{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:21:15Z","timestamp":1793215275177,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ebiom.2024.105228","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T21:03:34Z","timestamp":1721077414000},"page":"105228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGF\u03b2 as key predictors"],"prefix":"10.1016","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-8767","authenticated-orcid":false,"given":"Enric","family":"Domingo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2853-0842","authenticated-orcid":false,"given":"Sanjay","family":"Rathee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Blake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8402-8670","authenticated-orcid":false,"given":"Leslie","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sebag-Montefiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Gollins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubina","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Richman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Quirke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keara","family":"Redmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Chatzipli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6718-855X","authenticated-orcid":false,"given":"Alessandro","family":"Barberis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvana","family":"Hassanieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umair","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Youdell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ultan","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Koelzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Leedham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Blake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Buffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enric","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Koelzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Leedham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Maughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillies","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Robineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Youdell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Quirke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Richman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sebag-Montefiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Seymour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Dunne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lawler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keara","family":"Redmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Salto-Tellez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Chatzipli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ultan","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Beggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Cazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dion","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"Whalley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Harkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Hsi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Horgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca M.","family":"Buffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0580-5065","authenticated-orcid":false,"given":"Timothy S.","family":"Maughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ebiom.2024.105228_bib2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.6004\/jnccn.2020.0032","article-title":"NCCN guidelines insights: rectal cancer, version 6.2020","volume":"18","author":"Benson","year":"2020","journal-title":"J\u00a0Natl Compr Canc Netw"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105228_bib3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s12957-021-02415-y","article-title":"A\u00a0meta-analysis of the watch-and-wait strategy versus total mesorectal excision for rectal cancer exhibiting complete clinical response after neoadjuvant chemoradiotherapy","volume":"19","author":"Yu","year":"2021","journal-title":"World J Surg Oncol"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105228_bib4","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1200\/JCO.2005.00.406","article-title":"Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy","volume":"23","author":"Ghadimi","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ebiom.2024.105228_bib5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13014-016-0623-9","article-title":"Predicting multi-class responses to preoperative chemoradiotherapy in rectal cancer patients","volume":"11","author":"Gim","year":"2016","journal-title":"Radiat Oncol"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105228_bib6","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1007\/s10350-007-277-7","article-title":"Microarray gene expression profiling for predicting complete response to preoperative chemoradiotherapy in patients with advanced rectal cancer","volume":"50","author":"Kim","year":"2007","journal-title":"Dis Colon Rectum"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105228_bib7","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3390\/cancers12040800","article-title":"A\u00a0nine-gene signature for predicting the response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer","volume":"12","author":"Park","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105228_bib8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/jcp.25441","article-title":"Gene and MicroRNA expression are predictive of tumor response in rectal adenocarcinoma patients treated with preoperative chemoradiotherapy","volume":"232","author":"Millino","year":"2017","journal-title":"J\u00a0Cell Physiol"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105228_bib9","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1158\/0008-5472.CAN-05-3834","article-title":"Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles","volume":"66","author":"Watanabe","year":"2006","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105228_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cgh.2007.10.022","article-title":"Microarray-based prediction of tumor response to neoadjuvant radiochemotherapy of patients with locally advanced rectal cancer","volume":"6","author":"Rimkus","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105228_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112189","article-title":"Expression profiling of rectal tumors defines response to neoadjuvant treatment related genes","volume":"9","author":"Palma","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105228_bib12","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1080\/15384047.2015.1046652","article-title":"A\u00a0functional