{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:48:38Z","timestamp":1790196518200,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0578"],"award-info":[{"award-number":["2024NSFSC0578"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473646"],"award-info":[{"award-number":["82473646"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["23LCYJ013"],"award-info":[{"award-number":["23LCYJ013"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["82325043"],"award-info":[{"award-number":["82325043"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["82301924"],"award-info":[{"award-number":["82301924"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2707602"],"award-info":[{"award-number":["2024YFC2707602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023ZYD0120"],"award-info":[{"award-number":["2023ZYD0120"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ebiom.2025.106008","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T01:23:24Z","timestamp":1763169804000},"page":"106008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Longitudinal alterations of gut microbiota associated with intrahepatic cholestasis of pregnancy: results from a large cohort study in China"],"prefix":"10.1016","volume":"122","author":[{"given":"Dan","family":"Shan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhaonan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingru","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1089-7945","authenticated-orcid":false,"given":"An","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Sheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9350-9230","authenticated-orcid":false,"given":"Xiong-Fei","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41572-025-00633-2","article-title":"Intrahepatic cholestasis of pregnancy","volume":"11","author":"Dajti","year":"2025","journal-title":"Nat Rev Dis Primers"},{"issue":"13","key":"10.1016\/j.ebiom.2025.106008_bib2","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1111\/1471-0528.17206","article-title":"Intrahepatic cholestasis of pregnancy: green-top guideline no. 43 June 2022","volume":"129","author":"Girling","year":"2022","journal-title":"BJOG"},{"issue":"10174","key":"10.1016\/j.ebiom.2025.106008_bib3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0140-6736(18)31877-4","article-title":"Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses","volume":"393","author":"Ovadia","year":"2019","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106008_bib4","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1016\/j.ajog.2020.11.002","article-title":"Society for maternal-fetal medicine consult series #53: intrahepatic cholestasis of pregnancy: replaces consult #13, April 2011","volume":"224","author":"Lee","year":"2021","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106008_bib5","first-page":"97","article-title":"[Guidelines for clinical diagnosis, treatment and management of intrahepatic cholestasis of pregnancy (2024)]","volume":"59","year":"2024","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/s12876-020-01510-w","article-title":"Characterization of gut microbiota associated with clinical parameters in intrahepatic cholestasis of pregnancy","volume":"20","author":"Li","year":"2020","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.ebiom.2025.106008_bib7","article-title":"Intrahepatic cholestasis of pregnancy increases inflammatory susceptibility in neonatal offspring by modulating gut microbiota","volume":"13","author":"Lin","year":"2022","journal-title":"Front Immunol"},{"issue":"9","key":"10.1016\/j.ebiom.2025.106008_bib8","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/s42255-021-00452-1","article-title":"Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling","volume":"3","author":"Schneider","year":"2021","journal-title":"Nat Metab"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib9","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/s41467-023-36981-4","article-title":"Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy","volume":"14","author":"Tang","year":"2023","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib10","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2181930","article-title":"Cholestasis: exploring the triangular relationship of gut microbiota-bile acid-cholestasis and the potential probiotic strategies","volume":"15","author":"Yu","year":"2023","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s12866-023-02983-x","article-title":"Profiles and integration of the gut microbiome and fecal metabolites in severe intrahepatic cholestasis of pregnancy","volume":"23","author":"Li","year":"2023","journal-title":"BMC Microbiol"},{"issue":"46","key":"10.1016\/j.ebiom.2025.106008_bib12","doi-asserted-by":"crossref","first-page":"7338","DOI":"10.3748\/wjg.v26.i46.7338","article-title":"Response of gut microbiota to serum metabolome changes in intrahepatic cholestasis of pregnant patients","volume":"26","author":"Li","year":"2020","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ebiom.2025.106008_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.635680","article-title":"Alterations of the human gut microbiota in intrahepatic cholestasis of pregnancy","volume":"11","author":"Zhan","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"issue":"9","key":"10.1016\/j.ebiom.2025.106008_bib14","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.autrev.2017.07.002","article-title":"Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases","volume":"16","author":"Li","year":"2017","journal-title":"Autoimmun Rev"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1530\/EJE-21-0118","article-title":"Circulating fatty acids and risk of gestational diabetes mellitus: prospective analyses in China","volume":"185","author":"Pan","year":"2021","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"10.1016\/j.ebiom.2025.106008_bib16","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"6","key":"10.1016\/j.ebiom.2025.106008_bib17","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for prediction of metagenome functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat Biotechnol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme 4","volume":"67","author":"Bates","year":"2015","journal-title":"J Stat Softw"},{"issue":"13","key":"10.1016\/j.ebiom.2025.106008_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest