{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:52:23Z","timestamp":1793674343248,"version":"4.5.1"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000143","name":"Alzheimer Society of Canada","doi-asserted-by":"publisher","award":["0000000082"],"award-info":[{"award-number":["0000000082"]}],"id":[{"id":"10.13039\/501100000143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000304","name":"Parkinson's UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NU21-04-00535"],"award-info":[{"award-number":["NU21-04-00535"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1195830"],"award-info":[{"award-number":["1195830"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015569","name":"Consortium canadien en neurod\u00e9g\u00e9n\u00e9rescence associ\u00e9e au vieillissement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W000229\/1"],"award-info":[{"award-number":["MR\/W000229\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-INBS-0006"],"award-info":[{"award-number":["ANR-11-INBS-0006"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012295","name":"NIHR Newcastle Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000190","name":"University of Alberta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EO2107"],"award-info":[{"award-number":["01EO2107"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009307","name":"Parkinson Society Canada","doi-asserted-by":"publisher","award":["-2023-0000000122"],"award-info":[{"award-number":["-2023-0000000122"]}],"id":[{"id":"10.13039\/501100009307","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ebiom.2025.105753","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T19:32:29Z","timestamp":1748547149000},"page":"105753","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder"],"prefix":"10.1016","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5598-4110","authenticated-orcid":false,"given":"Stephen","family":"Joza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Delva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Vo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8177-0028","authenticated-orcid":false,"given":"Marie","family":"Filiatrault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8442-6873","authenticated-orcid":false,"given":"Max","family":"Tweedale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Postuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Dagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Dusek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Marecek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-9642","authenticated-orcid":false,"given":"Zsoka","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0773-5373","authenticated-orcid":false,"given":"John-Paul","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Firbank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Donaghy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Leh\u00e9ricy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Arnulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Bekadar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Benchetrit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Brice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Brochard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliz\u00e9","family":"Chalan\u00e7on","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Colsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Cormier-Dequaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Corvol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Czernecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Degos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Delorme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Dodet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Dongmo-Kenfack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Habert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Ichou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Ihle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Gall\u00e9a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Gaurav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Alexandrine","family":"Glachant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grabli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Hainque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Jeancolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Laganot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Leh\u00e9ricy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Lesage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smaranda","family":"Leu-Semenescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Maheo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Mangone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Laure","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelie","family":"M\u00e9neret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poornima","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Mochel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Perlbarg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dijana","family":"Petrovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Pineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadya","family":"Pyatigorskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Rivaud-Pechoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Roze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sambin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Socha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Tenenhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Valabregue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Vidailhet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Yahia-Cherif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Vidailhet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Corvol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"ICEBERG Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2977-8660","authenticated-orcid":false,"given":"Richard","family":"Camicioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Chertkow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Matar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylena A.","family":"Ehgoetz Martens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7150-4142","authenticated-orcid":false,"given":"Lachlan","family":"Churchill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sommerauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinah","family":"R\u00f6ttgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Borghammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline","family":"Knudsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan K.