{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:08:57Z","timestamp":1794272937348,"version":"4.9.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EJ2202B"],"award-info":[{"award-number":["01EJ2202B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ebiom.2025.105743","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T08:58:27Z","timestamp":1747040307000},"page":"105743","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["A probiotic approach identifies a Treg-centred immunoregulation via modulation of gut microbiota metabolites in people with multiple sclerosis and healthy individuals"],"prefix":"10.1016","volume":"116","author":[{"given":"Constantin","family":"Tr\u00e4ger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Freudenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Heckscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Dettmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Oefner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Liebisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hiergeist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Gessner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Hyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemens","family":"Angstwurm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf A.","family":"Linker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9371-4314","authenticated-orcid":false,"given":"Stefanie","family":"Haase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2025.105743_bib1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrneurol.2016.187","article-title":"Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis","volume":"13","author":"Olsson","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.ebiom.2025.105743_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11481-010-9201-3","article-title":"Epstein\u2013Barr virus infection and multiple sclerosis: a review","volume":"5","author":"Ascherio","year":"2010","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.1016\/j.ebiom.2025.105743_bib3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2025.105743_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s40120-017-0086-4","article-title":"Vitamin D and multiple sclerosis: a comprehensive review","volume":"7","author":"Sintzel","year":"2017","journal-title":"Neurol Ther"},{"key":"10.1016\/j.ebiom.2025.105743_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016149","article-title":"Smoking and multiple sclerosis: an updated meta-analysis","volume":"6","author":"Handel","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2025.105743_bib6","doi-asserted-by":"crossref","DOI":"10.1177\/1759091414568185","article-title":"Nutrition facts in multiple sclerosis","volume":"7","author":"Riccio","year":"2015","journal-title":"ASN Neuro"},{"key":"10.1016\/j.ebiom.2025.105743_bib7","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028936","article-title":"Multiple sclerosis pathology","volume":"8","author":"Lassmann","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.ebiom.2025.105743_bib8","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri3871","article-title":"Immunopathology of multiple sclerosis","volume":"15","author":"Dendrou","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ebiom.2025.105743_bib9","doi-asserted-by":"crossref","DOI":"10.1177\/17562864211007687","article-title":"Inflammation in multiple sclerosis","volume":"14","author":"Haase","year":"2021","journal-title":"Ther Adv Neurol Disord"},{"key":"10.1016\/j.ebiom.2025.105743_bib10","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.4049\/jimmunol.169.9.4712","article-title":"Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis","volume":"169","author":"Kohm","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.ebiom.2025.105743_bib11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s40478-014-0163-1","article-title":"Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS","volume":"2","author":"Koutrolos","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.ebiom.2025.105743_bib12","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2011.03.018","article-title":"Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation","volume":"34","author":"Chaudhry","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.ebiom.2025.105743_bib13","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1084\/jem.20031579","article-title":"Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis","volume":"199","author":"Viglietta","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2025.105743_bib14","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1002\/eji.201847807","article-title":"The role of the gut microbiota and microbial metabolites in neuroinflammation","volume":"50","author":"Haase","year":"2020","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ebiom.2025.105743_bib15","series-title":"Translational Neuroimmunology in Multiple Sclerosis","first-page":"113","article-title":"Chapter 9 - gut microbiota in multiple sclerosis: a bioreactor driving brain autoimmunity","author":"Wekerle","year":"2016"},{"key":"10.1016\/j.ebiom.2025.105743_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci10040234","article-title":"Microbiome in multiple sclerosis; where are we, what we know and do not know","volume":"10","author":"Boziki","year":"2020","journal-title":"Brain Sci"},{"key":"10.1016\/j.ebiom.2025.105743_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12015","article-title":"Alterations of the human gut microbiome in multiple sclerosis","volume":"7","author":"Jangi","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2025.105743_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137429","article-title":"Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia XIVa and IV