{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:06:03Z","timestamp":1790283963999,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["0320213090"],"award-info":[{"award-number":["0320213090"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022M3A9D3016848"],"award-info":[{"award-number":["2022M3A9D3016848"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-RS-2023-00279801"],"award-info":[{"award-number":["NRF-RS-2023-00279801"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1C1C1012634"],"award-info":[{"award-number":["2022R1C1C1012634"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1A4A3034038"],"award-info":[{"award-number":["2022R1A4A3034038"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1C1B5045586"],"award-info":[{"award-number":["2018R1C1B5045586"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A2C1100479"],"award-info":[{"award-number":["2020R1A2C1100479"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30 AR072577"],"award-info":[{"award-number":["P30 AR072577"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR077607"],"award-info":[{"award-number":["R01 AR077607"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30 AR070253"],"award-info":[{"award-number":["P30 AR070253"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR080659"],"award-info":[{"award-number":["R01 AR080659"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ebiom.2024.105339","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T16:48:18Z","timestamp":1726764498000},"page":"105339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Therapeutic single-cell landscape: methotrexate exacerbates interstitial lung disease by compromising the stemness of alveolar epithelial cells under systemic inflammation"],"prefix":"10.1016","volume":"108","author":[{"given":"Sung Hae","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0285-5972","authenticated-orcid":false,"given":"Seyoung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8955-6168","authenticated-orcid":false,"given":"Jeong Jun","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Uk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Jeong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Taek","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak-Jae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Je","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong Yang","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-4618","authenticated-orcid":false,"given":"Jeffrey A.","family":"Sparks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-7044","authenticated-orcid":false,"given":"Jeong Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ebiom.2024.105339_bib1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrrheum.2014.149","article-title":"Interstitial lung disease in connective tissue disease\u2014mechanisms and management","volume":"10","author":"Wells","year":"2014","journal-title":"Nat Rev Rheumatol"},{"issue":"10354","key":"10.1016\/j.ebiom.2024.105339_bib2","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0140-6736(22)01052-2","article-title":"Interstitial lung diseases","volume":"400","author":"Wijsenbeek","year":"2022","journal-title":"Lancet"},{"issue":"160","key":"10.1016\/j.ebiom.2024.105339_bib3","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0011-2021","article-title":"Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management","volume":"30","author":"Kadura","year":"2021","journal-title":"Eur Respir Rev"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105339_bib4","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1378\/chest.09-0444","article-title":"Rheumatoid arthritis-associated interstitial lung disease: the relevance of histopathologic and radiographic pattern","volume":"136","author":"Kim","year":"2009","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105339_bib5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s40674-020-00160-z","article-title":"Rheumatoid arthritis-associated interstitial lung disease: current update on prevalence, risk factors, and pharmacologic treatment","volume":"6","author":"Huang","year":"2020","journal-title":"Curr Treatm Opt Rheumatol"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105339_bib6","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/rheumatology\/kez337","article-title":"Methotrexate and interstitial lung disease: controversies and questions. A narrative review of the literature","volume":"58","author":"Fragoulis","year":"2019","journal-title":"Rheumatology"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105339_bib7","first-page":"153","article-title":"Methotrexate-induced pulmonary toxicity","volume":"20","author":"Jakubovic","year":"2013","journal-title":"Can Respir J"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105339_bib8","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/art.41452","article-title":"Pulmonary adverse events in patients receiving low-dose methotrexate in the randomized, double-blind, placebo-controlled cardiovascular inflammation reduction trial","volume":"72","author":"Sparks","year":"2020","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105339_bib9","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00079-2021","article-title":"The case of methotrexate and the lung: Dr Jekyll and Mr Hyde","volume":"57","author":"Cottin","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ebiom.2024.105339_bib10","article-title":"Methotrexate and rheumatoid arthritis associated interstitial lung disease","author":"Juge","year":"2020","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105339_bib11","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/art.38322","article-title":"Methotrexate and lung disease in rheumatoid arthritis: a meta-analysis of randomized controlled trials","volume":"66","author":"Conway","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105339_bib12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2131\/jts.35.653","article-title":"Induction of pulmonary fibrosis by methotrexate treatment in mice lung in\u00a0vivo and in\u00a0vitro","volume":"35","author":"Ohbayashi","year":"2010","journal-title":"J\u00a0Toxicol Sci"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105339_bib13","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.arbres.2015.03.018","article-title":"Protective effects of infliximab on lung injury induced by methotrexate","volume":"51","author":"Kurt","year":"2015","journal-title":"Arch Bronconeumol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105339_bib14","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1038\/s41598-023-34143-6","article-title":"The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity","volume":"13","author":"Abosrea","year":"2023","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105339_bib15","doi-asserted-by":"crossref","first-page":"e233640","DOI":"10.1001\/jamanetworkopen.2023.3640","article-title":"Incidence of interstitial lung disease in patients with rheumatoid arthritis treated with biologic and targeted synthetic disease-modifying antirheumatic drugs","volume":"6","author":"Baker","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105339_bib16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s13075-015-0835-7","article-title":"Incidence