{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:27:55Z","timestamp":1788294475608,"version":"build-2803163510"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL139634"],"award-info":[{"award-number":["R01 HL139634"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["U19AI168643"],"award-info":[{"award-number":["U19AI168643"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["K01HL153941"],"award-info":[{"award-number":["K01HL153941"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["P01HL132825"],"award-info":[{"award-number":["P01HL132825"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["U01HG008685"],"award-info":[{"award-number":["U01HG008685"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["K01HL17526"],"award-info":[{"award-number":["K01HL17526"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["R01HL123915"],"award-info":[{"award-number":["R01HL123915"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["K01HL146980"],"award-info":[{"award-number":["K01HL146980"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["R01HL141826"],"award-info":[{"award-number":["R01HL141826"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["R01HL169300"],"award-info":[{"award-number":["R01HL169300"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL155742"],"award-info":[{"award-number":["R01HL155742"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL127332"],"award-info":[{"award-number":["R01 HL127332"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ebiom.2024.105534","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T13:03:43Z","timestamp":1735563823000},"page":"105534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["miRNAome-metabolome wide association study reveals effects of miRNA regulation in eosinophilia and airflow obstruction in childhood asthma"],"prefix":"10.1016","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3036-2080","authenticated-orcid":false,"given":"Rinku","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Mendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofina","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Prince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Hecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel S.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E.","family":"Wheelock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-5320","authenticated-orcid":false,"given":"Juan C.","family":"Celed\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clary","family":"Clish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gertszen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelan G.","family":"Tantisira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott T.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lasky-Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5566-2712","authenticated-orcid":false,"given":"Michael","family":"McGeachie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"38","key":"10.1016\/j.ebiom.2024.105534_bib1","doi-asserted-by":"crossref","first-page":"32883","DOI":"10.1074\/jbc.R110.197046","article-title":"Allergic asthma: influence of genetic and environmental factors","volume":"286","author":"Mukherjee","year":"2011","journal-title":"J\u00a0Biol Chem"},{"issue":"10122","key":"10.1016\/j.ebiom.2024.105534_bib2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0140-6736(17)33311-1","article-title":"Asthma","volume":"391","author":"Papi","year":"2018","journal-title":"Lancet (London, England)"},{"issue":"10379","key":"10.1016\/j.ebiom.2024.105534_bib3","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0140-6736(22)02125-0","article-title":"Asthma","volume":"401","author":"Porsbjerg","year":"2023","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ebiom.2024.105534_bib4","series-title":"Services 2019 national health interview survey data. U.S. Department of health & human","year":"2020"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105534_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/pai.13780","article-title":"Gene-environment interactions in childhood asthma revisited; expanding the interaction concept","volume":"33","author":"Hernandez-Pacheco","year":"2022","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.ebiom.2024.105534_bib6","doi-asserted-by":"crossref","DOI":"10.3402\/ecrj.v2.24643","article-title":"Genetics of asthma: an introduction for the clinician","volume":"2","author":"Thomsen","year":"2015","journal-title":"Eur Clin Respir J"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105534_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167969","article-title":"Stability of circulating blood-based MicroRNAs - pre-analytic methodological considerations","volume":"12","author":"Glinge","year":"2017","journal-title":"PLoS One"},{"issue":"30","key":"10.1016\/j.ebiom.2024.105534_bib8","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ebiom.2024.105534_bib9","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O\u2019Brien","year":"2018","journal-title":"Front Endocrinol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105534_bib10","doi-asserted-by":"crossref","first-page":"1093-","DOI":"10.1016\/j.jaci.2020.08.019","article-title":"Enhancing the prediction of childhood asthma remission: integrating clinical factors with {microRNAs","volume":"147","author":"Wang","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.ebiom.2024.105534_bib11","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jaci.2017.01.023","article-title":"Asthma remission: predicting future airways responsiveness using an miRNA network","volume":"140","author":"McGeachie","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.ebiom.2024.105534_bib12","article-title":"Metabolomics for biomarker discovery: moving to the clinic","volume":"2015","author":"Zhang","year":"2015","journal-title":"BioMed Res Int"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105534_bib13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40246-018-0134-x","article-title":"Beyond