{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:38:23Z","timestamp":1787063903053,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005902","name":"Institute for Clinical and Translational Research, University of Wisconsin, Madison","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005902","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007923","name":"University of Wisconsin Carbone Cancer Center","doi-asserted-by":"publisher","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}],"id":[{"id":"10.13039\/100007923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ebiom.2024.105496","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T08:37:25Z","timestamp":1733992645000},"page":"105496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Safety and toxicity of Iopofosine I 131 (CLR 131) with external beam radiation therapy in recurrent or metastatic head and neck cancer: results of a phase 1 single-centre, open-label, single-arm, dose escalation and dose expansion study"],"prefix":"10.1016","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5902-7430","authenticated-orcid":false,"given":"Justine Yang","family":"Bruce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Burr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Kimple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8282-6660","authenticated-orcid":false,"given":"David P.","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menggang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari M.","family":"Piaskowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany A.","family":"Glazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1208-0568","authenticated-orcid":false,"given":"Patrick","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory K.","family":"Hartig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"McCulloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Wieland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Trask","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarrod","family":"Longcor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7294-4180","authenticated-orcid":false,"given":"Nicole","family":"Rogus-Pulia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve Y.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7467-9816","authenticated-orcid":false,"given":"Bryan","family":"Bednarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Harari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ebiom.2024.105496_bib1","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1634\/theoncologist.2009-0289","article-title":"Changes in survival in head and neck cancers in the late 20th and early 21st century: a period analysis","volume":"15","author":"Pulte","year":"2010","journal-title":"Oncologist"},{"issue":"7 Suppl","key":"10.1016\/j.ebiom.2024.105496_bib2","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1002\/cncr.23654","article-title":"Head and neck cancer: an evolving treatment paradigm","volume":"113","author":"Cognetti","year":"2008","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105496_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients","volume":"92","author":"Pignon","year":"2009","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105496_bib4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.oooo.2016.01.007","article-title":"Osteoradionecrosis following treatment for head and neck cancer and the effect of radiotherapy dosimetry: the Guy's and St Thomas' Head and Neck Cancer Unit experience","volume":"122","author":"De Felice","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"17","key":"10.1016\/j.ebiom.2024.105496_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15174321","article-title":"Hypothyroidism following radiotherapy for head and neck cancer: a systematic review of the literature and opportunities to improve the therapeutic ratio","volume":"15","author":"Rooney","year":"2023","journal-title":"Cancers"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105496_bib6","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.ijrobp.2011.06.1998","article-title":"Practical considerations in the re-irradiation of recurrent and second primary head-and-neck cancer: who, why, how, and how much?","volume":"81","author":"Chen","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105496_bib7","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.ijrobp.2011.01.004","article-title":"Reirradiation for head-and-neck cancer: delicate balance between effectiveness and toxicity","volume":"81","author":"Hoebers","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105496_bib8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.oraloncology.2004.07.006","article-title":"A\u00a0review on re-irradiation for recurrent and second primary head and neck cancer","volume":"41","author":"Kasperts","year":"2005","journal-title":"Oral Oncol"},{"issue":"240","key":"10.1016\/j.ebiom.2024.105496_bib9","doi-asserted-by":"crossref","first-page":"240ra75","DOI":"10.1126\/scitranslmed.3007646","article-title":"Alkylphosphocholine analogs for broad-spectrum cancer imaging and therapy","volume":"6","author":"Weichert","year":"2014","journal-title":"Sci Transl Med"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105496_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1517\/13543776.17.4.385","article-title":"Antitumour ether liquids: proapoptotic agents with multiple therapeutic indications","volume":"17","author":"Mollinedo","year":"2007","journal-title":"Expert Opin Ther Pat"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105496_bib11","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.radonc.2015.06.015","article-title":"Therapeutic combination of radiolabeled CLR1404 with external beam radiation in head and neck cancer model systems","volume":"116","author":"Morris","year":"2015","journal-title":"Radiother Oncol"},{"issue":"15","key":"10.1016\/j.ebiom.2024.105496_bib12","article-title":"A\u00a0phase I, multicenter, open-label dosimetry study of I-131-CLR1404 in patients with relapsed or refractory advanced solid tumors who have failed standard therapy or for whom no standard therapy exists","volume":"30","author":"Chao","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105496_bib13","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3109\/07357907.2015.1081691","article-title":"A\u00a0phase 1, multi-center, open-label, dose-escalation study of I-CLR1404 in subjects with relapsed or refractory advanced solid malignancies","volume":"33","author":"Lubner","year":"2015","journal-title":"Cancer Invest"},{"issue":"Supplement_1","key":"10.1016\/j.ebiom.2024.105496_bib14","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1182\/blood-2019-131014","article-title":"Fractionated