biological network centered on XRCC3: a new possible marker of chemoradiotherapy resistance in rectal cancer patients","volume":"16","author":"Agostini","year":"2015","journal-title":"Cancer Biol Ther"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105228_bib13","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1093\/annonc\/mdy143","article-title":"Neoadjuvant rectal score as individual-level surrogate for disease-free survival in rectal cancer in the CAO\/ARO\/AIO-04 randomized phase III trial","volume":"29","author":"Fokas","year":"2018","journal-title":"Ann Oncol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105228_bib14","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/gcc.22512","article-title":"Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery","volume":"57","author":"Hu","year":"2018","journal-title":"Genes Chromosomes Cancer"},{"issue":"7438","key":"10.1016\/j.ebiom.2024.105228_bib15","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature11935","article-title":"Replication stress links structural and numerical cancer chromosomal instability","volume":"494","author":"Burrell","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2024.105228_bib16","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1038\/s41598-024-51381-4","article-title":"Robustness and reproducibility for AI learning in biomedical sciences: RENOIR","volume":"14","author":"Barberis","year":"2024","journal-title":"Sci Rep"},{"issue":"18","key":"10.1016\/j.ebiom.2024.105228_bib18","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1158\/1078-0432.CCR-22-1102","article-title":"Biological misinterpretation of transcriptional signatures in tumor samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data","volume":"28","author":"Fisher","year":"2022","journal-title":"Clin Cancer Res"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105228_bib19","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.3967","article-title":"The consensus molecular subtypes of colorectal cancer","volume":"21","author":"Guinney","year":"2015","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105228_bib20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41698-024-00580-3","article-title":"Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy.","volume":"8","author":"Lafarge","year":"2024","journal-title":"NPJ Precis Oncol"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105228_bib21","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1038\/s41591-022-01930-z","article-title":"Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer","volume":"28","author":"Chatila","year":"2022","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105228_bib22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ijrobp.2009.05.056","article-title":"Systems biology modeling of the radiation sensitivity network: a biomarker discovery platform","volume":"75","author":"Chatila","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105228_bib23","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ijrobp.2022.03.006","article-title":"The radiosensitivity index gene signature identifies distinct tumor immune microenvironment characteristics associated with susceptibility to radiation therapy","volume":"113","author":"Grass","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105228_bib24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ccell.2022.01.004","article-title":"Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer","volume":"40","author":"Nicolas","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ebiom.2024.105228_bib25","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3389\/fonc.2019.00799","article-title":"Misrepair in context: TGF\u03b2 regulation of DNA repair","volume":"9","author":"Liu","year":"2019","journal-title":"Front Oncol"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105228_bib26","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming growth factor-beta signaling in immunity and cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"issue":"7693","key":"10.1016\/j.ebiom.2024.105228_bib27","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature25492","article-title":"TGFbeta drives immune evasion in genetically reconstituted colon cancer metastasis","volume":"554","author":"Tauriello","year":"2018","journal-title":"Nature"},{"issue":"15_suppl","key":"10.1016\/j.ebiom.2024.105228_bib28","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1200\/JCO.2021.39.15_suppl.3573","article-title":"Efficacy and safety of vactosertib and pembrolizumab combination in patients with previously treated microsatellite stable metastatic colorectal cancer","volume":"39","author":"Kim","year":"2021","journal-title":"J\u00a0Clin Oncol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105228_bib29","article-title":"ComBat-seq: batch effect adjustment for RNA-seq count data","volume":"2","author":"Zhang","year":"2020","journal-title":"NAR Genom Bioinform"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105228_bib30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1470-2045(20)30555-6","article-title":"Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial","volume":"22","author":"Bahadoer","year":"2021","journal-title":"Lancet Oncol"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105228_bib31","doi-asserted-by":"crossref","first-page":"e1555","DOI":"10.1002\/onco.13824","article-title":"Total neoadjuvant therapy (TNT) versus standard neoadjuvant chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis","volume":"26","author":"Liu","year":"2021","journal-title":"Oncologist"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105228_bib32","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.30097","article-title":"Total neoadjuvant therapy vs standard therapy in locally advanced rectal cancer: a systematic review and meta-analysis","volume":"3","author":"Kasi","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105228_bib33","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1158\/2767-9764.CRC-23-0502","article-title":"Stratification to neoadjuvant radiotherapy in rectal cancer by regimen and transcriptional signatures","volume":"4","author":"Mahmood","year":"2024","journal-title":"Cancer Research Comms"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424002639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424002639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T14:55:47Z","timestamp":1728399347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424002639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":31,"alternative-id":["S2352396424002639"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105228","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGF\u03b2 as key predictors","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105228"}}