{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:30:23Z","timestamp":1786987823780,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["HT9425-23-1-0100"],"award-info":[{"award-number":["HT9425-23-1-0100"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ebiom.2025.106053","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T17:25:52Z","timestamp":1764696352000},"page":"106053","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Neural synaptic vesicle autoimmunity following aerosolized porcine neural tissue exposure: insights into autoimmune inflammatory polyradiculoneuropathy"],"prefix":"10.1016","volume":"122","author":[{"given":"Shannon R.","family":"Hinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranjal","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2185-4385","authenticated-orcid":false,"given":"Naveen K.","family":"Paramasivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. James B.","family":"Dyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda A.","family":"Lennon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Lachance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Rezk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carley","family":"Karsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reghann G.","family":"LaFrance-Corey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"Staff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1442-5707","authenticated-orcid":false,"given":"Sybil C.","family":"Hrstka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Zekeridou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McKeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean J.","family":"Pittock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinta","family":"Lleix\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Querol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra","family":"Dasari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-9045","authenticated-orcid":false,"given":"Divyanshu","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ebiom.2025.106053_bib1","first-page":"122","article-title":"Investigation of progressive inflammatory neuropathy among swine slaughterhouse workers--Minnesota, 2007-2008","volume":"57","year":"2008","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106053_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1474-4422(09)70296-0","article-title":"An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive study","volume":"9","author":"Lachance","year":"2010","journal-title":"Lancet Neurology"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106053_bib3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ana.22674","article-title":"Potassium channel complex autoimmunity induced by inhaled brain tissue aerosol","volume":"71","author":"Meeusen","year":"2012","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106053_bib4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/epi.17164","article-title":"CASPR2-IgG-associated autoimmune seizures","volume":"63","author":"Garrido Sanabria","year":"2022","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106053_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/jnnp-2016-314758","article-title":"Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies","volume":"88","author":"Lang","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"10.1016\/j.ebiom.2025.106053_bib6","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1111\/ene.14959","article-title":"European academy of neurology\/peripheral nerve society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force-second revision","volume":"28","author":"Van den Bergh","year":"2021","journal-title":"Eur J Neurol"},{"issue":"12","key":"10.1016\/j.ebiom.2025.106053_bib7","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1111\/ene.16073","article-title":"European academy of neurology\/peripheral nerve society guideline on diagnosis and treatment of guillain-barr\u00e9 syndrome","volume":"30","author":"van Doorn","year":"2023","journal-title":"Eur J Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106053_bib8","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000001014","article-title":"Updated diagnostic criteria for paraneoplastic neurologic syndromes","volume":"8","author":"Graus","year":"2021","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"8","key":"10.1016\/j.ebiom.2025.106053_bib9","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1001\/jamaneurol.2022.1357","article-title":"Identification of caveolae-associated protein 4 autoantibodies as a biomarker of immune-mediated rippling muscle disease in adults","volume":"79","author":"Dubey","year":"2022","journal-title":"JAMA Neurol"},{"issue":"9","key":"10.1016\/j.ebiom.2025.106053_bib10","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41596-018-0025-6","article-title":"PhIP-Seq characterization of serum antibodies using oligonucleotide-encoded peptidomes","volume":"13","author":"Mohan","year":"2018","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ebiom.2025.106053_bib11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55053","article-title":"Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq","volume":"9","author":"Vazquez","year":"2020","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106053_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1056\/NEJMoa1816721","article-title":"Kelch-like protein 11 antibodies in seminoma-associated paraneoplastic encephalitis","volume":"381","author":"Mandel-Brehm","year":"2019","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106053_bib13","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/ana.26050","article-title":"Leucine zipper 4 autoantibody: a novel germ cell tumor and paraneoplastic biomarker","volume":"89","author":"Dubey","year":"2021","journal-title":"Ann Neurol"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106053_bib14","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/brain\/awab014","article-title":"Antibodies to the Caspr1\/contactin-1 complex in chronic inflammatory demyelinating polyradiculoneuropathy","volume":"144","author":"Pascual-Go\u00f1i","year":"2021","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106053_bib15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/ana.27142","article-title":"Long-term follow up in Anti-Contactin-1 autoimmune nodopathy","volume":"97","author":"Caballero-\u00c1vila","year":"2025","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106053_bib16","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000001098","article-title":"Clinical and laboratory features in Anti-NF155 autoimmune nodopathy","volume":"9","author":"Mart\u00edn-Aguilar","year":"2022","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106053_bib17","doi-asserted-by":"crossref","first-page":"e427","DOI":"10.1212\/WNL.0000000000009189","article-title":"Antibodies against nodo-paranodal proteins are not present in genetic neuropathies","volume":"95","author":"Mart\u00edn-Aguilar","year":"2020","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.ebiom.2025.106053_bib18","doi-asserted-by":"crossref","first-page":"e954","DOI":"10.1212\/WNL.0000000000008061","article-title":"Autoimmune gait disturbance accompanying adaptor protein-3B2-IgG","volume":"93","author":"Honorat","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.ebiom.2025.106053_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113520","article-title":"Proteomic analysis of