{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:37:09Z","timestamp":1792442229977,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2020YFA0509400"],"award-info":[{"award-number":["2020YFA0509400"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004147","name":"Tsinghua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972462"],"award-info":[{"award-number":["81972462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473018"],"award-info":[{"award-number":["82473018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ebiom.2024.105503","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T13:27:08Z","timestamp":1734096428000},"page":"105503","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["OPG promotes lung metastasis by reducing CXCL10 production of monocyte-derived macrophages and decreasing NK cell recruitment"],"prefix":"10.1016","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0794-5718","authenticated-orcid":false,"given":"Haitian","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4486-6143","authenticated-orcid":false,"given":"Guoyuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengjiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-2096","authenticated-orcid":false,"given":"Xuxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8062-1215","authenticated-orcid":false,"given":"Hanqiu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ebiom.2024.105503_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41591-020-01195-4","article-title":"Targeting metastatic cancer","volume":"27","author":"Ganesh","year":"2021","journal-title":"Nat Med"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105503_bib2","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nm.3909","article-title":"The prognostic landscape of genes and infiltrating immune cells across human cancers","volume":"21","author":"Gentles","year":"2015","journal-title":"Nat Med"},{"issue":"7355","key":"10.1016\/j.ebiom.2024.105503_bib3","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10138","article-title":"CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis","volume":"475","author":"Qian","year":"2011","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105503_bib4","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41573-022-00520-5","article-title":"Macrophages as tools and targets in cancer therapy","volume":"21","author":"Mantovani","year":"2022","journal-title":"Nat Rev Drug Discov"},{"issue":"7868","key":"10.1016\/j.ebiom.2024.105503_bib5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-021-03651-8","article-title":"Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells","volume":"595","author":"Casanova-Acebes","year":"2021","journal-title":"Nature"},{"issue":"23","key":"10.1016\/j.ebiom.2024.105503_bib6","doi-asserted-by":"crossref","first-page":"11238","DOI":"10.1158\/0008-5472.CAN-06-1278","article-title":"Macrophages regulate the angiogenic switch in a mouse model of breast cancer","volume":"66","author":"Lin","year":"2006","journal-title":"Cancer Res"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105503_bib7","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.cell.2023.02.020","article-title":"Macrophages at the interface of the co-evolving cancer ecosystem","volume":"186","author":"Kloosterman","year":"2023","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105503_bib8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41568-022-00547-1","article-title":"A\u00a0timeline of tumour-associated macrophage biology","volume":"23","author":"Cassetta","year":"2023","journal-title":"Nat Rev Cancer"},{"issue":"17","key":"10.1016\/j.ebiom.2024.105503_bib9","doi-asserted-by":"crossref","first-page":"6662","DOI":"10.1073\/pnas.1121623109","article-title":"The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors","volume":"109","author":"Willingham","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105503_bib10","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ccell.2020.12.023","article-title":"Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance","volume":"39","author":"Lin","year":"2021","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105503_bib11","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/s41590-022-01267-2","article-title":"The complex role of tumor-infiltrating macrophages","volume":"23","author":"Christofides","year":"2022","journal-title":"Nat Immunol"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105503_bib12","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.4049\/jimmunol.1403215","article-title":"Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs","volume":"194","author":"Sharma","year":"2015","journal-title":"J\u00a0Immunol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105503_bib13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41590-023-01428-x","article-title":"Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs","volume":"24","author":"Wang","year":"2023","journal-title":"Nat Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105503_bib14","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41590-023-01475-4","article-title":"TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer","volume":"24","author":"Park","year":"2023","journal-title":"Nat Immunol"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105503_bib15","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.immuni.2021.06.012","article-title":"Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1","volume":"54","author":"Keerthivasan","year":"2021","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105503_bib16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41590-022-01388-8","article-title":"Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis","volume":"24","author":"Ding","year":"2023","journal-title":"Nat Immunol"},{"issue":"7084","key":"10.1016\/j.ebiom.2024.105503_bib17","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nature04524","article-title":"Regulation of cancer cell migration and bone metastasis by RANKL","volume":"440","author":"Jones","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2024.105503_bib18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1101\/sqb.2016.81.030775","article-title":"Tumor-stroma interactions in bone metastasis: molecular mechanisms and therapeutic implications","volume":"81","author":"Zheng","year":"2016","journal-title":"Cold Spring Harb Symp Quant Biol"},{"issue":"6656","key":"10.1016\/j.ebiom.2024.105503_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/36593","article-title":"A\u00a0homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function","volume":"390","author":"Anderson","year":"1997","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ebiom.2024.105503_bib20","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41571-018-0095-y","article-title":"Roles of the RANKL\u2013RANK axis in antitumour immunity \u2014 implications for