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-6069","authenticated-orcid":false,"given":"Dario","family":"Arnaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Orso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Mattioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Roccatagliata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oury","family":"Monchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5786-3278","authenticated-orcid":false,"given":"Shady","family":"Rahayel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6645","key":"10.1016\/j.ebiom.2025.105753_bib1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-Synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105753_bib2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/brain\/aww291","article-title":"Trajectories of prediagnostic functioning in Parkinson's disease","volume":"140","author":"Darweesh","year":"2017","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105753_bib3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41582-021-00486-9","article-title":"Prodromal Parkinson disease subtypes \u2014 key to understanding heterogeneity","volume":"17","author":"Berg","year":"2021","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"10.1016\/j.ebiom.2025.105753_bib4","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1093\/brain\/awad072","article-title":"Progression of clinical markers in prodromal Parkinson's disease and dementia with Lewy bodies: a multicentre study","volume":"146","author":"Joza","year":"2023","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.ebiom.2025.105753_bib5","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1093\/brain\/awac187","article-title":"Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression","volume":"145","author":"Rahayel","year":"2022","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.ebiom.2025.105753_bib6","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1093\/brain\/awad044","article-title":"Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies","volume":"146","author":"Rahayel","year":"2023","journal-title":"Brain"},{"issue":"20","key":"10.1016\/j.ebiom.2025.105753_bib7","doi-asserted-by":"crossref","first-page":"e1759","DOI":"10.1212\/WNL.0000000000005523","article-title":"Cortical and subcortical gray matter bases of cognitive deficits in REM sleep behavior disorder","volume":"90","author":"Rahayel","year":"2018","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105753_bib8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ana.25962","article-title":"A prodromal brain-clinical pattern of cognition in synucleinopathies","volume":"89","author":"Rahayel","year":"2021","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ebiom.2025.105753_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41531-019-0079-3","article-title":"Cortical thinning in patients with REM sleep behavior disorder is associated with clinical progression","volume":"5","author":"Pereira","year":"2019","journal-title":"NPJ Parkinsons Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105753_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/alz.13386","article-title":"Prodromal dementia with Lewy bodies in REM sleep behavior disorder: a multicenter study","volume":"20","author":"Joza","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105753_bib11","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/brain\/awab440","article-title":"Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns","volume":"145","author":"Rahayel","year":"2021","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.ebiom.2025.105753_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000495","article-title":"Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation","volume":"17","author":"Zheng","year":"2019","journal-title":"PLoS Biol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105753_bib13","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1162\/netn_a_00296","article-title":"Predicting longitudinal brain atrophy in Parkinson's disease using a Susceptible-Infected-Removed agent-based model","volume":"7","author":"Abdelgawad","year":"2023","journal-title":"Netw Neurosci"},{"key":"10.1016\/j.ebiom.2025.105753_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2021.101495","article-title":"Structural and functional magnetic resonance imaging in isolated REM sleep behavior disorder: a systematic review of studies using neuroimaging software","volume":"59","author":"Campabadal","year":"2021","journal-title":"Sleep Med Rev"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105753_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40035-023-00356-y","article-title":"Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder: a prospective cohort study","volume":"12","author":"Shin","year":"2023","journal-title":"Transl Neurodegener"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105753_bib16","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1038\/s41467-018-05892-0","article-title":"Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference","volume":"9","author":"Young","year":"2018","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105753_bib17","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1017\/cjn.2019.27","article-title":"The comprehensive assessment of neurodegeneration and dementia: Canadian cohort study","volume":"46","author":"Chertkow","year":"2019","journal-title":"Can J Neurol Sci"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105753_bib18","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/jmri.26197","article-title":"The Canadian dementia imaging protocol: harmonizing national cohorts","volume":"49","author":"Duchesne","year":"2019","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.ebiom.2025.105753_bib19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fninf.2018.00085","article-title":"National