{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:10:02Z","timestamp":1793661002586,"version":"4.5.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-048"],"award-info":[{"award-number":["2021-I2M-1-048"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2306300"],"award-info":[{"award-number":["2023YFC2306300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["ZYYCXTD-D-202208"],"award-info":[{"award-number":["ZYYCXTD-D-202208"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004147","name":"Tsinghua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","award":["3332024193"],"award-info":[{"award-number":["3332024193"]}],"id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241056"],"award-info":[{"award-number":["82241056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["824B2001"],"award-info":[{"award-number":["824B2001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170015"],"award-info":[{"award-number":["82170015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030002"],"award-info":[{"award-number":["82030002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470007"],"award-info":[{"award-number":["82470007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ebiom.2025.105738","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T13:55:56Z","timestamp":1747144556000},"page":"105738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Influenza A virus dissemination and infection leads to tissue resident cell injury and dysfunction in viral sepsis"],"prefix":"10.1016","volume":"116","author":[{"given":"Ying","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yameng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guming","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6991-0350","authenticated-orcid":false,"given":"Bin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ebiom.2025.105738_bib1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/irv.12470","article-title":"The hidden burden of influenza: a review of the extra-pulmonary complications of influenza infection","volume":"11","author":"Sellers","year":"2017","journal-title":"Influenza Other Respir Viruses"},{"issue":"9","key":"10.1016\/j.ebiom.2025.105738_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/v10090497","article-title":"Zoonotic potential of influenza A viruses: a comprehensive overview","volume":"10","author":"Mostafa","year":"2018","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib3","doi-asserted-by":"crossref","first-page":"106.e1","DOI":"10.1016\/j.jcrc.2011.05.016","article-title":"Cardiac manifestations in patients with pandemic (H1N1) 2009 virus infection needing intensive care","volume":"27","author":"Chacko","year":"2012","journal-title":"J Crit Care"},{"key":"10.1016\/j.ebiom.2025.105738_bib4","article-title":"Myocarditis associated with influenza A H1N1pdm2009","volume":"2012","author":"Ukimura","year":"2012","journal-title":"Influenza Res Treat"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105738_bib5","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1111\/j.1750-2659.2011.00287.x","article-title":"Liver involvement during influenza infection: perspective on the 2009 influenza pandemic","volume":"6","author":"Papic","year":"2012","journal-title":"Influenza Other Respir Viruses"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/cc10046","article-title":"Acute kidney injury in critical ill patients affected by influenza A (H1N1) virus infection","volume":"15","author":"Martin-Loeches","year":"2011","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105738_bib7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/irv.12925","article-title":"The burden of seasonal influenza in Italy: a systematic review of influenza-related complications, hospitalizations, and mortality","volume":"16","author":"Giacchetta","year":"2022","journal-title":"Influenza Other Respir Viruses"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105738_bib8","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.2353\/ajpath.2006.050875","article-title":"Kupffer cell-dependent hepatitis occurs during influenza infection","volume":"168","author":"Polakos","year":"2006","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105738_bib9","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/jmv.27627","article-title":"The mechanism of multiple organ dysfunction syndrome in patients with COVID-19","volume":"94","author":"Zhao","year":"2022","journal-title":"J Med Virol"},{"issue":"8","key":"10.1016\/j.ebiom.2025.105738_bib10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international Consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"10229","key":"10.1016\/j.ebiom.2025.105738_bib11","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"issue":"157","key":"10.1016\/j.ebiom.2025.105738_bib12","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0038-2020","article-title":"Respiratory viral sepsis: epidemiology, pathophysiology, diagnosis and treatment","volume":"29","author":"Gu","year":"2020","journal-title":"Eur Respir Rev"},{"issue":"10235","key":"10.1016\/j.ebiom.2025.105738_bib13","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0140-6736(20)30920-X","article-title":"SARS-CoV-2 and viral sepsis: observations and