{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:02:54Z","timestamp":1792526574086,"version":"4.5.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["B2024201087"],"award-info":[{"award-number":["B2024201087"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20240813180400002"],"award-info":[{"award-number":["JCYJ20240813180400002"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20241202152800001"],"award-info":[{"award-number":["JCYJ20241202152800001"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20230807111401002"],"award-info":[{"award-number":["JCYJ20230807111401002"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220530144403008"],"award-info":[{"award-number":["JCYJ20220530144403008"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220818103607015"],"award-info":[{"award-number":["JCYJ20220818103607015"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373602"],"award-info":[{"award-number":["82373602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1515120054"],"award-info":[{"award-number":["2023B1515120054"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110497"],"award-info":[{"award-number":["2023A1515110497"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ebiom.2025.105968","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T05:03:36Z","timestamp":1761368616000},"page":"105968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Interactive effects of Bisphenol F exposure and TLR4 rs4986790 on unexplained miscarriage"],"prefix":"10.1016","volume":"121","author":[{"given":"Manli","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaishuai","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Depeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qigang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7845-3331","authenticated-orcid":false,"given":"Huidong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ebiom.2025.105968_bib1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/humrep\/deu299","article-title":"Terminology for pregnancy loss prior to viability: a consensus statement from the ESHRE early pregnancy special interest group","volume":"30","author":"Kolte","year":"2015","journal-title":"Hum Reprod"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105968_bib2","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.fertnstert.2012.06.048","article-title":"Evaluation and treatment of recurrent pregnancy loss: a committee opinion","volume":"98","year":"2012","journal-title":"Fertil Steril"},{"issue":"10285","key":"10.1016\/j.ebiom.2025.105968_bib3","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","article-title":"Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105968_bib4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41572-020-00228-z","article-title":"Recurrent pregnancy loss","volume":"6","author":"Dimitriadis","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105968_bib5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/bdra.23014","article-title":"A systematic review to calculate background miscarriage rates using life table analysis","volume":"94","author":"Ammon Avalos","year":"2012","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105968_bib6","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1038\/s41467-023-40616-z","article-title":"A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus","volume":"14","author":"Spisak","year":"2023","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.ebiom.2025.105968_bib7","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/s42255-023-00847-2","article-title":"The rs1421085 variant within FTO promotes brown fat thermogenesis","volume":"5","author":"Zhang","year":"2023","journal-title":"Nat Metab"},{"key":"10.1016\/j.ebiom.2025.105968_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104647","article-title":"Dissecting shared genetic architecture between obesity and multiple sclerosis","volume":"93","author":"Zeng","year":"2023","journal-title":"eBioMedicine"},{"key":"10.1016\/j.ebiom.2025.105968_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105807","article-title":"Metabolome-wide Mendelian randomisation reveals causal links between circulating metabolites and type 1 diabetes","volume":"117","author":"Jumentier","year":"2025","journal-title":"eBioMedicine"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105968_bib10","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1038\/s41467-020-19742-5","article-title":"The genetic architecture of sporadic and multiple consecutive miscarriage","volume":"11","author":"Laisk","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105968_bib11","first-page":"150","article-title":"Systematic review and meta-analysis of genetic association studies in idiopathic recurrent spontaneous abortion","volume":"107","author":"Pereza","year":"2017","journal-title":"F S Rep"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105968_bib12","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1177\/1933719110364248","article-title":"Genome-wide screening for risk loci of idiopathic recurrent miscarriage in a Han Chinese population: a pilot study","volume":"17","author":"Li","year":"2010","journal-title":"Reprod Sci"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105968_bib13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1159\/000468931","article-title":"Increased toll-like receptor-myeloid differentiation factor 88 expression at the maternal-fetal interface is associated with spontaneous abortion","volume":"82","author":"He","year":"2017","journal-title":"Gynecol Obstet Invest"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105968_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13044","article-title":"Excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of toll-like receptor 4","volume":"80","author":"Heim","year":"2018","journal-title":"Am