{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:26:40Z","timestamp":1792099600171,"version":"4.4.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2021\/005069"],"award-info":[{"award-number":["CRG\/2021\/005069"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ebiom.2025.105658","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T01:05:00Z","timestamp":1743469500000},"page":"105658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Efflux pump modulation by Montelukast and its roles in restoring antibiotic susceptibility in multidrug-resistant Staphylococcus aureus"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0439-5065","authenticated-orcid":false,"given":"Suvendu","family":"Ojha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8175-8144","authenticated-orcid":false,"given":"Simran","family":"Sinsinwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarmistha","family":"Biswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinkilata","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3352-4508","authenticated-orcid":false,"given":"Tushar Kant","family":"Beuria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ebiom.2025.105658_bib4","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.chembiol.2011.05.014","article-title":"Targeting MgrA-mediated virulence regulation in Staphylococcus aureus","volume":"18","author":"Sun","year":"2011","journal-title":"Chem Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105658_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4103\/ijmr.IJMR_2079_17","article-title":"Efflux pump inhibitors for bacterial pathogens: from bench to bedside","volume":"149","author":"Sharma","year":"2019","journal-title":"Indian J Med Res"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1874285801307010059","article-title":"Multidrug efflux pumps in Staphylococcus aureus: an update","volume":"7","author":"Costa","year":"2013","journal-title":"Open Microbiol J"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105658_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.GPP3-0057-2018","article-title":"Antibiotic resistance and the MRSA problem","volume":"7","author":"Vestergaard","year":"2019","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.ebiom.2025.105658_bib8","series-title":"Antimicrobial Drug Efflux Pumps in Staphylococcus aureus. Efflux-mediated Antimicrobial Resistance in Bacteria","first-page":"165","author":"Sapula","year":"2016"},{"issue":"13","key":"10.1016\/j.ebiom.2025.105658_bib9","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1128\/JB.185.13.3703-3710.2003","article-title":"Mgr, a novel global regulator in Staphylococcus aureus","volume":"185","author":"Luong","year":"2003","journal-title":"J\u00a0Bacteriol"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105658_bib10","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1046\/j.1365-2958.2003.03503.x","article-title":"Characterization of RAT, an autolysis regulator in Staphylococcus aureus","volume":"48","author":"Ingavale","year":"2003","journal-title":"Mol Microbiol"},{"issue":"11","key":"10.1016\/j.ebiom.2025.105658_bib11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nchembio820","article-title":"An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus","volume":"2","author":"Chen","year":"2006","journal-title":"Nat Chem Biol"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105658_bib12","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1128\/JB.188.5.1899-1910.2006","article-title":"Transcription profiling of the mgrA regulon in Staphylococcus aureus","volume":"188","author":"Luong","year":"2006","journal-title":"J\u00a0Bacteriol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105658_bib13","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1128\/JB.182.3.664-671.2000","article-title":"Expression of the multidrug resistance transporter NorA from Staphylococcus aureus is modified by a two-component regulatory system","volume":"182","author":"Fournier","year":"2000","journal-title":"J\u00a0Bacteriol"},{"issue":"22","key":"10.1016\/j.ebiom.2025.105658_bib14","doi-asserted-by":"crossref","first-page":"7375","DOI":"10.1128\/JB.01068-08","article-title":"Posttranslational modification influences the effects of MgrA on norA expression in Staphylococcus aureus","volume":"190","author":"Truong-Bolduc","year":"2008","journal-title":"J\u00a0Bacteriol"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105658_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0272417","article-title":"Promising FDA-approved drugs with efflux pump inhibitory activities against clinical isolates of Staphylococcus aureus","volume":"17","author":"Abdel-Karim","year":"2022","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105658_bib16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pupt.2007.08.004","article-title":"Differential responses to various classes of drugs in a model of allergic rhinitis in guinea pigs","volume":"21","author":"Suleimani","year":"2008","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.ebiom.2025.105658_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00364","article-title":"IL33: roles in allergic inflammation and therapeutic perspectives","volume":"10","author":"Chan","year":"2019","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib20","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5455\/OVJ.2023.v13.i1.5","article-title":"Evaluation of efflux pump inhibitory activity of some plant extracts and using them as adjuvants to potentiate the inhibitory activity of some antibiotics against Staphylococcus aureus","volume":"13","author":"Al-Sallami","year":"2023","journal-title":"Open Vet J"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105658_bib21","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ijantimicag.2007.12.015","article-title":"Demonstration of intrinsic efflux activity of Escherichia coli K-12 AG100 by an automated ethidium bromide method","volume":"31","author":"Viveiros","year":"2008","journal-title":"Int J Antimicrob Agents"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-88099-6","article-title":"Anandamide alters the membrane properties, halts the cell division and prevents drug efflux in multidrug resistant Staphylococcus aureus","volume":"11","author":"Banerjee","year":"2021","journal-title":"Sci Rep"},{"issue":"SUPPL. 