{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:53:03Z","timestamp":1792889583094,"version":"4.5.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ebiom.2024.105383","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T16:17:38Z","timestamp":1728145058000},"page":"105383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis"],"prefix":"10.1016","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6029-7123","authenticated-orcid":false,"given":"Yue","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayatri","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey A.","family":"Sakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9072-8184","authenticated-orcid":false,"given":"Samuel","family":"Teener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Bakulski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan J.","family":"Traynor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla","family":"Karnovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Batterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva L.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen A.","family":"Sartor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-6637","authenticated-orcid":false,"given":"Stephen A.","family":"Goutman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10360","key":"10.1016\/j.ebiom.2024.105383_bib1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0140-6736(22)01272-7","article-title":"Amyotrophic lateral sclerosis","volume":"400","author":"Feldman","year":"2022","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105383_bib2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S1474-4422(21)00465-8","article-title":"Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis","volume":"21","author":"Goutman","year":"2022","journal-title":"Lancet Neurol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105383_bib3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1474-4422(21)00414-2","article-title":"Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis","volume":"21","author":"Goutman","year":"2022","journal-title":"Lancet Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105383_bib4","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000200079","article-title":"Cumulative genetic score and C9orf72 repeat status independently contribute to amyotrophic lateral sclerosis risk in 2 case-control studies","volume":"9","author":"Dou","year":"2023","journal-title":"Neurol Genet"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105383_bib5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41582-023-00867-2","article-title":"The amyotrophic lateral sclerosis exposome: recent advances and future directions","volume":"19","author":"Goutman","year":"2023","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.ebiom.2024.105383_bib6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/B978-0-444-64076-5.00039-9","article-title":"Emerging understanding of the genotype-phenotype relationship in amyotrophic lateral sclerosis","volume":"148","author":"Goutman","year":"2018","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.ebiom.2024.105383_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neurobiolaging.2022.04.003","article-title":"Methylome analysis of ALS patients and presymptomatic mutation carriers in blood cells","volume":"116","author":"Ruf","year":"2022","journal-title":"Neurobiol Aging"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105383_bib8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1001\/jamaneurol.2016.0594","article-title":"Association of environmental toxins with amyotrophic lateral sclerosis","volume":"73","author":"Su","year":"2016","journal-title":"JAMA Neurol"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105383_bib9","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00420-022-01874-4","article-title":"Associations of self-reported occupational exposures and settings to ALS: a case-control study","volume":"95","author":"Goutman","year":"2022","journal-title":"Int Arch Occup Environ Health"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105383_bib10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1136\/jnnp-2023-332121","article-title":"Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case\/control cohort","volume":"95","author":"Goutman","year":"2024","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"3-4","key":"10.1016\/j.ebiom.2024.105383_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/21678421.2022.2127324","article-title":"Occupational history associates with ALS survival and onset segment","volume":"24","author":"Goutman","year":"2023","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105383_bib12","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1136\/jnnp-2018-319785","article-title":"High plasma concentrations of organic pollutants negatively impact survival in amyotrophic lateral sclerosis","volume":"90","author":"Goutman","year":"2019","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105383_bib13","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nrneurol.2015.57","article-title":"Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era","volume":"11","author":"Paez-Colasante","year":"2015","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105383_bib14","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1093\/hmg\/ddac250","article-title":"miRNA analysis reveals novel dysregulated pathways in amyotrophic lateral sclerosis","volume":"32","author":"Hur","year":"2023","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105383_bib15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00441-014-1815-y","article-title":"Glial epigenetics in neuroinflammation and neurodegeneration","volume":"356","author":"Staszewski","year":"2014","journal-title":"Cell Tissue Res"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105383_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35049533","article-title":"DNA