J Reprod Immunol"},{"issue":"10","key":"10.1016\/j.ebiom.2025.105968_bib15","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1136\/ard.2006.065037","article-title":"Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies","volume":"66","author":"Pierangeli","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105968_bib16","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.3892\/etm.2016.3796","article-title":"Toll-like receptor 4 gene is associated with recurrent spontaneous miscarriage in Uygur and Han women in Xinjiang","volume":"12","author":"Jiao","year":"2016","journal-title":"Exp Ther Med"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105968_bib17","article-title":"Emerging contaminants: a one health perspective","volume":"5","author":"Wang","year":"2024","journal-title":"Innovation (Camb)"},{"issue":"8","key":"10.1016\/j.ebiom.2025.105968_bib18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1080\/10408444.2022.2144711","article-title":"Regulatory roles of non-coding RNAs and m6A modification in trophoblast functions and the occurrence of its related adverse pregnancy outcomes","volume":"52","author":"Rong","year":"2022","journal-title":"Crit Rev Toxicol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105968_bib19","doi-asserted-by":"crossref","DOI":"10.1289\/EHP10477","article-title":"BPDE, the migration and invasion of human trophoblast cells, and occurrence of miscarriage in humans: roles of a novel lncRNA-HZ09","volume":"131","author":"Dai","year":"2023","journal-title":"Environ Health Perspect"},{"issue":"13","key":"10.1016\/j.ebiom.2025.105968_bib20","article-title":"Defective homologous recombination repair by up-regulating Lnc-HZ10\/Ahr loop in human trophoblast cells induced miscarriage","volume":"11","author":"Chen","year":"2024","journal-title":"Adv Sci (Weinh)"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105968_bib21","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1021\/acsnano.3c11734","article-title":"Polystyrene nanoplastics activate autophagy and suppress trophoblast cell migration\/invasion and migrasome formation to induce miscarriage","volume":"18","author":"Wan","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105968_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12989-024-00574-w","article-title":"Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage","volume":"21","author":"Wan","year":"2024","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.ebiom.2025.105968_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103073","article-title":"Hypoxia causes trophoblast cell ferroptosis to induce miscarriage through lnc-HZ06\/HIF1\u03b1-SUMO\/NCOA4 axis","volume":"70","author":"Tian","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.ebiom.2025.105968_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.133035","article-title":"Dichloroacetic acid and trichloroacetic acid as disinfection by-products in drinking water are endocrine-disrupting chemicals","volume":"466","author":"Chen","year":"2024","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.ebiom.2025.105968_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.116956","article-title":"Sorption and leaching behaviors between aged MPs and BPA in water: the role of BPA binding modes within plastic matrix","volume":"195","author":"Sun","year":"2021","journal-title":"Water Res"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105968_bib26","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1007\/s11356-019-07111-9","article-title":"Human exposure of bisphenol A and its analogues: understandings from human urinary excretion data and wastewater-based epidemiology","volume":"27","author":"Wang","year":"2020","journal-title":"Environ Sci Pollut Res Int"},{"issue":"11","key":"10.1016\/j.ebiom.2025.105968_bib27","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1021\/acs.est.5b05387","article-title":"Bisphenol analogues other than BPA: environmental occurrence, human exposure, and Toxicity-A review","volume":"50","author":"Chen","year":"2016","journal-title":"Environ Sci Technol"},{"issue":"10","key":"10.1016\/j.ebiom.2025.105968_bib28","doi-asserted-by":"crossref","DOI":"10.1289\/EHP4664","article-title":"Associations of trimester-specific exposure to bisphenols with size at birth: a Chinese prenatal cohort study","volume":"127","author":"Hu","year":"2019","journal-title":"Environ Health Perspect"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105968_bib29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cell.2019.03.004","article-title":"Gene-environment interaction in the era of precision medicine","volume":"177","author":"Li","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2025.105968_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106681","article-title":"Fluoride exposure and children's intelligence: gene-Environment interaction based on SNP-set, gene and pathway analysis, using a case-control design based on a cross-sectional study","volume":"155","author":"Yu","year":"2021","journal-title":"Environ Int"},{"issue":"Pt 3","key":"10.1016\/j.ebiom.2025.105968_bib31","article-title":"Urinary bisphenol A and its interaction with CYP17A1 rs743572 are associated with breast cancer risk","volume":"286","author":"He","year":"2022","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105968_bib32","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1021\/acs.est.2c07389","article-title":"Metal exposure promotes colorectal tumorigenesis via the aberrant N6-Methyladenosine modification of ATP13A3","volume":"57","author":"Li","year":"2023","journal-title":"Environ Sci Technol"},{"issue":"11","key":"10.1016\/j.ebiom.2025.105968_bib33","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202152707","article-title":"LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5","volume":"22","author":"Zheng","year":"2021","journal-title":"EMBO