{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:26:10Z","timestamp":1792175170268,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020731","name":"Walter and Eliza Hall Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2008092"],"award-info":[{"award-number":["2008092"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2016908"],"award-info":[{"award-number":["2016908"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008717","name":"Sylvia and Charles Viertel Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","award":["2020\/1085469-0"],"award-info":[{"award-number":["2020\/1085469-0"]}],"id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ebiom.2025.106087","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T16:24:21Z","timestamp":1766247861000},"page":"106087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Elevated SARS-CoV-2 IgG4 in plasma and mucosa following repeated mRNA boosters impact antibody functions to Omicron and sarbecoviruses"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0780-9422","authenticated-orcid":false,"given":"Kevin J.","family":"Selva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Shi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alther L.","family":"Enriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Carissa","family":"Aurelia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-3197","authenticated-orcid":false,"given":"Jennifer","family":"Audsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"Kent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily M.","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Kiernan-Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Judy","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine M.","family":"Trevillyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Pymm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai-Hong","family":"Tham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1596-2259","authenticated-orcid":false,"given":"Laura E.","family":"Downie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam K.","family":"Wheatley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Juno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Kent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0020-9704","authenticated-orcid":false,"given":"Amy W.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ebiom.2025.106087_bib2","doi-asserted-by":"crossref","first-page":"8395","DOI":"10.1038\/s41467-024-52194-9","article-title":"Predicting COVID-19 booster immunogenicity against future SARS-CoV-2 variants and the benefits of vaccine updates","volume":"15","author":"Cromer","year":"2024","journal-title":"Nat Commun"},{"issue":"17","key":"10.1016\/j.ebiom.2025.106087_bib3","doi-asserted-by":"crossref","DOI":"10.1172\/JCI181244","article-title":"Randomized controlled trial reveals no benefit to a 3-month delay in COVID-19 mRNA booster vaccine","volume":"134","author":"Lee","year":"2024","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106087_bib4","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.187075","article-title":"Randomized trial of same- versus opposite-arm coadministration of inactivated influenza and SARS-CoV-2 mRNA vaccines","volume":"10","author":"Lee","year":"2025","journal-title":"JCI Insight"},{"issue":"79","key":"10.1016\/j.ebiom.2025.106087_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.ade2798","article-title":"Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination","volume":"8","author":"Irrgang","year":"2023","journal-title":"Sci Immunol"},{"issue":"18","key":"10.1016\/j.ebiom.2025.106087_bib6","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.172470","article-title":"Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections","volume":"8","author":"Selva","year":"2023","journal-title":"JCI Insight"},{"issue":"9","key":"10.1016\/j.ebiom.2025.106087_bib7","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ads1482","article-title":"Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant","volume":"11","author":"Aurelia","year":"2025","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106087_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12979-024-00466-9","article-title":"Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults","volume":"21","author":"Gelderloos","year":"2024","journal-title":"Immun Ageing"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106087_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinf.2024.106119","article-title":"Altered IgG4 antibody response to repeated mRNA versus recombinant protein SARS-CoV-2 vaccines","volume":"88","author":"Kalkeri","year":"2024","journal-title":"J Infect"},{"key":"10.1016\/j.ebiom.2025.106087_bib10","article-title":"mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine","volume":"13","author":"Buhre","year":"2022","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106087_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/v16020187","article-title":"The Anti-SARS-CoV-2 IgG1 and IgG3 antibody isotypes with limited neutralizing capacity against Omicron elicited in a Latin population a switch toward IgG4 after multiple doses with the mRNA Pfizer-BioNTech vaccine","volume":"16","author":"Espino","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.ebiom.2025.106087_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijid.2023.11.028","article-title":"The appearance of anti-spike receptor binding domain immunoglobulin G4 responses after repetitive immunization with messenger RNA-based COVID-19 vaccines","volume":"139","author":"Yoshimura","year":"2024","journal-title":"Int J Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106087_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-40103-x","article-title":"Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history","volume":"13","author":"Kiszel","year":"2023","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.ebiom.2025.106087_bib14","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1097\/INF.0000000000004488","article-title":"Delayed induction of noninflammatory SARS-CoV-2 spike-specific IgG4 antibodies detected 1 year after BNT162b2 vaccination in children","volume":"43","author":"Kobbe","year":"2024","journal-title":"Pediatr Infect Dis J"},{"issue":"8","key":"10.1016\/j.ebiom.2025.106087_bib15","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nbt.1553","article-title":"Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo","volume":"27","author":"Labrijn","year":"2009","journal-title":"Nat Biotechnol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106087_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112014","article-title":"Bivalent intra-spike binding provides durability against emergent Omicron lineages: results from a global consortium","volume":"42","author":"Callaway","year":"2023","journal-title":"Cell Rep"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106087_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinf.2025.106473","article-title":"Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections","volume":"90","author":"Martin Perez","year":"2025","journal-title":"J Infect"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106087_bib18","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3390\/v17050666","article-title":"Impact of vaccine-elicited anti-spike IgG4 antibodies on Fc-effector functions against SARS-CoV-2","volume":"17","author":"Dionne","year":"2025","journal-title":"Viruses"},{"issue":"7","key":"10.1016\/j.ebiom.2025.106087_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116000","article-title":"Spike-specific IgG4 generated post BNT162b2 mRNA vaccination is inhibitory when directly competing with functional IgG subclasses","volume":"44","author":"Tam","year":"2025","journal-title":"Cell Rep"},{"issue":"10","key":"10.1016\/j.ebiom.2025.106087_bib20","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/imcb.12685","article-title":"Mucosal antibody responses following Vaxzevria vaccination","volume":"101","author":"Selva","year":"2023","journal-title":"Immunol Cell Biol"},{"issue":"770","key":"10.1016\/j.ebiom.2025.106087_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adn2364","article-title":"Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa","volume":"16","author":"Declercq","year":"2024","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ebiom.2025.106087_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1330864","article-title":"Intramuscular vaccination against SARS-CoV-2 transiently induces neutralizing IgG rather than IgA in the saliva","volume":"15","author":"Winklmeier","year":"2024","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106087_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109822","article-title":"Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain","volume":"37","author":"Wheatley","year":"2021","journal-title":"Cell Rep"},{"issue":"19","key":"10.1016\/j.ebiom.2025.106087_bib24","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2101918118","article-title":"Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice","volume":"118","author":"Pymm","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"29","key":"10.1016\/j.ebiom.2025.106087_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg5301","article-title":"Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection","volume":"9","author":"Lee","year":"2023","journal-title":"Sci Adv"},{"issue":"7","key":"10.1016\/j.ebiom.2025.106087_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003656","article-title":"SARS-CoV-2 neutralizing antibodies: longevity, breadth, and evasion by emerging viral variants","volume":"18","author":"Tea","year":"2021","journal-title":"PLoS Med"},{"issue":"8","key":"10.1016\/j.ebiom.2025.106087_bib27","article-title":"Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination","volume":"5","author":"Voss","year":"2024","journal-title":"Cell Rep Med"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106087_bib28","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.jaci.2023.01.005","article-title":"The role of IgG(1) and IgG(4) as dominant IgE-blocking antibodies shifts during allergen immunotherapy","volume":"151","author":"Strobl","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ebiom.2025.106087_bib29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ebiom.2019.11.006","article-title":"Two years of treatment with the recombinant grass pollen allergy vaccine BM32 induces a continuously increasing allergen-specific IgG(4) response","volume":"50","author":"Eckl-Dorna","year":"2019","journal-title":"eBioMedicine"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106087_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02250-23","article-title":"The post-COVID-19 population has a high prevalence of cross-reactive antibodies to spikes from all Orthocoronavirinae genera","volume":"15","author":"Singh","year":"2024","journal-title":"mBio"},{"issue":"15","key":"10.1016\/j.ebiom.2025.106087_bib31","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1016\/j.cell.2021.06.005","article-title":"SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2","volume":"184","author":"Amanat","year":"2021","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106087_bib32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41541-024-00817-z","article-title":"Impact