{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:44:25Z","timestamp":1794271465628,"version":"4.9.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG073886"],"award-info":[{"award-number":["R21AG073886"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R33 AG061456"],"award-info":[{"award-number":["R33 AG061456"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016997","name":"Noaber Foundation","doi-asserted-by":"publisher","award":["T32-AG023480"],"award-info":[{"award-number":["T32-AG023480"]}],"id":[{"id":"10.13039\/100016997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016638","name":"U.S. Highbush Blueberry Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ebiom.2025.105612","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T03:34:58Z","timestamp":1740454498000},"page":"105612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"special_numbering":"C","title":["A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1667-2106","authenticated-orcid":false,"given":"Courtney L.","family":"Millar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ike","family":"Iloputaife","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Baldyga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani M.","family":"Norling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afroditi","family":"Boulougoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7237-1954","authenticated-orcid":false,"given":"Theodoros","family":"Vichos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Tchkonia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Deisinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Pirtskhalava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Kirkland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Travison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis A.","family":"Lipsitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ebiom.2025.105612_bib1","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41591-022-01923-y","article-title":"Cellular senescence and senolytics: the path to the clinic","volume":"28","author":"Chaib","year":"2022","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105612_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s43587-023-00365-6","article-title":"Senescent cells, senolytics and tissue repair: the devil may be in the dosing","volume":"3","author":"Khosla","year":"2023","journal-title":"Nat Aging"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105612_bib3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s40262-020-00872-4","article-title":"Clinical pharmacokinetics and pharmacodynamics of dasatinib","volume":"59","author":"Lev\u00eaque","year":"2020","journal-title":"Clin Pharmacokinet"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105612_bib4","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1177\/00912700122010366","article-title":"Pharmacokinetics and bioavailability of quercetin glycosides in humans","volume":"41","author":"Graefe","year":"2001","journal-title":"J\u00a0Clin Pharmacol"},{"issue":"13","key":"10.1016\/j.ebiom.2025.105612_bib5","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1016\/j.celrep.2018.03.002","article-title":"Regulation of cellular senescence by polycomb chromatin modifiers through distinct DNA damage- and histone methylation-dependent pathways","volume":"22","author":"Ito","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.ebiom.2025.105612_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Coppe","year":"2010","journal-title":"Annu Rev Pathol"},{"issue":"8","key":"10.1016\/j.ebiom.2025.105612_bib7","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu","year":"2018","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105612_bib8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/gerona\/gls191","article-title":"Motoric cognitive risk syndrome and the risk of dementia","volume":"68","author":"Verghese","year":"2013","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105612_bib9","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jalz.2019.03.011","article-title":"Motoric cognitive risk syndrome and predictors of transition to dementia: a multicenter study","volume":"15","author":"Verghese","year":"2019","journal-title":"Alzheimers Dement"},{"issue":"s1","key":"10.1016\/j.ebiom.2025.105612_bib10","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.3233\/JAD-181227","article-title":"Gait dysfunction in Motoric cognitive risk syndrome","volume":"71","author":"Ayers","year":"2019","journal-title":"J\u00a0Alzheimers Dis"},{"key":"10.1016\/j.ebiom.2025.105612_bib11","article-title":"Cellular senescence as a driver of cognitive decline triggered by chronic unpredictable stress","volume":"15","author":"Lin","year":"2021","journal-title":"Neurobiol Stress"},{"key":"10.1016\/j.ebiom.2025.105612_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.646924","article-title":"Cellular senescence in brain aging","volume":"13","author":"Sikora","year":"2021","journal-title":"Front Aging Neurosci"},{"issue":"13","key":"10.1016\/j.ebiom.2025.105612_bib13","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1001\/jama.2018.12440","article-title":"Aging, cell senescence, and chronic disease: emerging therapeutic strategies","volume":"320","author":"Tchkonia","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.ebiom.2025.105612_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/bs.irn.2020.03.019","article-title":"Cellular senescence in aging and age-related diseases: implications for neurodegenerative diseases","volume":"155","author":"Wissler Gerdes","year":"2020","journal-title":"Int Rev Neurobiol"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105612_bib15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","article-title":"Senolytic therapy alleviates Abeta-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model","volume":"22","author":"Zhang","year":"2019","journal-title":"Nat Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105612_bib16","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1038\/s41467-022-33226-8","article-title":"Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.ebiom.2025.105612_bib17","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nm.4385","article-title":"Targeting