genomics: understanding exposotypes through metabolomics","volume":"12","author":"Rattray","year":"2018","journal-title":"Hum Genomics"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105534_bib14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3390\/metabo9060117","article-title":"Integration of metabolomic and other omics data in population-based study designs: an epidemiological perspective","volume":"9","author":"Chu","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.ebiom.2024.105534_bib15","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1111\/all.13916","article-title":"Circulating miRNAs as diagnostic tool for discrimination of respiratory disease: asthma, asthma-chronic obstructive pulmonary disease (COPD) overlap and COPD","volume":"74","author":"Rodrigo-Mu\u00f1oz","year":"2019","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105534_bib16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/cells9020276","article-title":"miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis","volume":"9","author":"Condrat","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105534_bib17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41392-023-01399-3","article-title":"Small molecule metabolites: discovery of biomarkers and therapeutic targets","volume":"8","author":"Qiu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.ebiom.2024.105534_bib18","article-title":"Metabolomics identifies metabolite markers in plasma and extracellular vesicles within plasma in patients with asthma","volume":"565","author":"Chang","year":"2024","journal-title":"Clin Chim Acta"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105534_bib19","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/1354750X.2020.1810320","article-title":"Serum {MicroRNA} on inflammation: a literature review of mouse model studies","volume":"25","author":"Lee","year":"2020","journal-title":"Biomarkers"},{"key":"10.1016\/j.ebiom.2024.105534_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2020.00191","article-title":"Airway remodeling in asthma","volume":"7","author":"Hough","year":"2020","journal-title":"Front Med"},{"issue":"12","key":"10.1016\/j.ebiom.2024.105534_bib21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11882-022-01050-1","article-title":"Recent miRNA research in asthma","volume":"22","author":"Sharma","year":"2022","journal-title":"Curr Allergy Asthma Rep"},{"issue":"7","key":"10.1016\/j.ebiom.2024.105534_bib22","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/metabo11070430","article-title":"Potential metabolic biomarkers in adult asthmatics","volume":"11","author":"Sim","year":"2021","journal-title":"Metabolites"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105534_bib23","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.chest.2016.10.008","article-title":"Asthma metabolomics and the potential for integrative omics in research and the clinic","volume":"151","author":"Kelly","year":"2017","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105534_bib24","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41591-022-01714-5","article-title":"Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma","volume":"28","author":"Kachroo","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2024.105534_bib25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jbior.2018.09.001","article-title":"Sphingolipids and their enigmatic role in asthma","volume":"70","author":"Sturgill","year":"2018","journal-title":"Adv Biol Regul"},{"key":"10.1016\/j.ebiom.2024.105534_bib26","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1038\/s41564-019-0574-7","article-title":"Author Correction: elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance","volume":"4","author":"Levan","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.ebiom.2024.105534_bib27","article-title":"L-carnitine improves the asthma control in children with moderate persistent asthma","volume":"2012","author":"Al-Biltagi","year":"2012","journal-title":"J\u00a0Allergy"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105534_bib28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41580-021-00354-w","article-title":"MicroRNA-mediated regulation of glucose and lipid metabolism","volume":"22","author":"Agbu","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5985","key":"10.1016\/j.ebiom.2024.105534_bib29","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1126\/science.1189123","article-title":"MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis","volume":"328","author":"Najafi-Shoushtari","year":"2010","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105534_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125171","article-title":"MicroRNA-27a contributes to rhabdomyosarcoma cell proliferation by suppressing RARA and RXRA","volume":"10","author":"Tombolan","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105534_bib31","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.chest.2018.05.038","article-title":"An integrative transcriptomic and metabolomic study of lung function in children with asthma","volume":"154","author":"Kelly","year":"2018","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105534_bib32","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1164\/rccm.202105-1268OC","article-title":"Metabo-endotypes of asthma reveal differences in lung function: discovery and validation in two TOPMed cohorts","volume":"205","author":"Kelly","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105534_bib33","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/j.jaci.2020.11.048","article-title":"{COPD-associated} miR-145-5p is downregulated in early-decline {FEV1} trajectories in childhood asthma","volume":"147","author":"Tiwari","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"D1","key":"10.1016\/j.ebiom.2024.105534_bib34","doi-asserted-by":"crossref","first-page":"D211","DOI":"10.1093\/nar\/gkab808","article-title":"miRNATissueAtlas2: an update to the human miRNA tissue atlas","volume":"50","author":"Keller","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ebiom.2024.105534_bib35","series-title":"Mediation analysis bt - partial least squares structural equation modeling (PLS-SEM) using R: a workbook","first-page":"139","author":"Hair","year":"2021"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105534_bib36","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1038\/s41467-024-48507-7","article-title":"Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations","volume":"15","author":"Szczesny","year":"2024","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105534_bib37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10787-022-01097-6","article-title":"MicroRNAs-mediated regulation pathways in rheumatic diseases","volume":"31","author":"Assadiasl","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ebiom.2024.105534_bib38","article-title":"MicroRNAs as immune regulators and biomarkers in tuberculosis","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"issue":"Suppl 1","key":"10.1016\/j.ebiom.2024.105534_bib39","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.33549\/physiolres.934398","article-title":"Biomarkers of bronchial asthma","volume":"69","author":"Kunc","year":"2020","journal-title":"Physiol Res"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105534_bib40","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00018-022-04228-y","article-title":"miRNA-guided reprogramming of glucose and glutamine metabolism and its impact on cell adhesion\/migration during solid tumor progression","volume":"79","author":"Quirico","year":"2022","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105534_bib41","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1038\/s41598-020-62255-w","article-title":"microRNA and metabolite signatures linked to early consequences of lethal radiation","volume":"10","author":"Chakraborty","year":"2020","journal-title":"Sci Rep"},{"issue":"36","key":"10.1016\/j.ebiom.2024.105534_bib42","doi-asserted-by":"crossref","first-page":"39151","DOI":"10.18632\/oncotarget.5341","article-title":"Subpathway-GMir: identifying miRNA-mediated metabolic subpathways by integrating condition-specific genes, microRNAs, and pathway topologies","volume":"6","author":"Feng","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.ebiom.2024.105534_bib43","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molimm.2016.09.004","article-title":"MiR-143-3p controls TGF-\u03b21-induced cell proliferation and extracellular matrix production in airway smooth muscle via negative regulation of the nuclear\u00a0factor of activated T cells 1","volume":"78","author":"Cheng","year":"2016","journal-title":"Mol Immunol"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105534_bib44","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.3892\/mmr.2020.11536","article-title":"{LncRNA} {OIP5-AS1} aggravates house dust mite-induced inflammatory responses in human bronchial epithelial cells via the {miR-143-3p\/HMGB1} axis","volume":"22","author":"Cai","year":"2020","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105534_bib45","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/all.12063","article-title":"Asthma severity in childhood and metabolomic profiling of breath condensate","volume":"68","author":"Carraro","year":"2013","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105534_bib46","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1165\/rcmb.2005-0306OC","article-title":"Retinoic acid inhibits airway smooth muscle cell migration","volume":"34","author":"Day","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105534_bib47","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00726-012-1361-4","article-title":"Taurine and inflammatory diseases","volume":"46","author":"Marcinkiewicz","year":"2014","journal-title":"Amino Acids"},{"issue":"13","key":"10.1016\/j.ebiom.2024.105534_bib48","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.3390\/ijerph17134758","article-title":"Alterations in serum-free amino acid profiles in childhood asthma","volume":"17","author":"Matysiak","year":"2020","journal-title":"Int J Environ Res Public Health"},{"issue":"6","key":"10.1016\/j.ebiom.2024.105534_bib49","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41574-022-00678-3","article-title":"Metabolomic profiling of adrenal function in asthma","volume":"18","author":"Starling","year":"2022","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105534_bib50","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1038\/s41598-021-82734-y","article-title":"microRNA let-7i-5p mediates the relationship between muscle fat infiltration and neck pain disability following motor vehicle collision: a preliminary study","volume":"11","author":"Elliott","year":"2021","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105534_bib51","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/gepi.21875","article-title":"Integrative analysis of micro-RNA, gene expression, and survival of glioblastoma multiforme","volume":"39","author":"Huang","year":"2015","journal-title":"Genet Epidemiol"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105534_bib52","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41591-021-01266-0","article-title":"Plasma metabolites to profile pathways in noncommunicable disease multimorbidity","volume":"27","author":"Pietzner","year":"2021","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.ebiom.2024.105534_bib53","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nm.4297","article-title":"The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue","volume":"23","author":"Lynes","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2024.105534_bib54","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/978-1-4615-0077-3_49","article-title":"Taurine and the lung: which role in