Rep"},{"issue":"21","key":"10.1016\/j.ebiom.2025.105968_bib34","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/CIRCULATIONAHA.122.061940","article-title":"SOX17 enhancer variants disrupt transcription factor binding and enhancer inactivity drives pulmonary hypertension","volume":"147","author":"Walters","year":"2023","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105968_bib35","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/humupd\/dms015","article-title":"Extravillous trophoblast and decidual natural killer cells: a remodelling partnership","volume":"18","author":"Wallace","year":"2012","journal-title":"Hum Reprod Update"},{"issue":"99-1010","key":"10.1016\/j.ebiom.2025.105968_bib36","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.placenta.2005.12.006","article-title":"The uterine spiral arteries in human pregnancy: facts and controversies","volume":"27","author":"Pijnenborg","year":"2006","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105968_bib37","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/path.1927","article-title":"Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion","volume":"208","author":"Ball","year":"2006","journal-title":"J Pathol"},{"issue":"9","key":"10.1016\/j.ebiom.2025.105968_bib38","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.placenta.2010.06.017","article-title":"Cadherins in the human placenta--epithelial-mesenchymal transition (EMT) and placental development","volume":"31","author":"Kokkinos","year":"2010","journal-title":"Placenta"},{"issue":"9","key":"10.1016\/j.ebiom.2025.105968_bib39","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1631\/jzus.B2101024","article-title":"Reduced cell invasion may be a characteristic of placental defects in pregnant women of advanced maternal age at single-cell level","volume":"23","author":"Zhang","year":"2022","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.ebiom.2025.105968_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108750","article-title":"BaP\/BPDE suppresses human trophoblast cell migration\/invasion and induces unexplained miscarriage by up-regulating a novel lnc-HZ11 in extracellular vesicles: an intercellular study","volume":"188","author":"Mi","year":"2024","journal-title":"Environ Int"},{"issue":"7","key":"10.1016\/j.ebiom.2025.105968_bib41","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1021\/acs.est.6b00032","article-title":"Urinary concentrations of bisphenols and their association with biomarkers of oxidative stress in people living near E-Waste recycling facilities in China","volume":"50","author":"Zhang","year":"2016","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.ebiom.2025.105968_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.125987","article-title":"Occurrence of bisphenol A and its alternatives in paired urine and indoor dust from Chinese university students: implications for human exposure","volume":"247","author":"Zhang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ebiom.2025.105968_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107446","article-title":"Bisphenol A analogues in associations with serum hormone levels among reproductive-aged Chinese men","volume":"167","author":"Zeng","year":"2022","journal-title":"Environ Int"},{"key":"10.1016\/j.ebiom.2025.105968_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136100","article-title":"Serum concentration of bisphenol analogues in pregnant women in China","volume":"707","author":"Li","year":"2020","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.ebiom.2025.105968_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121393","article-title":"FTO-Nrf2 axis regulates bisphenol F-induced leydig cell toxicity in an m6A-YTHDF2-dependent manner","volume":"325","author":"Zhou","year":"2023","journal-title":"Environ Pollut"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105968_bib46","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1007\/s11356-017-9709-7","article-title":"Low-concentration BPAF- and BPF-induced cell biological effects are mediated by ROS in MCF-7 breast cancer cells","volume":"25","author":"Lei","year":"2018","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.ebiom.2025.105968_bib47","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ecoenv.2018.08.102","article-title":"Low-concentration BPF induced cell biological responses by the ER\u03b1 and GPER1-mediated signaling pathways in MCF-7 breast cancer cells","volume":"165","author":"Lei","year":"2018","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.ebiom.2025.105968_bib48","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.intimp.2016.02.030","article-title":"In vitro impact of bisphenols BPA, BPF, BPAF and 17\u03b2-estradiol (E2) on human monocyte-derived dendritic cell generation, maturation and function","volume":"34","author":"\u0160vajger","year":"2016","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105968_bib49","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.immuni.2023.03.003","article-title":"The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome","volume":"56","author":"Zhu","year":"2023","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105968_bib50","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12985-022-01909-9","article-title":"A \u039442PD1 fusion-expressing DNA vaccine elicits enhanced adaptive immune response to HIV-1: the key role of TLR4","volume":"19","author":"Cheng","year":"2022","journal-title":"Virol J"},{"key":"10.1016\/j.ebiom.2025.105968_bib51","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.chemosphere.2018.06.089","article-title":"Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S: comparative in vitro and in vivo studies on the sperms and testicular tissues of