{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:43:12Z","timestamp":1791837792003,"version":"4.3.4"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ebiom.2024.105462","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T21:21:58Z","timestamp":1732828918000},"page":"105462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-level analysis from a multicentre clinical trial"],"prefix":"10.1016","volume":"110","author":[{"given":"Valeria","family":"Hasenmajer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Sbardella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sciarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Simeoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pivonello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Ceccato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Pofi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-2809","authenticated-orcid":false,"given":"Marianna","family":"Minnetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3803-4350","authenticated-orcid":false,"given":"Davide","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Bonaventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Barbagallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Giannetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Alunni Fegatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Conia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Navigli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Arnaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Scaroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Pivonello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Gianfrilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Anna","family":"Venneri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-5417","authenticated-orcid":false,"given":"Andrea M.","family":"Isidori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6650","key":"10.1016\/j.ebiom.2024.105462_bib1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1126\/science.adh7723","article-title":"Regulating light pollution: more than just the night sky","volume":"380","author":"Morgan-Taylor","year":"2023","journal-title":"Science"},{"issue":"14","key":"10.1016\/j.ebiom.2024.105462_bib2","doi-asserted-by":"crossref","DOI":"10.1172\/JCI170998","article-title":"Circadian disruption, clock genes, and metabolic health","volume":"134","author":"Schrader","year":"2024","journal-title":"J\u00a0Clin Invest"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105462_bib3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1210\/er.2016-1083","article-title":"Circadian rhythm and sleep disruption: causes, metabolic consequences, and countermeasures","volume":"37","author":"Potter","year":"2016","journal-title":"Endocr Rev"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105462_bib4","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S1470-2045(07)70373-X","article-title":"Carcinogenicity of shift-work, painting, and fire-fighting","volume":"8","author":"Straif","year":"2007","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105462_bib5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s40572-017-0155-y","article-title":"Night shift work and risk of breast cancer","volume":"4","author":"Hansen","year":"2017","journal-title":"Curr Environ Health Rep"},{"key":"10.1016\/j.ebiom.2024.105462_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.semcancer.2023.03.003","article-title":"\"Time\" for obesity-related cancer: the role of the circadian rhythm in cancer pathogenesis and treatment","volume":"91","author":"Miro","year":"2023","journal-title":"Semin Cancer Biol"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105462_bib7","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1210\/en.2012-1486","article-title":"Glucocorticoids as entraining signals for peripheral circadian oscillators","volume":"153","author":"Pezuk","year":"2012","journal-title":"Endocrinology"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105462_bib8","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1152\/physiolgenomics.00001.2012","article-title":"Entrainment of peripheral clock genes by cortisol","volume":"44","author":"Mavroudis","year":"2012","journal-title":"Physiol Genomics"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105462_bib9","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/jc.2008-0125","article-title":"The diagnosis of cushing's syndrome: an endocrine society clinical practice guideline","volume":"93","author":"Nieman","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105462_bib10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11102-014-0569-6","article-title":"Incidence of Cushing's syndrome and Cushing's disease in commercially-insured patients <65 years old in the United States","volume":"18","author":"Broder","year":"2015","journal-title":"Pituitary"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105462_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13114","article-title":"Clinical presentation and etiology of Cushing's syndrome: data from ERCUSYN","volume":"34","author":"Valassi","year":"2022","journal-title":"J\u00a0Neuroendocrinol"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105462_bib12","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S2213-8587(16)00086-3","article-title":"Complications of Cushing's syndrome: state of the art","volume":"4","author":"Pivonello","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105462_bib13","doi-asserted-by":"crossref","DOI":"10.1530\/EC-24-0046","article-title":"Venous thromboembolism in Cushing syndrome: results from an EuRRECa and Endo-ERN survey","volume":"13","author":"Cherenko","year":"2024","journal-title":"Endocr Connect"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105462_bib14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/HJH.0000000000000415","article-title":"The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications","volume":"33","author":"Isidori","year":"2015","journal-title":"J\u00a0Hypertens"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105462_bib15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.tem.2020.04.004","article-title":"The immune system in cushing's syndrome","volume":"31","author":"Hasenmajer","year":"2020","journal-title":"Trends Endocrinol Metabol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105462_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/ejendo\/lvae083","article-title":"Whole blood transcriptomic signature of Cushing's syndrome","volume":"191","author":"Birtolo","year":"2024","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105462_bib17","article-title":"Increased mortality persists after treatment of cushing's disease: a matched nationwide cohort