{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:41:41Z","timestamp":1792597301849,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021170","name":"Brain Tumour Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.ebiom.2024.105211","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T14:41:12Z","timestamp":1719240072000},"page":"105211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Targeting histone deacetylase 6 (HDAC6) to enhance radiation therapy in meningiomas in a 2D and 3D in\u00a0vitro study"],"prefix":"10.1016","volume":"105","author":[{"given":"Juri","family":"Na","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahana","family":"Shaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Oliver","family":"Hanemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.ebiom.2024.105211_bib1","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1038\/onc.2010.609","article-title":"Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes","volume":"30","author":"Kalamarides","year":"2011","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105211_bib2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105211_bib3","doi-asserted-by":"crossref","first-page":"E461","DOI":"10.1093\/neuros\/nyy610","article-title":"Malignant meningioma: an international multicentre retrospective study","volume":"85","author":"Champeaux","year":"2019","journal-title":"Neurosurgery"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105211_bib4","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S1470-2045(17)30155-9","article-title":"DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis","volume":"18","author":"Sahm","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ebiom.2024.105211_bib5","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3389\/fonc.2020.01523","article-title":"An overview of managements in meningiomas","volume":"10","author":"Zhao","year":"2020","journal-title":"Front Oncol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105211_bib6","doi-asserted-by":"crossref","first-page":"CNS72","DOI":"10.2217\/cns-2021-0003","article-title":"Meningioma: not always a benign tumor. A review of advances in the treatment of meningiomas","volume":"10","author":"Maggio","year":"2021","journal-title":"CNS Oncol"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105211_bib7","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/neuros\/nyx312","article-title":"Predictors of treatment response and survival outcomes in meningioma recurrence with atypical or anaplastic histology","volume":"82","author":"Chohan","year":"2018","journal-title":"Neurosurgery"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105211_bib8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.5483\/BMBRep.2015.48.3.242","article-title":"Role of histone deacetylase 2 and its posttranslational modifications in cardiac hypertrophy","volume":"48","author":"Eom","year":"2015","journal-title":"BMB Rep"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105211_bib9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s12276-020-0382-4","article-title":"A\u00a0short guide to histone deacetylases including recent progress on class II enzymes","volume":"52","author":"Park","year":"2020","journal-title":"Exp Mol Med"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105211_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13148-019-0800-4","article-title":"Elevated HDAC activity and altered histone phospho-acetylation confer acquired radio-resistant phenotype to breast cancer cells","volume":"12","author":"Sharda","year":"2020","journal-title":"Clin Epigenetics"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105211_bib11","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/neuonc\/nor072","article-title":"AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas","volume":"13","author":"Bush","year":"2011","journal-title":"Neuro Oncol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105211_bib12","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00280-020-04229-3","article-title":"A\u00a0phase 1 trial of the histone deacetylase inhibitor AR-42 in patients with neurofibromatosis type 2-associated tumors and advanced solid malignancies","volume":"87","author":"Collier","year":"2021","journal-title":"Cancer Chemother Pharmacol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105211_bib13","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/lio2.643","article-title":"Early phase clinical studies of AR-42, a histone deacetylase inhibitor, for neurofibromatosis type 2-associated vestibular schwannomas and meningiomas","volume":"6","author":"Welling","year":"2021","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105211_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41392-022-01221-6","article-title":"Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105211_bib15","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41388-020-01550-2","article-title":"HDAC6 promotes growth, migration\/invasion, and self-renewal of rhabdomyosarcoma","volume":"40","author":"Pham","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.ebiom.2024.105211_bib16","article-title":"The role of HDAC6 in cancer","volume":"2011","author":"Aldana-Masangkay","year":"2011","journal-title":"J\u00a0Biomed Biotechnol"},{"key":"10.1016\/j.ebiom.2024.105211_bib17","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.2147\/OTT.S194986","article-title":"Histone deacetylase 6 is overexpressed and promotes tumor growth of colon cancer through regulation of the MAPK\/ERK signal pathway","volume":"12","author":"Zhang","year":"2019","journal-title":"OncoTargets Ther"},{"issue":"19","key":"10.1016\/j.ebiom.2024.105211_bib18","doi-asserted-by":"crossref","first-page":"12686","DOI":"10.1074\/jbc.C700185200","article-title":"HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization","volume":"283","author":"Li","year":"2008","journal-title":"J\u00a0Biol