{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:01:43Z","timestamp":1790013703893,"version":"4.0.1"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ebiom.2024.105238","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T18:03:35Z","timestamp":1720807415000},"page":"105238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Identifying the earliest-occurring clinically targetable precursors of late-onset Alzheimer's disease"],"prefix":"10.1016","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-6285","authenticated-orcid":false,"given":"Bruce M.","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-8171","authenticated-orcid":false,"given":"Kai-Christian","family":"Sonntag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ebiom.2024.105238_bib1","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/alz.13016","article-title":"2023 Alzheimer's disease facts and figures","volume":"19","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"10284","key":"10.1016\/j.ebiom.2024.105238_bib2","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105238_bib3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","article-title":"Role of genes and environments for explaining Alzheimer disease","volume":"63","author":"Gatz","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.ebiom.2024.105238_bib4","article-title":"Are new Alzheimer drugs better than older drugs?","volume":"31","author":"Molchan","year":"2023","journal-title":"JAMA Intern Med"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105238_bib5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S1474-4422(23)00176-X","article-title":"Complexity is the simple truth about Alzheimer's disease","volume":"22","author":"Frisoni","year":"2023","journal-title":"Lancet Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105238_bib6","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer's disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat Genet"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105238_bib7","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.1038\/s41380-021-01068-3","article-title":"Brain cells derived from Alzheimer's disease patients have multiple specific innate abnormalities in energy metabolism","volume":"26","author":"Ryu","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.ebiom.2024.105238_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.697578","article-title":"Hypothesis and theory: characterizing abnormalities of energy metabolism using a cellular platform as a personalized medicine approach for Alzheimer's disease","volume":"9","author":"Ryu","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105238_bib9","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.neurobiolaging.2009.04.002","article-title":"Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease","volume":"30","author":"Price","year":"2009","journal-title":"Neurobiol Aging"},{"issue":"5123","key":"10.1016\/j.ebiom.2024.105238_bib10","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105238_bib11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41582-023-00789-z","article-title":"A\u00a0global view of the genetic basis of Alzheimer disease","volume":"19","author":"Reitz","year":"2023","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13024-018-0298-9","article-title":"New insights into the role of TREM2 in Alzheimer's disease","volume":"13","author":"Gratuze","year":"2018","journal-title":"Mol Neurodegener"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105238_bib13","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ejhg.2017.87","article-title":"Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy","volume":"25","author":"Holstege","year":"2017","journal-title":"Eur J Hum Genet"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105238_bib14","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.celrep.2019.01.023","article-title":"REST and neural gene network dysregulation in iPSC models of Alzheimer's disease","volume":"26","author":"Meyer","year":"2019","journal-title":"Cell Rep"},{"issue":"21","key":"10.1016\/j.ebiom.2024.105238_bib15","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1016\/j.neuron.2021.08.003","article-title":"Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors","volume":"109","author":"Lagomarsino","year":"2021","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105238_bib16","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1016\/j.celrep.2018.04.097","article-title":"Modeling late-onset sporadic Alzheimer's disease through BMI1 deficiency","volume":"23","author":"Flamier","year":"2018","journal-title":"Cell Rep"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105238_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111200","article-title":"APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-kB activation","volume":"40","author":"Arnaud","year":"2022","journal-title":"Cell Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105238_bib18","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.stemcr.2023.01.004","article-title":"BMP4-SMAD1\/5\/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs in senescence-related conditions","volume":"18","author":"Nakatsu","year":"2023","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.ebiom.2024.105238_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104511","article-title":"The complex genetic architecture of Alzheimer's disease: novel insights and future directions","volume":"90","author":"Andrews","year":"2023","journal-title":"eBioMedicine"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105238_bib20","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.tins.2023.03.005","article-title":"Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease","volume":"46","author":"Young-Pearse","year":"2023","journal-title":"Trends Neurosci"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105238_bib21","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3233\/JAD-170585","article-title":"Mitochondria