rats","volume":"209","author":"Ullah","year":"2018","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105968_bib52","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/0748233719831528","article-title":"Bisphenol A analogues bisphenol B, bisphenol F, and bisphenol S induce oxidative stress, disrupt daily sperm production, and damage DNA in rat spermatozoa: a comparative in vitro and in vivo study","volume":"35","author":"Ullah","year":"2019","journal-title":"Toxicol Ind Health"},{"key":"10.1016\/j.ebiom.2025.105968_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113268","article-title":"Bisphenol F blocks Leydig cell maturation and steroidogenesis in pubertal male rats through suppressing androgen receptor signaling and activating G-protein coupled estrogen receptor 1 (GPER1) signaling","volume":"167","author":"Li","year":"2022","journal-title":"Food Chem Toxicol"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105968_bib54","first-page":"425","article-title":"Acute toxicity of bisphenol A in rats","volume":"50","author":"Pant","year":"2012","journal-title":"Indian J Exp Biol"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105968_bib55","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1046\/j.1365-3083.2002.01091.x","article-title":"Heme oxygenase is downregulated in stress-triggered and interleukin-12-mediated murine abortion","volume":"55","author":"Zenclussen","year":"2002","journal-title":"Scand J Immunol"},{"issue":"W1","key":"10.1016\/j.ebiom.2025.105968_bib56","doi-asserted-by":"crossref","first-page":"W350","DOI":"10.1093\/nar\/gky300","article-title":"DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability","volume":"46","author":"Rodrigues","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ebiom.2025.105968_bib57","article-title":"Caffeine intake interacts with Asian gene variants in Parkinson's disease: a study in 4488 subjects","volume":"40","author":"Ong","year":"2023","journal-title":"Lancet Reg Health West Pac"},{"issue":"6","key":"10.1016\/j.ebiom.2025.105968_bib58","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/molehr\/gar003","article-title":"A genome-wide scan in affected sibling pairs with idiopathic recurrent miscarriage suggests genetic linkage","volume":"17","author":"Kolte","year":"2011","journal-title":"Mol Hum Reprod"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105968_bib59","first-page":"1955","article-title":"Pro-atherogenic activation of A7r5 cells induced by the oxLDL\/\u03b22GPI\/anti-\u03b22GPI complex","volume":"42","author":"Wang","year":"2018","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.ebiom.2025.105968_bib60","article-title":"Antiphospholipid syndrome","volume":"4","author":"Schreiber","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105968_bib61","doi-asserted-by":"crossref","DOI":"10.1289\/EHP10640","article-title":"Evaluating the effects of BPA and TBBPA exposure on pregnancy loss and maternal-fetal immune cells in mice","volume":"130","author":"Reed","year":"2022","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ebiom.2025.105968_bib62","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.envpol.2019.01.116","article-title":"Effects of perinatal exposure to BPA, BPF and BPAF on liver function in male mouse offspring involving in oxidative damage and metabolic disorder","volume":"247","author":"Meng","year":"2019","journal-title":"Environ Pollut"},{"issue":"Pt 1","key":"10.1016\/j.ebiom.2025.105968_bib63","article-title":"Environmental level of bisphenol F induced reproductive toxicity toward zebrafish","volume":"806","author":"Mu","year":"2022","journal-title":"Sci Total Environ"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105968_bib64","doi-asserted-by":"crossref","DOI":"10.59717\/j.xinn-med.2025.100128","article-title":"Dendritic cells instruct T cell anti-tumor immunity and immunotherapy response","volume":"3","author":"Xiao","year":"2025","journal-title":"Innov Med"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105968_bib65","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105968_bib66","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/bjh.12587","article-title":"The role of TLR4 in pathophysiology of antiphospholipid syndrome-associated thrombosis and pregnancy morbidity","volume":"164","author":"Xie","year":"2014","journal-title":"Br J Haematol"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105968_bib67","doi-asserted-by":"crossref","first-page":"12583","DOI":"10.1080\/21655979.2022.2074620","article-title":"EZH2 enhances proliferation and migration of trophoblast cell lines by blocking GADD45A-mediated p38\/MAPK signaling pathway","volume":"13","author":"Qian","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.ebiom.2025.105968_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.782792","article-title":"Inhibition of HMGB1 ameliorates the maternal-fetal interface destruction in unexplained recurrent spontaneous abortion by suppressing pyroptosis activation","volume":"12","author":"Zhu","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2025.105968_bib69","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.placenta.2025.04.012","article-title":"Baicalein prevents pregnancy loss by maintaining regulatory T cell activation through inhibition of the TLR4\/NF-\u03baB signaling pathway","volume":"165","author":"Huang","year":"2025","journal-title":"Placenta"},{"key":"10.1016\/j.ebiom.2025.105968_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2024.05.137","article-title":"Toll-like receptor 4 (TLR4) deficiency impedes Toxoplasma gondii excreted-secreted antigens (ESA)-induced abortion","volume":"154","author":"Huang","year":"2024","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105968_bib71","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2018.06.014","article-title":"Risk SNP-mediated promoter-enhancer switching drives