asthma?","volume":"526","author":"Santangelo","year":"2003","journal-title":"Adv Exp Med Biol"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105534_bib55","first-page":"1277","article-title":"Metabolites associated with circulating interleukin-6 in older adults","volume":"72","author":"Lustgarten","year":"2016","journal-title":"Journals Gerontol Ser A"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105534_bib56","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ped4.12270","article-title":"Association of vitamin A status with lung function in children and adolescents with cystic fibrosis","volume":"5","author":"Loukou","year":"2021","journal-title":"Pediatr Investig"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105534_bib57","doi-asserted-by":"crossref","first-page":"643","DOI":"10.4049\/jimmunol.1500736","article-title":"Metabolomic endotype of asthma","volume":"195","author":"Comhair","year":"2015","journal-title":"J\u00a0Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2024.105534_bib58","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1164\/ajrccm.155.2.9032174","article-title":"Levels of amino acids and related compounds in bronchoalveolar lavage fluids of asthmatic patients","volume":"155","author":"Hofford","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"issue":"49","key":"10.1016\/j.ebiom.2024.105534_bib59","doi-asserted-by":"crossref","first-page":"40898","DOI":"10.1074\/jbc.M112.393728","article-title":"Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis","volume":"287","author":"Liu","year":"2012","journal-title":"J\u00a0Biol Chem"},{"issue":"10","key":"10.1016\/j.ebiom.2024.105534_bib60","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nm.4176","article-title":"Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation","volume":"22","author":"Fujimura","year":"2016","journal-title":"Nat Med"},{"issue":"170","key":"10.1016\/j.ebiom.2024.105534_bib61","article-title":"The re-emerging role of linoleic acid in paediatric asthma","volume":"32","author":"Naughten","year":"2023","journal-title":"Eur Respir Rev an Off J Eur Respir Soc"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105534_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2004.10.001","article-title":"Epoxide hydrolases: their roles and interactions with lipid metabolism","volume":"44","author":"Newman","year":"2005","journal-title":"Prog Lipid Res"},{"issue":"8","key":"10.1016\/j.ebiom.2024.105534_bib63","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1194\/jlr.R057588","article-title":"Cytosolic phospholipase A\u2082: physiological function and role in disease","volume":"56","author":"Leslie","year":"2015","journal-title":"J\u00a0Lipid Res"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105534_bib64","first-page":"940","article-title":"A\u00a0decade of molecular biology of retinoic acid receptors","volume":"10","author":"Chambon","year":"1996","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105534_bib65","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/thx.2005.047373","article-title":"Serum carotenoids, vitamins A and E, and 8 year lung function decline in a general population","volume":"61","author":"Gu\u00e9n\u00e9gou","year":"2006","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.ebiom.2024.105534_bib66","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.04407-2020","article-title":"Dietary intake of vitamin A, lung function and incident asthma in childhood","volume":"58","author":"Talaei","year":"2021","journal-title":"Eur Respir J"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105534_bib67","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1136\/thx.2010.145524","article-title":"Maternal vitamin A supplementation improves lung function in offspring","volume":"65","author":"Checkley","year":"2010","journal-title":"Thorax"},{"issue":"suppl 59","key":"10.1016\/j.ebiom.2024.105534_bib68","article-title":"Effect of retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness","volume":"46","author":"Fujii","year":"2015","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105534_bib69","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12931-017-0507-z","article-title":"Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma","volume":"18","author":"Fujii","year":"2017","journal-title":"Respir Res"},{"issue":"3","key":"10.1016\/j.ebiom.2024.105534_bib70","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1165\/rcmb.2006-0453OC","article-title":"Epithelium expression and function of retinoid receptors in asthma","volume":"38","author":"Druilhe","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2024.105534_bib71","doi-asserted-by":"crossref","DOI":"10.1038\/srep35710","article-title":"Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD+ and retinoic acid","volume":"6","author":"Moretti","year":"2016","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.ebiom.2024.105534_bib72","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/metabo9090179","article-title":"Pharmacometabolomics of bronchodilator response in asthma and the role of age-metabolite interactions","volume":"9","author":"Kelly","year":"2019","journal-title":"Metabolites"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642400570X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235239642400570X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T03:57:29Z","timestamp":1741924649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235239642400570X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":72,"alternative-id":["S235239642400570X"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105534","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miRNAome-metabolome wide association study reveals effects of miRNA regulation in eosinophilia and airflow obstruction in childhood asthma","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2024.105534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105534"}}