and mitochondrial cascades in Alzheimer's disease","volume":"62","author":"Swerdlow","year":"2018","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.ebiom.2024.105238_bib22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer's disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement (N Y)"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib23","first-page":"15","article-title":"Glucose metabolism is a better marker for predicting clinical Alzheimer's disease than amyloid or tau","volume":"4","author":"Hammond","year":"2022","journal-title":"J\u00a0Cell Immunol"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105238_bib24","doi-asserted-by":"crossref","first-page":"e1127","DOI":"10.1212\/WNL.0000000000207595","article-title":"Association between fluctuations in blood lipid levels over time with incident Alzheimer disease and Alzheimer disease related dementias","volume":"101","author":"Moser","year":"2023","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/nan.12753","article-title":"Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease","volume":"48","author":"Viejo","year":"2022","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.stem.2007.05.014","article-title":"Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution","volume":"1","author":"Maherali","year":"2007","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105238_bib27","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s12015-021-10254-3","article-title":"Human iPSC-derived neural models for studying Alzheimer's disease: from neural stem cells to cerebral organoids","volume":"18","author":"Barak","year":"2022","journal-title":"Stem Cell Rev Rep"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105238_bib28","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3390\/brainsci12050552","article-title":"Advances in recapitulating Alzheimer's disease phenotypes using human induced pluripotent stem cell-based in\u00a0vitro models","volume":"12","author":"Hasan","year":"2022","journal-title":"Brain Sci"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105238_bib29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3390\/cells12030420","article-title":"The breakthroughs and caveats of using human pluripotent stem cells in modeling Alzheimer's disease","volume":"12","author":"Sahlgren Bendtsen","year":"2023","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105238_bib30","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.neuron.2019.10.002","article-title":"Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits","volume":"104","author":"Linaro","year":"2019","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105238_bib31","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.3390\/cells10061470","article-title":"iPSC preparation and epigenetic memory: does the tissue origin matter?","volume":"10","author":"Scesa","year":"2021","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105238_bib32","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrn.2017.107","article-title":"The use of brain organoids to investigate neural development and disease","volume":"18","author":"Di Lullo","year":"2017","journal-title":"Nat Rev Neurosci"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105238_bib33","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.3415","article-title":"Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture","volume":"12","author":"Pasca","year":"2015","journal-title":"Nat Methods"},{"issue":"13","key":"10.1016\/j.ebiom.2024.105238_bib34","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.cell.2022.05.017","article-title":"Cholesterol and matrisome pathways dysregulated in astrocytes and microglia","volume":"185","author":"Tcw","year":"2022","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105238_bib35","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13658","article-title":"Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease","volume":"21","author":"Ryu","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.ebiom.2024.105238_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.scr.2018.01.019","article-title":"Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-\u03b2 and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients","volume":"27","author":"Birnbaum","year":"2018","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.ebiom.2024.105238_bib37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jprot.2018.04.032","article-title":"Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients","volume":"182","author":"Chen","year":"2018","journal-title":"J\u00a0Proteomics"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105238_bib38","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.stemcr.2019.08.004","article-title":"PSEN1DeltaE9, APPswe, and APOE4 confer disparate phenotypes in human iPSC-derived microglia","volume":"13","author":"Konttinen","year":"2019","journal-title":"Stem Cell Rep"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105238_bib39","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.stem.2013.01.009","article-title":"Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular A\u03b2 and differential drug responsiveness","volume":"12","author":"Kondo","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib40","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12864-015-1262-5","article-title":"Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks","volume":"16","author":"Hossini","year":"2015","journal-title":"BMC Genomics"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib41","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13195-017-0317-z","article-title":"Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation","volume":"9","author":"Ochalek","year":"2017","journal-title":"Alzheimer's Res Ther"},{"issue":"22","key":"10.1016\/j.ebiom.2024.105238_bib42","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1089\/scd.2020.0103","article-title":"Human induced pluripotent stem cell-derived