{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:36:47Z","timestamp":1790012207823,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024075","name":"Region Syddanmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK135290"],"award-info":[{"award-number":["R01DK135290"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK064324"],"award-info":[{"award-number":["R01DK064324"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK138055"],"award-info":[{"award-number":["R01DK138055"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["7R01DK13207202"],"award-info":[{"award-number":["7R01DK13207202"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK123564"],"award-info":[{"award-number":["R01DK123564"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK125858"],"award-info":[{"award-number":["R01DK125858"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["A4726"],"award-info":[{"award-number":["A4726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK135290"],"award-info":[{"award-number":["R01DK135290"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK125858"],"award-info":[{"award-number":["R01DK125858"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK064324"],"award-info":[{"award-number":["R01DK064324"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["7R01DK13207202"],"award-info":[{"award-number":["7R01DK13207202"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK123564"],"award-info":[{"award-number":["R01DK123564"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK138055"],"award-info":[{"award-number":["R01DK138055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004196","name":"Odense Universitetshospital","doi-asserted-by":"publisher","award":["A5157"],"award-info":[{"award-number":["A5157"]}],"id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004196","name":"Odense Universitetshospital","doi-asserted-by":"publisher","award":["128-A5303"],"award-info":[{"award-number":["128-A5303"]}],"id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ebiom.2025.106012","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T03:26:00Z","timestamp":1762313160000},"page":"106012","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Soluble urokinase receptor is a kidney-specific vasoconstrictor"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3990-2197","authenticated-orcid":false,"given":"Sebastian Buhl","family":"Rasmussen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8649-4640","authenticated-orcid":false,"given":"Rasmus Bo","family":"Lindhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Gyarmati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Bistrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisse Rye","family":"Ostrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8876-8871","authenticated-orcid":false,"given":"Changli","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4092-6185","authenticated-orcid":false,"given":"Janos","family":"Peti-Peterdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Svenningsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Reiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Berg","family":"Ravn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2025.106012_bib1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.ebiom.2025.106012_bib2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/nep.14132","article-title":"Definitions, phenotypes, and subphenotypes in acute kidney injury-Moving towards precision medicine","volume":"28","author":"Rodrigues","year":"2023","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.ebiom.2025.106012_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneph.2017.184","article-title":"Paradigms of acute kidney injury in the intensive care setting","volume":"14","author":"Kellum","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ebiom.2025.106012_bib4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1155\/2009\/504294","article-title":"suPAR: the molecular crystal ball","volume":"27","author":"Thun\u00f8","year":"2009","journal-title":"Dis Markers"},{"key":"10.1016\/j.ebiom.2025.106012_bib5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.26444\/aaem\/167464","article-title":"A comprehensive review and meta-analysis of suPAR as a predictor of acute kidney injury","volume":"30","author":"Jankowski","year":"2023","journal-title":"Ann Agric Environ Med"},{"key":"10.1016\/j.ebiom.2025.106012_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10157-022-02300-2","article-title":"Predictive value of suPAR in AKI: a systematic review and meta-analysis","volume":"27","author":"Huang","year":"2023","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.ebiom.2025.106012_bib7","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1056\/NEJMoa1911481","article-title":"Soluble urokinase receptor and acute kidney injury","volume":"382","author":"Hayek","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ebiom.2025.106012_bib8","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.165740","article-title":"suPAR links a dysregulated immune response to tissue inflammation and sepsis-induced acute kidney injury","volume":"8","author":"Nusshag","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.ebiom.2025.106012_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015457","article-title":"Sex differences in circulating soluble urokinase-type plasminogen activator receptor (suPAR) levels and adverse outcomes in coronary artery disease","volume":"9","author":"Mehta","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ebiom.2025.106012_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-72377-w","article-title":"Soluble urokinase plasminogen activator receptor level in individuals of advanced age","volume":"10","author":"Wlazel","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2025.106012_bib11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12882-021-02322-0","article-title":"Prognostic value of suPAR and hsCRP on acute kidney injury after cardiac surgery","volume":"22","author":"Rasmussen","year":"2021","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.ebiom.2025.106012_bib12","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1053\/j.jvca.2020.10.049","article-title":"Prognostic value of soluble urokinase-type plasminogen activator receptor and high-sensitivity C-Reactive protein on postoperative mortality in patients undergoing elective on-pump cardiac surgery","volume":"35","author":"Rasmussen","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.ebiom.2025.106012_bib13","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1213\/ANE.0000000000002920","article-title":"Propensity score methods: theory and practice for anesthesia research","volume":"127","author":"Schulte","year":"2018","journal-title":"Anesth Analg"},{"key":"10.1016\/j.ebiom.2025.106012_bib14","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","article-title":"New Creatinine- and cystatin C-Based equations to estimate GFR without race","volume":"385","author":"Inker","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ebiom.2025.106012_bib15","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.ebiom.2025.106012_bib16","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fmed.2018.00292","article-title":"Comparative