neuroinformatics framework for canadian consortium on neurodegeneration in aging (CCNA)","volume":"12","author":"Mohaddes","year":"2018","journal-title":"Front Neuroinform"},{"issue":"12","key":"10.1016\/j.ebiom.2025.105753_bib20","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/acn3.644","article-title":"The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort","volume":"5","author":"Marek","year":"2018","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.ebiom.2025.105753_bib21","series-title":"International Classification of Sleep Disorders","first-page":"383","year":"2014"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105753_bib22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"issue":"16","key":"10.1016\/j.ebiom.2025.105753_bib23","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1002\/mds.21740","article-title":"The REM sleep behavior disorder screening questionnaire--a new diagnostic instrument","volume":"22","author":"Stiasny-Kolster","year":"2007","journal-title":"Mov Disord"},{"key":"10.1016\/j.ebiom.2025.105753_bib24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuroimage.2019.01.014","article-title":"Qoala-T: a supervised-learning tool for quality control of FreeSurfer segmented MRI data","volume":"189","author":"Klapwijk","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.ebiom.2025.105753_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118174","article-title":"Quality control strategies for brain MRI segmentation and parcellation: practical approaches and recommendations - insights from the Maastricht study","volume":"237","author":"Monereo-S\u00e1nchez","year":"2021","journal-title":"Neuroimage"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105753_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsz062","article-title":"Brain atrophy in Parkinson's disease with polysomnography-confirmed REM sleep behavior disorder","volume":"42","author":"Rahayel","year":"2019","journal-title":"Sleep"},{"key":"10.1016\/j.ebiom.2025.105753_bib27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3389\/fnagi.2014.00264","article-title":"The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer's disease","volume":"6","author":"Voevodskaya","year":"2014","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105753_bib28","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41591-021-01309-6","article-title":"Four distinct trajectories of tau deposition identified in Alzheimer's disease","volume":"27","author":"Vogel","year":"2021","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105753_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad048","article-title":"Uncovering spatiotemporal patterns of atrophy in progressive supranuclear palsy using unsupervised machine learning","volume":"5","author":"Scotton","year":"2023","journal-title":"Brain Communications"},{"key":"10.1016\/j.ebiom.2025.105753_bib30","author":"Fortin"},{"key":"10.1016\/j.ebiom.2025.105753_bib31","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuroimage.2017.11.024","article-title":"Harmonization of cortical thickness measurements across scanners and sites","volume":"167","author":"Fortin","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.ebiom.2025.105753_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116956","article-title":"Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA","volume":"218","author":"Radua","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.ebiom.2025.105753_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101943","article-title":"The Canadian dementia imaging protocol: harmonization validity for morphometry measurements","volume":"24","author":"Potvin","year":"2019","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.ebiom.2025.105753_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.softx.2021.100811","article-title":"pySuStaIn: A Python implementation of the Subtype and Stage Inference algorithm","volume":"16","author":"Aksman","year":"2021","journal-title":"SoftwareX"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105753_bib35","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1111\/2041-210X.13022","article-title":"dispRity: A modular R package for measuring disparity","volume":"9","author":"Guillerme","year":"2018","journal-title":"Methods Ecol Evol"},{"key":"10.1016\/j.ebiom.2025.105753_bib36","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-33226-6_13","article-title":"BrainPainter: A Software for the Visualisation of Brain Structures, Biomarkers and Associated Pathological Processes","author":"Marinescu","year":"2019"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105753_bib37","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/jgs.18124","article-title":"Conversion between the Montreal cognitive assessment and the mini-mental status examination","volume":"71","author":"Fasnacht","year":"2023","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.ebiom.2025.105753_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102421","article-title":"Cortical gray matter progression in idiopathic REM sleep behavior disorder and its relation to cognitive decline","volume":"28","author":"Campabadal","year":"2020","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.ebiom.2025.105753_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2023.103523","article-title":"Network connectivity and local transcriptomic vulnerability underpin cortical atrophy progression in Parkinson's disease","volume":"40","author":"Vo","year":"2023","journal-title":"Neuroimage Clin"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105753_bib40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/brain\/awac069","article-title":"Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia","volume":"146","author":"Shafiei","year":"2023","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105753_bib41","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac013","article-title":"Longitudinal atrophy in prodromal dementia with Lewy bodies points to cholinergic degeneration","volume":"4","author":"Kantarci","year":"2022","journal-title":"Brain Commun"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105753_bib42","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jalz.2018.09.011","article-title":"A