{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T04:03:22Z","timestamp":1775102602027,"version":"3.50.1"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009748","name":"Ernhold Lundstr\u00f6ms stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","award":["2019\/318"],"award-info":[{"award-number":["2019\/318"]}],"id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","award":["LU STYR 2019\/2046"],"award-info":[{"award-number":["LU STYR 2019\/2046"]}],"id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006189","name":"Direkt\u00f6r\u00a0Albert P\u00e5hlssons Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF200C0063465"],"award-info":[{"award-number":["NNF200C0063465"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["2023-01989"],"award-info":[{"award-number":["2023-01989"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031584","name":"Deutsches Zentrum f\u00fcr Diabetesforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009761","name":"Hulda och E Conrad Mossfelts Stiftelse f\u00f6r Vetenskaplig Forskning Inom Hj\u00e4rt- och K\u00e4rlsjukdomarnas Omr\u00e5de","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008001","name":"Universit\u00e4t zu K\u00f6ln","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001729","name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["2019\\u2013885003"],"award-info":[{"award-number":["2019\\u2013885003"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["Swedish Heart and Lung Foundation"],"award-info":[{"award-number":["Swedish Heart and Lung Foundation"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["European Research Council"],"award-info":[{"award-number":["European Research Council"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["82DZD06D03"],"award-info":[{"award-number":["82DZD06D03"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["2019-61406"],"award-info":[{"award-number":["2019-61406"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["209933838 \\u2013 SFB 1052"],"award-info":[{"award-number":["209933838 \\u2013 SFB 1052"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ebiom.2025.106105","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T10:47:40Z","timestamp":1768042060000},"page":"106105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genetic dissection of serum pro-neurotensin suggests potential causal impact on brain structure"],"prefix":"10.1016","volume":"124","author":[{"given":"Jana","family":"Breitfeld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhil","family":"Velluva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frauke","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-5331","authenticated-orcid":false,"given":"Janne","family":"Pott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronny","family":"Baber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Stumvoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Le Duc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Witte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7242-437X","authenticated-orcid":false,"given":"Alice","family":"Giontella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olle","family":"Melander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0290-5423","authenticated-orcid":false,"given":"Peter","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"T\u00f6njes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ebiom.2025.106105_bib1","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab038","article-title":"The role of central neurotensin in regulating feeding and body weight","volume":"162","author":"Ramirez-Virella","year":"2021","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106105_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23042209","article-title":"New insights in the control of fat homeostasis: the role of neurotensin","volume":"23","author":"Barchetta","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"14","key":"10.1016\/j.ebiom.2025.106105_bib3","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/jama.2012.12998","article-title":"Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality","volume":"308","author":"Melander","year":"2012","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106105_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41537-023-00425-1","article-title":"Alterations of serum neuropeptide levels and their relationship to cognitive impairment and psychopathology in male patients with chronic schizophrenia","volume":"10","author":"Sun","year":"2024","journal-title":"Schizophrenia (Heidelb)"},{"key":"10.1016\/j.ebiom.2025.106105_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.739287","article-title":"Effect of monoclonal antibody blockade of long fragment neurotensin on weight loss, behavior, and metabolic traits after high-fat diet induced obesity","volume":"12","author":"Wu","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"10.1016\/j.ebiom.2025.106105_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076460","article-title":"Neurotensin gene rs2234762 CG variant associates with reduced circulating Pro-NT levels and predicts lower insulin resistance in overweight\/obese children","volume":"24","author":"Sentinelli","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"7603","key":"10.1016\/j.ebiom.2025.106105_bib7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nature17662","article-title":"An obligatory role for neurotensin in high-fat-diet-induced obesity","volume":"533","author":"Li","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106105_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/npp.2009.129","article-title":"The reward circuit: linking primate anatomy and human imaging","volume":"35","author":"Haber","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106105_bib9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41366-020-00702-4","article-title":"Higher BMI, but not obesity-related genetic polymorphisms, correlates with lower structural connectivity of the reward network in a population-based study","volume":"45","author":"Beyer","year":"2021","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.ebiom.2025.106105_bib10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neuroimage.2015.02.012","article-title":"Affected connectivity organization of the reward system structure in obesity","volume":"111","author":"Marqu\u00e9s-Iturria","year":"2015","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106105_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2796.1993.tb00647.x","article-title":"The