analysis of podocyte foot process morphology in three species by 3D super-resolution microscopy","volume":"5","author":"Artelt","year":"2018","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.ebiom.2025.106012_bib17","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1038\/s41467-023-40165-5","article-title":"SuPAR mediates viral response proteinuria by rapidly changing podocyte function","volume":"14","author":"Wei","year":"2023","journal-title":"Nat Commun"},{"issue":"Suppl","key":"10.1016\/j.ebiom.2025.106012_bib18","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1016\/S0925-4773(03)00099-6","article-title":"Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain","volume":"119","author":"Hayashi","year":"2002","journal-title":"Mech Dev"},{"key":"10.1016\/j.ebiom.2025.106012_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.32417","article-title":"T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse","volume":"6","author":"Dong","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.ebiom.2025.106012_bib20","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1038\/nm.3405","article-title":"Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags","volume":"19","author":"Hackl","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2025.106012_bib21","doi-asserted-by":"crossref","first-page":"F495","DOI":"10.1152\/ajprenal.00521.2005","article-title":"Quantitative imaging of basic functions in renal (patho)physiology","volume":"291","author":"Kang","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ebiom.2025.106012_bib22","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10654-014-9930-3","article-title":"The Danish civil registration system as a tool in epidemiology","volume":"29","author":"Schmidt","year":"2014","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.ebiom.2025.106012_bib23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"10.1016\/j.ebiom.2025.106012_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v042.i08","article-title":"MatchIt: nonparametric preprocessing for parametric causal inference","volume":"42","author":"Ho","year":"2011","journal-title":"J Stat Softw"},{"key":"10.1016\/j.ebiom.2025.106012_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229566","article-title":"Normothermic machine perfusion of ischaemically damaged porcine kidneys with autologous, allogeneic porcine and human red blood cells","volume":"15","author":"Pool","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2025.106012_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-50101-7","article-title":"Cold preflush of porcine kidney grafts prior to normothermic machine perfusion aggravates ischemia reperfusion injury","volume":"9","author":"Fabry","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2025.106012_bib27","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000230813","article-title":"Renal blood flow during acute renal failure in man","volume":"28","author":"Prowle","year":"2009","journal-title":"Blood Purif"},{"key":"10.1016\/j.ebiom.2025.106012_bib28","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nm.4362","article-title":"A tripartite complex of suPAR, APOL1 risk variants and \u03b1(v)\u03b2(3) integrin on podocytes mediates chronic kidney disease","volume":"23","author":"Hayek","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2025.106012_bib29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000071886","article-title":"Integrins as unique receptors for vascular control","volume":"40","author":"Martinez-Lemus","year":"2003","journal-title":"J Vasc Res"},{"key":"10.1016\/j.ebiom.2025.106012_bib30","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm.2411","article-title":"Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis","volume":"17","author":"Wei","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2025.106012_bib31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nm.4242","article-title":"Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease","volume":"23","author":"Hahm","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2025.106012_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/ALN.0000000000001461","article-title":"Effects of cardiopulmonary bypass on renal perfusion, filtration, and oxygenation in patients undergoing cardiac surgery","volume":"126","author":"Lannemyr","year":"2017","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ebiom.2025.106012_bib33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ekir.2016.11.004","article-title":"Soluble urokinase-type plasminogen activator receptor (suPAR) and impaired kidney function in the population-based malm\u00f6 diet and cancer study","volume":"2","author":"Schulz","year":"2017","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.ebiom.2025.106012_bib34","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1093\/ckj\/sfac048","article-title":"Soluble urokinase plasminogen activator receptor and decline in kidney function among patients without kidney disease","volume":"15","author":"Iversen","year":"2022","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.ebiom.2025.106012_bib35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cell.2024.10.045","article-title":"Atlas of the plasma proteome in health and disease in 53,026 adults","volume":"188","author":"Deng","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2025.106012_bib36","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.amjcard.2012.08.008","article-title":"Usefulness of soluble urokinase plasminogen activator receptor to predict repeat myocardial infarction and mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous intervention","volume":"110","author":"Lyngbaek","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ebiom.2025.106012_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098923","article-title":"Unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use","volume":"9","author":"Gozdzik","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2025.106012_bib38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1213\/ANE.0b013e3181e4255f","article-title":"Aortic cross-clamping and reperfusion in pigs reduces microvascular oxygenation by altered systemic and regional blood flow distribution","volume":"111","author":"Siegemund","year":"2010","journal-title":"Anesth Analg"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425004566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425004566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:54:05Z","timestamp":1773280445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425004566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":38,"alternative-id":["S2352396425004566"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.106012","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Soluble urokinase receptor is a kidney-specific vasoconstrictor","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.106012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106012"}}