hypotheses","volume":"395","author":"Li","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2025.105738_bib14","article-title":"Poor clinical outcomes in respiratory viral sepsis: a retrospective observational study","author":"Cao","year":"2024","journal-title":"ERJ Open Res"},{"issue":"8","key":"10.1016\/j.ebiom.2025.105738_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160777","article-title":"Sustained viremia and high viral load in respiratory tract secretions are predictors for death in immunocompetent adults with adenovirus pneumonia","volume":"11","author":"Gu","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4161\/viru.25436","article-title":"Host innate immune responses to sepsis","volume":"5","author":"Wiersinga","year":"2014","journal-title":"Virulence"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib17","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/jmv.26232","article-title":"The cytokine storm and COVID-19","volume":"93","author":"Hu","year":"2021","journal-title":"J Med Virol"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105738_bib18","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00281-017-0636-y","article-title":"New fronts emerge in the influenza cytokine storm","volume":"39","author":"Guo","year":"2017","journal-title":"Semin Immunopathol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/cmi.2015.74","article-title":"The cytokine storm of severe influenza and development of immunomodulatory therapy","volume":"13","author":"Liu","year":"2016","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib20","first-page":"36","article-title":"Comparison of clinical laboratory tests between bacterial sepsis and SARS-CoV-2-associated viral sepsis","volume":"7","author":"Ren","year":"2020","journal-title":"Mil Med Res"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cjtee.2021.11.001","article-title":"Severe COVID-19-associated sepsis is different from classical sepsis induced by pulmonary infection with carbapenem-resistant klebsiella pneumonia (CrKP)","volume":"25","author":"Wu","year":"2022","journal-title":"Chin J Traumatol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41392-022-00907-1","article-title":"The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication","volume":"7","author":"Ning","year":"2022","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105738_bib23","doi-asserted-by":"crossref","DOI":"10.1186\/cc4984","article-title":"Extrapulmonary manifestations of severe respiratory syncytial virus infection--a systematic review","volume":"10","author":"Eisenhut","year":"2006","journal-title":"Crit Care"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105738_bib24","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.chest.2020.11.071","article-title":"Risk factors of viral RNAaemia and its association with clinical prognosis among patients with severe COVID-19","volume":"159","author":"Li","year":"2021","journal-title":"Chest"},{"issue":"5677","key":"10.1016\/j.ebiom.2025.105738_bib25","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/bmj.4.5677.208","article-title":"Proved viraemia in Asian influenza (Hong Kong variant) during incubation period","volume":"4","author":"Khakpour","year":"1969","journal-title":"Br Med J"},{"issue":"23","key":"10.1016\/j.ebiom.2025.105738_bib26","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.5694\/j.1326-5377.1971.tb92768.x","article-title":"Viraemia in influenza. A report of two cases","volume":"2","author":"Lehmann","year":"1971","journal-title":"Med J Aust"},{"issue":"7941","key":"10.1016\/j.ebiom.2025.105738_bib27","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41586-022-05542-y","article-title":"SARS-CoV-2 infection and persistence in the human body and brain at autopsy","volume":"612","author":"Stein","year":"2022","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105738_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF01314671","article-title":"Type A influenza: postmortem virus isolations from different organs in human lethal cases","volume":"53","author":"Frankov\u00e1","year":"1977","journal-title":"Arch Virol"},{"issue":"22","key":"10.1016\/j.ebiom.2025.105738_bib29","doi-asserted-by":"crossref","first-page":"15464","DOI":"10.1074\/jbc.M602404200","article-title":"Streptococcus pneumoniae recruits complement factor H through the amino terminus of CbpA","volume":"281","author":"Lu","year":"2006","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.ebiom.2025.105738_bib30","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1177\/0271678X20943823","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"40","author":"Percie du Sert","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"issue":"19","key":"10.1016\/j.ebiom.2025.105738_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm5371","article-title":"Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis","volume":"8","author":"Kenney","year":"2022","journal-title":"Sci Adv"},{"issue":"49","key":"10.1016\/j.ebiom.2025.105738_bib32","doi-asserted-by":"crossref","first-page":"9246","DOI":"10.1016\/j.vaccine.2011.09.110","article-title":"Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL\/6 mice","volume":"29","author":"Lorenzo","year":"2011","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105738_bib33","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cels.2018.05.008","article-title":"Dissection