of ageing on homologous and human-coronavirus-reactive antibodies after SARS-CoV-2 vaccination or infection","volume":"9","author":"Zhou","year":"2024","journal-title":"NPJ Vaccines"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106087_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-92475-x","article-title":"Study of coronavirus diversity in wildlife in Northern Cambodia suggests continuous circulation of SARS-CoV-2-related viruses in bats","volume":"15","author":"Guillebaud","year":"2025","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106087_bib35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s44298-024-00067-9","article-title":"Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses","volume":"2","author":"Renner","year":"2024","journal-title":"Npj Viruses"},{"issue":"15","key":"10.1016\/j.ebiom.2025.106087_bib36","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1056\/NEJMoa2108453","article-title":"Pan-Sarbecovirus neutralizing antibodies in BNT162b2-Immunized SARS-CoV-1 survivors","volume":"385","author":"Tan","year":"2021","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.ebiom.2025.106087_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012724","article-title":"Profiling serum immunodominance following SARS-CoV-2 primary and breakthrough infection reveals distinct variant-specific epitope usage and immune imprinting","volume":"20","author":"Seow","year":"2024","journal-title":"PLoS Pathog"},{"issue":"8047","key":"10.1016\/j.ebiom.2025.106087_bib38","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41586-024-08315-x","article-title":"Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1","volume":"637","author":"Jian","year":"2025","journal-title":"Nature"},{"issue":"7993","key":"10.1016\/j.ebiom.2025.106087_bib39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41586-023-06753-7","article-title":"Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting","volume":"625","author":"Yisimayi","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106087_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-71047-5","article-title":"An unexpected IgE anti-receptor binding domain response following natural infection and different types of SARS-CoV-2 vaccines","volume":"14","author":"Portilho","year":"2024","journal-title":"Sci Rep"},{"issue":"110","key":"10.1016\/j.ebiom.2025.106087_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adr6787","article-title":"COVID-19 vaccine type controls stromal reprogramming in draining lymph nodes","volume":"10","author":"Fair-Makela","year":"2025","journal-title":"Sci Immunol"},{"issue":"7","key":"10.1016\/j.ebiom.2025.106087_bib42","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1111\/all.16089","article-title":"Suppressed IgG4 class switching in dupilumab- and TNF inhibitor-treated patients after mRNA vaccination","volume":"79","author":"Valk","year":"2024","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106087_bib43","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofae144","article-title":"Concurrent administration of COVID-19 and Influenza vaccines enhances spike-specific antibody responses","volume":"11","author":"Barouch","year":"2024","journal-title":"Open Forum Infect Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106087_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinf.2025.106543","article-title":"Anti-Spike IgG4 and Fc effector responses: the impact of SARS-CoV-2 vaccine platform\u2013specific priming and immune imprinting","volume":"91","author":"Kalkeri","year":"2025","journal-title":"J Infect"},{"key":"10.1016\/j.ebiom.2025.106087_bib45","article-title":"Multi-step antibody class switching in a primary human response is restricted after IGHG2 and dependent on B cell maturation stage","volume":"2025","author":"Garcia","year":"2025","journal-title":"bioRxiv"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106087_bib46","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1016\/S1473-3099(25)00015-5","article-title":"Virological and antigenic characteristics of SARS-CoV-2 variants LF.7.2.1, NP.1, and LP.8.1","volume":"25","author":"Liu","year":"2025","journal-title":"Lancet Infect Dis"},{"issue":"6","key":"10.1016\/j.ebiom.2025.106087_bib47","article-title":"Decay of Fc-dependent antibody functions after mild to moderate COVID-19","volume":"2","author":"Lee","year":"2021","journal-title":"Cell Rep Med"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106087_bib48","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1038\/s41467-021-22236-7","article-title":"Systems serology detects functionally distinct coronavirus antibody features in children and elderly","volume":"12","author":"Selva","year":"2021","journal-title":"Nat Commun"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425005377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425005377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:10:49Z","timestamp":1773936649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425005377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":46,"alternative-id":["S2352396425005377"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.106087","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated SARS-CoV-2 IgG4 in plasma and mucosa following repeated mRNA boosters impact antibody functions to Omicron and sarbecoviruses","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.106087","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106087"}}