package: tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J Stat Softw"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/EDE.0b013e318230e861","article-title":"Accounting for bias due to selective attrition: the example of smoking and cognitive decline","volume":"23","author":"Weuve","year":"2012","journal-title":"Epidemiology"},{"key":"10.1016\/j.ebiom.2025.106008_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jclinepi.2015.12.005","article-title":"A calibration hierarchy for risk models was defined: from utopia to empirical data","volume":"74","author":"Van Calster","year":"2016","journal-title":"J Clin Epidemiol"},{"issue":"8","key":"10.1016\/j.ebiom.2025.106008_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v009.i08","article-title":"Analysis of complex survey samples","volume":"9","author":"Lumley","year":"2004","journal-title":"J Stat Softw"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106008_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J Stat Softw"},{"key":"10.1016\/j.ebiom.2025.106008_bib25","series-title":"Latrend: a framework for clustering longitudinal data","author":"Teuling","year":"2024"},{"issue":"19","key":"10.1016\/j.ebiom.2025.106008_bib26","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1093\/bioinformatics\/btv349","article-title":"CCLasso: correlation inference for compositional data through lasso","volume":"31","author":"Fang","year":"2015","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106008_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaa290","article-title":"NetCoMi: network construction and comparison for microbiome data in R","volume":"22","author":"Peschel","year":"2021","journal-title":"Brief Bioinform"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106008_bib28","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s43588-022-00247-8","article-title":"Large-scale microbiome data integration enables robust biomarker identification","volume":"2","author":"Xiao","year":"2022","journal-title":"Nat Comput Sci"},{"key":"10.1016\/j.ebiom.2025.106008_bib29","series-title":"Mediation: r package for causal mediation analysis","author":"Tingley","year":"2014"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106008_bib30","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.chom.2019.07.004","article-title":"Obese individuals with and without type 2 diabetes show different gut microbial functional capacity and composition","volume":"26","author":"Thingholm","year":"2019","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106008_bib31","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1002\/imt2.96","article-title":"Integration of multiomics with precision nutrition for gestational diabetes: study protocol for the westlake precision birth cohort","volume":"2","author":"Liang","year":"2023","journal-title":"iMeta"},{"issue":"38","key":"10.1016\/j.ebiom.2025.106008_bib32","doi-asserted-by":"crossref","first-page":"12014","DOI":"10.1021\/acs.jafc.2c04817","article-title":"Nuciferine protects against high-fat diet-induced hepatic steatosis via modulation of gut microbiota and bile acid metabolism in rats","volume":"70","author":"Sun","year":"2022","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.clnu.2023.11.001","article-title":"Altered gut microbiome associated with metabolic-associated fatty liver disease in Chinese children","volume":"43","author":"Ji","year":"2024","journal-title":"Clin Nutr"},{"key":"10.1016\/j.ebiom.2025.106008_bib34","article-title":"Integrative analysis of gut microbiota and fecal metabolites in metabolic associated fatty liver disease patients","volume":"13","author":"Yang","year":"2022","journal-title":"Front Microbiol"},{"issue":"8","key":"10.1016\/j.ebiom.2025.106008_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2025.105276","article-title":"Effects of dietary supplementation with bile acids on growth performance, antioxidant capacity, lipid metabolism, and cecal microbiota of Danzhou chickens","volume":"104","author":"Yu","year":"2025","journal-title":"Poult Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib36","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1186\/s12884-022-05235-4","article-title":"Distribution of endotoxin in maternal and fetal body with intrahepatic cholestasis of pregnancy and its association with adverse fetal outcome","volume":"22","author":"Huang","year":"2022","journal-title":"BMC Pregnancy Childbirth"},{"issue":"15","key":"10.1016\/j.ebiom.2025.106008_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202100096","article-title":"Propionate and butyrate produced by gut microbiota after probiotic supplementation attenuate lung metastasis of melanoma cells in mice","volume":"65","author":"Chen","year":"2021","journal-title":"Mol Nutr Food Res"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106008_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/nu11040923","article-title":"Precision nutrition and the microbiome, part I: current state of the science","volume":"11","author":"Mills","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib39","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/pathogens3010014","article-title":"Metabolism of cholesterol and bile acids by the gut microbiota","volume":"3","author":"Gerard","year":"2013","journal-title":"Pathogens"},{"issue":"6","key":"10.1016\/j.ebiom.2025.106008_bib40","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004779","article-title":"Gut microbiota and metabolites associate with outcomes of immune checkpoint inhibitor-treated unresectable hepatocellular carcinoma","volume":"10","author":"Lee","year":"2022","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.ebiom.2025.106008_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1467414","article-title":"Dynamic changes of gut microbiota between the first and second trimester for women with gestational diabetes mellitus and their correlations with BMI: a nested cohort study in China","volume":"15","author":"Zhong","year":"2024","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ebiom.2025.106008_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1352267","article-title":"An altered gut microbiome in pre-eclampsia: cause or