{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:28:16Z","timestamp":1785803296517,"version":"3.56.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ebiom.2024.105367","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T12:21:04Z","timestamp":1727353264000},"page":"105367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Monitoring of Pseudomonas aeruginosa mutational resistome dynamics using an enrichment panel for direct sequencing of clinical samples"],"prefix":"10.1016","volume":"108","author":[{"given":"Sara","family":"Cortes-Lara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Medina-Reatiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester del","family":"Barrio-Tofi\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A.","family":"Gomis-Font","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Cabot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"G\u00f3mez-Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Ayestar\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asunci\u00f3n","family":"Colomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Palou-Rotger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Oteo-Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa del","family":"Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-3173","authenticated-orcid":false,"given":"Rafael","family":"Cant\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Horcajada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"L\u00f3pez-Causap\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9327-1894","authenticated-orcid":false,"given":"Antonio","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2024.105367_bib1","doi-asserted-by":"crossref","first-page":"e00031","DOI":"10.1128\/CMR.00031-19","article-title":"Epidemiology and treatment of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa Infections","volume":"32","author":"Horcajada","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ebiom.2024.105367_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1586\/17476348.2015.995640","article-title":"The problems of antibiotic resistance in cystic fibrosis and solutions","volume":"9","author":"L\u00f3pez-Causap\u00e9","year":"2015","journal-title":"Expert Rev Respir Med"},{"key":"10.1016\/j.ebiom.2024.105367_bib3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105367_bib4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2024.105367_bib5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.drup.2015.08.002","article-title":"The increasing threat of Pseudomonas aeruginosa high-risk clones","volume":"21-22","author":"Oliver","year":"2015","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.ebiom.2024.105367_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.106196","article-title":"Pseudomonas aeruginosa epidemic high-risk clones and their association with horizontally-acquired \u03b2-lactamases: 2020 update","volume":"56","author":"Del Barrio-Tofi\u00f1o","year":"2020","journal-title":"Int J Antimicrob Agents"},{"issue":"23","key":"10.1016\/j.ebiom.2024.105367_bib7","article-title":"Pseudomonas aeruginosa antimicrobial susceptibility profiles, resistance mechanisms and international clonal lineages: update from ESGARS-ESCMID\/ISARPAE group","volume":"S1198-743X","author":"Oliver","year":"2023","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ebiom.2024.105367_bib8","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cmi.2017.09.001","article-title":"New agents for the treatment of infections with Gram-negative bacteria: restoring the miracle or false dawn?","volume":"23","author":"Wright","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ebiom.2024.105367_bib9","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1093\/jac\/dkx424","article-title":"Mechanisms leading to in\u00a0vivo ceftolozane\/tazobactam resistance development during the treatment of infections caused by MDR Pseudomonas aeruginosa","volume":"73","author":"Fraile-Ribot","year":"2018","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.ebiom.2024.105367_bib10","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/cid\/ciac097","article-title":"Evolution of imipenem-relebactam resistance following treatment of multidrug-resistant Pseudomonas aeruginosa pneumonia","volume":"75","author":"Shields","year":"2022","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105367_bib11","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3389\/fmicb.2018.00685","article-title":"The versatile mutational resistome of Pseudomonas aeruginosa","volume":"9","author":"L\u00f3pez-Causap\u00e9","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ebiom.2024.105367_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsre\/fuab026","article-title":"Pseudomonas aeruginosa: a clinical and genomics update","volume":"45","author":"Pelegrin","year":"2021","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.ebiom.2024.105367_bib13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.cmi.2016.11.012","article-title":"The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST subcommittee","volume":"23","author":"Ellington","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ebiom.2024.105367_bib14","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.cmi.2021.05.011","article-title":"Predicting Pseudomonas aeruginosa susceptibility phenotypes from whole genome sequence resistome analysis","volume":"27","author":"Cortes-Lara","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ebiom.2024.105367_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13358","article-title":"Genomics of antibiotic-resistance prediction in Pseudomonas aeruginosa","volume":"1435","author":"Jeukens","year":"2019","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ebiom.2024.105367_bib16","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910264","article-title":"Predicting antimicrobial resistance in Pseudomonas aeruginosa with machine learning-enabled molecular diagnostics","volume":"12","author":"Khaledi","year":"2020","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.ebiom.2024.105367_bib17","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1038\/s41467-021-22814-9","article-title":"Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection","volume":"12","author":"Wheatley","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2024.105367_bib18","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1469-0691.2005.01251.x","article-title":"Contribution