{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:54:04Z","timestamp":1767873244469,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP253fa627001"],"award-info":[{"award-number":["JP253fa627001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25wm0125002"],"award-info":[{"award-number":["JP25wm0125002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21nf0101625"],"award-info":[{"award-number":["JP21nf0101625"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institutes of Health National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["75N93021C00014"],"award-info":[{"award-number":["75N93021C00014"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ebiom.2025.105794","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T14:30:56Z","timestamp":1749220256000},"page":"105794","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["An mRNA vaccine encoding the SARS-CoV-2 Omicron XBB.1.5 receptor-binding domain protects mice from the JN.1 variant"],"prefix":"10.1016","volume":"117","author":[{"given":"Ryuta","family":"Uraki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Kiso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsumi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7768-5157","authenticated-orcid":false,"given":"Seiya","family":"Yamayoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Halfmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpi","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehul S.","family":"Suthar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago J.S.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Jounai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Miyaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-8296","authenticated-orcid":false,"given":"Yoshihiro","family":"Kawaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ebiom.2025.105794_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41541-023-00800-0","article-title":"An mRNA vaccine encoding the SARS-CoV-2 receptor-binding domain protects mice from various Omicron variants","volume":"9","author":"Uraki","year":"2024","journal-title":"NPJ Vaccines"},{"issue":"11","key":"10.1016\/j.ebiom.2025.105794_bib2","doi-asserted-by":"crossref","first-page":"e457","DOI":"10.1016\/S1473-3099(23)00573-X","article-title":"Antigenicity and infectivity characterisation of SARS-CoV-2 BA.2.86","volume":"23","author":"Yang","year":"2023","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105794_bib3","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1016\/S1473-3099(23)00744-2","article-title":"Fast evolution of SARS-CoV-2 BA.2.86 to JN.1 under heavy immune pressure","volume":"24","author":"Yang","year":"2024","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105794_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.chom.2024.01.014","article-title":"XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1","volume":"32","author":"Wang","year":"2024","journal-title":"Cell Host Microbe"},{"issue":"7992","key":"10.1016\/j.ebiom.2025.105794_bib5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41586-023-06750-w","article-title":"Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike","volume":"624","author":"Wang","year":"2023","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105794_bib6","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S1473-3099(23)00070-1","article-title":"Antiviral and bivalent vaccine efficacy against an omicron XBB.1.5 isolate","volume":"23","author":"Uraki","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ebiom.2025.105794_bib7","article-title":"XBB.1.5 monovalent booster improves antibody binding and neutralization against emerging SARS-CoV-2 Omicron variants","author":"Jain","year":"2024","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105794_bib8","article-title":"Development of a rapid focus reduction neutralization test assay for measuring SARS-CoV-2 neutralizing antibodies","volume":"131","author":"Vanderheiden","year":"2020","journal-title":"Curr Protoc Immunol"},{"key":"10.1016\/j.ebiom.2025.105794_bib9","series-title":"R: a language and environment for statistical computing","year":"2023"},{"key":"10.1016\/j.ebiom.2025.105794_bib10","series-title":"FSA: Fisheries stock analysis. R package version 0.9.5","author":"Ogle","year":"2023"},{"key":"10.1016\/j.ebiom.2025.105794_bib11","series-title":"DescTools: tools for descriptive statistics. R package version 0.99.48","author":"Signorell","year":"2023"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105794_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme 4","volume":"67","author":"Bates","year":"2015","journal-title":"J Stat Softw"},{"key":"10.1016\/j.ebiom.2025.105794_bib13","article-title":"Emmeans: estimated marginal means, aka least-squares means","volume":"1.8.5","author":"Lenth","year":"2023","journal-title":"R package version"},{"issue":"18","key":"10.1016\/j.ebiom.2025.105794_bib14","doi-asserted-by":"crossref","first-page":"9318","DOI":"10.1128\/JVI.01049-10","article-title":"T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice","volume":"84","author":"Zhao","year":"2010","journal-title":"J Virol"},{"issue":"64","key":"10.1016\/j.ebiom.2025.105794_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abl4509","article-title":"Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2","volume":"6","author":"Israelow","year":"2021","journal-title":"Sci Immunol"},{"key":"10.1016\/j.ebiom.2025.105794_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s44298-024-00063-z","article-title":"Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants","volume":"2","author":"Piepenbrink","year":"2024","journal-title":"Npj Viruses"},{"issue":"8047","key":"10.1016\/j.ebiom.2025.105794_bib17","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41586-024-08315-x","article-title":"Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1","volume":"637","author":"Jian","year":"2025","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105794_bib18","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1016\/S1473-3099(23)00813-7","article-title":"Virological characteristics of the SARS-CoV-2 JN.1 variant","volume":"24","author":"Kaku","year":"2024","journal-title":"Lancet Infect Dis"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105794_bib19","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/s41591-021-01386-7","article-title":"CD8(+) T cells contribute to survival in patients with COVID-19 and hematologic cancer","volume":"27","author":"Bange","year":"2021","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105794_bib20","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1016\/S2666-5247(23)00255-0","article-title":"Durability and cross-reactive immune memory to SARS-CoV-2 in individuals 2 years after recovery from COVID-19: a longitudinal cohort study","volume":"5","author":"Guo","year":"2024","journal-title":"Lancet Microbe"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105794_bib21","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41591-022-01715-4","article-title":"Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern","volume":"28","author":"Wratil","year":"2022","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105794_bib22","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cell.2021.01.050","article-title":"Maturation and persistence of the anti-SARS-CoV-2 memory B cell response","volume":"184","author":"Sokal","year":"2021","journal-title":"Cell"},{"issue":"7904","key":"10.1016\/j.ebiom.2025.105794_bib23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41586-022-04527-1","article-title":"Germinal centre-driven maturation of B cell response to mRNA vaccination","volume":"604","author":"Kim","year":"2022","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105794_bib24","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.cell.2022.01.018","article-title":"Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination","volume":"185","author":"Roltgen","year":"2022","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105794_bib25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1473-3099(22)00816-7","article-title":"Humoral immune evasion of the omicron subvariants BQ.1.1 and XBB","volume":"23","author":"Uraki","year":"2023","journal-title":"Lancet Infect Dis"},{"issue":"6583","key":"10.1016\/j.ebiom.2025.105794_bib26","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.abn8652","article-title":"Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement","volume":"375","author":"McCallum","year":"2022","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105794_bib27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S1473-3099(22)00805-2","article-title":"Omicron BQ.1 and BQ.1.1 escape neutralisation by omicron subvariant breakthrough infection","volume":"23","author":"Jiang","year":"2023","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105794_bib28","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S1473-3099(23)00051-8","article-title":"Enhanced transmissibility, infectivity, and immune resistance of the SARS-CoV-2 omicron XBB.1.5 variant","volume":"23","author":"Uriu","year":"2023","journal-title":"Lancet Infect Dis"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425002385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425002385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T16:18:27Z","timestamp":1762618707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425002385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":28,"alternative-id":["S2352396425002385"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105794","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An mRNA vaccine encoding the SARS-CoV-2 Omicron XBB.1.5 receptor-binding domain protects mice from the JN.1 variant","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105794","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105794"}}