Malmo Diet and Cancer Study. Design and feasibility","volume":"233","author":"Berglund","year":"1993","journal-title":"J Intern Med"},{"issue":"6","key":"10.1016\/j.ebiom.2025.106105_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00008469-200112000-00003","article-title":"The Malm\u00f6 Diet and Cancer Study: representativity, cancer incidence and mortality in participants and non-participants","volume":"10","author":"Manjer","year":"2001","journal-title":"Eur J Cancer Prev"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106105_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10654-020-00695-4","article-title":"The Malm\u00f6 Offspring Study (MOS): design, methods and first results","volume":"36","author":"Brunkwall","year":"2021","journal-title":"Eur J Epidemiol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106105_bib14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12944-020-01361-0","article-title":"Magnitude of rise in proneurotensin is related to amount of triglyceride appearance in blood after standardized oral intake of both saturated and unsaturated fat","volume":"19","author":"Fawad","year":"2020","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.ebiom.2025.106105_bib15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1186\/s12889-015-1983-z","article-title":"The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany","volume":"15","author":"Loeffler","year":"2015","journal-title":"BMC Public Health"},{"issue":"23","key":"10.1016\/j.ebiom.2025.106105_bib16","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.1093\/hmg\/ddp423","article-title":"Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs","volume":"18","author":"T\u00f6njes","year":"2009","journal-title":"Hum Mol Genet"},{"issue":"9","key":"10.1016\/j.ebiom.2025.106105_bib17","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/ejhg.2011.65","article-title":"Genetic variation in the Sorbs of eastern Germany in the context of broader European genetic diversity","volume":"19","author":"Veeramah","year":"2011","journal-title":"Eur J Hum Genet"},{"issue":"7","key":"10.1016\/j.ebiom.2025.106105_bib18","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.peptides.2006.01.021","article-title":"Proneurotensin 1-117, a stable neurotensin precursor fragment identified in human circulation","volume":"27","author":"Ernst","year":"2006","journal-title":"Peptides"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106105_bib19","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/nprot.2014.071","article-title":"Quality control and conduct of genome-wide association meta-analyses","volume":"9","author":"Winkler","year":"2014","journal-title":"Nat Protoc"},{"issue":"18","key":"10.1016\/j.ebiom.2025.106105_bib20","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1093\/hmg\/ddx280","article-title":"Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution","volume":"26","author":"M\u00e4gi","year":"2017","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106105_bib21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41588-024-02044-7","article-title":"A scalable variational inference approach for increased mixed-model association power","volume":"57","author":"Loya","year":"2025","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2025.106105_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.atherosclerosis.2017.02.018","article-title":"Genome-wide meta-analysis identifies novel loci of plaque burden in carotid artery","volume":"259","author":"Pott","year":"2017","journal-title":"Atherosclerosis"},{"issue":"D1","key":"10.1016\/j.ebiom.2025.106105_bib23","doi-asserted-by":"crossref","first-page":"D635","DOI":"10.1093\/nar\/gkw1104","article-title":"Ensembl 2017","volume":"45","author":"Aken","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.ebiom.2025.106105_bib24","doi-asserted-by":"crossref","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","article-title":"The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)","volume":"45","author":"MacArthur","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"6235","key":"10.1016\/j.ebiom.2025.106105_bib25","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"genomics","year":"2015","journal-title":"Science"},{"issue":"16","key":"10.1016\/j.ebiom.2025.106105_bib26","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1093\/hmg\/ddv194","article-title":"Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci","volume":"24","author":"Kirsten","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106105_bib27","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"Kircher","year":"2014","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.ebiom.2025.106105_bib28","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106105_bib29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: a tool for genome-wide complex trait analysis","volume":"88","author":"Yang","year":"2011","journal-title":"Am J Hum Genet"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106105_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120758","article-title":"A multivariate genome-wide association analysis of 10 LDL subfractions, and their response to statin treatment, in 1868 Caucasians","volume":"10","author":"Shim","year":"2015","journal-title":"PLoS One"},{"issue":"6569","key":"10.1016\/j.ebiom.2025.106105_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj1541","article-title":"Mapping the proteo-genomic convergence of human diseases","volume":"374","author":"Pietzner","year":"2021","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106105_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007889","article-title":"Integrating predicted transcriptome from multiple tissues improves association detection","volume":"15","author":"Barbeira","year":"2019","journal-title":"PLoS Genet"},{"issue":"6509","key":"10.1016\/j.ebiom.2025.106105_bib33","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","year":"2020","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.ebiom.2025.106105_bib34","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/s41588-022-01154-4","article-title":"Genetic control of RNA splicing and its distinct role in complex trait variation","volume":"54","author":"Qi","year":"2022","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106105_bib35","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1038\/s41467-024-47005-0","article-title":"Genetic control of DNA