Chem"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105211_bib19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.celrep.2012.09.016","article-title":"Regulation of CD133 by HDAC6 promotes beta-catenin signaling to suppress cancer cell differentiation","volume":"2","author":"Mak","year":"2012","journal-title":"Cell Rep"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105211_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/cancers8070067","article-title":"Molecular genetics of intracranial meningiomas with emphasis on canonical Wnt signalling","volume":"8","author":"Pecina-Slaus","year":"2016","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105211_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13045-017-0471-6","article-title":"Wnt\/beta-catenin pathway: modulating anticancer immune response","volume":"10","author":"Pai","year":"2017","journal-title":"J\u00a0Hematol Oncol"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105211_bib22","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1002\/1097-0142(19891201)64:11<2243::AID-CNCR2820641110>3.0.CO;2-S","article-title":"Establishment of a human malignant meningioma cell line with amplified c-myc oncogene","volume":"64","author":"Tanaka","year":"1989","journal-title":"Cancer"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105211_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12071744","article-title":"The potential of MLN3651 in combination with selumetinib as a treatment for merlin-deficient meningioma","volume":"12","author":"Lyons Rimmer","year":"2020","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105211_bib24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.surneu.2007.06.031","article-title":"A\u00a0comparison of the cell lines used in meningioma research","volume":"70","author":"Ragel","year":"2008","journal-title":"Surg Neurol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105211_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41419-021-03437-w","article-title":"SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells","volume":"12","author":"Na","year":"2021","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105211_bib26","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s40478-023-01677-9","article-title":"A\u00a0novel patient-derived meningioma spheroid model as a tool to study and treat epithelial-to-mesenchymal transition (EMT) in meningiomas","volume":"11","author":"van de Weijer","year":"2023","journal-title":"Acta Neuropathol Commun"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105211_bib27","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1007\/s11033-014-3215-5","article-title":"Valid application of western blotting","volume":"41","author":"Wu","year":"2014","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.ebiom.2024.105211_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ebiom.2018.12.048","article-title":"Proteomic analysis discovers the differential expression of novel proteins and phosphoproteins in meningioma including NEK9, HK2 and SET and deregulation of RNA metabolism","volume":"40","author":"Dunn","year":"2019","journal-title":"eBioMedicine"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105211_bib29","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat Biotechnol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105211_bib30","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2018.02.052","article-title":"An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics","volume":"173","author":"Liu","year":"2018","journal-title":"Cell"},{"issue":"7874","key":"10.1016\/j.ebiom.2024.105211_bib31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41586-021-03850-3","article-title":"A\u00a0clinically applicable integrative molecular classification of meningiomas","volume":"597","author":"Nassiri","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2024.105211_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.594","article-title":"The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphoma","volume":"6","author":"Barneda-Zahonero","year":"2015","journal-title":"Cell Death Dis"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105211_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178322","article-title":"Genomic profile of human meningioma cell lines","volume":"12","author":"Mei","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105211_bib34","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.canlet.2011.08.022","article-title":"Chk2-mediated G2\/M cell cycle arrest maintains radiation resistance in malignant meningioma cells","volume":"313","author":"Gogineni","year":"2011","journal-title":"Cancer Lett"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105211_bib35","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.3892\/ijmm.2014.1731","article-title":"Downregulation of p16(ink4a) inhibits cell proliferation and induces G1 cell cycle arrest in cervical cancer cells","volume":"33","author":"Zhang","year":"2014","journal-title":"Int J Mol Med"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105211_bib36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1134\/S0006297918010091","article-title":"Interaction between RAD51 and MCM complex is essential for RAD51 foci forming in colon cancer HCT116 cells","volume":"83","author":"Huang","year":"2018","journal-title":"Biochemistry (Mosc)"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105211_bib37","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/abbs\/gmu129","article-title":"Knockdown of c-Myc inhibits cell proliferation by negatively regulating the Cdk\/Rb\/E2F pathway in nasopharyngeal carcinoma cells","volume":"47","author":"Niu","year":"2015","journal-title":"Acta Biochim Biophys