of influenza infection in vivo by single-cell RNA sequencing","volume":"6","author":"Steuerman","year":"2018","journal-title":"Cell Syst"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105738_bib34","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","article-title":"Scrublet: Computational identification of cell doublets in single-cell transcriptomic data","volume":"8","author":"Wolock","year":"2019","journal-title":"Cell Syst"},{"issue":"12","key":"10.1016\/j.ebiom.2025.105738_bib35","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat Methods"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105738_bib36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"issue":"19","key":"10.1016\/j.ebiom.2025.105738_bib37","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1016\/j.cell.2023.07.034","article-title":"A pan-cancer single-cell panorama of human natural killer cells","volume":"186","author":"Tang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2025.105738_bib38","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.32303","article-title":"Extreme heterogeneity of influenza virus infection in single cells","volume":"7","author":"Russell","year":"2018","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105738_bib39","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib40","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1038\/s41467-017-02402-6","article-title":"The podoplanin-CLEC-2 axis inhibits inflammation in sepsis","volume":"8","author":"Rayes","year":"2017","journal-title":"Nat Commun"},{"issue":"39","key":"10.1016\/j.ebiom.2025.105738_bib41","doi-asserted-by":"crossref","first-page":"24313","DOI":"10.1074\/jbc.272.39.24313","article-title":"A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase\/N-acetylmannosamine kinase","volume":"272","author":"Hinderlich","year":"1997","journal-title":"J Biol Chem"},{"issue":"39","key":"10.1016\/j.ebiom.2025.105738_bib42","doi-asserted-by":"crossref","first-page":"24319","DOI":"10.1074\/jbc.272.39.24319","article-title":"A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase\/N-acetylmannosamine kinase","volume":"272","author":"St\u00e4sche","year":"1997","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105738_bib43","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1096\/fj.06-7880com","article-title":"Avian influenza receptor expression in H5N1-infected and noninfected human tissues","volume":"22","author":"Yao","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.ebiom.2025.105738_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101812","article-title":"Hepatic sialic acid synthesis modulates glucose homeostasis in both liver and skeletal muscle","volume":"78","author":"Peng","year":"2023","journal-title":"Mol Metab"},{"issue":"15","key":"10.1016\/j.ebiom.2025.105738_bib45","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00416-22","article-title":"Influenza A virus agnostic receptor tropism revealed using a novel biological system with terminal sialic acid knockout cells","volume":"96","author":"Kamiki","year":"2022","journal-title":"J Virol"},{"issue":"11","key":"10.1016\/j.ebiom.2025.105738_bib46","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1001\/archsurg.1994.01420350064008","article-title":"Acute-phase hepatocytes regulate liver sinusoidal cell mediator production","volume":"129","author":"Bankey","year":"1994","journal-title":"Arch Surg"},{"issue":"17","key":"10.1016\/j.ebiom.2025.105738_bib47","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1016\/j.jmb.2016.03.018","article-title":"Heme synthesis and acquisition in bacterial pathogens","volume":"428","author":"Choby","year":"2016","journal-title":"J Mol Biol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.apsb.2019.12.003","article-title":"Xenobiotic receptors in mediating the effect of sepsis on drug metabolism","volume":"10","author":"Lv","year":"2020","journal-title":"Acta Pharm Sin B"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105738_bib49","article-title":"Bile duct epithelial tight junctions and barrier function","volume":"1","author":"Rao","year":"2013","journal-title":"Tissue Barriers"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105738_bib50","doi-asserted-by":"crossref","first-page":"620","DOI":"10.6009\/jjrt.65.620","article-title":"[Observer performance of PACS-oriented digitized mammography in the detection of fibrils, microcalcifications, and masses: a phantom study]","volume":"65","author":"Yamada","year":"2009","journal-title":"Nihon Hoshasen Gijutsu Gakkai Zasshi"},{"key":"10.1016\/j.ebiom.2025.105738_bib51","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1056\/NEJM196310312691807","article-title":"Human influenza infection with proved viremia. Report of a case","volume":"269","author":"Naficy","year":"1963","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105738_bib52","first-page":"435","article-title":"Postsplenectomy sepsis due to influenzal viremia and pneumococcemia","volume":"115","author":"Roberts","year":"1976","journal-title":"Can Med Assoc J"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib53","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1080\/22221751.2020.1754135","article-title":"Novel