of clonal dissemination and selection of mutants during therapy to Pseudomonas aeruginosa antimicrobial resistance in an intensive care unit setting","volume":"11","author":"Juan","year":"2005","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ebiom.2024.105367_bib19","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1126\/science.288.5469.1251","article-title":"High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection","volume":"288","author":"Oliver","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2024.105367_bib20","doi-asserted-by":"crossref","first-page":"7910","DOI":"10.1128\/JB.01147-08","article-title":"Genetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutation","volume":"190","author":"Mena","year":"2008","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.ebiom.2024.105367_bib21","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01822-19","article-title":"Dynamic emergence of mismatch repair deficiency facilitates rapid evolution of ceftazidime-avibactam resistance in Pseudomonas aeruginosa acute infection","volume":"10","author":"Khil","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.ebiom.2024.105367_bib22","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/s41467-022-28188-w","article-title":"Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections","volume":"13","author":"Chung","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2024.105367_bib23","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1038\/s41598-017-05621-5","article-title":"Evolution of the Pseudomonas aeruginosa mutational resistome in an international cystic fibrosis clone","volume":"7","author":"L\u00f3pez-Causap\u00e9","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2024.105367_bib24","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1128\/JCM.42.12.5644-5649.2004","article-title":"Development of a multilocus sequence typing scheme for the opportunistic pathogen Pseudomonas aeruginosa","volume":"42","author":"Curran","year":"2004","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.ebiom.2024.105367_bib25","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/35023079","article-title":"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen","volume":"406","author":"Stover","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2024.105367_bib26","article-title":"Accuracy of next generation sequencing platforms","volume":"1","author":"Fox","year":"2014","journal-title":"Next Gener Seq Appl"},{"key":"10.1016\/j.ebiom.2024.105367_bib27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1348-0421.2009.00137.x","article-title":"Classification of OprD sequence and correlation with antimicrobial activity of carbapenem agents in Pseudomonas aeruginosa clinical isolates collected in Japan","volume":"53","author":"Sanbongi","year":"2009","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.ebiom.2024.105367_bib28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/ng.3148","article-title":"Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis","volume":"47","author":"Marvig","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2024.105367_bib29","series-title":"ggplot2: elegant graphics for data analysis","year":"2016"},{"key":"10.1016\/j.ebiom.2024.105367_bib30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/gbe\/evy259","article-title":"The Pseudomonas aeruginosa pan-genome provides new insights on its population structure, horizontal gene transfer, and pathogenicity","volume":"11","author":"Freschi","year":"2019","journal-title":"Genome Biol Evol"},{"key":"10.1016\/j.ebiom.2024.105367_bib31","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1128\/AAC.48.7.2665-2672.2004","article-title":"Detection and susceptibility testing of hypermutable Pseudomonas aeruginosa strains with the Etest and disk diffusion","volume":"48","author":"Maci\u00e1","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ebiom.2024.105367_bib32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40168-018-0426-3","article-title":"Improving saliva shotgun metagenomics by chemical host DNA depletion","volume":"6","author":"Marotz","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.ebiom.2024.105367_bib33","article-title":"chewBBACA: a complete suite for gene-by-gene schema creation and strain identification","volume":"4","author":"Silva","year":"2018","journal-title":"Microb Genom"},{"key":"10.1016\/j.ebiom.2024.105367_bib34","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ebiom.2024.105367_bib35","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ebiom.2024.105367_bib36","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1128\/AAC.01720-16","article-title":"Deciphering the resistome of the widespread Pseudomonas aeruginosa sequence type 175 international high-risk clone through whole-genome sequencing","volume":"60","author":"Cabot","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ebiom.2024.105367_bib37","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1128\/AAC.01024-08","article-title":"Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients","volume":"53","author":"Vettoretti","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ebiom.2024.105367_bib38","doi-asserted-by":"crossref","first-page":"7.21.1","DOI":"10.1002\/0471142727.mb0721s112","article-title":"Overview of target enrichment strategies","volume":"112","author":"Kozarewa","year":"2015","journal-title":"Curr Protoc Mol Biol"},{"key":"10.1016\/j.ebiom.2024.105367_bib39","doi-asserted-by":"crossref","first-page":"e1063","DOI":"10.1016\/S2666-5247(23)00285-9","article-title":"Innovations in genomic antimicrobial resistance surveillance","volume":"4","author":"Wheeler","year":"2023","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.ebiom.2024.105367_bib40","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.00526-22","article-title":"Evaluation of metagenomic and targeted next-generation sequencing workflows for detection of respiratory pathogens from bronchoalveolar lavage fluid specimens","volume":"60","author":"Gaston","year":"2022","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.ebiom.2024.105367_bib41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12896-023-00804-7","article-title":"Highly multiplexed targeted sequencing strategy for infectious disease surveillance","volume":"23","author":"Hern\u00e1ndez-Neuta","year":"2023","journal-title":"BMC