dosing of CLR 131 in patients with relapsed or refractory multiple myeloma (RRMM)","volume":"134","author":"Ailawadhi","year":"2019","journal-title":"Blood"},{"issue":"15_suppl","key":"10.1016\/j.ebiom.2024.105496_bib15","doi-asserted-by":"crossref","first-page":"7561","DOI":"10.1200\/JCO.2021.39.15_suppl.7561","article-title":"Treatment free remission (TFR) and overall response rate (ORR) results in patients with relapsed\/refractory Waldenstrom's macroglobulinemia (WM) treated with CLR 131","volume":"39","author":"Ailawadhi","year":"2021","journal-title":"J\u00a0Clin Oncol"},{"issue":"Supplement 1","key":"10.1016\/j.ebiom.2024.105496_bib16","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1182\/blood-2021-152682","article-title":"CLR 131 (iopofosine I-131) treatment in triple class refractory and beyond multiple myeloma patients: preliminary efficacy and safety results from the phase 2 clover-1 trial","volume":"138","author":"Ailawadhi","year":"2021","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105496_bib17","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41408-022-00725-2","article-title":"Iopofosine I-131 treatment in late-line patients with relapsed\/refractory multiple myeloma post anti-BCMA immunotherapy","volume":"12","author":"Longcor","year":"2022","journal-title":"Blood Cancer J"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105496_bib18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3857\/roj.2021.00640","article-title":"Re-irradiation for recurrent or second primary head and neck cancer","volume":"39","author":"Lee","year":"2021","journal-title":"Radiat Oncol J"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105496_bib19","first-page":"155","article-title":"Development and validation of RAPID: a patient-specific Monte Carlo three-dimensional internal dosimetry platform","volume":"33","author":"Besemer","year":"2018","journal-title":"Cancer Biother Radiopharm"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105496_bib20","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1002\/mp.15699","article-title":"Validation of Monte Carlo (131) I radiopharmaceutical dosimetry workflow using a 3D-printed anthropomorphic head and neck phantom","volume":"49","author":"Adam","year":"2022","journal-title":"Med Phys"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105496_bib21","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1118\/1.1644532","article-title":"Validation of GEANT4, an object-oriented Monte Carlo toolkit, for simulations in medical physics","volume":"31","author":"Carrier","year":"2004","journal-title":"Med Phys"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105496_bib22","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0168-9002(03)01368-8","article-title":"GEANT4-a simulation toolkit","volume":"506","author":"Agostinelli","year":"2003","journal-title":"Nucl Instrum Meth A"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105496_bib23","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/cncr.34079","article-title":"Refining measurement of swallowing safety in the dynamic imaging grade of swallowing toxicity (DIGEST) criteria: validation of DIGEST version 2","volume":"128","author":"Hutcheson","year":"2022","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105496_bib24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105496_bib25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijrobp.2009.04.021","article-title":"Xerostomia after treatment for oral and oropharyngeal cancer using the University of Washington saliva domain and a Xerostomia-Related Quality-of-Life Scale","volume":"77","author":"Rogers","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"14","key":"10.1016\/j.ebiom.2024.105496_bib26","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1200\/JCO.2012.45.7903","article-title":"Modified toxicity probability interval design: a safer and more reliable method than the 3\u00a0+ 3 design for practical phase I trials","volume":"31","author":"Ji","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105496_bib27","doi-asserted-by":"crossref","first-page":"773","DOI":"10.4321\/S1130-01082004001100005","article-title":"Unstimulated salivary flow rate, pH and buffer capacity of saliva in healthy volunteers","volume":"96","author":"Fenoll-Palomares","year":"2004","journal-title":"Rev Esp Enferm Dig"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105496_bib28","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/lary.25778","article-title":"What is a clinically relevant difference in MDADI scores between groups of head and neck cancer patients?","volume":"126","author":"Hutcheson","year":"2016","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105496_bib29","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa1607427","article-title":"Phase 3 trial of (177)Lu-dotatate for midgut neuroendocrine tumors","volume":"376","author":"Strosberg","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105496_bib30","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1056\/NEJMoa2107322","article-title":"Lutetium-177-PSMA-617 for metastatic castration-resistant prostate cancer","volume":"385","author":"Sartor","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105496_bib31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1200\/JOP.19.00652","article-title":"Management of cancer therapy-associated oral mucositis","volume":"16","author":"Brown","year":"2020","journal-title":"JCO Oncol Pract"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105496_bib32","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.37265","article-title":"Severe oral mucositis after intensity-modulated radiation therapy for head and neck cancer","volume":"6","author":"Iovoli","year":"2023","journal-title":"JAMA Netw Open"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424005322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424005322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T03:09:19Z","timestamp":1736824159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424005322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":32,"alternative-id":["S2352396424005322"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105496","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and toxicity of Iopofosine I 131 (CLR 131) with external beam radiation therapy in recurrent or metastatic head and neck cancer: results of a phase 1 single-centre, open-label, single-arm, dose escalation and dose expansion study","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105496","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105496"}}