methylation in health and disease","volume":"1","author":"Robertson","year":"2000","journal-title":"Nat Rev Genet"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105383_bib17","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1097\/CM9.0000000000002090","article-title":"Epigenome-wide DNA methylation study of whole blood in patients with sporadic amyotrophic lateral sclerosis","volume":"135","author":"Cai","year":"2022","journal-title":"Chin Med J"},{"issue":"633","key":"10.1016\/j.ebiom.2024.105383_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj0264","article-title":"Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS","volume":"14","author":"Hop","year":"2022","journal-title":"Sci Transl Med"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105383_bib19","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41576-018-0004-3","article-title":"DNA methylation-based biomarkers and the epigenetic clock theory of ageing","volume":"19","author":"Horvath","year":"2018","journal-title":"Nat Rev Genet"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105383_bib20","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105383_bib21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2012.10.016","article-title":"Genome-wide methylation profiles reveal quantitative views of human aging rates","volume":"49","author":"Hannum","year":"2013","journal-title":"Mol Cell"},{"issue":"23","key":"10.1016\/j.ebiom.2024.105383_bib22","first-page":"9484","article-title":"DNA methylation GrimAge version 2","volume":"14","author":"Lu","year":"2022","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105383_bib23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18632\/aging.101684","article-title":"DNA methylation GrimAge strongly predicts lifespan and healthspan","volume":"11","author":"Lu","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105383_bib24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105383_bib25","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.18632\/aging.100859","article-title":"Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients","volume":"7","author":"Horvath","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ebiom.2024.105383_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101348","article-title":"A\u00a0systematic review of biological, social and environmental factors associated with epigenetic clock acceleration","volume":"69","author":"Oblak","year":"2021","journal-title":"Ageing Res Rev"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105383_bib27","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105383_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv907","article-title":"ENmix: a novel background correction method for Illumina HumanMethylation450 BeadChip","volume":"44","author":"Xu","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105383_bib29","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/bioinformatics\/btw691","article-title":"Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi","volume":"33","author":"Fortin","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ebiom.2024.105383_bib30","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54870","article-title":"Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm","volume":"9","author":"Belsky","year":"2020","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105383_bib31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13059-018-1448-7","article-title":"An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray","volume":"19","author":"Salas","year":"2018","journal-title":"Genome Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105383_bib32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A\u00a0hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"issue":"7422","key":"10.1016\/j.ebiom.2024.105383_bib33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"Genomes Project","year":"2012","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105383_bib34","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1101\/gr.261248.120","article-title":"Quantitative analysis of Y-Chromosome gene expression across 36 human tissues","volume":"30","author":"Godfrey","year":"2020","journal-title":"Genome Res"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105383_bib35","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s12883-021-02187-8","article-title":"Prediction of survival in amyotrophic lateral sclerosis: a nationwide, Danish cohort study","volume":"21","author":"Kjaeldgaard","year":"2021","journal-title":"BMC Neurol"},{"key":"10.1016\/j.ebiom.2024.105383_bib36","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105383_bib37","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s13059-021-02398-9","article-title":"Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging","volume":"22","author":"McCartney","year":"2021","journal-title":"Genome Biol"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105383_bib38","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41588-021-00973-1","article-title":"Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology","volume":"53","author":"van Rheenen","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2024.105383_bib39","doi-asserted-by":"crossref","first-page":"449","DOI":"10.12688\/wellcomeopenres.19995.2","article-title":"MendelianRandomization v0.9.0: updates to an R package for performing Mendelian randomization analyses using summarized data","volume":"8","author":"Patel","year":"2023","journal-title":"Wellcome Open Res"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105383_bib40","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giz082","article-title":"PRSice-2: polygenic Risk Score software for biobank-scale