{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:51:43Z","timestamp":1793832703446,"version":"4.6.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T00:00:00Z","timestamp":1717286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.ebiom.2024.105205","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:24:47Z","timestamp":1719275087000},"page":"105205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1491-9179","authenticated-orcid":false,"given":"Sara Elizabeth","family":"Stinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0135-8218","authenticated-orcid":false,"given":"Pauline","family":"Kromann Reim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2711-1259","authenticated-orcid":false,"given":"Morten Asp Vonsild","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik","family":"Lausten-Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Aas Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-9020","authenticated-orcid":false,"given":"Charlotte","family":"Br\u00f8ns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Vaag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Krag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5031-0125","authenticated-orcid":false,"given":"Cilius Esmann","family":"Fonvig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Grarup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluf","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"\u00c4ngquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorkild I.A.","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Christian","family":"Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-3831","authenticated-orcid":false,"given":"Torben","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2024.105205_bib1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrendo.2016.127","article-title":"Long-term metabolic risk among children born premature or small for gestational age","volume":"13","author":"Mericq","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.ebiom.2024.105205_bib2","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1007\/s00125-023-05936-1","article-title":"Birthweight is associated with clinical characteristics in people with recently diagnosed type 2 diabetes","volume":"66","author":"Hansen","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.ebiom.2024.105205_bib3","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1038\/ijosup.2015.23","article-title":"Birth weight and childhood obesity: a 12-country study","volume":"5","author":"Qiao","year":"2015","journal-title":"Int J Obes Suppl"},{"key":"10.1016\/j.ebiom.2024.105205_bib4","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s00431-012-1701-0","article-title":"Birth weight and overweight\/obesity in adults: a meta-analysis","volume":"171","author":"Zhao","year":"2012","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.ebiom.2024.105205_bib5","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1001\/jamapediatrics.2023.0799","article-title":"Effect measure modification by birth weight on the association between overweight or obesity and hypertension in children and adolescents","volume":"177","author":"Nugent","year":"2023","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.ebiom.2024.105205_bib6","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00431-013-2113-5","article-title":"Does low birth weight affect the presence of cardiometabolic risk factors in overweight and obese children?","volume":"172","author":"Ponzio","year":"2013","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.ebiom.2024.105205_bib7","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1056\/NEJMoa2109191","article-title":"Childhood cardiovascular risk factors and adult cardiovascular events","volume":"386","author":"Jacobs","year":"2022","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ebiom.2024.105205_bib8","article-title":"Association of birth weight with type 2 diabetes and glycemic traits: a mendelian randomization study","volume":"2","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ebiom.2024.105205_bib9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature19806","article-title":"Genome-wide associations for birth weight and correlations with adult disease","volume":"538","author":"Horikoshi","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2024.105205_bib10","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/s41588-019-0403-1","article-title":"Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors","volume":"51","author":"Warrington","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2024.105205_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/JCI165402","article-title":"Monogenic disease analysis establishes that fetal insulin accounts for half of human fetal growth","volume":"133","author":"Hughes","year":"2023","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ebiom.2024.105205_bib12","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00125-021-05386-7","article-title":"Two decades since the fetal insulin hypothesis: what have we learned from genetics?","volume":"64","author":"Hughes","year":"2021","journal-title":"Diabetologia"},{"key":"10.1016\/j.ebiom.2024.105205_bib13","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3109\/17477166.2011.575157","article-title":"Chronic care treatment of obese children and adolescents","volume":"6","author":"Holm","year":"2011","journal-title":"Int J Pediatr Obes"},{"key":"10.1016\/j.ebiom.2024.105205_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cca.2021.10.024","article-title":"Population-based pediatric reference values for serum parathyroid hormone, vitamin D, calcium, and phosphate in Danish\/North-European white children and adolescents","volume":"523","author":"Vissing Landgrebe","year":"2021","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ebiom.2024.105205_bib15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/sj.ijo.0801515","article-title":"Body mass index of 0 to 45-y-old Danes: reference values and comparison with published European reference values","volume":"25","author":"Nysom","year":"2001","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.ebiom.2024.105205_bib16","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.2337\/dc21-S002","article-title":"2. Classification and diagnosis of diabetes","volume":"44","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ebiom.2024.105205_bib17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jpeds.2021.11.014","article-title":"Neonatal anthropometrics and obesity treatment response in children and adolescents","volume":"242","year":"2022","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.ebiom.2024.105205_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12889-015-1813-3","article-title":"Socioeconomic