{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:08:35Z","timestamp":1793660915870,"version":"4.5.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:00:00Z","timestamp":1728172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children&apos;s Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005295","name":"American Academy of Pediatrics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI118608"],"award-info":[{"award-number":["U19AI118608"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI168643"],"award-info":[{"award-number":["U19AI168643"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ebiom.2024.105411","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T03:28:05Z","timestamp":1730172485000},"page":"105411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation"],"prefix":"10.1016","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9777-4456","authenticated-orcid":false,"given":"Andy Y.","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-7203","authenticated-orcid":false,"given":"Erica","family":"Acton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olubukola T.","family":"Idoko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey P.","family":"Shannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8778-8627","authenticated-orcid":false,"given":"Travis M.","family":"Blimkie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Falsafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oghenebrume","family":"Wariri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5070-3060","authenticated-orcid":false,"given":"Abdulazeez","family":"Imam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tida","family":"Dibbasey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tue Bjerg","family":"Bennike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga K.","family":"Smolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2183-4269","authenticated-orcid":false,"given":"Joann","family":"Diray-Arce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rym","family":"Ben-Othman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Montante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-6561","authenticated-orcid":false,"given":"Asimenia","family":"Angelidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oludare A.","family":"Odumade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Tebbutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-1945","authenticated-orcid":false,"given":"Ofer","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanno","family":"Steen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias R.","family":"Kollmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Kampmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5989-8503","authenticated-orcid":false,"given":"Robert E.W.","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3250-3246","authenticated-orcid":false,"given":"Amy H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Amenyogbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asimenia","family":"Angelidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rym","family":"Ben-Othman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tue","family":"Bennike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Blimkie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Bjerregaard-Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan R.","family":"Brinkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Brook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendyll","family":"Burnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Checkervarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Cooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoudou","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alansana","family":"Darboe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavjinder K.","family":"Dhillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tida","family":"Dibassey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joann","family":"Diray-Arce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Falsafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Fatou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian N.","family":"Golding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.W.","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J.","family":"Harbeson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel H.","family":"Hinshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annmarie","family":"Hoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olubukola T.","family":"Idoko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulazeez","family":"Imam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Kampmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Kirarock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias R.","family":"Kollmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan E.","family":"Karoly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lasky-Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"A","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"M","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnoush","family":"Malek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Marchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Masiria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Jim","family":"Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Paul","family":"Matlam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"McEnaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlyn","family":"McLoughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Montante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Morrocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorjoh","family":"Ndure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jainaba","family":"Njie-Jobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oludare A.","family":"Odumade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al","family":"Ozonoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jensen","family":"Pak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward P.K.