study","volume":"6","author":"Bengtsson","year":"2022","journal-title":"J\u00a0Endocr Soc"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105462_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12113103","article-title":"An optimal time for treatment-predicting circadian time by machine learning and mathematical modelling","volume":"12","author":"Hesse","year":"2020","journal-title":"Cancers"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105462_bib19","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1111\/j.1530-0277.2010.01278.x","article-title":"Reduced expression of circadian clock genes in male alcoholic patients","volume":"34","author":"Huang","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105462_bib20","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1210\/jc.2018-00346","article-title":"Circadian rhythm of glucocorticoid administration entrains clock genes in immune cells: a DREAM trial ancillary study","volume":"103","author":"Venneri","year":"2018","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105462_bib21","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1080\/07420528.2020.1758126","article-title":"Peripheral clock system circadian abnormalities in Cushing's disease","volume":"37","author":"Soares","year":"2020","journal-title":"Chronobiol Int"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105462_bib22","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1080\/07420520701800736","article-title":"Expression of clock genes in human peripheral blood mononuclear cells throughout the sleep\/wake and circadian cycles","volume":"24","author":"James","year":"2007","journal-title":"Chronobiol Int"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105462_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1152\/physiol.00018.2020","article-title":"Minimally invasive ways of determining circadian rhythms in humans","volume":"36","author":"Crnko","year":"2021","journal-title":"Physiology"},{"issue":"18","key":"10.1016\/j.ebiom.2024.105462_bib24","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1002\/sim.9803","article-title":"Experimental design and power calculation in omics circadian rhythmicity detection using the cosinor model","volume":"42","author":"Zong","year":"2023","journal-title":"Stat Med"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105462_bib25","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S2213-8587(21)00235-7","article-title":"Consensus on diagnosis and management of Cushing's disease: a guideline update","volume":"9","author":"Fleseriu","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105462_bib26","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1530\/EJE-22-0454","article-title":"Susceptibility and characteristics of infections in patients with glucocorticoid excess or insufficiency: the ICARO tool","volume":"187","author":"Minnetti","year":"2022","journal-title":"Eur J Endocrinol"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105462_bib27","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1210\/jc.2019-00803","article-title":"Endogenous circadian regulation of female reproductive hormones","volume":"104","author":"Rahman","year":"2019","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105462_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5344","article-title":"Development and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous analysis of androgens, estrogens, glucocorticoids and progestagens in human serum","volume":"36","author":"Iannone","year":"2022","journal-title":"Biomed Chromatogr"},{"key":"10.1016\/j.ebiom.2024.105462_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1742-4682-11-16","article-title":"Cosinor-based rhythmometry","volume":"11","author":"Cornelissen","year":"2014","journal-title":"Theor Biol Med Model"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105462_bib30","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/0748730410379711","article-title":"JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets","volume":"25","author":"Hughes","year":"2010","journal-title":"J\u00a0Biol Rhythms"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105462_bib31","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/j.1550-8528.1994.tb00097.x","article-title":"The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). 1932","volume":"2","author":"Cushing","year":"1994","journal-title":"Obes Res"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105462_bib32","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s11102-013-0522-0","article-title":"Elevated white blood cell counts in Cushing's disease: association with hypercortisolism","volume":"17","author":"Masri-Iraqi","year":"2014","journal-title":"Pituitary"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105462_bib33","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.idc.2007.06.001","article-title":"Hypercortisolemia and infection","volume":"21","author":"Fareau","year":"2007","journal-title":"Infect Dis Clin North Am"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105462_bib34","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0306-4530(96)00021-2","article-title":"Immune regulation in Cushing's syndrome: relationship to hypothalamic-pituitary-adrenal axis hormones","volume":"21","author":"Kronfol","year":"1996","journal-title":"Psychoneuroendocrinology"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105462_bib35","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/ejendo\/lvad151","article-title":"Inflammation-based scores in benign adrenocortical tumours are linked to the degree of cortisol excess: a retrospective single-centre study","volume":"189","author":"Favero","year":"2023","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105462_bib36","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1530\/EJE-21-1199","article-title":"Inflammatory biomarkers in the evaluation of pediatric endogenous Cushing syndrome","volume":"186","author":"Wurth","year":"2022","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105462_bib37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40635-015-0059-9","article-title":"Impairment of neutrophilic glucocorticoid receptor function in patients treated with steroids for septic shock","volume":"3","author":"Bergquist","year":"2015","journal-title":"Intensive Care Med Exp"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105462_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrendo.2015.168","article-title":"Hormonal control of T-cell development in health and disease","volume":"12","author":"Savino","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.ebiom.2024.105462_bib39","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.3389\/fimmu.2019.02035","article-title":"Human monocyte subsets and phenotypes