clusters","volume":"10","author":"Miyake","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2025.105743_bib19","article-title":"Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls","volume":"6","author":"Chen","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2025.105743_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/nu15040942","article-title":"Gut-microbiota, and multiple sclerosis: background, evidence, and perspectives","volume":"15","author":"Altieri","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.ebiom.2025.105743_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1700492","article-title":"High frequency of intestinal TH17 cells correlates with microbiota alterations and disease activity in multiple sclerosis","volume":"3","author":"Cosorich","year":"2017","journal-title":"Sci Adv"},{"key":"10.1016\/j.ebiom.2025.105743_bib22","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1073\/pnas.1711233114","article-title":"Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice","volume":"114","author":"Berer","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2025.105743_bib23","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem J"},{"key":"10.1016\/j.ebiom.2025.105743_bib24","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/s41423-020-00625-0","article-title":"Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids","volume":"18","author":"Kim","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.ebiom.2025.105743_bib25","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cell.2020.02.035","article-title":"Propionic acid shapes the multiple sclerosis disease course by an immunomodulatory mechanism","volume":"180","author":"Duscha","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2025.105743_bib26","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature24628","article-title":"Salt-responsive gut commensal modulates TH17 axis and disease","volume":"551","author":"Wilck","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2025.105743_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00385","article-title":"Lactobacillus reuteri reduces the severity of experimental autoimmune encephalomyelitis in mice by modulating gut microbiota","volume":"10","author":"He","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2025.105743_bib28","article-title":"Lactobacillus helveticus SBT2171 attenuates experimental autoimmune encephalomyelitis in mice","volume":"8","author":"Yamashita","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ebiom.2025.105743_bib29","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.immuni.2013.08.003","article-title":"Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22","volume":"39","author":"Zelante","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.ebiom.2025.105743_bib30","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nm.4106","article-title":"Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor","volume":"22","author":"Rothhammer","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2025.105743_bib31","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.clnu.2016.08.015","article-title":"Clinical and metabolic response to probiotic supplementation in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled trial","volume":"36","author":"Kouchaki","year":"2017","journal-title":"Clin Nutr"},{"key":"10.1016\/j.ebiom.2025.105743_bib32","article-title":"Probiotic supplementation and systemic inflammation in relapsing-remitting multiple sclerosis: a randomized, double-blind, placebo-controlled trial","volume":"16","author":"Rahimlou","year":"2022","journal-title":"Front Neurosci"},{"key":"10.1016\/j.ebiom.2025.105743_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jff.2018.10.023","article-title":"How probiotic bacteria influence the motor and mental behaviors as well as immunological and oxidative biomarkers in multiple sclerosis? A double blind clinical trial","volume":"52","author":"Salami","year":"2019","journal-title":"J Funct Foods"},{"key":"10.1016\/j.ebiom.2025.105743_bib34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/1352458517737390","article-title":"Investigation of probiotics in multiple sclerosis","volume":"24","author":"Tankou","year":"2018","journal-title":"Mult Scler"},{"key":"10.1016\/j.ebiom.2025.105743_bib35","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/ana.25244","article-title":"A probiotic modulates the microbiome and immunity in multiple sclerosis","volume":"83","author":"Tankou","year":"2018","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ebiom.2025.105743_bib36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ebiom.2025.105743_bib37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet J"},{"key":"10.1016\/j.ebiom.2025.105743_bib38","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ebiom.2025.105743_bib39","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2584","article-title":"VSEARCH: a versatile open source tool for metagenomics","volume":"4","author":"Rognes","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.ebiom.2025.105743_bib40","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s40168-018-0521-5","article-title":"IDTAXA: a novel approach for accurate taxonomic classification of microbiome sequences","volume":"6","author":"Murali","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.ebiom.2025.105743_bib41","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nbt.4229","article-title":"A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life","volume":"36","author":"Parks","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ebiom.2025.105743_bib42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13059-022-02655-5","article-title":"LinDA: linear models for differential abundance analysis of microbiome compositional data","volume":"23","author":"Zhou","year":"2022","journal-title":"Genome Biol"},{"key":"10.1016\/j.ebiom.2025.105743_bib43","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.1021\/acs.analchem.8b01278","article-title":"A