inequality and mortality - a regional Danish cohort study","volume":"15","author":"Ullits","year":"2015","journal-title":"BMC Publ Health"},{"key":"10.1016\/j.ebiom.2024.105205_bib19","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/pr.2015.160","article-title":"LMS tables for waist-circumference and waist-height ratio Z-scores in children aged 5-19 y in NHANES III: association with cardio-metabolic risks","volume":"78","author":"Sharma","year":"2015","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ebiom.2024.105205_bib20","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-1904","article-title":"Clinical Practice guideline for screening and management of high blood pressure in children and adolescents","volume":"140","author":"Flynn","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.ebiom.2024.105205_bib21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ajhg.2021.11.008","article-title":"Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort","volume":"109","author":"Priv\u00e9","year":"2022","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ebiom.2024.105205_bib22","series-title":"R: a language and environment for statistical computing","year":"2021"},{"key":"10.1016\/j.ebiom.2024.105205_bib23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1530\/EJE-21-1221","article-title":"Increased liver fat associates with severe metabolic perturbations in low birth weight men","volume":"186","author":"Br\u00f8ns","year":"2022","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ebiom.2024.105205_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jpeds.2017.03.007","article-title":"Low and high birth weights are risk factors for nonalcoholic fatty liver disease in children","volume":"187","author":"Newton","year":"2017","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.ebiom.2024.105205_bib25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000328198","article-title":"Obesity defined as excess storage of inert triglycerides--do we need a paradigm shift?","volume":"4","author":"S\u00f8rensen","year":"2011","journal-title":"Obes Facts"},{"key":"10.1016\/j.ebiom.2024.105205_bib26","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.2337\/db20-0070","article-title":"Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity","volume":"69","author":"Yaghootkar","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.ebiom.2024.105205_bib27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S2213-8587(13)70120-7","article-title":"Adiponectin and its receptors: implications for obesity-associated diseases and longevity","volume":"2","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.ebiom.2024.105205_bib28","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(13)60311-6","article-title":"Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease","volume":"382","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2024.105205_bib29","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41586-023-06563-x","article-title":"Large-scale plasma proteomics comparisons through genetics and disease associations","volume":"622","author":"Eldjarn","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2024.105205_bib30","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.2337\/db07-1476","article-title":"Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans","volume":"57","author":"Zhang","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.ebiom.2024.105205_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.metop.2020.100030","article-title":"Association of circulating FGF-21 levels in the first week of life and postnatal growth in hospitalized preterm infants","volume":"5","author":"Joung","year":"2020","journal-title":"Metabol Open"},{"key":"10.1016\/j.ebiom.2024.105205_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110436","article-title":"HAO1 negatively regulates liver macrophage activation via the NF-\u03baB pathway in alcohol-associated liver disease","volume":"99","author":"Chen","year":"2022","journal-title":"Cell Signal"},{"key":"10.1016\/j.ebiom.2024.105205_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-16944-3","article-title":"Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice","volume":"12","author":"Kawamura","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2024.105205_bib34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11154-021-09688-4","article-title":"The TWEAK\/Fn14\/CD163 axis-implications for metabolic disease","volume":"23","author":"Ratajczak","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.ebiom.2024.105205_bib35","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jacl.2016.02.015","article-title":"Identification and characterization of two novel mutations in the LPL gene causing type I hyperlipoproteinemia","volume":"10","author":"Pingitore","year":"2016","journal-title":"J\u00a0Clin Lipidol"},{"key":"10.1016\/j.ebiom.2024.105205_bib36","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1172\/JCI44945","article-title":"Loss of IL-15 receptor \u03b1 alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles","volume":"121","author":"Pistilli","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ebiom.2024.105205_bib37","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1038\/oby.2007.285","article-title":"Protein array reveals differentially expressed proteins in subcutaneous adipose tissue in obesity","volume":"15","author":"Skopkov\u00e1","year":"2007","journal-title":"Obesity"},{"key":"10.1016\/j.ebiom.2024.105205_bib38","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s42255-022-00525-9","article-title":"Impaired phosphocreatine metabolism in white adipocytes promotes inflammation","volume":"4","author":"Maqdasy","year":"2022","journal-title":"Nat Metab"},{"key":"10.1016\/j.ebiom.2024.105205_bib39","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/hmg\/ddab356","article-title":"Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight","volume":"31","author":"Thompson","year":"2022","journal-title":"Hum Mol Genet"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424002408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424002408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T02:23:42Z","timestamp":1728354222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424002408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":39,"alternative-id":["S2352396424002408"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105205","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interplay between birth weight and obesity in determining childhood and adolescent cardiometabolic risk","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105205","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105205"}}