therapy","volume":"15","author":"Ahern","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"issue":"7335","key":"10.1016\/j.ebiom.2024.105503_bib21","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nature09707","article-title":"Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling","volume":"470","author":"Tan","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105503_bib22","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1038\/s41467-020-20138-8","article-title":"Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells","volume":"11","author":"Gomez-Aleza","year":"2020","journal-title":"Nat Commun"},{"issue":"19","key":"10.1016\/j.ebiom.2024.105503_bib23","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1158\/0008-5472.CAN-15-2745","article-title":"RANK signaling blockade reduces breast cancer recurrence by inducing tumor cell differentiation","volume":"76","author":"Yoldi","year":"2016","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105503_bib24","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s43018-022-00353-6","article-title":"Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs","volume":"3","author":"Hongu","year":"2022","journal-title":"Nat Cancer"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105503_bib25","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1002\/ijc.32329","article-title":"Integration of whole-genome sequencing and functional screening identifies a prognostic signature for lung metastasis in triple-negative breast cancer","volume":"145","author":"Xie","year":"2019","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105503_bib26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ccell.2017.06.009","article-title":"Control of metastasis by NK cells","volume":"32","author":"Lopez-Soto","year":"2017","journal-title":"Cancer Cell"},{"issue":"20","key":"10.1016\/j.ebiom.2024.105503_bib27","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1158\/0008-5472.CAN-23-1097","article-title":"Harnessing natural killer cells for lung cancer therapy","volume":"83","author":"Ma","year":"2023","journal-title":"Cancer Res"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105503_bib28","doi-asserted-by":"crossref","first-page":"709-+","DOI":"10.1038\/s43018-020-0068-9","article-title":"Resistance to natural killer cell immunosurveillance confers a selective advantage to polyclonal metastasis","volume":"1","author":"Lo","year":"2020","journal-title":"Nature Cancer"},{"issue":"7958","key":"10.1016\/j.ebiom.2024.105503_bib29","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/s41586-023-05880-5","article-title":"STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma","volume":"616","author":"Hu","year":"2023","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.ebiom.2024.105503_bib30","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1158\/0008-5472.CAN-13-3017","article-title":"Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30","volume":"74","author":"Schlecker","year":"2014","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105503_bib31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1182\/blood-2004-06-2272","article-title":"Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells","volume":"105","author":"Palumbo","year":"2005","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105503_bib32","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ccell.2023.01.001","article-title":"Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance","volume":"41","author":"Liu","year":"2023","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105503_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2016.02.025","article-title":"Metastatic latency and immune evasion through autocrine inhibition of WNT","volume":"165","author":"Malladi","year":"2016","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105503_bib34","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/s41590-019-0417-y","article-title":"The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis","volume":"20","author":"Mattiola","year":"2019","journal-title":"Nat Immunol"},{"issue":"6263","key":"10.1016\/j.ebiom.2024.105503_bib35","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.aac9407","article-title":"Patrolling monocytes control tumor metastasis to the lung","volume":"350","author":"Hanna","year":"2015","journal-title":"Science"},{"issue":"383","key":"10.1016\/j.ebiom.2024.105503_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aag1166","article-title":"The druggable genome and support for target identification and validation in drug development","volume":"9","author":"Finan","year":"2017","journal-title":"Sci Transl Med"},{"issue":"6377","key":"10.1016\/j.ebiom.2024.105503_bib37","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.aao1710","article-title":"A\u00a0major chromatin regulator determines resistance of tumor cells to T cell-mediated killing","volume":"359","author":"Pan","year":"2018","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105503_bib38","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s13059-014-0554-4","article-title":"MAGeCK enables robust identification of essential genes from genome-scale CRISPR\/Cas9 knockout screens","volume":"15","author":"Li","year":"2014","journal-title":"Genome Biol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105503_bib39","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41596-018-0113-7","article-title":"Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute","volume":"14","author":"Wang","year":"2019","journal-title":"Nat Protoc"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105503_bib40","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105503_bib41","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv1507","article-title":"TCGAbiolinks: an R\/Bioconductor package for integrative analysis of TCGA data","volume":"44","author":"Colaprico","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105503_bib42","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"issue":"16","key":"10.1016\/j.ebiom.2024.105503_bib43","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1093\/bioinformatics\/bti525","article-title":"BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis","volume":"21","author":"Durinck","year":"2005","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105503_bib44","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat Methods"},{"issue":"15","key":"10.1016\/j.ebiom.2024.105503_bib45","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1158\/0008-5472.CAN-16-0544","article-title":"Adenosine 2B receptor expression on cancer cells promotes metastasis","volume":"76","author":"Mittal","year":"2016","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105503_bib46","first-page":"1399","article-title":"Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor","volume":"52","author":"Aslakson","year":"1992","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105503_bib47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cell.2016.02.065","article-title":"Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma","volume":"165","author":"Hugo","year":"2016","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105503_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002201","article-title":"Mutational profile of metastatic breast cancers: a retrospective analysis","volume":"13","author":"Lefebvre","year":"2016","journal-title":"PLoS