Biotechnol"},{"key":"10.1016\/j.ebiom.2024.105367_bib42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40168-017-0387-y","article-title":"In-depth resistome analysis by targeted metagenomics","volume":"6","author":"Lanza","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.ebiom.2024.105367_bib43","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1093\/cid\/ciy801","article-title":"Rapid molecular diagnostics to inform empiric use of ceftazidime\/avibactam and ceftolozane\/tazobactam against Pseudomonas aeruginosa: PRIMERS IV","volume":"68","author":"Evans","year":"2019","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105367_bib44","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00981-15","article-title":"Selective sweeps and parallel pathoadaptation drive Pseudomonas aeruginosa evolution in the cystic fibrosis lung","volume":"6","author":"Diaz Caballero","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.ebiom.2024.105367_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0265129","article-title":"Genomic heterogeneity underlies multidrug resistance in Pseudomonas aeruginosa: a population-level analysis beyond susceptibility testing","volume":"17","author":"Rojas","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2024.105367_bib46","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02142-19","article-title":"Hypermutator Pseudomonas aeruginosa exploits multiple genetic pathways to develop multidrug resistance during long-term infections in the airways of cystic fibrosis patients","volume":"64","author":"Colque","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ebiom.2024.105367_bib47","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1038\/s41467-023-39416-2","article-title":"Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients","volume":"14","author":"Diaz Caballero","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2024.105367_bib48","article-title":"Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysis","volume":"34","author":"Sastre-Femenia","year":"2023","journal-title":"Lancet Reg Health Eur"},{"key":"10.1016\/j.ebiom.2024.105367_bib49","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/cid\/cix182","article-title":"Ceftolozane-tazobactam for the treatment of multidrug-resistant Pseudomonas aeruginosa infections: clinical effectiveness and evolution of resistance","volume":"65","author":"Haidar","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105367_bib50","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/cid\/ciac268","volume":"75","author":"Tamma","year":"2022","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ebiom.2024.105367_bib51","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cmi.2021.11.025","article-title":"European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine)","volume":"28","author":"Paul","year":"2022","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ebiom.2024.105367_bib52","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01663-22","article-title":"Longitudinal evolution of the Pseudomonas-Derived Cephalosporinase (PDC) structure and activity in a cystic fibrosis patient treated with \u03b2-lactams","volume":"13","author":"Colque","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.ebiom.2024.105367_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411618","article-title":"Involvement of acquired tobramycin resistance in the shift to the viable but non-culturable state in Pseudomonas aeruginosa","volume":"24","author":"Mangiaterra","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2024.105367_bib54","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00414-23","article-title":"Ceftolozane-tazobactam against Pseudomonas aeruginosa cystic fibrosis clinical isolates in the hollow-fiber infection model: challenges imposed by hypermutability and heteroresistance","volume":"67","author":"Tait","year":"2023","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ebiom.2024.105367_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2023.106887","article-title":"Ceftolozane\/tazobactam plus tobramycin against free-floating and biofilm bacteria of hypermutable Pseudomonas aeruginosa epidemic strains: resistance mechanisms and synergistic activity","volume":"62","author":"Agyeman","year":"2023","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ebiom.2024.105367_bib56","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41579-020-00477-5","article-title":"Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis","volume":"19","author":"Rossi","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ebiom.2024.105367_bib57","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nrmicro2907","article-title":"Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective","volume":"10","author":"Folkesson","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ebiom.2024.105367_bib58","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/apm.12673","article-title":"Antibiotic treatment of biofilm infections","volume":"125","author":"Ciofu","year":"2017","journal-title":"APMIS"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105367_bib59","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/jb.179.2.417-422.1997","article-title":"Proliferation of mutators in a cell population","volume":"179","author":"Mao","year":"1997","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.ebiom.2024.105367_bib60","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1093\/jac\/dkad172","article-title":"In\u00a0vitro dynamics and mechanisms of cefiderocol resistance development in wild-type, mutator and XDR Pseudomonas aeruginosa","volume":"78","author":"Gomis-Font","year":"2023","journal-title":"J\u00a0Antimicrob Chemother"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424004031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424004031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T19:11:21Z","timestamp":1732821081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424004031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":60,"alternative-id":["S2352396424004031"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105367","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monitoring of Pseudomonas aeruginosa mutational resistome dynamics using an enrichment panel for direct sequencing of clinical samples","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105367","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105367"}}