cellular senescence prevents age-related bone loss in mice","volume":"23","author":"Farr","year":"2017","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105612_bib18","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1007\/s11357-022-00685-2","article-title":"Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study","volume":"44","author":"Fielding","year":"2022","journal-title":"GeroScience"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105612_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glad257","article-title":"Biomarkers of cellular senescence predict the onset of mobility disability and are reduced by physical activity in older adults","volume":"79","author":"Fielding","year":"2024","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105612_bib20","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/gerona\/glx134","article-title":"Cellular senescence biomarker p16INK4a+ cell burden in thigh adipose is associated with poor physical function in older women","volume":"73","author":"Justice","year":"2018","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105612_bib21","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/acel.12458","article-title":"Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice","volume":"15","author":"Roos","year":"2016","journal-title":"Aging Cell"},{"issue":"46","key":"10.1016\/j.ebiom.2025.105612_bib22","doi-asserted-by":"crossref","first-page":"E6301","DOI":"10.1073\/pnas.1515386112","article-title":"JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age","volume":"112","author":"Xu","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ebiom.2025.105612_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebiom.2017.04.013","article-title":"Cellular senescence: a translational perspective","volume":"21","author":"Kirkland","year":"2017","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105612_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12840","article-title":"Tau protein aggregation is associated with cellular senescence in the brain","volume":"17","author":"Musi","year":"2018","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105612_bib25","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cmet.2018.12.008","article-title":"Obesity-induced cellular senescence drives anxiety and impairs neurogenesis","volume":"29","author":"Ogrodnik","year":"2019","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105612_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13296","article-title":"Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice","volume":"20","author":"Ogrodnik","year":"2021","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105612_bib27","first-page":"22","article-title":"Senolytic therapy to modulate the progression of Alzheimer's Disease (SToMP-AD) - outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease","volume":"9","author":"Orr","year":"2023","journal-title":"Res Sq"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105612_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.14283\/jpad.2021.62","article-title":"Senolytic therapy to modulate the progression of alzheimer's disease (SToMP-AD): a pilot clinical trial","volume":"9","author":"Gonzales","year":"2022","journal-title":"J\u00a0Prev Alzheimers Dis"},{"key":"10.1016\/j.ebiom.2025.105612_bib29","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study","volume":"40","author":"Justice","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2025.105612_bib30","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"issue":"9","key":"10.1016\/j.ebiom.2025.105612_bib31","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1038\/s41591-024-03096-2","article-title":"Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial","volume":"30","author":"Farr","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2025.105612_bib32","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1038\/s41591-023-02543-w","article-title":"Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial","volume":"29","author":"Gonzales","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2025.105612_bib33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tma.2023.10.004","article-title":"Rationale and design of STAMINA: senolytics to alleviate mobility issues and neurological impairments in aging, a geroscience feasibility study","volume":"7","author":"Millar","year":"2023","journal-title":"Transl Med Aging"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105612_bib34","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/jgs.19225","article-title":"Comparison of targeted web-based advertising versus traditional methods for recruiting older adults into clinical trials","volume":"73","author":"Baldyga","year":"2024","journal-title":"J\u00a0Am Geriatr Soc"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105612_bib35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/geront\/10.1_Part_1.20","article-title":"Progress in development of the index of ADL","volume":"10","author":"Katz","year":"1970","journal-title":"Gerontol"},{"key":"10.1016\/j.ebiom.2025.105612_bib36","series-title":"Trailmaking Tests A and B","year":"1944"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105612_bib37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0887-6177(03)00039-8","article-title":"Trail Making Test A and B: normative data stratified by age and education","volume":"19","author":"Tombaugh","year":"2004","journal-title":"Arch Clin Neuropsychol"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105612_bib38","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J\u00a0Am Geriatr Soc"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105612_bib39","doi-asserted-by":"crossref","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","article-title":"A\u00a0short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission","volume":"49","author":"Guralnik","year":"1994","journal-title":"J\u00a0Gerontol"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105612_bib40","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/ptj\/82.2.128","article-title":"Age-and