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Pettengill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec","family":"Plotkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Pomat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Richmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elishia","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Saleu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilica","family":"Sanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guzman","family":"Sanchez-Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Schaltz-Buchholzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey P.","family":"Shannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga K.","family":"Smolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanno","family":"Steen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Strandmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Syphurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Tebbutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita H.J.","family":"van den Biggelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon D.","family":"van Haren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natallia","family":"Varankovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Vignolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Vo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oghenebrume","family":"Wariri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ebiom.2024.105411_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105411_bib2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41390-021-01749-3","article-title":"Neonatal sepsis definitions from randomised clinical trials","volume":"93","author":"Hayes","year":"2023","journal-title":"Pediatr Res"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105411_bib3","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/archdischild-2020-320217","article-title":"Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis","volume":"106","author":"Fleischmann","year":"2021","journal-title":"Arch Dis Child"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105411_bib4","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S1473-3099(19)30414-1","article-title":"Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-Saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines","volume":"19","author":"Okomo","year":"2019","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105411_bib5","first-page":"283","article-title":"Risk factors for Group B Streptococcus colonisation and disease in Gambian women and their infants","volume":"72","author":"Le Doare","year":"2016","journal-title":"J\u00a0Infect"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105411_bib6","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1001\/jama.2022.24388","article-title":"Effect of intrapartum azithromycin vs placebo on neonatal sepsis and death: a randomized clinical trial","volume":"329","author":"Roca","year":"2023","journal-title":"JAMA"},{"issue":"13","key":"10.1016\/j.ebiom.2024.105411_bib8","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa1100441","article-title":"Treatment of neonatal sepsis with intravenous immune globulin","volume":"365","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105411_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.clp.2021.03.012","article-title":"Biomarkers for the diagnosis of neonatal sepsis","volume":"48","author":"Cantey","year":"2021","journal-title":"Clin Perinatol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105411_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000346057","article-title":"Antibiotic use in newborns with transient tachypnea of the newborn","volume":"103","author":"Weintraub","year":"2013","journal-title":"Neonatology"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105411_bib11","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2019-2576","article-title":"The Spartacus problem: diagnostic inefficiency of neonatal sepsis","volume":"144","author":"Cantey","year":"2019","journal-title":"Pediatrics"},{"issue":"10142","key":"10.1016\/j.ebiom.2024.105411_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0140-6736(18)31127-9","article-title":"Causes and incidence of community-acquired serious infections among young children in south Asia (ANISA): an observational cohort study","volume":"392","author":"Saha","year":"2018","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105411_bib13","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2019-1105","article-title":"Newborn antibiotic exposures and association with proven bloodstream infection","volume":"144","author":"Schulman","year":"2019","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-28525-z","article-title":"Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial","volume":"13","author":"Reyman","year":"2022","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105411_bib15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/INF.0b013e318256905c","article-title":"Use of the complete blood cell count in early-onset neonatal sepsis","volume":"31","author":"Hornik","year":"2012","journal-title":"Pediatr Infect Dis J"},{"issue":"23","key":"10.1016\/j.ebiom.2024.105411_bib16","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1080\/14767058.2020.1856068","article-title":"C-reactive protein in early-onset neonatal sepsis \u2013 a cutoff point for CRP value as a predictor of early-onset neonatal sepsis in term and late preterm infants early after birth?","volume":"35","author":"Yochpaz","year":"2022","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib17","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12879-017-2396-7","article-title":"Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis","volume":"17","author":"Pontrelli","year":"2017","journal-title":"BMC Infect Dis"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105411_bib18","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/clinchem\/46.10.1583","article-title":"Serum procalcitonin concentrations in term delivering mothers and their healthy offspring: a longitudinal study","volume":"46","author":"Assumma","year":"2000","journal-title":"Clin Chem"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105411_bib19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00011-018-1149-4","article-title":"Soluble TREM-1 as a predictive factor of neonatal sepsis: a meta-analysis","volume":"67","author":"Bellos","year":"2018","journal-title":"Inflamm Res"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105411_bib20","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1001\/jamapediatrics.2022.1647","article-title":"Presepsin for the diagnosis of neonatal early-onset sepsis: a systematic review and meta-analysis","volume":"176","author":"Poggi","year":"2022","journal-title":"JAMA