validated, fast method for quantification of sterols and gut microbiome derived 5\u03b1\/\u03b2-stanols in human feces by isotope dilution LC\u2013high-resolution MS","volume":"90","author":"Sch\u00f6tt","year":"2018","journal-title":"Anal Chem"},{"key":"10.1016\/j.ebiom.2025.105743_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/biom9040121","article-title":"Quantification of fecal short chain fatty acids by liquid chromatography tandem mass spectrometry-investigation of pre-analytic stability","volume":"9","author":"Liebisch","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.ebiom.2025.105743_bib45","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1007\/s00216-011-5436-y","article-title":"Quantitative profiling of tryptophan metabolites in serum, urine, and cell culture supernatants by liquid chromatography-tandem mass spectrometry","volume":"401","author":"Zhu","year":"2011","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.ebiom.2025.105743_bib46","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1186\/1475-2859-10-S1-S17","article-title":"Immunomodulatory mechanisms of lactobacilli","volume":"10","author":"Wells","year":"2011","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.ebiom.2025.105743_bib47","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.biopha.2017.08.117","article-title":"Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance","volume":"95","author":"Salehipour","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.ebiom.2025.105743_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009009","article-title":"A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells","volume":"5","author":"Lavasani","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2025.105743_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.623451","article-title":"Lactobacillus acidipiscis induced regulatory gamma delta T cells and attenuated experimental autoimmune encephalomyelitis","volume":"12","author":"Ren","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2025.105743_bib50","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2025.105743_bib51","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1126\/science.1160062","article-title":"CTLA-4 control over Foxp3+ regulatory T cell function","volume":"322","author":"Wing","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2025.105743_bib52","first-page":"34","article-title":"Immunosuppressive effects of two probiotics, Lactobacillus paracasei DSM 13434 and Lactobacillus plantarum DSM 15312, on CD4+ T cells of multiple sclerosis patients","volume":"22","author":"Chakamian","year":"2023","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"10.1016\/j.ebiom.2025.105743_bib53","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1943289","article-title":"Probiotic and commensal gut microbial therapies in multiple sclerosis and its animal models: a comprehensive review","volume":"13","author":"Blais","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ebiom.2025.105743_bib54","article-title":"Indole-3-acetic acid alters intestinal microbiota and alleviates ankylosing spondylitis in mice","volume":"13","author":"Shen","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2025.105743_bib55","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.87458","article-title":"Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice","volume":"12","author":"Ding","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.ebiom.2025.105743_bib56","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1111\/febs.14956","article-title":"AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1) by recruiting Sp1","volume":"286","author":"Ye","year":"2019","journal-title":"FEBS J"},{"key":"10.1016\/j.ebiom.2025.105743_bib57","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13578-023-01046-y","article-title":"Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation","volume":"13","author":"Chen","year":"2023","journal-title":"Cell Biosci"},{"key":"10.1016\/j.ebiom.2025.105743_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/nu15194282","article-title":"Colon-targeted delivery of indole acetic acid helps regulate gut motility by activating the AHR signaling pathway","volume":"15","author":"Chen","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.ebiom.2025.105743_bib59","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature06880","article-title":"Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor","volume":"453","author":"Quintana","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2025.105743_bib60","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ni.1915","article-title":"Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell\u2013like and Foxp3+ regulatory T cells","volume":"11","author":"Gandhi","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ebiom.2025.105743_bib61","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000933","article-title":"Aryl hydrocarbon receptor plasma agonist activity correlates with disease activity in progressive MS","volume":"8","author":"Tsaktanis","year":"2021","journal-title":"Neurol Neuroimmunol Neuroinflamm"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425001872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425001872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T08:17:24Z","timestamp":1749629844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425001872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":61,"alternative-id":["S2352396425001872"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105743","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A probiotic approach identifies a Treg-centred immunoregulation via modulation of gut microbiota metabolites in people with multiple sclerosis and healthy individuals","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105743","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105743"}}