human iPSC-derived sensory neurons implicates cell stress and microtubule dynamics dysfunction in bortezomib-induced peripheral neurotoxicity","volume":"335","author":"Hrstka","year":"2021","journal-title":"Exp Neurol"},{"issue":"9","key":"10.1016\/j.ebiom.2025.106053_bib20","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1080\/15592294.2019.1625672","article-title":"DNA methylation patterns in human iPSC-derived sensory neuronal differentiation","volume":"14","author":"Ankam","year":"2019","journal-title":"Epigenetics"},{"issue":"7","key":"10.1016\/j.ebiom.2025.106053_bib21","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nbt.2249","article-title":"Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat Biotechnol"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106053_bib22","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/art.20156","article-title":"Antibodies to microtubule-associated protein 2 in patients with neuropsychiatric systemic lupus erythematosus","volume":"50","author":"Williams","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106053_bib23","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3109\/14397595.2015.1123345","article-title":"Antibodies to microtubule-associated protein-2 in the cerebrospinal fluid are a useful diagnostic biomarker for neuropsychiatric systemic lupus erythematosus","volume":"26","author":"Yamada","year":"2016","journal-title":"Mod Rheumatol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106053_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneuroim.2008.03.018","article-title":"Synaptophysin is an autoantigen in paraneoplastic neuropathy","volume":"197","author":"Tschernatsch","year":"2008","journal-title":"J Neuroimmunol"},{"issue":"12","key":"10.1016\/j.ebiom.2025.106053_bib25","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1038\/s41379-018-0110-y","article-title":"A common classification framework for neuroendocrine neoplasms: an international agency for research on cancer (IARC) and world health organization (WHO) expert consensus proposal","volume":"31","author":"Rindi","year":"2018","journal-title":"Mod Pathol"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106053_bib26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11910-023-01264-4","article-title":"Growing spectrum of autoimmune nodopathies","volume":"23","author":"Gupta","year":"2023","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"6","key":"10.1016\/j.ebiom.2025.106053_bib27","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.str.2007.04.011","article-title":"Structure of synaptophysin: a hexameric MARVEL-Domain channel protein","volume":"15","author":"Arthur","year":"2007","journal-title":"Structure"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106053_bib28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/jnc.15499","article-title":"Synaptophysin-dependent synaptobrevin-2 trafficking at the presynapse-mechanism and function","volume":"159","author":"Cousin","year":"2021","journal-title":"J Neurochem"},{"key":"10.1016\/j.ebiom.2025.106053_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2021.740318","article-title":"Room for two: the synaptophysin\/synaptobrevin complex","volume":"13","author":"White","year":"2021","journal-title":"Front Synaptic Neurosci"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106053_bib30","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.neuron.2011.04.001","article-title":"Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons","volume":"70","author":"Kwon","year":"2011","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106053_bib31","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.neuroscience.2006.05.010","article-title":"Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury","volume":"141","author":"Sun","year":"2006","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106053_bib32","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1038\/s41598-019-40967-y","article-title":"Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn","volume":"9","author":"Chung","year":"2019","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.ebiom.2025.106053_bib33","article-title":"Increased synaptophysin is involved in inflammation-induced heat hyperalgesia mediated by cyclin-dependent kinase 5 in rats","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.ebiom.2025.106053_bib34","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1083\/jcb.149.7.1443","article-title":"Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity","volume":"149","author":"Frey","year":"2000","journal-title":"J Cell Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106053_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0166-2236(96)10072-2","article-title":"GAP-43: an intrinsic determinant of neuronal development and plasticity","volume":"20","author":"Benowitz","year":"1997","journal-title":"Trends Neurosci"},{"issue":"11","key":"10.1016\/j.ebiom.2025.106053_bib36","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1161\/01.STR.29.11.2381","article-title":"Enhanced neocortical neural sprouting, synaptogenesis, and behavioral recovery with D-amphetamine therapy after neocortical infarction in rats","volume":"29","author":"Stroemer","year":"1998","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.ebiom.2025.106053_bib37","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1177\/1352458520951046","article-title":"MOG-IgG1 and co-existence of neuronal autoantibodies","volume":"27","author":"Kunchok","year":"2021","journal-title":"Mult Scler"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106053_bib38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jaut.2012.05.002","article-title":"Epidemiology of environmental exposures and human autoimmune diseases: findings from a national institute of environmental health sciences expert panel workshop","volume":"39","author":"Miller","year":"2012","journal-title":"J Autoimmun"},{"key":"10.1016\/j.ebiom.2025.106053_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103841","article-title":"Intranasal COVID-19 vaccines: from bench to bed","volume":"76","author":"Alu","year":"2022","journal-title":"eBioMedicine"},{"key":"10.1016\/j.ebiom.2025.106053_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121180","article-title":"Intranasal vaccine: factors to consider in research and development","volume":"609","author":"Xu","year":"2021","journal-title":"Int J Pharm"},{"key":"10.1016\/j.ebiom.2025.106053_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2022.111726","article-title":"Synaptophysin and chromogranin A expression analysis in human tumors","volume":"555","author":"Uhlig","year":"2022","journal-title":"Mol Cell Endocrinol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425004979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425004979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:57:51Z","timestamp":1782496671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425004979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":41,"alternative-id":["S2352396425004979"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.106053","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neural synaptic vesicle autoimmunity following aerosolized porcine neural tissue exposure: insights into autoimmune inflammatory polyradiculoneuropathy","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.106053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106053"}}