clocks and cancer","volume":"342","author":"Kelleher","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ebiom.2024.105175_bib9","article-title":"Insomnia and circadian sleep disorders in ovarian cancer: evaluation and management of underestimated modifiable factors potentially contributing to morbidity","volume":"31","author":"Palagini","year":"2021","journal-title":"J\u00a0Sleep Res"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105175_bib10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/oemed-2012-101146","article-title":"Nightshift work and risk of ovarian cancer","volume":"70","author":"Bhatti","year":"2013","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.ebiom.2024.105175_bib11","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.3389\/fonc.2020.01006","article-title":"Association between night-shift work and cancer risk: updated systematic review and meta-analysis","volume":"10","author":"Dun","year":"2020","journal-title":"Front Oncol"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105175_bib12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/annweh\/wxaa017","article-title":"Use of a Canadian population-based surveillance cohort to test relationships between shift work and breast, ovarian, and prostate cancer","volume":"64","author":"Harris","year":"2020","journal-title":"Ann Work Expo Health"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105175_bib13","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1158\/1055-9965.EPI-18-1112","article-title":"Shift work patterns, chronotype, and epithelial ovarian cancer risk","volume":"28","author":"Leung","year":"2019","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105175_bib14","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s10552-015-0640-2","article-title":"Urinary melatonin and risk of ovarian cancer","volume":"26","author":"Poole","year":"2015","journal-title":"Cancer Causes Control"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105175_bib15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41588-019-0361-7","article-title":"Biological and clinical insights from genetics of insomnia symptoms","volume":"51","author":"Lane","year":"2019","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105175_bib16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/ije\/dyh132","article-title":"Mendelian randomization: prospects, potentials, and limitations","volume":"33","author":"Smith","year":"2004","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105175_bib17","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/ng.3826","article-title":"Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer","volume":"49","author":"Phelan","year":"2017","journal-title":"Nat Genet"},{"issue":"23","key":"10.1016\/j.ebiom.2024.105175_bib18","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1158\/1078-0432.CCR-15-0632","article-title":"Genome-wide analysis identifies novel loci associated with ovarian cancer outcomes: findings from the ovarian cancer association consortium","volume":"21","author":"Johnatty","year":"2015","journal-title":"Clin Cancer Res"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105175_bib19","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/s41588-022-01124-w","article-title":"Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways","volume":"54","author":"Watanabe","year":"2022","journal-title":"Nat Genet"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105175_bib20","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/bioinformatics\/btaa985","article-title":"An iterative approach to detect pleiotropy and perform Mendelian Randomization analysis using GWAS summary statistics","volume":"37","author":"Zhu","year":"2021","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105175_bib21","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105175_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010596","article-title":"Strategies to investigate and mitigate collider bias in genetic and Mendelian randomisation studies of disease progression","volume":"19","author":"Mitchell","year":"2023","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ebiom.2024.105175_bib23","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians","volume":"362","author":"Davies","year":"2018","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105175_bib24","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/ije\/dyx102","article-title":"Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption","volume":"46","author":"Hartwig","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105175_bib25","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105175_bib26","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105175_bib27","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105175_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007081","article-title":"Orienting the causal relationship between imprecisely measured traits using GWAS summary data","volume":"13","author":"Hemani","year":"2017","journal-title":"PLoS Genet"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105175_bib29","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1214\/19-AOS1866","article-title":"Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score","volume":"48","author":"Zhao","year":"2020","journal-title":"Ann Stat"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105175_bib30","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/s41467-019-09432-2","article-title":"Mendelian randomization analysis using mixture models for robust and efficient estimation of causal effects","volume":"10","author":"Qi","year":"2019","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105175_bib31","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1093\/ije\/dyy265","article-title":"Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression","volume":"47","author":"Bowden","year":"2018","journal-title":"Int J Epidemiol"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105175_bib32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/aje\/kwu283","article-title":"Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects","volume":"181","author":"Burgess","year":"2015","journal-title":"Am J Epidemiol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105175_bib33","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/s41467-019-08917-4","article-title":"Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates","volume":"10","author":"Dashti","year":"2019","journal-title":"Nat Commun"},{"issue":"20","key":"10.1016\/j.ebiom.2024.105175_bib34","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1093\/hmg\/ddy271","article-title":"Meta-analysis of genome-wide association studies for height