in major chronic inflammatory diseases","volume":"10","author":"Kapellos","year":"2019","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105462_bib40","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1161\/ATVBAHA.111.230979","article-title":"CD14dimCD16+ and CD14+CD16+ monocytes in obesity and during weight loss: relationships with fat mass and subclinical atherosclerosis","volume":"31","author":"Poitou","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105462_bib41","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/oby.21887","article-title":"Increased adipocyte size, macrophage infiltration, and adverse local adipokine profile in perirenal fat in cushing's syndrome","volume":"25","author":"Roerink","year":"2017","journal-title":"Obesity"},{"key":"10.1016\/j.ebiom.2024.105462_bib42","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.3389\/fimmu.2020.01743","article-title":"Innate rhythms: clocks at the center of monocyte and macrophage function","volume":"11","author":"Timmons","year":"2020","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105462_bib43","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/imm.13053","article-title":"Daily variation in macrophage phagocytosis is clock-independent and dispensable for cytokine production","volume":"157","author":"Geiger","year":"2019","journal-title":"Immunology"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105462_bib44","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/ejendo\/lvad041","article-title":"Low-grade inflammation during the glucocorticoid withdrawal phase in patients with Cushing's syndrome","volume":"188","author":"Vogel","year":"2023","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105462_bib45","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3109\/07420528.2013.775654","article-title":"Diurnal redistribution of human lymphocytes and their temporal associations with salivary cortisol","volume":"30","author":"Trifonova","year":"2013","journal-title":"Chronobiol Int"},{"issue":"72","key":"10.1016\/j.ebiom.2024.105462_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abm2465","article-title":"The circadian immune system","volume":"7","author":"Wang","year":"2022","journal-title":"Sci Immunol"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105462_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029801","article-title":"Circadian clocks in mouse and human CD4+ T cells","volume":"6","author":"Bollinger","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105462_bib48","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.immuni.2018.01.004","article-title":"Glucocorticoids drive diurnal oscillations in T cell distribution and responses by inducing interleukin-7 receptor and CXCR4","volume":"48","author":"Shimba","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.ebiom.2024.105462_bib49","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev-physiol-021909-135821","article-title":"The mammalian circadian timing system: organization and coordination of central and peripheral clocks","volume":"72","author":"Dibner","year":"2010","journal-title":"Annu Rev Physiol"},{"issue":"45","key":"10.1016\/j.ebiom.2024.105462_bib50","doi-asserted-by":"crossref","first-page":"16219","DOI":"10.1073\/pnas.1408886111","article-title":"A\u00a0circadian gene expression atlas in mammals: implications for biology and medicine","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105462_bib51","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1172\/JCI120874","article-title":"High-accuracy determination of internal circadian time from a single blood sample","volume":"128","author":"Wittenbrink","year":"2018","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105462_bib52","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1530\/JOE-20-0066","article-title":"Fixing the broken clock in adrenal disorders: focus on glucocorticoids and chronotherapy","volume":"246","author":"Minnetti","year":"2020","journal-title":"J\u00a0Endocrinol"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105462_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025612","article-title":"Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man","volume":"6","author":"Charmandari","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105462_bib54","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00109-005-0697-6","article-title":"Atypical patterns of circadian clock gene expression in human peripheral blood mononuclear cells","volume":"83","author":"Teboul","year":"2005","journal-title":"J\u00a0Mol Med (Berl)"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105462_bib55","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neures.2008.01.012","article-title":"Expression profiles of 10 circadian clock genes in human peripheral blood mononuclear cells","volume":"61","author":"Kusanagi","year":"2008","journal-title":"Neurosci Res"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105462_bib56","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S2213-8587(17)30398-4","article-title":"Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial","volume":"6","author":"Isidori","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"21","key":"10.1016\/j.ebiom.2024.105462_bib57","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1111\/febs.16095","article-title":"Venn diagram analysis overestimates the extent of circadian rhythm reprogramming","volume":"289","author":"Pelikan","year":"2022","journal-title":"FEBS J"},{"key":"10.1016\/j.ebiom.2024.105462_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.747549","article-title":"A\u00a0new clinical model to estimate the pre-test probability of cushing's syndrome: the cushing score","volume":"12","author":"Parasiliti-Caprino","year":"2021","journal-title":"Front Endocrinol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105462_bib59","doi-asserted-by":"crossref","DOI":"10.1093\/ejendo\/lvac016","article-title":"Lack of sensitivity of diagnostic Cushing-scores in Germany: a multicenter validation","volume":"188","author":"Braun","year":"2023","journal-title":"Eur J Endocrinol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424004985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424004985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T21:58:56Z","timestamp":1733954336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424004985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":59,"alternative-id":["S2352396424004985"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105462","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-level analysis from a multicentre clinical trial","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105462","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105462"}}