prostate cancer through lncRNA PCAT19","volume":"174","author":"Hua","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2025.105968_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105286","article-title":"Accurate identification of genes associated with brain disorders by integrating heterogeneous genomic data into a Bayesian framework","volume":"107","author":"He","year":"2024","journal-title":"EBioMedicine"},{"issue":"10","key":"10.1016\/j.ebiom.2025.105968_bib73","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00018-022-04540-7","article-title":"The rs1001179 SNP and CpG methylation regulate catalase expression in chronic lymphocytic leukemia","volume":"79","author":"Galasso","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ebiom.2025.105968_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134741","article-title":"BaP\/BPDE exposure causes human trophoblast cell dysfunctions and induces miscarriage by up-regulating lnc-HZ06-regulated IL1B","volume":"476","author":"Guo","year":"2024","journal-title":"J Hazard Mater"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105968_bib75","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s42003-021-02038-9","article-title":"Sperm modulate uterine immune parameters relevant to embryo implantation and reproductive success in mice","volume":"4","author":"Schjenken","year":"2021","journal-title":"Commun Biol"},{"issue":"11","key":"10.1016\/j.ebiom.2025.105968_bib76","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41582-022-00714-w","article-title":"Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics","volume":"18","author":"Migliore","year":"2022","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.ebiom.2025.105968_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105146","article-title":"Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer","volume":"104","author":"Papadimitriou","year":"2024","journal-title":"eBioMedicine"},{"issue":"3","key":"10.1016\/j.ebiom.2025.105968_bib78","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000517284","article-title":"The association between TREM2 gene and late-onset Alzheimer's disease in Chinese Han population","volume":"68","author":"Sun","year":"2022","journal-title":"Gerontology"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105968_bib79","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/iji.12524","article-title":"Associations of toll-like receptor 4 and 2 gene polymorphisms with susceptibility to ankylosing spondylitis: a meta-analysis","volume":"48","author":"Gao","year":"2021","journal-title":"Int J Immunogenet"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105968_bib80","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jdermsci.2016.04.014","article-title":"TLR2 and TLR4 polymorphisms in Southern Chinese Psoriasis Vulgaris patients","volume":"83","author":"Shi","year":"2016","journal-title":"J Dermatol Sci"},{"issue":"5","key":"10.1016\/j.ebiom.2025.105968_bib81","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/codi.15550","article-title":"A case-control study examining the association of smad7 and TLR single nucleotide polymorphisms on the risk of colorectal cancer in ulcerative colitis","volume":"23","author":"Reilly","year":"2021","journal-title":"Colorectal Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2025.105968_bib82","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/76048","article-title":"TLR4 mutations are associated with endotoxin hyporesponsiveness in humans","volume":"25","author":"Arbour","year":"2000","journal-title":"Nat Genet"},{"issue":"10","key":"10.1016\/j.ebiom.2025.105968_bib83","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1080\/15548627.2024.2362122","article-title":"The novel lnc-HZ12 suppresses autophagy degradation of BBC3 by preventing its interactions with HSPA8 to induce trophoblast cell apoptosis","volume":"20","author":"Zhao","year":"2024","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105968_bib84","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41467-022-28240-9","article-title":"Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance","volume":"13","author":"Lebeau","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2025.105968_bib85","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1053\/j.gastro.2023.03.233","article-title":"Long-term exposure to fine particulate matter and incidence of esophageal cancer: a prospective study of 0.5 million Chinese adults","volume":"165","author":"Sun","year":"2023","journal-title":"Gastroenterology"},{"issue":"46","key":"10.1016\/j.ebiom.2025.105968_bib86","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi8716","article-title":"Anionic nanoplastic contaminants promote Parkinson's disease-associated \u03b1-synuclein aggregation","volume":"9","author":"Liu","year":"2023","journal-title":"Sci Adv"},{"issue":"4","key":"10.1016\/j.ebiom.2025.105968_bib87","doi-asserted-by":"crossref","DOI":"10.59717\/j.xinn-med.2024.100093","article-title":"Interpretable learning predicts miscarriage using pre-pregnancy serum metabolites","volume":"2","author":"Tang","year":"2024","journal-title":"Innov Med"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425004128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425004128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:38:45Z","timestamp":1778873925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425004128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":87,"alternative-id":["S2352396425004128"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105968","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interactive effects of Bisphenol F exposure and TLR4 rs4986790 on unexplained miscarriage","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.105968","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105968"}}