gender-related test performance in community-dwelling elderly people: six-minute walk test, berg balance scale, timed up & go test, and gait speeds","volume":"82","author":"Steffen","year":"2002","journal-title":"Phys Ther"},{"issue":"8","key":"10.1016\/j.ebiom.2025.105612_bib41","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.cmet.2024.07.006","article-title":"Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function","volume":"36","author":"Wang","year":"2024","journal-title":"Cell Metab"},{"issue":"9","key":"10.1016\/j.ebiom.2025.105612_bib42","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI22475","article-title":"Ink4a\/Arf expression is a biomarker of aging","volume":"114","author":"Krishnamurthy","year":"2004","journal-title":"J\u00a0Clin Investig"},{"issue":"12","key":"10.1016\/j.ebiom.2025.105612_bib43","doi-asserted-by":"crossref","first-page":"1966:1","DOI":"10.3390\/cells11121966","article-title":"The senescence markers p16INK4A, p14ARF\/p19ARF, and p21 in organ development and homeostasis","volume":"11","author":"Wagner","year":"2022","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105612_bib44","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1474-9726.2009.00489.x","article-title":"Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging","volume":"8","author":"Liu","year":"2009","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105612_bib45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","article-title":"Death by TNF: a road to inflammation","volume":"23","author":"van Loo","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ebiom.2025.105612_bib46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neurobiolaging.2023.05.012","article-title":"Matrix metalloproteinases are associated with brain atrophy in cognitively unimpaired individuals","volume":"131","author":"Aksnes","year":"2023","journal-title":"Neurobiol Aging"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105612_bib47","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s43018-023-00712-x","article-title":"The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2","volume":"5","author":"Chaib","year":"2024","journal-title":"Nat Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105612_bib48","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s13063-019-3485-2","article-title":"Recruitment of men to a multi-centre diabetes prevention trial: an evaluation of traditional and online promotional strategies","volume":"20","author":"Bracken","year":"2019","journal-title":"Trials"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105612_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1014610325059","article-title":"Recruitment of older participants in frailty\/injury prevention studies","volume":"3","author":"Ory","year":"2002","journal-title":"Prev Sci"},{"issue":"11","key":"10.1016\/j.ebiom.2025.105612_bib50","doi-asserted-by":"crossref","first-page":"e1142","DOI":"10.1212\/WNL.0000000000200817","article-title":"Clinically relevant changes for cognitive outcomes in preclinical and prodromal cognitive stages: implications for clinical alzheimer trials","volume":"99","author":"Borland","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.ebiom.2025.105612_bib51","article-title":"Is the difference real, is the difference relevant: the minimal detectable and clinically important changes in the Montreal Cognitive Assessment","volume":"6","author":"Lindvall","year":"2024","journal-title":"Cereb Circ Cogn Behav"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105612_bib52","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1159\/000518939","article-title":"Minimal clinically important difference of executive function performance in older adults who fall: a secondary analysis of a randomized controlled trial","volume":"68","author":"Jehu","year":"2021","journal-title":"Gerontology"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105612_bib53","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.gaitpost.2009.10.002","article-title":"Meaningful change in measures of gait variability in older adults","volume":"31","author":"Brach","year":"2010","journal-title":"Gait Posture"},{"issue":"12","key":"10.1016\/j.ebiom.2025.105612_bib54","first-page":"2670","article-title":"Stride length predicts adverse clinical events in older adults: a systematic review and meta-analysis","volume":"10","author":"Byty\u00e7i","year":"2021","journal-title":"J\u00a0Clin Med"},{"issue":"10","key":"10.1016\/j.ebiom.2025.105612_bib55","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","article-title":"Cellular senescence: the good, the bad and the unknown","volume":"18","author":"Huang","year":"2022","journal-title":"Nat Rev Nephrol"},{"issue":"11","key":"10.1016\/j.ebiom.2025.105612_bib56","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.18632\/aging.101328","article-title":"TNF\u03b1-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion","volume":"9","author":"Kandhaya-Pillai","year":"2017","journal-title":"Aging (Albany NY)"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105612_bib57","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1474-9726.2006.00231.x","article-title":"p16INK4A is a robust in\u00a0vivo biomarker of cellular aging in human skin","volume":"5","author":"Ressler","year":"2006","journal-title":"Aging Cell"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425000568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425000568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:37:58Z","timestamp":1778873878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425000568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":57,"alternative-id":["S2352396425000568"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105612","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105612","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105612"}}