Pediatr"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105411_bib21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/children7120309","article-title":"Relevance of biomarkers currently in use or research for practical diagnosis approach of neonatal early-onset sepsis","volume":"7","author":"Hincu","year":"2020","journal-title":"Children"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105411_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/jpids\/pix021","article-title":"Validation of the Sepsis MetaScore for diagnosis of neonatal sepsis","volume":"7","author":"Sweeney","year":"2018","journal-title":"J\u00a0Pediatr Infect Dis Soc"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105411_bib23","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1586\/1744666X.2014.942288","article-title":"Immune responses in neonates","volume":"10","author":"Basha","year":"2014","journal-title":"Expert Rev Clin Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib24","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/s41467-019-08794-x","article-title":"Dynamic molecular changes during the first week of human life follow a robust developmental trajectory","volume":"10","author":"Lee","year":"2019","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105411_bib25","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.clp.2012.09.009","article-title":"Physiology of transition from intrauterine to extrauterine life","volume":"39","author":"Hillman","year":"2012","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.ebiom.2024.105411_bib26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fped.2020.00005","article-title":"Advantages and limitations of the neonatal immune system","volume":"8","author":"Tsafaras","year":"2020","journal-title":"Front Pediatr"},{"key":"10.1016\/j.ebiom.2024.105411_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.578505","article-title":"Preparing for life: plasma proteome changes and immune system development during the first week of human life","volume":"11","author":"Bennike","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2024.105411_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3389\/fped.2020.00197","article-title":"Clinical protocol for a longitudinal cohort study employing systems biology to identify markers of vaccine immunogenicity in newborn infants in the Gambia and Papua New Guinea","volume":"8","author":"Idoko","year":"2020","journal-title":"Front Pediatr"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib29","article-title":"A\u00a0cloud-based bioinformatic analytic infrastructure and data management Core for the expanded program on immunization consortium","volume":"5","author":"Vignolo","year":"2021","journal-title":"J\u00a0Clin Transl Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib30","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12887-016-0618-6","article-title":"Comparison of early onset sepsis and community-acquired late onset sepsis in infants less than 3 months of age","volume":"16","author":"Bulkowstein","year":"2016","journal-title":"BMC Pediatr"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/CMR.00031-13","article-title":"Early-onset neonatal sepsis","volume":"27","author":"Simonsen","year":"2014","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105411_bib32","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/pch\/pxx023","article-title":"Management of term infants at increased risk for early-onset bacterial sepsis","volume":"22","author":"Jefferies","year":"2017","journal-title":"Paediatr Child Health"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105411_bib33","doi-asserted-by":"crossref","DOI":"10.1093\/nargab\/lqaa078","article-title":"ComBat-seq: batch effect adjustment for RNA-seq count data","volume":"2","author":"Zhang","year":"2020","journal-title":"NAR Genomics Bioinforma"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105411_bib34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib35","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12859-017-1559-2","article-title":"Reactome pathway analysis: a high-performance in-memory approach","volume":"18","author":"Fabregat","year":"2017","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.ebiom.2024.105411_bib36","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.229","article-title":"Pathway-GPS and SIGORA: identifying relevant pathways based on the over-representation of their gene-pair signatures","volume":"1","author":"Foroushani","year":"2013","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1471-2105-12-253","article-title":"Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems","volume":"12","author":"L\u00ea Cao","year":"2011","journal-title":"BMC Bioinf"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105411_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005752","article-title":"mixOmics: an R package for \u2018omics feature selection and multiple data integration","volume":"13","author":"Rohart","year":"2017","journal-title":"PLoS Comput Biol"},{"issue":"11\u201312","key":"10.1016\/j.ebiom.2024.105411_bib39","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.2119\/molmed.2011.00169","article-title":"The influence of developmental age on the early transcriptomic response of children with septic shock","volume":"17","author":"Wynn","year":"2011","journal-title":"Mol Med Camb Mass"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-Seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.ebiom.2024.105411_bib41","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12859-016-0994-9","article-title":"Sample size calculation while controlling false discovery rate for differential expression analysis with RNA-sequencing experiments","volume":"17","author":"Bi","year":"2016","journal-title":"BMC Bioinf"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib42","article-title":"The utility of the neutrophil-lymphocyte ratio as an early diagnostic marker in neonatal sepsis","volume":"13","author":"Panda","year":"2021","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.12669\/pjms.35.1.99","article-title":"Immature to total neutrophil ratio as an early indicator of early neonatal sepsis","volume":"35","author":"Saboohi","year":"2019","journal-title":"Pak J Med Sci"},{"key":"10.1016\/j.ebiom.2024.105411_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103776","article-title":"Predicting sepsis severity at first clinical presentation: the