data","volume":"8","author":"Choi","year":"2019","journal-title":"GigaScience"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105383_bib41","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000953","article-title":"Amyotrophic lateral sclerosis survival associates with neutrophils in a sex-specific manner","volume":"8","author":"Murdock","year":"2021","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105383_bib42","article-title":"NK cells associate with ALS in a sex- and age-dependent manner","volume":"6","author":"Murdock","year":"2021","journal-title":"JCI Insight"},{"issue":"1-2","key":"10.1016\/j.ebiom.2024.105383_bib43","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/21678421.2017.1367401","article-title":"Increase in DNA methylation in patients with amyotrophic lateral sclerosis carriers of not fully penetrant SOD1 mutations","volume":"19","author":"Coppede","year":"2018","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1016\/j.ebiom.2024.105383_bib44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.brainres.2014.02.015","article-title":"Characterization of DNA hypermethylation in the cerebellum of c9FTD\/ALS patients","volume":"1584","author":"Belzil","year":"2014","journal-title":"Brain Res"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105383_bib45","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s13311-013-0205-6","article-title":"Aberrant regulation of DNA methylation in amyotrophic lateral sclerosis: a new target of disease mechanisms","volume":"10","author":"Martin","year":"2013","journal-title":"Neurotherapeutics"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105383_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052672","article-title":"Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis","volume":"7","author":"Figueroa-Romero","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105383_bib47","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1136\/jnnp-2022-330931","article-title":"Epigenetic clocks in neurodegenerative diseases: a systematic review","volume":"94","author":"Yang","year":"2023","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105383_bib48","doi-asserted-by":"crossref","first-page":"8254","DOI":"10.1038\/s41598-019-44765-4","article-title":"Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression","volume":"9","author":"Tarr","year":"2019","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105383_bib49","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1136\/jnnp-2016-313592","article-title":"Genetic and epigenetic study of ALS-discordant identical twins with double mutations in SOD1 and ARHGEF28","volume":"87","author":"Zhang","year":"2016","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105383_bib50","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13073-019-0667-1","article-title":"Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing","volume":"11","author":"Zhang","year":"2019","journal-title":"Genome Med"},{"key":"10.1016\/j.ebiom.2024.105383_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1272135","article-title":"Exploring epigenetic drift and rare epivariations in amyotrophic lateral sclerosis by epigenome-wide association study","volume":"15","author":"Brusati","year":"2023","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105383_bib52","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41531-023-00492-2","article-title":"Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder","volume":"9","author":"Baldelli","year":"2023","journal-title":"NPJ Parkinsons Dis"},{"key":"10.1016\/j.ebiom.2024.105383_bib53","first-page":"429","article-title":"Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease","volume":"10","author":"McCartney","year":"2018","journal-title":"Alzheimer's Dementia"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105383_bib54","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1002\/mds.29574","article-title":"DNA methylation age acceleration is not associated with age of onset in Parkinson\u2019s disease","volume":"38","author":"Gaare","year":"2023","journal-title":"Mov Disord"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105383_bib55","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00401-020-02131-z","article-title":"DNA methylation age acceleration is associated with ALS age of onset and survival","volume":"139","author":"Zhang","year":"2020","journal-title":"Acta Neuropathol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105383_bib56","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00401-017-1713-y","article-title":"DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients","volume":"134","author":"Zhang","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105383_bib57","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.neuron.2023.01.010","article-title":"Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects","volume":"111","author":"Workman","year":"2023","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105383_bib58","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neurol.2019.09.008","article-title":"The effects of diet and sex in amyotrophic lateral sclerosis","volume":"176","author":"Pape","year":"2020","journal-title":"Rev Neurol (Paris)"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105383_bib59","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/17482961003610853","article-title":"The sex ratio in amyotrophic lateral sclerosis: a population based study","volume":"11","author":"Manjaly","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1016\/j.ebiom.2024.105383_bib60","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.63425","article-title":"Sex differences in biological aging with a focus on human studies","volume":"10","author":"Hagg","year":"2021","journal-title":"Elife"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105383_bib61","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/oxfordjournals.aje.a009070","article-title":"Occupational