and body mass index in approximately 700000 individuals of European ancestry","volume":"27","author":"Yengo","year":"2018","journal-title":"Hum Mol Genet"},{"issue":"7520","key":"10.1016\/j.ebiom.2024.105175_bib35","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13545","article-title":"Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche","volume":"514","author":"Perry","year":"2014","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105175_bib36","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ng.3412","article-title":"Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair","volume":"47","author":"Day","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2024.105175_bib37","article-title":"The MRC IEU OpenGWAS data infrastructure","volume":"2020.08.10","author":"Elsworth","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.ebiom.2024.105175_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2021.102057","article-title":"Sleep problems and risk of cancer incidence and mortality in an older cohort: the Cardiovascular Health Study (CHS)","volume":"76","author":"Sillah","year":"2022","journal-title":"Cancer Epidemiol"},{"issue":"10177","key":"10.1016\/j.ebiom.2024.105175_bib39","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0140-6736(18)32552-2","article-title":"Epithelial ovarian cancer","volume":"393","author":"Lheureux","year":"2019","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105175_bib40","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3322\/caac.21559","article-title":"Epithelial ovarian cancer: evolution of management in the era of precision medicine","volume":"69","author":"Lheureux","year":"2019","journal-title":"CA Cancer J Clin"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105175_bib41","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.3390\/diagnostics13081425","article-title":"Endometriosis-related ovarian cancers: evidence for a dichotomy in the histogenesis of the two associated histotypes","volume":"13","author":"Bergamini","year":"2023","journal-title":"Diagnostics"},{"key":"10.1016\/j.ebiom.2024.105175_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.856235","article-title":"Sleep disruption and cancer: chicken or the egg?","volume":"16","author":"Berisha","year":"2022","journal-title":"Front Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105175_bib43","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ygyno.2020.07.029","article-title":"When will I feel normal again? Trajectories and predictors of persistent symptoms and poor wellbeing after primary chemotherapy for ovarian cancer","volume":"159","author":"Beesley","year":"2020","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105175_bib44","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.ygyno.2020.06.500","article-title":"Insomnia and its association with quality of life in women with ovarian cancer","volume":"158","author":"Ross","year":"2020","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ebiom.2024.105175_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2021.102074","article-title":"Ovarian cancer survival by stage, histotype, and pre-diagnostic lifestyle factors, in the prospective UK Million Women Study","volume":"76","author":"Gaitskell","year":"2022","journal-title":"Cancer Epidemiol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105175_bib46","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/bjc.2015.245","article-title":"Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium","volume":"113","author":"Nagle","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ebiom.2024.105175_bib47","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.sleep.2019.02.018","article-title":"The course of cancer-related insomnia: don't expect it to disappear after cancer treatment","volume":"58","author":"Schieber","year":"2019","journal-title":"Sleep Med"},{"key":"10.1016\/j.ebiom.2024.105175_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2022.101615","article-title":"Systematic review and meta-analysis of cognitive-behavioural therapy for insomnia on subjective and actigraphy-measured sleep and comorbid symptoms in cancer survivors","volume":"63","author":"Squires","year":"2022","journal-title":"Sleep Med Rev"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105175_bib49","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1365-2648.2007.04560.x","article-title":"Efficacy of an insomnia intervention on fatigue, mood and quality of life in breast cancer survivors","volume":"61","author":"Dirksen","year":"2008","journal-title":"J\u00a0Adv Nurs"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105175_bib50","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/tbj.12862","article-title":"Management of side effects during and post-treatment in breast cancer survivors","volume":"24","author":"Palesh","year":"2018","journal-title":"Breast J"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105175_bib51","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1038\/s41467-019-09718-5","article-title":"Polygenic prediction via Bayesian regression and continuous shrinkage priors","volume":"10","author":"Ge","year":"2019","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105175_bib52","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2116729119","article-title":"The 103,200-arm acceleration dataset in the UK Biobank revealed a landscape of human sleep phenotypes","volume":"119","author":"Katori","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105175_bib53","first-page":"877","article-title":"Racial\/ethnic differences in sleep disturbances: the multi-ethnic study of atherosclerosis (MESA)","volume":"38","author":"Chen","year":"2015","journal-title":"Sleep"},{"issue":"23","key":"10.1016\/j.ebiom.2024.105175_bib54","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.1158\/1078-0432.CCR-16-1119","article-title":"Racial\/ethnic disparities in ovarian cancer treatment and survival","volume":"22","author":"Bandera","year":"2016","journal-title":"Clin Cancer Res"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642400210X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642400210X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T13:21:47Z","timestamp":1718544107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235239642400210X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":54,"alternative-id":["S235239642400210X"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105175","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of insomnia on ovarian cancer risk and survival: a\u00a0Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105175","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105175"}}