{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:13:37Z","timestamp":1792034017978,"version":"4.4.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023452","name":"Hanarth Fund Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ebiom.2025.105643","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T10:48:39Z","timestamp":1742294919000},"page":"105643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Clinical outcomes and genomic profiles of MAP2K1-mutated primary cutaneous melanocytic tumours"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6656-8967","authenticated-orcid":false,"given":"Chiel F.","family":"Ebbelaar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.L.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie C.M.","family":"Speet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"Schutgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sietske","family":"Zoetemeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Cleton-Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke R.","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben E.","family":"Breimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0014-8625","authenticated-orcid":false,"given":"Lourens T.","family":"Bloem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy W.J.","family":"de Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco","family":"van Doorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karijn P.M.","family":"Suijkerbuijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.R.","family":"Schrader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willeke A.M.","family":"Blokx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ebiom.2025.105643_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/ng.1026","article-title":"Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma","volume":"44","author":"Nikolaev","year":"2011","journal-title":"Nat Genet"},{"issue":"8","key":"10.1016\/j.ebiom.2025.105643_bib2","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41379-022-01026-6","article-title":"Towards diagnostic criteria for malignant deep penetrating melanocytic tumours using single nucleotide polymorphism array and next-generation sequencing","volume":"35","author":"Ebbelaar","year":"2022","journal-title":"Mod Pathol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105643_bib3","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s41467-017-00758-3","article-title":"Combined activation of MAP kinase pathway and \u03b2-catenin signaling cause deep penetrating nevi","volume":"8","author":"Yeh","year":"2017","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.ebiom.2025.105643_bib4","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1097\/PAS.0000000000002131","article-title":"Clinical, morphologic, and molecular features of benign and intermediate-grade melanocytic tumours with activating mutations in MAP2K1","volume":"47","author":"Fumero-Vel\u00e1zquez","year":"2023","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105643_bib5","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/bjd.19118","article-title":"A\u00a0mosaic variant in MAP2K1 is associated with giant naevus spilus-type congenital melanocytic naevus and melanoma development","volume":"183","author":"Muthiah","year":"2020","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ebiom.2025.105643_bib6","series-title":"WHO classification of skin tumours","year":"2023"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105643_bib7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00428-020-02940-3","article-title":"Expanding spectrum of 'spitzoid' lesions: a small series of 4 cases with MAP2K1 mutations","volume":"479","author":"Kerckhoffs","year":"2021","journal-title":"Virchows Arch"},{"issue":"11","key":"10.1016\/j.ebiom.2025.105643_bib8","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/cup.14502","article-title":"MAP2K1-mutated melanocytic tumours have reproducible histopathologic features and share similarities with melanocytic tumours with BRAF V600E mutations","volume":"50","author":"Alomari","year":"2023","journal-title":"J\u00a0Cutan Pathol"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105643_bib9","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1158\/2159-8290.CD-17-1452","article-title":"Allele-specific mechanisms of activation of MEK1 mutants determine their properties","volume":"8","author":"Gao","year":"2018","journal-title":"Cancer Discov"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105643_bib10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1158\/1535-7163.MCT-22-0302","article-title":"High-throughput functional evaluation of MAP2K1 variants in cancer","volume":"22","author":"Mizuno","year":"2023","journal-title":"Mol Cancer Ther"},{"issue":"12","key":"10.1016\/j.ebiom.2025.105643_bib11","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1038\/s41379-020-0581-5","article-title":"Melanoma with in-frame deletion of MAP2K1: a distinct molecular subtype of cutaneous melanoma mutually exclusive from BRAF, NRAS, and NF1 mutations","volume":"33","author":"Williams","year":"2020","journal-title":"Mod Pathol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105643_bib12","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/cup.14586","article-title":"Sclerosing melanocytic tumours with MAP2K1 in-frame deletions and copy number gains in 15q: a distinctive pathway of nevogenesis","volume":"51","author":"Hamad","year":"2024","journal-title":"J\u00a0Cutan Pathol"},{"issue":"15","key":"10.1016\/j.ebiom.2025.105643_bib13","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1158\/0008-5472.CAN-20-0865","article-title":"Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK mutants in cancer","volume":"80","author":"Hanrahan","year":"2020","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105643_bib14","first-page":"19","article-title":"Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive","volume":"29","author":"Casparie","year":"2007","journal-title":"Cell Oncol"},{"issue":"11","key":"10.1016\/j.ebiom.2025.105643_bib15","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/DAD.0000000000001795","article-title":"Melanocytic neoplasms with MAP2K1 in-frame deletions and Spitz morphology","volume":"42","author":"Sunshine","year":"2020","journal-title":"Am J Dermatopathol"},{"issue":"10","key":"10.1016\/j.ebiom.2025.105643_bib16","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1097\/PAS.0000000000000902","article-title":"Genomic analysis of pigmented epithelioid melanocytomas reveals recurrent alterations in PRKAR1A and PRKCA genes","volume":"41","author":"Cheng","year":"2017","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105643_bib17","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/PAS.0000000000001195","article-title":"Distinct genomic patterns in pigmented epithelioid melanocytoma: a molecular and histologic analysis of 16 cases","volume":"43","author":"Isales","year":"2019","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ebiom.2025.105643_bib18","article-title":"The spectrum of Spitz melanocytic lesions: from morphologic diagnosis to molecular classification","volume":"12","author":"Cheng","year":"2022","journal-title":"Front Oncol"},{"issue":"9","key":"10.1016\/j.ebiom.2025.105643_bib19","first-page":"1871","article-title":"Follow-up recommendations for patients with American Joint Committee on Cancer stages I-III malignant melanoma","volume":"86","author":"Poo-Hwu","year":"1999","journal-title":"Cancer"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425000878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425000878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T04:31:55Z","timestamp":1744691515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425000878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":19,"alternative-id":["S2352396425000878"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105643","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical outcomes and genomic profiles of MAP2K1-mutated primary cutaneous melanocytic tumours","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105643","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105643"}}