methylation is largely shared across European and East Asian populations","volume":"15","author":"Hatton","year":"2024","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106105_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"issue":"11","key":"10.1016\/j.ebiom.2025.106105_bib37","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ng.3406","article-title":"An atlas of genetic correlations across human diseases and traits","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106105_bib38","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD Score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.ebiom.2025.106105_bib39","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1038\/s41588-019-0511-y","article-title":"Genetic architecture of subcortical brain structures in 38,851 individuals","volume":"51","author":"Satizabal","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2025.106105_bib40","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fcvm.2018.00051","article-title":"Common methods for performing Mendelian randomization","volume":"5","author":"Teumer","year":"2018","journal-title":"Front Cardiovasc Med"},{"issue":"7","key":"10.1016\/j.ebiom.2025.106105_bib41","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"issue":"6","key":"10.1016\/j.ebiom.2025.106105_bib42","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/ije\/dyx034","article-title":"MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data","volume":"46","author":"Yavorska","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ebiom.2025.106105_bib43","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.nicl.2015.01.005","article-title":"Patterns of brain structural connectivity differentiate normal weight from overweight subjects","volume":"7","author":"Gupta","year":"2015","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.ebiom.2025.106105_bib44","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neubiorev.2021.08.019","article-title":"Dysregulated resting state functional connectivity and obesity: a systematic review","volume":"131","author":"Syan","year":"2021","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.ebiom.2025.106105_bib45","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3389\/fneur.2019.00425","article-title":"10Kin1day: a Bottom-Up neuroimaging initiative","volume":"10","author":"van den Heuvel","year":"2019","journal-title":"Front Neurol"},{"issue":"20","key":"10.1016\/j.ebiom.2025.106105_bib47","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1093\/bioinformatics\/btw392","article-title":"ABAEnrichment: an R package to test for gene set expression enrichment in the adult and developing human brain","volume":"32","author":"Grote","year":"2016","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106105_bib48","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.bbadis.2017.12.036","article-title":"Role of central neurotensin in regulating feeding: implications for the development and treatment of body weight disorders","volume":"1864","author":"Schroeder","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.ebiom.2025.106105_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108005","article-title":"Neurotensin in reward processes","volume":"167","author":"Torruella-Su\u00e1rez","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ebiom.2025.106105_bib50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fendo.2013.00036","article-title":"Diverse roles of neurotensin agonists in the central nervous system","volume":"4","author":"Boules","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"22","key":"10.1016\/j.ebiom.2025.106105_bib46","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1007\/s00018-011-0822-3","article-title":"Composition and functional role of the mucus layers in the intestine","volume":"68","author":"Johansson","year":"2011","journal-title":"Cell Mol Life Sci"},{"issue":"12","key":"10.1016\/j.ebiom.2025.106105_bib51","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1136\/gutjnl-2020-322260","article-title":"Mucus barrier, mucins and gut microbiota: the expected slimy partners?","volume":"69","author":"Paone","year":"2020","journal-title":"Gut"},{"issue":"6157","key":"10.1016\/j.ebiom.2025.106105_bib52","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1126\/science.1237910","article-title":"Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals","volume":"342","author":"Shan","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2025.106105_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155534","article-title":"Increased meal-induced neurotensin response predicts successful maintenance of weight loss - data from a randomized controlled trial","volume":"143","author":"Brethvad","year":"2023","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106105_bib54","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jcmgh.2021.09.006","article-title":"Neurotensin regulates proliferation and stem cell function in the small intestine in a nutrient-dependent manner","volume":"13","author":"Rock","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106105_bib55","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jcmgh.2020.07.003","article-title":"Muc2 mucin and nonmucin microbiota confer distinct innate host defense in disease susceptibility and colonic injury","volume":"11","author":"Leon-Coria","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.ebiom.2025.106105_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2023.152115","article-title":"Association between neuropeptides and mucins in Crohn's disease mucous cells","volume":"125","author":"Miller","year":"2023","journal-title":"Acta Histochem"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106105_bib57","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00418-003-0585-5","article-title":"Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid\/liquid interfaces","volume":"120","author":"Falkowski","year":"2003","journal-title":"Histochem Cell Biol"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106105_bib58","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3390\/cells4020178","article-title":"Scavenger receptor structure and function in health and disease","volume":"4","author":"Zani","year":"2015","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.ebiom.2025.106105_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/biom9090454","article-title":"Discovery of the liver hyaluronan receptor for endocytosis (HARE) and its progressive