consequence","volume":"14","author":"Deady","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"issue":"9","key":"10.1016\/j.ebiom.2025.106008_bib43","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1097\/CM9.0000000000000734","article-title":"Gut microbiota dysbiosis in preeclampsia patients in the second and third trimesters","volume":"133","author":"Wang","year":"2020","journal-title":"Chin Med J (Engl)"},{"issue":"10","key":"10.1016\/j.ebiom.2025.106008_bib44","article-title":"The gut microbiome dynamically associates with host glucose metabolism throughout pregnancy: longitudinal findings from a matched case-control study of gestational diabetes mellitus","volume":"10","author":"Sun","year":"2023","journal-title":"Adv Sci (Weinh)"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106008_bib45","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.immuni.2023.01.017","article-title":"Gut microbiota in pregnancy, please don't change me now","volume":"56","author":"Nascimento","year":"2023","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106008_bib46","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/19490976.2015.1086056","article-title":"Pregnancy-related changes in the maternal gut microbiota are dependent upon the mother's periconceptional diet","volume":"6","author":"Gohir","year":"2015","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106008_bib47","first-page":"30","article-title":"Can first-trimester aspartate aminotransferase\/platelet ratio index score predict intrahepatic cholestasis of pregnancy?","volume":"4","author":"Gok","year":"2023","journal-title":"Hepatol Forum"},{"key":"10.1016\/j.ebiom.2025.106008_bib48","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.17613","article-title":"Evaluation of alanine aminotransferase\/aspartate aminotransferase ratio and high-density lipoprotein for predicting neonatal adverse outcomes associated with intrahepatic cholestasis of pregnancy","volume":"12","author":"Fan","year":"2024","journal-title":"PeerJ"},{"key":"10.1016\/j.ebiom.2025.106008_bib49","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jare.2024.11.003","article-title":"Biological functions and pharmacological behaviors of bile acids in metabolic diseases","volume":"75","author":"Zhuang","year":"2025","journal-title":"J Adv Res"},{"issue":"10","key":"10.1016\/j.ebiom.2025.106008_bib50","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/apt.16602","article-title":"Review article: therapeutic aspects of bile acid signalling in the gut-liver axis","volume":"54","author":"Simbrunner","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"issue":"11","key":"10.1016\/j.ebiom.2025.106008_bib51","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut-liver axis and gut microbiota in health and liver disease","volume":"21","author":"Hsu","year":"2023","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106008_bib52","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","article-title":"Alcohol, liver disease and the gut microbiota","volume":"16","author":"Bajaj","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"19","key":"10.1016\/j.ebiom.2025.106008_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914857","article-title":"The physiological and pathological role of Acyl-CoA oxidation","volume":"24","author":"Szrok-Jurga","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2025.106008_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122228","article-title":"Depletion of S-adenosylmethionine induced by arsenic exposure is involved in liver injury of rat through perturbing histone H3K36 trimethylation dependent bile acid metabolism","volume":"334","author":"Ma","year":"2023","journal-title":"Environ Pollut"},{"key":"10.1016\/j.ebiom.2025.106008_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.916866","article-title":"PPARalpha: a potential therapeutic target of cholestasis","volume":"13","author":"Ye","year":"2022","journal-title":"Front Pharmacol"},{"issue":"12","key":"10.1016\/j.ebiom.2025.106008_bib56","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02702-24","article-title":"Microbiome-producing SCFAs are associated with preterm birth via trophoblast function modulation","volume":"15","author":"Meng","year":"2024","journal-title":"mBio"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106008_bib58","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s11255-024-04191-6","article-title":"Potential trimethylamine (TMA)-producing bacteria in patients with chronic kidney disease undergoing hemodialysis","volume":"57","author":"Alvarenga","year":"2025","journal-title":"Int Urol Nephrol"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106008_bib59","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13937","article-title":"Are systemic inflammation markers reliable for diagnosing intrahepatic cholestasis of pregnancy? A retrospective cohort study","volume":"92","author":"\u00d6zkan","year":"2024","journal-title":"Am J Reprod Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106008_bib60","doi-asserted-by":"crossref","first-page":"379","DOI":"10.5603\/gpl.102459","article-title":"The role of the systemic inflammatory response index (SIRI) and other maternal biochemical markers in determining the severity of intrahepatic cholestasis of pregnancy","volume":"96","author":"Kanza Gul","year":"2025","journal-title":"Ginekol Pol"},{"issue":"14","key":"10.1016\/j.ebiom.2025.106008_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23147924","article-title":"Maternal acetate supplementation reverses blood pressure increase in Male offspring induced by exposure to minocycline during pregnancy and lactation","volume":"23","author":"Hsu","year":"2022","journal-title":"Int J Mol Sci"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425004529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425004529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:40:38Z","timestamp":1778874038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425004529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":60,"alternative-id":["S2352396425004529"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.106008","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal alterations of gut microbiota associated with intrahepatic cholestasis of pregnancy: results from a large cohort study in China","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.106008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106008"}}