role of endotypes and mechanistic signatures","volume":"75","author":"Baghela","year":"2022","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105411_bib45","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/01.PCC.0000149131.72248.E6","article-title":"International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics","volume":"6","author":"Goldstein","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.ebiom.2024.105411_bib46","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3389\/fnins.2018.00821","article-title":"Heat shock proteins regulatory role in neurodevelopment","volume":"12","author":"Miller","year":"2018","journal-title":"Front Neurosci"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105411_bib47","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.4049\/jimmunol.1401417","article-title":"Functions of heat shock proteins in pathways of the innate and adaptive immune system","volume":"193","author":"Binder","year":"2014","journal-title":"J\u00a0Immunol"},{"issue":"17","key":"10.1016\/j.ebiom.2024.105411_bib48","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.3390\/ijms20174255","article-title":"HSP-target of therapeutic agents in sepsis treatment","volume":"20","author":"Vulczak","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105411_bib49","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1164\/rccm.201701-0066OC","article-title":"Improved risk stratification in pediatric septic shock using both protein and mRNA biomarkers. PERSEVERE-XP","volume":"196","author":"Wong","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105411_bib50","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S2213-2600(16)00046-1","article-title":"Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study","volume":"4","author":"Davenport","year":"2016","journal-title":"Lancet Respir Med"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105411_bib51","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1111\/jcmm.17156","article-title":"Patients with hypothermic sepsis have a unique gene expression profile compared to patients with fever and sepsis","volume":"26","author":"Harmon","year":"2022","journal-title":"J\u00a0Cell Mol Med"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105411_bib52","first-page":"445","article-title":"Transcriptomic correlates of organ failure extent in sepsis","volume":"70","author":"Almansa","year":"2015","journal-title":"J\u00a0Infect"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105411_bib53","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1473-3099(14)70710-8","article-title":"Infection-induced inflammation and cerebral injury in preterm infants","volume":"14","author":"Strunk","year":"2014","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105411_bib54","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3390\/cells11020203","article-title":"Cell cycle regulation by heat shock transcription factors","volume":"11","author":"Tokunaga","year":"2022","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105411_bib55","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s12519-021-00505-1","article-title":"Prediction modelling in the early detection of neonatal sepsis","volume":"18","author":"Sahu","year":"2022","journal-title":"World J Pediatr"},{"key":"10.1016\/j.ebiom.2024.105411_bib56","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3389\/fped.2020.00525","article-title":"Neonatal sepsis diagnosis decision-making based on artificial neural networks","volume":"8","author":"Helguera-Repetto","year":"2020","journal-title":"Front Pediatr"},{"key":"10.1016\/j.ebiom.2024.105411_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2019.11.020","article-title":"Sensitivity of the Kaiser Permanente early-onset sepsis calculator: a systematic review and meta-analysis","volume":"19","author":"Pettinger","year":"2020","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.ebiom.2024.105411_bib58","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9390140","article-title":"Sepsis and oxidative stress in the newborn: from pathogenesis to novel therapeutic targets","volume":"2018","author":"Poggi","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ebiom.2024.105411_bib59","first-page":"5030","article-title":"Mitochondrial mechanisms of sepsis-induced organ failure","volume":"13","author":"Exline","year":"2008","journal-title":"Front Biosci J Virtual Libr"},{"issue":"18","key":"10.1016\/j.ebiom.2024.105411_bib60","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1042\/CS20190351","article-title":"Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model","volume":"133","author":"Manfredini","year":"2019","journal-title":"Clin Sci"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105411_bib61","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.molmed.2016.02.001","article-title":"An immunological perspective on neonatal sepsis","volume":"22","author":"Kan","year":"2016","journal-title":"Trends Mol Med"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105411_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1486","article-title":"The immunologic Warburg effect: evidence and therapeutic opportunities in autoimmunity","volume":"12","author":"Kornberg","year":"2020","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105411_bib63","doi-asserted-by":"crossref","first-page":"O928","DOI":"10.1111\/1469-0691.12661","article-title":"Recurrent late-onset sepsis in the neonatal intensive care unit: incidence, clinical characteristics and risk factors","volume":"20","author":"Tsai","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ebiom.2024.105411_bib64","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2147\/CLEP.S35693","article-title":"Pediatric sepsis in the developing world: challenges in defining sepsis and issues in post-discharge mortality","volume":"4","author":"Wiens","year":"2012","journal-title":"Clin Epidemiol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642400447X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642400447X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:38:46Z","timestamp":1778873926000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235239642400447X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":63,"alternative-id":["S235239642400447X"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105411","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105411","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105411"}}