signature pattern of cortical atrophy in dementia with Lewy bodies: a study on 333 patients from the European DLB consortium","volume":"15","author":"Oppedal","year":"2019","journal-title":"Alzheimers Dement"},{"issue":"17","key":"10.1016\/j.ebiom.2025.105753_bib43","doi-asserted-by":"crossref","first-page":"e1843","DOI":"10.1212\/WNL.0000000000200947","article-title":"Longitudinal patterns of cortical atrophy on MRI in patients with Alzheimer disease with and without Lewy body pathology","volume":"99","author":"Constant","year":"2022","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105753_bib44","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.neurobiolaging.2014.07.005","article-title":"Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies","volume":"36","author":"Nedelska","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105753_bib45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41531-023-00556-3","article-title":"Two distinct trajectories of clinical and neurodegeneration events identified in Parkinson\u2019s disease","volume":"9","author":"Zhou","year":"2023","journal-title":"NPJ Parkinsons Dis"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105753_bib46","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1093\/brain\/awz111","article-title":"Evolution of prodromal Parkinson's disease and dementia with Lewy bodies: a prospective study","volume":"142","author":"Fereshtehnejad","year":"2019","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105753_bib47","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/brain\/awz030","article-title":"Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study","volume":"142","author":"Postuma","year":"2019","journal-title":"Brain"},{"issue":"Pt 10","key":"10.1016\/j.ebiom.2025.105753_bib48","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1093\/brain\/aww193","article-title":"Amyloid-\u03b2 deposition and regional grey matter atrophy rates in dementia with Lewy bodies","volume":"139","author":"Sarro","year":"2016","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105753_bib49","doi-asserted-by":"crossref","DOI":"10.4172\/2161-0460.1000444","article-title":"The contribution of tau, amyloid-beta and alpha-synuclein pathology to dementia in Lewy body disorders","volume":"8","author":"Irwin","year":"2018","journal-title":"J Alzheimers Dis Parkinsonism"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105753_bib50","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsad198","article-title":"Cerebrospinal-fluid biomarkers for predicting phenoconversion in patients with isolated rapid-eye movement sleep behavior disorder","volume":"47","author":"Fernandes","year":"2024","journal-title":"Sleep"},{"key":"10.1016\/j.ebiom.2025.105753_bib51","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awaf003","article-title":"Plasma pTau181 and amyloid markers predict conversion to dementia in idiopathic REM sleep behaviour disorder","author":"Delva","year":"2025","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105753_bib52","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1212\/WNL.0000000000207393","article-title":"\u03b2-Amyloid load on PET along the continuum of dementia with Lewy bodies","volume":"101","author":"Diaz-Galvan","year":"2023","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105753_bib53","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00702-023-02633-6","article-title":"The brain-first vs. body-first model of Parkinson's disease with comparison to alternative models","volume":"130","author":"Borghammer","year":"2023","journal-title":"J Neural Transm (Vienna)"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105753_bib54","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/ana.25239","article-title":"How does dementia with Lewy bodies start? prodromal cognitive changes in REM sleep behavior disorder","volume":"83","author":"Marchand","year":"2018","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105753_bib55","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3233\/JPD-240002","article-title":"Parkinson's disease and dementia with Lewy bodies: one and the same","volume":"14","author":"Borghammer","year":"2024","journal-title":"J Parkinsons Dis"},{"issue":"22","key":"10.1016\/j.ebiom.2025.105753_bib56","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1016\/j.cub.2019.09.026","article-title":"The sublaterodorsal tegmental nucleus functions to couple brain state and motor activity during REM sleep and wakefulness","volume":"29","author":"Torontali","year":"2019","journal-title":"Curr Biol"},{"issue":"10","key":"10.1016\/j.ebiom.2025.105753_bib57","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1093\/brain\/awab191","article-title":"The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson's disease","volume":"144","author":"Biondetti","year":"2021","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105753_bib58","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41531-023-00557-2","article-title":"Magnetic susceptibility changes in the brainstem reflect REM sleep without atonia severity in isolated REM sleep behavior disorder","volume":"9","author":"Nepozitek","year":"2023","journal-title":"NPJ Parkinsons Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105753_bib59","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10072-016-2744-1","article-title":"Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson's disease: a meta and meta-regression analysis","volume":"38","author":"Zhang","year":"2017","journal-title":"Neurol Sci"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425001975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425001975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T16:17:12Z","timestamp":1762618632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425001975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":59,"alternative-id":["S2352396425001975"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105753","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.09.05.24313131","asserted-by":"object"}]},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105753","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105753"}}