1","key":"10.1016\/j.ebiom.2025.105658_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jac\/48.suppl_1.5","article-title":"Determination of minimum inhibitory concentrations","volume":"48","author":"Andrews","year":"2001","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.ebiom.2025.105658_bib26","article-title":"Synergistic microbicidal effect of AUR and PEITC against Staphylococcus aureus skin infection","volume":"12","author":"Chen","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.ebiom.2025.105658_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.02762","article-title":"Clinically approved drugs inhibit the Staphylococcus aureus multidrug NorA efflux pump and reduce biofilm formation","volume":"10","author":"Zimmermann","year":"2019","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/s12860-020-00316-8","article-title":"MazEF-rifampicin interaction suggests a mechanism for rifampicin induced inhibition of persisters","volume":"21","author":"Alexander","year":"2020","journal-title":"BMC Mol Cell Biol"},{"key":"10.1016\/j.ebiom.2025.105658_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.02153","article-title":"Microbe-derived indole metabolite demonstrates potent multidrug efflux pump inhibition in Staphylococcus aureus","volume":"10","author":"Tambat","year":"2019","journal-title":"Front Microbiol"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105658_bib30","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1128\/AAC.44.4.827-834.2000","article-title":"Multiparameter flow cytometric analysis of antibiotic effects on membrane potential, membrane permeability, and bacterial counts of Staphylococcus aureus and Micrococcus luteus","volume":"44","author":"Novo","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"issue":"23","key":"10.1016\/j.ebiom.2025.105658_bib31","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1002\/1873-3468.14759","article-title":"The cell division protein ZapE is targeted by the antibiotic aztreonam to induce cell filamentation in Escherichia coli","volume":"597","author":"Guru","year":"2023","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ebiom.2025.105658_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3469525","article-title":"Cytotoxicity evaluation of endodontic pins on L929 cell line","volume":"2019","author":"Cannella","year":"2019","journal-title":"Biomed Res Int"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105658_bib34","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib35","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20203034","article-title":"Biochemical characterization of an E. coli cell division factor FtsE shows ATPase cycles similar to the NBDs of ABC-transporters","volume":"41","author":"Mallick","year":"2021","journal-title":"Biosci Rep"},{"issue":"12","key":"10.1016\/j.ebiom.2025.105658_bib36","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/pro.2809","article-title":"Robust and convenient analysis of protein thermal and chemical stability","volume":"24","author":"Niklasson","year":"2015","journal-title":"Protein Sci"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105658_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G\u2217Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav Res Methods"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105658_bib38","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3181\/00379727-127-32768","article-title":"A\u00a0quantitative difference in the immune response between male and female mice","volume":"127","author":"Terres","year":"1968","journal-title":"Proc Soc Exp Biol Med"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105658_bib39","doi-asserted-by":"crossref","first-page":"657","DOI":"10.4049\/jimmunol.1700810","article-title":"Innate sex bias of Staphylococcus aureus skin infection is driven by \u03b1-hemolysin","volume":"200","author":"Castleman","year":"2018","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-59012-4","article-title":"The effect of group size, age and handling frequency on inter-male aggression in CD 1 mice","volume":"10","author":"Jirkof","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib41","article-title":"Aggression in group-housed male mice: a systematic review","volume":"13","author":"Weber","year":"2022","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.ebiom.2025.105658_bib42","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jim.2014.04.007","article-title":"Mouse models for infectious diseases caused by Staphylococcus aureus","volume":"410","author":"Kim","year":"2014","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.ebiom.2025.105658_bib43","doi-asserted-by":"crossref","first-page":"869","DOI":"10.12659\/MSM.892932","article-title":"Montelukast inhibits pentylenetetrazol-induced seizures in rats","volume":"21","author":"Cevik","year":"2015","journal-title":"Med Sci Monit"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105658_bib44","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1021\/acsinfecdis.1c00281","article-title":"A\u00a0microbe-derived efflux pump inhibitor of the resistance-nodulation-cell division protein restores antibiotic susceptibility in Escherichia coli and Pseudomonas