Med"},{"issue":"7403","key":"10.1016\/j.ebiom.2024.105503_bib49","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10983","article-title":"The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups","volume":"486","author":"Curtis","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2024.105503_bib50","article-title":"The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes","volume":"7","author":"Pereira","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2024.105503_bib51","series-title":"Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis","author":"Garcia-Recio","year":"2022"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105503_bib52","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105503_bib53","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer","volume":"20","author":"Dongre","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105503_bib54","doi-asserted-by":"crossref","DOI":"10.1111\/pcmr.12091","article-title":"Differential expression and tumor necrosis factor-mediated regulation of TNFRSF11b\/osteoprotegerin production by human melanomas","volume":"26","author":"Oliver","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"issue":"39","key":"10.1016\/j.ebiom.2024.105503_bib55","doi-asserted-by":"crossref","first-page":"36241","DOI":"10.1074\/jbc.M104319200","article-title":"Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-\u03b2 (TGF-\u03b2) -: mapping of the OPG promoter region that mediates TGF-\u03b2 effects","volume":"276","author":"Thirunavukkarasu","year":"2001","journal-title":"J\u00a0Biol Chem"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105503_bib56","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming growth factor-beta signaling in immunity and cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105503_bib57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41571-020-0403-1","article-title":"TGFbeta biology in cancer progression and immunotherapy","volume":"18","author":"Derynck","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105503_bib58","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41571-021-00588-9","article-title":"Harnessing cytokines and chemokines for cancer therapy","volume":"19","author":"Propper","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105503_bib59","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41420-022-01042-0","article-title":"The roles of osteoprotegerin in cancer, far beyond a bone player","volume":"8","author":"Wang","year":"2022","journal-title":"Cell Death Discov"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105503_bib60","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/cas.12112","article-title":"Functional roles of tumor necrosis factor-related apoptosis-inducing ligandDR5 interaction in B16F10 cells by activating the nuclear factor-B pathway to induce metastatic potential","volume":"104","author":"Takahashi","year":"2013","journal-title":"Cancer Sci"},{"issue":"6717","key":"10.1016\/j.ebiom.2024.105503_bib61","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"Kong","year":"1999","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105503_bib62","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105503_bib63","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ccr.2010.11.009","article-title":"HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF","volume":"19","author":"Rolny","year":"2011","journal-title":"Cancer Cell"},{"issue":"25","key":"10.1016\/j.ebiom.2024.105503_bib64","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1056\/NEJMoa021967","article-title":"A\u00a0gene-expression signature as a predictor of survival in breast cancer","volume":"347","author":"van de Vijver","year":"2002","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105503_bib65","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.immuni.2021.01.012","article-title":"Chemokines and the immune response to cancer","volume":"54","author":"Ozga","year":"2021","journal-title":"Immunity"},{"issue":"15","key":"10.1016\/j.ebiom.2024.105503_bib66","doi-asserted-by":"crossref","first-page":"7701","DOI":"10.1158\/0008-5472.CAN-06-0709","article-title":"Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer","volume":"66","author":"Walser","year":"2006","journal-title":"Cancer Res"},{"issue":"459","key":"10.1016\/j.ebiom.2024.105503_bib67","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat7807","article-title":"The hallmarks of successful anticancer immunotherapy","volume":"10","author":"Galluzzi","year":"2018","journal-title":"Sci Transl Med"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105503_bib68","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1158\/2159-8290.CD-18-0367","article-title":"Fundamental mechanisms of immune checkpoint blockade therapy","volume":"8","author":"Wei","year":"2018","journal-title":"Cancer Discov"},{"issue":"19","key":"10.1016\/j.ebiom.2024.105503_bib69","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1158\/1078-0432.CCR-17-0606","article-title":"Co-Administration of RANKL and CTLA4 antibodies enhances lymphocyte-mediated antitumor immunity in mice","volume":"23","author":"Ahern","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ebiom.2024.105503_bib70","article-title":"Therapeutic interruption of T cell development generates high-affinity T cells that escape exhaustion and improve cancer immunotherapy","author":"Dhuey","year":"2022","journal-title":"bioRxiv"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105503_bib71","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.cell.2022.03.009","article-title":"Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody","volume":"185","author":"Li","year":"2022","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105503_bib72","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2116271119","article-title":"Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis","volume":"119","author":"Qiu","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105503_bib73","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/nrc2465","article-title":"The TRAIL apoptotic pathway in cancer onset, progression and therapy","volume":"8","author":"Johnstone","year":"2008","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105503_bib74","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ccr.2009.05.017","article-title":"Latent bone metastasis in breast cancer tied to Src-dependent survival signals","volume":"16","author":"Zhang","year":"2009","journal-title":"Cancer Cell"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424005395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396424005395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T08:09:48Z","timestamp":1736842188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396424005395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":74,"alternative-id":["S2352396424005395"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105503","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"OPG promotes lung metastasis by reducing CXCL10 production of monocyte-derived macrophages and decreasing NK cell recruitment","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105503","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105503"}}