exposures and amyotrophic lateral sclerosis. A population-based case-control study","volume":"145","author":"McGuire","year":"1997","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105383_bib62","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/oemed-2018-105469","article-title":"Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark","volume":"76","author":"Dickerson","year":"2019","journal-title":"Occup Environ Med"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105383_bib63","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/j.1468-1331.2012.03769.x","article-title":"Exposure to environmental toxins and the risk of sporadic motor neuron disease: an expanded Australian case-control study","volume":"19","author":"Pamphlett","year":"2012","journal-title":"Eur J Neurol"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105383_bib64","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1212\/WNL.41.7.1077","article-title":"Epidemiologic correlates of sporadic amyotrophic lateral sclerosis","volume":"41","author":"Armon","year":"1991","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105383_bib65","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/aje\/kwy069","article-title":"Amyotrophic lateral sclerosis and exposure to diesel exhaust in a Danish cohort","volume":"187","author":"Dickerson","year":"2018","journal-title":"Am J Epidemiol"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105383_bib66","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1021\/acs.est.2c09005","article-title":"Association of PM2.5 components with acceleration of aging: moderating role of sex hormones","volume":"57","author":"Pan","year":"2023","journal-title":"Environ Sci Technol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105383_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-13892-w","article-title":"Association between DNA methylation variability and self-reported exposure to heavy metals","volume":"12","author":"Freydenzon","year":"2022","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105383_bib68","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000242","article-title":"Increased ratio of\u00a0circulating neutrophils to monocytes in amyotrophic lateral\u00a0sclerosis","volume":"3","author":"Murdock","year":"2016","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105383_bib69","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1001\/jamaneurol.2017.2255","article-title":"Correlation of peripheral immunity with rapid amyotrophic lateral sclerosis progression","volume":"74","author":"Murdock","year":"2017","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.ebiom.2024.105383_bib70","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neurobiolaging.2021.04.013","article-title":"Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts","volume":"105","author":"Gerou","year":"2021","journal-title":"Neurobiol Aging"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105383_bib71","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41467-022-35494-w","article-title":"Molecular subtypes of ALS are associated with differences in patient prognosis","volume":"14","author":"Eshima","year":"2023","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105383_bib72","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/s13311-019-00811-7","article-title":"Therapeutic role of neuregulin 1 type III in SOD1-linked amyotrophic lateral sclerosis","volume":"17","author":"Modol-Caballero","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105383_bib73","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/NEN.0b013e3182423c43","article-title":"Aberrant neuregulin 1 signaling in amyotrophic lateral sclerosis","volume":"71","author":"Song","year":"2012","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"issue":"R2","key":"10.1016\/j.ebiom.2024.105383_bib74","doi-asserted-by":"crossref","first-page":"R105","DOI":"10.1093\/hmg\/ddx247","article-title":"Ageing as a risk factor for ALS\/FTD","volume":"26","author":"Niccoli","year":"2017","journal-title":"Hum Mol Genet"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105383_bib75","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00018-023-04769-w","article-title":"ALS is imprinted in the chromatin accessibility of blood cells","volume":"80","author":"Kuhlwein","year":"2023","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ebiom.2024.105383_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.imu.2019.100193","article-title":"Identification of molecular signatures and pathways common to blood cells and brain tissue of amyotrophic lateral sclerosis patients","volume":"16","author":"Rahman","year":"2019","journal-title":"Inform Med Unlocked"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105383_bib77","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13028","article-title":"Reversal of epigenetic aging and immunosenescent trends in humans","volume":"18","author":"Fahy","year":"2019","journal-title":"Aging Cell"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105383_bib78","doi-asserted-by":"crossref","first-page":"9419","DOI":"10.18632\/aging.202913","article-title":"Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial","volume":"13","author":"Fitzgerald","year":"2021","journal-title":"Aging (Albany NY)"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424004195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424004195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:38:28Z","timestamp":1732063108000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424004195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":78,"alternative-id":["S2352396424004195"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105383","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105383","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105383"}}