neural cells from Alzheimer's disease patients exhibited different susceptibility to oxidative stress","volume":"29","author":"Zhang","year":"2020","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.ebiom.2024.105238_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/srep31450","article-title":"Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease","volume":"6","author":"Balez","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105238_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202000004","article-title":"A\u00a0long-living bioengineered neural tissue platform to study neurodegeneration","volume":"20","author":"Rouleau","year":"2020","journal-title":"Macromol Biosci"},{"key":"10.1016\/j.ebiom.2024.105238_bib45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1326-9-3","article-title":"Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death","volume":"9","author":"Duan","year":"2014","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.ebiom.2024.105238_bib46","doi-asserted-by":"crossref","DOI":"10.1089\/ars.2023.0395","article-title":"Increased neuronal nitric oxide synthase in Alzheimer's disease mediates spontaneous calcium signaling and divergent glutamatergic calcium responses","author":"Balez","year":"2024","journal-title":"Antioxid Redox Signal"},{"issue":"7384","key":"10.1016\/j.ebiom.2024.105238_bib47","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature10821","article-title":"Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells","volume":"482","author":"Israel","year":"2012","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105238_bib48","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer's disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ebiom.2024.105238_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1101216","article-title":"Pooled analysis of frontal lobe transcriptomic data identifies key mitophagy gene changes in Alzheimer's disease brain","volume":"15","author":"Mei","year":"2023","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.ebiom.2024.105238_bib50","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.toxlet.2021.12.009","article-title":"iPSC-derived cortical neurons to study sporadic Alzheimer disease: a transcriptome comparison with post-mortem brain samples","volume":"356","author":"Verheijen","year":"2022","journal-title":"Toxicol Lett"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib51","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1038\/s41467-020-19264-0","article-title":"APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids","volume":"11","author":"Zhao","year":"2020","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105238_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.89","article-title":"Aberrant iPSC-derived human astrocytes in Alzheimer's disease","volume":"8","author":"Jones","year":"2017","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib53","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3233\/JAD-180722","article-title":"Pathological changes in Alzheimer's disease analyzed using induced pluripotent stem cell-derived human microglia-like cells","volume":"67","author":"Xu","year":"2019","journal-title":"J\u00a0Alzheimers Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib54","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40478-023-01554-5","article-title":"Myelin in Alzheimer's disease: culprit or bystander?","volume":"11","author":"Maitre","year":"2023","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.ebiom.2024.105238_bib55","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/978-981-13-9913-8_12","article-title":"Oligodendroglial cells in Alzheimer's disease","volume":"1175","author":"Butt","year":"2019","journal-title":"Adv Exp Med Biol"},{"issue":"16","key":"10.1016\/j.ebiom.2024.105238_bib56","doi-asserted-by":"crossref","first-page":"6826","DOI":"10.7150\/thno.72685","article-title":"A\u00a0sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies","volume":"12","author":"Wasielewska","year":"2022","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105238_bib57","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s43587-021-00158-9","article-title":"Dissection of the polygenic architecture of neuronal A\u03b2 production using a large sample of individual iPSC lines derived from Alzheimer's disease patients","volume":"2","author":"Kondo","year":"2022","journal-title":"Nat Aging"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105238_bib58","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/ana.25455","article-title":"Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in Alzheimer disease","volume":"85","author":"Wadhwani","year":"2019","journal-title":"Ann Neurol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105238_bib59","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41591-018-0004-z","article-title":"Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector","volume":"24","author":"Wang","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2024.105238_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135208","article-title":"Increased GABAergic development in iPSC-derived neurons from patients with sporadic Alzheimer's disease","volume":"735","author":"Tang","year":"2020","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.ebiom.2024.105238_bib61","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neulet.2016.12.060","article-title":"Increased susceptibility to A\u03b2 toxicity in neuronal cultures derived from familial Alzheimer's disease (PSEN1-A246E) induced pluripotent stem cells","volume":"639","author":"Armijo","year":"2017","journal-title":"Neurosci Lett"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105238_bib62","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.stemcr.2021.07.017","article-title":"APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and A\u03b2 generation","volume":"16","author":"Lee","year":"2021","journal-title":"Stem Cell