Sin"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105211_bib38","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.canlet.2016.06.001","article-title":"HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma","volume":"379","author":"Wang","year":"2016","journal-title":"Cancer Lett"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105211_bib39","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/s41419-021-04182-w","article-title":"Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis"},{"issue":"14","key":"10.1016\/j.ebiom.2024.105211_bib40","article-title":"High-throughput mechanistic screening of epigenetic compounds for the potential treatment of meningiomas","volume":"10","author":"Tatman","year":"2021","journal-title":"J\u00a0Clin Med"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105211_bib41","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/bjc.2013.21","article-title":"Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair","volume":"108","author":"Groselj","year":"2013","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105211_bib42","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1016\/j.apsb.2023.02.007","article-title":"Targeting histone deacetylases for cancer therapy: trends and challenges","volume":"13","author":"Liang","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.ebiom.2024.105211_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.938391","article-title":"Inhibition of HDAC6 with CAY10603 ameliorates diabetic kidney disease by suppressing NLRP3 inflammasome","volume":"13","author":"Hou","year":"2022","journal-title":"Front Pharmacol"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105211_bib44","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1093\/nar\/gkx126","article-title":"RAD51 interconnects between DNA replication, DNA repair and immunity","volume":"45","author":"Bhattacharya","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105211_bib45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3174\/ng.1700066","article-title":"Complications of radiotherapy and radiosurgery in the brain and spine","volume":"8","author":"Barisano","year":"2018","journal-title":"Neurographics"},{"issue":"21","key":"10.1016\/j.ebiom.2024.105211_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300164","article-title":"In\u00a0vitro 3D spheroid model preserves tumor microenvironment of hot and cold breast cancer subtypes","volume":"12","author":"Dhandapani","year":"2023","journal-title":"Adv Healthc Mater"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105211_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12061478","article-title":"Patient-derived orthotopic xenograft (PDOX) mouse models of primary and recurrent meningioma","volume":"12","author":"Zhang","year":"2020","journal-title":"Cancers"},{"issue":"2\u20133","key":"10.1016\/j.ebiom.2024.105211_bib48","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/pmic.201400328","article-title":"Multipronged quantitative proteomic analyses indicate modulation of various signal transduction pathways in human meningiomas","volume":"15","author":"Sharma","year":"2015","journal-title":"Proteomics"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105211_bib49","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1101\/gad.231944.113","article-title":"Loss of beta-catenin triggers oxidative stress and impairs hematopoietic regeneration","volume":"28","author":"Lento","year":"2014","journal-title":"Genes Dev"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105211_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13071633","article-title":"Are we benign? What can Wnt signaling pathway and epithelial to mesenchymal transition tell us about intracranial meningioma progression","volume":"13","author":"Bukovac","year":"2021","journal-title":"Cancers"},{"issue":"79","key":"10.1016\/j.ebiom.2024.105211_bib51","doi-asserted-by":"crossref","first-page":"50017","DOI":"10.1039\/C7RA10057D","article-title":"Sinomenine inhibits ovarian cancer cell growth and metastasis by mediating the Wnt\/beta-catenin pathway via targeting MCM2","volume":"7","author":"Li","year":"2017","journal-title":"Rsc Adv"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105211_bib52","doi-asserted-by":"crossref","first-page":"290","DOI":"10.4331\/wjbc.v6.i4.290","article-title":"Regulation of MYC gene expression by aberrant Wnt\/beta-catenin signaling in colorectal cancer","volume":"6","author":"Rennoll","year":"2015","journal-title":"World J Biol Chem"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105211_bib53","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11060-010-0291-9","article-title":"Tumor grade-related NDRG2 gene expression in primary and recurrent intracranial meningiomas","volume":"102","author":"Skiriute","year":"2011","journal-title":"J\u00a0Neuro Oncol"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105211_bib54","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.celrep.2017.02.076","article-title":"Trimethylation and acetylation of beta-catenin at lysine 49 represent key elements in ESC pluripotency","volume":"18","author":"Hoffmeyer","year":"2017","journal-title":"Cell Rep"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424002469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424002469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T13:53:02Z","timestamp":1726753982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424002469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":54,"alternative-id":["S2352396424002469"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105211","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting histone deacetylase 6 (HDAC6) to enhance radiation therapy in meningiomas in a 2D and 3D in\u00a0vitro study","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105211","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105211"}}