and complications of interstitial lung disease in users of tocilizumab, rituximab, abatacept and anti-tumor necrosis factor \u03b1 agents, a retrospective cohort study","volume":"17","author":"Curtis","year":"2015","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105339_bib17","first-page":"43","article-title":"Evolution of imaging findings, laboratory and functional parameters in rheumatoid arthritis patients after one year of treatment with anti-TNF-\u03b1 agents","volume":"35","author":"Detorakis","year":"2017","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105339_bib18","doi-asserted-by":"crossref","first-page":"356","DOI":"10.7326\/0003-4819-127-5-199709010-00003","article-title":"Risk factors for methotrexate-induced lung injury in patients with rheumatoid arthritis. A multicenter, case-control study. Methotrexate-Lung Study Group","volume":"127","author":"Alarc\u00f3n","year":"1997","journal-title":"Ann Intern Med"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105339_bib19","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1002\/art.1780401016","article-title":"Clinical, laboratory, radiographic, and histopathologic features of methotrexate-associated lung injury in patients with rheumatoid arthritis: a multicenter study with literature review","volume":"40","author":"Kremer","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105339_bib20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J\u00a0Pathol"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105339_bib21","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat Med"},{"issue":"6965","key":"10.1016\/j.ebiom.2024.105339_bib22","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nature02119","article-title":"Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice","volume":"426","author":"Sakaguchi","year":"2003","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105339_bib23","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13075-017-1407-9","article-title":"Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model","volume":"19","author":"Jeong","year":"2017","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105339_bib24","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4049\/jimmunol.1303255","article-title":"GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice","volume":"193","author":"Shiomi","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.ebiom.2024.105339_bib25","article-title":"Na\u00efve arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigen","author":"Ashouri","year":"2022","journal-title":"bioRxiv"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105339_bib26","doi-asserted-by":"crossref","first-page":"120","DOI":"10.14348\/molcells.2023.0002","article-title":"Single-cell genomics for investigating pathogenesis of inflammatory diseases","volume":"46","author":"Jung","year":"2023","journal-title":"Mol Cells"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105339_bib27","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.4049\/jimmunol.1000848","article-title":"Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function","volume":"185","author":"Tanaka","year":"2010","journal-title":"J\u00a0Immunol"},{"issue":"49","key":"10.1016\/j.ebiom.2024.105339_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abd1554","article-title":"Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19","volume":"5","author":"Lee","year":"2020","journal-title":"Sci Immunol"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105339_bib29","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105339_bib30","first-page":"234","article-title":"Association of serum biomarkers with pulmonary involvement of rheumatoid arthritis interstitial lung disease: from KORAIL cohort baseline data","volume":"28","author":"Moon","year":"2021","journal-title":"J\u00a0Rheum Dis"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105339_bib31","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1093\/rheumatology\/keac651","article-title":"Methotrexate, leflunomide and tacrolimus use and the progression of rheumatoid arthritis-associated interstitial lung disease","volume":"62","author":"Kim","year":"2023","journal-title":"Rheumatology"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105339_bib32","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1093\/rheumatology\/kead027","article-title":"Lung function trajectory of rheumatoid arthritis-associated interstitial lung disease","volume":"62","author":"Chang","year":"2023","journal-title":"Rheumatology"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105339_bib33","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13075-019-1963-2","article-title":"Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates interstitial lung disease in SKG mice","volume":"21","author":"Sendo","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ebiom.2024.105339_bib34","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3389\/fimmu.2018.01544","article-title":"IL-17A(+)GM-CSF(+) neutrophils are the major infiltrating cells in interstitial lung disease in an autoimmune arthritis model","volume":"9","author":"Kwon","year":"2018","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105339_bib35","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1165\/rcmb.2020-0095MA","article-title":"Single-nucleus RNA-sequencing profiling of mouse lung. Reduced dissociation bias and improved rare cell-type detection compared with single-cell RNA sequencing","volume":"63","author":"Koenitzer","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105339_bib36","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.stem.2020.06.020","article-title":"Inflammatory signals induce AT2 cell-derived damage-associated transient progenitors that mediate alveolar regeneration","volume":"27","author":"Choi","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105339_bib37","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.stem.2011.07.007","article-title":"Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci","volume":"9","author":"Zacharek","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105339_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112451","article-title":"Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1","volume":"42","author":"Cardenas-Diaz","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.ebiom.2024.105339_bib39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41586-023-06816-9","article-title":"Dictionary of immune responses to cytokines at single-cell resolution","volume":"625","author":"Cui","year":"2023","journal-title":"Nature"},{"issue":"26","key":"10.1016\/j.ebiom.2024.105339_bib40","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1016\/j.cell.2021.11.018","article-title":"Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity","volume":"184","author":"Schnell","year":"2021","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105339_bib41","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/art.42476","article-title":"Analysis of single-cell transcriptome and surface protein expression in ankylosing spondylitis identifies OX40-positive and glucocorticoid-induced tumor necrosis factor receptor-positive pathogenic Th17 