pathogenic characteristics of highly pathogenic avian influenza virus H7N9: viraemia and extrapulmonary infection","volume":"9","author":"Wu","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.ebiom.2025.105738_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103736","article-title":"Influenza A virus infection induces liver injury in mice","volume":"137","author":"Zhang","year":"2019","journal-title":"Microb Pathog"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105738_bib55","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.1537-2995.2007.01264.x","article-title":"Influenza viremia and the potential for blood-borne transmission","volume":"47","author":"Likos","year":"2007","journal-title":"Transfusion"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105738_bib56","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/01913123.2011.574249","article-title":"Multiple organ invasion by viruses: pathological characteristics in three fatal cases of the 2009 pandemic influenza A\/H1N1","volume":"35","author":"Ru","year":"2011","journal-title":"Ultrastruct Pathol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105738_bib57","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1309\/AJCP1Y6LLHWSKYHW","article-title":"Evidence of renal infection in fatal cases of 2009 pandemic influenza A (H1N1)","volume":"136","author":"Carmona","year":"2011","journal-title":"Am J Clin Pathol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105738_bib58","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/cvr\/cvq358","article-title":"Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis","volume":"89","author":"Pan","year":"2011","journal-title":"Cardiovasc Res"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105738_bib59","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1038\/s41564-024-01713-x","article-title":"Influenza virus uses mGluR2 as an endocytic receptor to enter cells","volume":"9","author":"Ni","year":"2024","journal-title":"Nat Microbiol"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105738_bib60","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3109\/13550280009091953","article-title":"Experimental influenza causes a non-permissive viral infection of brain, liver and muscle","volume":"6","author":"Davis","year":"2000","journal-title":"J Neurovirol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105738_bib61","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/cvr\/cvaa117","article-title":"Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death","volume":"117","author":"Filgueiras-Rama","year":"2021","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105738_bib62","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cell.2020.03.040","article-title":"Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense","volume":"181","author":"Zheng","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib63","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1080\/22221751.2022.2056523","article-title":"Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells","volume":"11","author":"Yu","year":"2022","journal-title":"Emerg Microbes Infect"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib64","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41420-023-01766-7","article-title":"Immune dysregulation in sepsis: experiences, lessons and perspectives","volume":"9","author":"Cao","year":"2023","journal-title":"Cell Death Discov"},{"issue":"7865","key":"10.1016\/j.ebiom.2025.105738_bib65","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41586-021-03570-8","article-title":"COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets","volume":"595","author":"Delorey","year":"2021","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105738_bib66","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/cvr\/cvab322","article-title":"Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart","volume":"118","author":"Br\u00e4uninger","year":"2022","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib67","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13073-022-01108-9","article-title":"Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury","volume":"14","author":"Hinze","year":"2022","journal-title":"Genome Med"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105738_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4254\/wjh.v16.i1.1","article-title":"Molecular mechanisms underlying SARS-CoV-2 hepatotropism and liver damage","volume":"16","author":"Quarleri","year":"2024","journal-title":"World J Hepatol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425001823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425001823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:39:10Z","timestamp":1778873950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425001823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":68,"alternative-id":["S2352396425001823"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105738","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influenza A virus dissemination and infection leads to tissue resident cell injury and dysfunction in viral sepsis","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105738","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105738"}}