aeruginosa","volume":"8","author":"Tambat","year":"2022","journal-title":"ACS Infect Dis"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105658_bib45","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1039\/D2RA06696C","article-title":"Efflux pump inhibitor combined with ofloxacin decreases MRSA biofilm formation by regulating the gene expression of NorA and quorum sensing","volume":"13","author":"Lu","year":"2023","journal-title":"RSC Adv"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105658_bib46","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/jac\/dkx432","article-title":"Effect of Staphylococcus aureus Tet38 native efflux pump on in\u00a0vivo response to tetracycline in a murine subcutaneous abscess model","volume":"73","author":"Chen","year":"2018","journal-title":"J\u00a0Antimicrob Chemother"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib47","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0091-6749(98)70054-5","article-title":"A\u00a0placebo-controlled, dose-ranging study of montelukast, a cysteinyl leukotriene-receptor antagonist. Montelukast Asthma Study Group","volume":"102","author":"Altman","year":"1998","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105658_bib48","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s10156-009-0680-1","article-title":"In\u00a0vivo and in\u00a0vitro effects of fluoroquinolones on lipopolysaccharide-induced pro-inflammatory cytokine production","volume":"15","author":"Ogino","year":"2009","journal-title":"J\u00a0Infect Chemother"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105658_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.106098","article-title":"Synergism of sophoraflavanone G with norfloxacin against effluxing antibiotic-resistant Staphylococcus aureus","volume":"56","author":"Sun","year":"2020","journal-title":"Int J Antimicrob Agents"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib50","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1128\/AAC.43.1.85","article-title":"Moxifloxacin (BAY12-8039), a new 8-methoxyquinolone, is active in a mouse model of tuberculosis","volume":"43","author":"Miyazaki","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105658_bib51","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ijid.2005.07.007","article-title":"The effect of treatment with moxifloxacin or azithromycin on acute bacterial rhinosinusitis in mice","volume":"10","author":"Luxameechanporn","year":"2006","journal-title":"Int J Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib52","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF03191381","article-title":"Cefotaxime pharmacokinetics after oral application in the form of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate microvesicles in rat","volume":"34","author":"Golocorbin-Kon","year":"2009","journal-title":"Eur J Drug Metab Pharmacokinet"},{"issue":"Suppl A","key":"10.1016\/j.ebiom.2025.105658_bib53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/jac\/6.suppl_A.55","article-title":"Cefotaxime and amikacin: results of in\u00a0vitro and in\u00a0vivo studies against gram-negative bacteria and Staphylococcus aureus. EORTC international antimicrobial therapy project group","volume":"6","author":"Klastersky","year":"1980","journal-title":"J\u00a0Antimicrob Chemother"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105658_bib54","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"\u0160ali","year":"1993","journal-title":"J\u00a0Mol Biol"},{"issue":"16","key":"10.1016\/j.ebiom.2025.105658_bib55","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J\u00a0Comput Chem"},{"issue":"766","key":"10.1016\/j.ebiom.2025.105658_bib57","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abj8194","article-title":"Serine-threonine phosphoregulation by PknB and Stp contributes to quiescence and antibiotic tolerance in Staphylococcus aureus","volume":"16","author":"Huemer","year":"2023","journal-title":"Sci Signal"},{"issue":"10","key":"10.1016\/j.ebiom.2025.105658_bib58","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1039\/C5AN02649K","article-title":"The importance of lag time extension in determining bacterial resistance to antibiotics","volume":"141","author":"Li","year":"2016","journal-title":"Analyst"},{"issue":"9","key":"10.1016\/j.ebiom.2025.105658_bib59","doi-asserted-by":"crossref","DOI":"10.1007\/s11538-023-01189-6","article-title":"Emergent lag phase in Flux-regulation models of bacterial growth","volume":"85","author":"Bate","year":"2023","journal-title":"Bull Math Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib60","first-page":"1","article-title":"Optimization and control in bacterial lag phase","volume":"11","author":"Schultz","year":"2014","journal-title":"BMC Biol"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105658_bib61","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1128\/AAC.00289-11","article-title":"Implication of the NorB efflux pump in the adaptation of Staphylococcus aureus to growth at acid pH and in resistance to moxifloxacin","volume":"55","author":"Truong-Bolduc","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"10.1016\/j.ebiom.2025.105658_bib62","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1128\/JB.00018-10","article-title":"Phosphorylation of MgrA and its effect on expression of the NorA and NorB efflux pumps of Staphylococcus aureus (NorA and NorB promoter)","volume":"192","author":"Truong-Bolduc","year":"2010","journal-title":"J\u00a0Bacteriol"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105658_bib63","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1128\/JB.187.7.2395-2405.2005","article-title":"MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus (NorA and NorB promoter)","volume":"187","author":"Truong-Bolduc","year":"2005","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.ebiom.2025.105658_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2018.00710","article-title":"Genetic