cells","volume":"75","author":"Yi","year":"2023","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105339_bib42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct Targeted Ther"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105339_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1189\/jlb.2A0514-257RR","article-title":"Proprotein convertase FURIN regulates T cell receptor-induced transactivation","volume":"98","author":"Ortutay","year":"2015","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.ebiom.2024.105339_bib44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2147\/TCRM.S81141","article-title":"Role of pirfenidone in the management of pulmonary fibrosis","volume":"13","author":"Meyer","year":"2017","journal-title":"Ther Clin Risk Manag"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105339_bib45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2019.11.027","article-title":"Progressive pulmonary fibrosis is caused by elevated mechanical tension on alveolar stem cells","volume":"180","author":"Wu","year":"2020","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105339_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237529","article-title":"Dysregulation of club cell biology in idiopathic pulmonary fibrosis","volume":"15","author":"Zuo","year":"2020","journal-title":"PLoS One"},{"issue":"23","key":"10.1016\/j.ebiom.2024.105339_bib47","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa1801562","article-title":"MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease","volume":"379","author":"Juge","year":"2018","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105339_bib48","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1164\/rccm.201804-0734OC","article-title":"Localization of secretory mucins MUC5AC and MUC5B in normal\/healthy human airways","volume":"199","author":"Okuda","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105339_bib49","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1038\/s41467-020-17358-3","article-title":"Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis","volume":"11","author":"Strunz","year":"2020","journal-title":"Nat Commun"},{"issue":"82","key":"10.1016\/j.ebiom.2024.105339_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.add8945","article-title":"Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation","volume":"8","author":"Fabre","year":"2023","journal-title":"Sci Immunol"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105339_bib51","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1093\/rheumatology\/kead122","article-title":"Quantitative interstitial lung disease scores in idiopathic inflammatory myopathies: longitudinal changes and clinical implications","volume":"62","author":"Yeo","year":"2023","journal-title":"Rheumatology"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105339_bib52","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri3600","article-title":"Alveolar macrophages: plasticity in a tissue-specific context","volume":"14","author":"Hussell","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105339_bib53","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.it.2020.08.008","article-title":"Teaching old dogs new tricks? The plasticity of lung alveolar macrophage subsets","volume":"41","author":"Kulikauskaite","year":"2020","journal-title":"Trends Immunol"},{"key":"10.1016\/j.ebiom.2024.105339_bib54","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1146\/annurev-immunol-032712-100019","article-title":"T\u00a0cell-mediated host immune defenses in the lung","volume":"31","author":"Chen","year":"2013","journal-title":"Annu Rev Immunol"},{"issue":"7210","key":"10.1016\/j.ebiom.2024.105339_bib55","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature07210","article-title":"T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance","volume":"455","author":"Pesu","year":"2008","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105339_bib56","doi-asserted-by":"crossref","first-page":"416","DOI":"10.15252\/embr.201439702","article-title":"Effects of inflammation on stem cells: together they strive?","volume":"16","author":"Kizil","year":"2015","journal-title":"EMBO Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105339_bib57","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13256-017-1333-0","article-title":"Methotrexate-induced Hypersensitivity Pneumonitis appearing after 30 years of use: a case report","volume":"11","author":"Salehi","year":"2017","journal-title":"J\u00a0Med Case Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105339_bib58","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41584-020-0373-9","article-title":"Methotrexate and its mechanisms of action in inflammatory arthritis","volume":"16","author":"Cronstein","year":"2020","journal-title":"Nat Rev Rheumatol"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105339_bib59","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1093\/rheumatology\/kez177","article-title":"The lung in a cohort of rheumatoid arthritis patients-an overview of different types of involvement and treatment","volume":"58","author":"Duarte","year":"2019","journal-title":"Rheumatology"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105339_bib60","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1093\/rheumatology\/keaa608","article-title":"Acute exacerbation of rheumatoid arthritis-associated interstitial lung disease: clinical features and prognosis","volume":"60","author":"Izuka","year":"2021","journal-title":"Rheumatology"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105339_bib61","first-page":"622","article-title":"Pulmonary complications of infliximab therapy in patients with rheumatoid arthritis","volume":"33","author":"Ost\u00f6r","year":"2006","journal-title":"J\u00a0Rheumatol"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105339_bib62","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1136\/ard.2009.120626","article-title":"Influence of anti-TNF therapy on mortality in patients with rheumatoid arthritis-associated interstitial lung disease: results from the British Society for Rheumatology Biologics Register","volume":"69","author":"Dixon","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105339_bib63","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1164\/rccm.200709-1446OC","article-title":"Treatment of idiopathic pulmonary fibrosis with etanercept: an exploratory, placebo-controlled trial","volume":"178","author":"Raghu","year":"2008","journal-title":"Am J Respir Crit Care Med"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642400375X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642400375X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:47:30Z","timestamp":1790282850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235239642400375X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":63,"alternative-id":["S235239642400375X"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105339","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic single-cell landscape: methotrexate exacerbates interstitial lung disease by compromising the stemness of alveolar epithelial cells under systemic inflammation","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105339","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105339"}}