Rep"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105238_bib63","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.neuron.2018.05.008","article-title":"APOE4 causes widespread molecular and cellular alterations associated with Alzheimer's disease phenotypes in human iPSC-derived brain cell types","volume":"98","author":"Lin","year":"2018","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib64","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.stemcr.2021.11.007","article-title":"APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes","volume":"17","author":"de Leeuw","year":"2022","journal-title":"Stem Cell Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108224","article-title":"PICALM rescues endocytic defects caused by the Alzheimer's disease risk factor APOE4","volume":"33","author":"Narayan","year":"2020","journal-title":"Cell Rep"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105238_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112994","article-title":"Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1","volume":"42","author":"Lee","year":"2023","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib67","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1038\/s41467-020-19227-5","article-title":"Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease","volume":"11","author":"McQuade","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18632\/aging.204478","article-title":"The complex determinants of Alzheimer's-type dementias","volume":"15","author":"Cohen","year":"2023","journal-title":"Aging (Albany NY)"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105238_bib69","first-page":"1","article-title":"Psychiatrists should investigate their patients less","volume":"46","author":"Butler","year":"2021","journal-title":"BJPsych Bull"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105238_bib70","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41583-018-0067-3","article-title":"Imaging the evolution and pathophysiology of Alzheimer disease","volume":"19","author":"Jagust","year":"2018","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105238_bib71","first-page":"103","article-title":"Blood flow and metabolism of the human brain in health and disease","volume":"18","author":"Kety","year":"1950","journal-title":"Trans Stud Coll Physicians Phila"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105238_bib72","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.3390\/ijms23073785","article-title":"Brain metabolic alterations in Alzheimer's disease","volume":"23","author":"Ardanaz","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105238_bib73","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41573-020-0072-x","article-title":"Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing","volume":"19","author":"Cunnane","year":"2020","journal-title":"Nat Rev Drug Discov"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105238_bib74","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1471-4159.2002.00997.x","article-title":"Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis","volume":"82","author":"Han","year":"2002","journal-title":"J\u00a0Neurochem"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105238_bib75","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.cmet.2018.05.011","article-title":"Hallmarks of brain aging: adaptive and pathological modification by metabolic states","volume":"27","author":"Mattson","year":"2018","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105238_bib76","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.stem.2018.12.013","article-title":"Cholesterol metabolism is a druggable axis that Independently regulates Tau and amyloid-\u03b2 in iPSC-derived Alzheimer's disease neurons","volume":"24","author":"van der Kant","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105238_bib77","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nn0403-345","article-title":"Alzheimer's disease: the cholesterol connection","volume":"6","author":"Puglielli","year":"2003","journal-title":"Nat Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib78","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s40478-023-01649-z","article-title":"Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer's disease pathogenesis","volume":"11","author":"Pomeshchik","year":"2023","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib79","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1038\/s41467-023-38704-1","article-title":"A\u00a0village in a dish model system for population-scale hiPSC studies","volume":"14","author":"Neavin","year":"2023","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105238_bib80","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1016\/j.celrep.2017.10.109","article-title":"iPSC-based compound screening and in\u00a0vitro trials identify a synergistic anti-amyloid \u03b2 combination for Alzheimer's disease","volume":"21","author":"Kondo","year":"2017","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105238_bib81","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13195-023-01244-3","article-title":"Shared genetic risk loci between Alzheimer's disease and related dementias, Parkinson's disease, and amyotrophic lateral sclerosis","volume":"15","author":"Wainberg","year":"2023","journal-title":"Alzheimer's Res Ther"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424002743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424002743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T23:34:53Z","timestamp":1724283293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424002743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":81,"alternative-id":["S2352396424002743"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105238","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identifying the earliest-occurring clinically targetable precursors of late-onset Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105238","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105238"}}