diversity of norA, coding for a main efflux pump of Staphylococcus aureus","volume":"9","author":"Costa","year":"2019","journal-title":"Front Genet"},{"issue":"45","key":"10.1016\/j.ebiom.2025.105658_bib65","doi-asserted-by":"crossref","first-page":"14036","DOI":"10.1073\/pnas.1509251112","article-title":"RNAIII of the Staphylococcus aureus agr system activates global regulator MgrA by stabilizing mRNA (MgrA promoter)","volume":"112","author":"Gupta","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.ebiom.2025.105658_bib66","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1128\/JB.01406-13","article-title":"Regulation of expression of abcA and its response to environmental conditions","volume":"196","author":"Villet","year":"2014","journal-title":"J\u00a0Bacteriol"},{"issue":"38","key":"10.1016\/j.ebiom.2025.105658_bib67","doi-asserted-by":"crossref","first-page":"15461","DOI":"10.1073\/pnas.1205952109","article-title":"Protein cysteine phosphorylation of SarA\/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance","volume":"109","author":"Sun","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105658_bib68","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1128\/JB.06503-11","article-title":"Reduced aeration affects the expression of the NorB efflux pump of Staphylococcus aureus by posttranslational modification of MgrA","volume":"194","author":"Truong-Bolduc","year":"2012","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.ebiom.2025.105658_bib69","first-page":"13","article-title":"Gel electrophoresis for phosphorylated proteins: a brief introduction","volume":"64","author":"Noguchi","year":"2020","journal-title":"J\u00a0Electroph"},{"key":"10.1016\/j.ebiom.2025.105658_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2022.104558","article-title":"Analysis of protein phosphorylation using Phos-tag gels","volume":"259","author":"O'Donoghue","year":"2022","journal-title":"J\u00a0Proteomics"},{"key":"10.1016\/j.ebiom.2025.105658_bib71","article-title":"Monitoring protein phosphorylation by acrylamide pendant Phos-TagTM in various plants","volume":"6","author":"Beke\u0161ov\u00e1","year":"2015","journal-title":"Front Plant Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib72","article-title":"Multidrug-resistant sepsis: a critical healthcare challenge","volume":"13","author":"Kumar","year":"2024","journal-title":"Antibiotics (Basel)"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105658_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms4010014","article-title":"Bacterial multidrug efflux pumps: much more than antibiotic resistance determinants","volume":"4","author":"Blanco","year":"2016","journal-title":"Microorganisms"},{"issue":"8","key":"10.1016\/j.ebiom.2025.105658_bib74","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1128\/JB.01819-06","article-title":"The transcriptional regulators NorG and MgrA modulate resistance to both quinolones and beta-lactams in Staphylococcus aureus","volume":"189","author":"Truong-Bolduc","year":"2007","journal-title":"J\u00a0Bacteriol"},{"key":"10.1016\/j.ebiom.2025.105658_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.737288","article-title":"Function and inhibitory mechanisms of multidrug efflux pumps","volume":"12","author":"Nishino","year":"2021","journal-title":"Front Microbiol"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105658_bib76","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3390\/antibiotics11040520","article-title":"Bacterial multidrug efflux pumps at the frontline of antimicrobial resistance: an overview","volume":"11","author":"Huang","year":"2022","journal-title":"Antibiotics"},{"issue":"9","key":"10.1016\/j.ebiom.2025.105658_bib77","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41579-018-0048-6","article-title":"Multidrug efflux pumps: structure, function and regulation","volume":"16","author":"Du","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ebiom.2025.105658_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.02990","article-title":"Inhibiting bacterial drug efflux pumps via phyto-therapeutics to combat threatening antimicrobial resistance","volume":"9","author":"Shriram","year":"2018","journal-title":"Front Microbiol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105658_bib79","doi-asserted-by":"crossref","DOI":"10.1128\/Spectrum.00951-21","article-title":"Repurposing approved drugs as fluoroquinolone potentiators to overcome efflux pump resistance in Staphylococcus aureus","volume":"9","author":"Mahey","year":"2021","journal-title":"Microbiol Spectr"},{"issue":"10","key":"10.1016\/j.ebiom.2025.105658_bib80","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/crj.13629","article-title":"Efficacy and safety of montelukast adjuvant therapy in adults with cough variant asthma: a systematic review and meta-analysis","volume":"17","author":"Xu","year":"2023","journal-title":"Clin Respir J"},{"key":"10.1016\/j.ebiom.2025.105658_bib81","author":"Wermuth"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425001021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425001021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T16:16:57Z","timestamp":1762618617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425001021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":72,"alternative-id":["S2352396425001021"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105658","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efflux pump modulation by Montelukast and its roles in restoring antibiotic susceptibility in multidrug-resistant Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105658","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105658"}}