emergence as the multi-ligand scavenger receptor Stabilin-2","volume":"9","author":"Weigel","year":"2019","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.ebiom.2025.106105_bib60","doi-asserted-by":"crossref","first-page":"G71","DOI":"10.1152\/ajpgi.00215.2010","article-title":"Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins","volume":"300","author":"Li","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"15","key":"10.1016\/j.ebiom.2025.106105_bib61","doi-asserted-by":"crossref","first-page":"12613","DOI":"10.1074\/jbc.M210211200","article-title":"FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products","volume":"278","author":"Tamura","year":"2003","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.ebiom.2025.106105_bib62","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s00109-006-0044-6","article-title":"Prohormone convertases differentially process pro-neurotensin\/neuromedin N in tissues and cell lines","volume":"84","author":"Kitabgi","year":"2006","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.ebiom.2025.106105_bib63","first-page":"85","article-title":"Neurotensin and neuromedin N are differentially processed from a common precursor by prohormone convertases in tissues and cell lines","volume":"50","author":"Kitabgi","year":"2010","journal-title":"Results Probl Cell Differ"},{"key":"10.1016\/j.ebiom.2025.106105_bib64","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3389\/fcimb.2019.00444","article-title":"Age-related changes in the gut microbiota modify brain lipid composition","volume":"9","author":"Albouery","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106105_bib65","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/jnc.15868","article-title":"Neurotensin and energy balance","volume":"166","author":"Gereau","year":"2023","journal-title":"J Neurochem"},{"key":"10.1016\/j.ebiom.2025.106105_bib66","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.ne.09.030186.002041","article-title":"Parallel organization of functionally segregated circuits linking basal ganglia and cortex","volume":"9","author":"Alexander","year":"1986","journal-title":"Annu Rev Neurosci"},{"issue":"2","key":"10.1016\/j.ebiom.2025.106105_bib67","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.conb.2008.07.002","article-title":"New insights on the subcortical representation of reward","volume":"18","author":"Hikosaka","year":"2008","journal-title":"Curr Opin Neurobiol"},{"issue":"6","key":"10.1016\/j.ebiom.2025.106105_bib68","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1017\/S1355617715000491","article-title":"Striatal and pallidal activation during reward modulated movement using a translational paradigm","volume":"21","author":"Bischoff-Grethe","year":"2015","journal-title":"J Int Neuropsychol Soc"},{"issue":"4","key":"10.1016\/j.ebiom.2025.106105_bib69","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41366-023-01451-w","article-title":"From the reward network to whole-brain metrics: structural connectivity in adolescents and young adults according to body mass index and genetic risk of obesity","volume":"48","author":"Prunell-Casta\u00f1\u00e9","year":"2024","journal-title":"Int J Obes (Lond)"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106105_bib70","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/1096-9861(20000828)424:3<461::AID-CNE5>3.0.CO;2-J","article-title":"Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain","volume":"424","author":"Villeneuve","year":"2000","journal-title":"J Comp Neurol"},{"issue":"5","key":"10.1016\/j.ebiom.2025.106105_bib71","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/BF02071313","article-title":"Neurotensin receptors: binding properties, transduction pathways, and structure","volume":"15","author":"Vincent","year":"1995","journal-title":"Cell Mol Neurobiol"},{"issue":"8","key":"10.1016\/j.ebiom.2025.106105_bib72","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/s42255-024-01108-6","article-title":"Feeding gut microbes to nourish the brain: unravelling the diet-microbiota-gut-brain axis","volume":"6","author":"Schneider","year":"2024","journal-title":"Nat Metab"},{"key":"10.1016\/j.ebiom.2025.106105_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.629729","article-title":"Neurotensin and xenin show positive correlations with perceived stress, anxiety, depressiveness and eating disorder symptoms in female Obese patients","volume":"15","author":"W\u00f6lk","year":"2021","journal-title":"Front Behav Neurosci"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106105_bib74","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0196-9781(92)90073-C","article-title":"Balance of glutamate and dopamine in the nucleus accumbens modulates self-stimulation behavior after injection of cholecystokinin and neurotensin in the rat brain","volume":"13","author":"Heidbreder","year":"1992","journal-title":"Peptides"},{"key":"10.1016\/j.ebiom.2025.106105_bib75","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.npep.2018.02.003","article-title":"Determination of neurotensin projections to the ventral tegmental area in mice","volume":"68","author":"Woodworth","year":"2018","journal-title":"Neuropeptides"},{"issue":"6","key":"10.1016\/j.ebiom.2025.106105_bib76","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/ejn.13858","article-title":"Diverse actions of the modulatory peptide neurotensin on central synaptic transmission","volume":"49","author":"Tschumi","year":"2019","journal-title":"Eur J Neurosci"},{"issue":"3","key":"10.1016\/j.ebiom.2025.106105_bib77","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nn.4487","article-title":"Hormonal gain control of a medial preoptic area social reward circuit","volume":"20","author":"McHenry","year":"2017","journal-title":"Nat Neurosci"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425005559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396425005559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:45:38Z","timestamp":1775097938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396425005559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":77,"alternative-id":["S2352396425005559"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.106105","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic dissection of serum pro-neurotensin suggests potential causal impact on brain structure","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2025.106105","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106105"}}