{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T18:05:28Z","timestamp":1792951528377,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk A\/S","doi-asserted-by":"publisher","award":["NNF21OC0070381"],"award-info":[{"award-number":["NNF21OC0070381"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004257","name":"Helse Vest RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["326300"],"award-info":[{"award-number":["326300"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["262652"],"award-info":[{"award-number":["262652"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["250317"],"award-info":[{"award-number":["250317"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["223250"],"award-info":[{"award-number":["223250"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["295910"],"award-info":[{"award-number":["295910"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005036","name":"Universitetet i Bergen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA199646"],"award-info":[{"award-number":["R01CA199646"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005029","name":"Helse Vest Regionalt Helsef\u00f8retak","doi-asserted-by":"publisher","award":["912035"],"award-info":[{"award-number":["912035"]}],"id":[{"id":"10.13039\/501100005029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005029","name":"Helse Vest Regionalt Helsef\u00f8retak","doi-asserted-by":"publisher","award":["911182"],"award-info":[{"award-number":["911182"]}],"id":[{"id":"10.13039\/501100005029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005029","name":"Helse Vest Regionalt Helsef\u00f8retak","doi-asserted-by":"publisher","award":["779"],"award-info":[{"award-number":["779"]}],"id":[{"id":"10.13039\/501100005029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005029","name":"Helse Vest Regionalt Helsef\u00f8retak","doi-asserted-by":"publisher","award":["F-12183-D10616"],"award-info":[{"award-number":["F-12183-D10616"]}],"id":[{"id":"10.13039\/501100005029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005029","name":"Helse Vest Regionalt Helsef\u00f8retak","doi-asserted-by":"publisher","award":["912146"],"award-info":[{"award-number":["912146"]}],"id":[{"id":"10.13039\/501100005029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008730","name":"Kreftforeningen","doi-asserted-by":"publisher","award":["182735"],"award-info":[{"award-number":["182735"]}],"id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008730","name":"Kreftforeningen","doi-asserted-by":"publisher","award":["6833652"],"award-info":[{"award-number":["6833652"]}],"id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["21 1888 Pj"],"award-info":[{"award-number":["21 1888 Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ebiom.2026.106135","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:50:01Z","timestamp":1770025801000},"page":"106135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A 3D ovarian cancer metastasis model using a decellularised peritoneal matrix to study therapy response"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2046-4764","authenticated-orcid":false,"given":"Christiane Helgestad","family":"Gjerde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Kleinmanns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Langer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-8419","authenticated-orcid":false,"given":"Gorka","family":"Ruiz de Garibay Ponce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezekiel","family":"Rozmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina Nyhus","family":"Stangeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calum","family":"Leitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1091-2502","authenticated-orcid":false,"given":"Rammah","family":"Elnour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh Nitin","family":"Dongre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okan","family":"Gultekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Forcados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Stensland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8787-5886","authenticated-orcid":false,"given":"Tuula Anneli","family":"Nyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"Lehti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"W\u00e4lchli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Gelebart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Elena","family":"Costea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiros","family":"Kotopoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Bj\u00f8rge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmet","family":"McCormack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ebiom.2026.106135_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"10177","key":"10.1016\/j.ebiom.2026.106135_bib2","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0140-6736(18)32552-2","article-title":"Epithelial ovarian cancer","volume":"393","author":"Lheureux","year":"2019","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.20892\/j.issn.2095-3941.2016.0084","article-title":"Epidemiology of ovarian cancer: a review","volume":"14","author":"Reid","year":"2017","journal-title":"Cancer Biol Med"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106135_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00428-012-1203-5","article-title":"Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features","volume":"460","author":"Prat","year":"2012","journal-title":"Virchows Arch"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/jnci\/djy071","article-title":"Invasive epithelial ovarian cancer survival by histotype and disease stage","volume":"111","author":"Peres","year":"2019","journal-title":"J Natl Cancer Inst"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106135_bib6","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S1470-2045(06)70939-1","article-title":"Mechanisms of transcoelomic metastasis in ovarian cancer","volume":"7","author":"Tan","year":"2006","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106135_bib7","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tice.2016.11.004","article-title":"The histophysiology and pathophysiology of the peritoneum","volume":"49","author":"van Baal","year":"2017","journal-title":"Tissue Cell"},{"issue":"41","key":"10.1016\/j.ebiom.2026.106135_bib9","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.3748\/wjg.v19.i41.6979","article-title":"Peritoneal carcinomatosis","volume":"19","author":"Coccolini","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106135_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1369\/0022155417742897","article-title":"Development of peritoneal carcinomatosis in epithelial ovarian cancer: a review","volume":"66","author":"van Baal","year":"2018","journal-title":"J Histochem Cytochem"},{"issue":"7941","key":"10.1016\/j.ebiom.2026.106135_bib11","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41586-022-05496-1","article-title":"Ovarian cancer mutational processes drive site-specific immune evasion","volume":"612","author":"V\u00e1zquez-Garc\u00eda","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2026.106135_bib12","article-title":"Spatial and temporal intra-tumoral heterogeneity in advanced HGSOC: implications for surgical and clinical outcomes","volume":"4","author":"Cunnea","year":"2023","journal-title":"Cell Rep Med"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib13","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1038\/s41467-021-24009-8","article-title":"Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance","volume":"12","author":"Pietil\u00e4","year":"2021","journal-title":"Nat Commun"},{"issue":"Pt 3","key":"10.1016\/j.ebiom.2026.106135_bib14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.semcancer.2022.03.012","article-title":"Chemotherapy as a regulator of extracellular matrix-cell communication: implications in therapy resistance","volume":"86","author":"Gonzalez-Molina","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.ebiom.2026.106135_bib15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fmolb.2019.00160","article-title":"Extracellular matrix in the tumor microenvironment and its impact on cancer therapy","volume":"6","author":"Henke","year":"2019","journal-title":"Front Mol Biosci"},{"issue":"Pt 24","key":"10.1016\/j.ebiom.2026.106135_bib16","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1242\/jcs.023820","article-title":"The extracellular matrix at a glance","volume":"123","author":"Frantz","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ebiom.2026.106135_bib17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.semcancer.2022.03.027","article-title":"Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment","volume":"86","author":"Schoutrop","year":"2022","journal-title":"Semin Cancer Biol"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106135_bib18","doi-asserted-by":"crossref","first-page":"T155","DOI":"10.1530\/ERC-16-0320","article-title":"Women in cancer thematic review: ovarian cancer\u2013peritoneal cell interactions promote extracellular matrix processing","volume":"23","author":"Ricciardelli","year":"2016","journal-title":"Endocr Relat Cancer"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106135_bib19","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1002\/ijc.32854","article-title":"Ovarian cancer-associated mesothelial cells induce acquired platinum-resistance in peritoneal metastasis via the FN1\/Akt signaling pathway","volume":"146","author":"Yoshihara","year":"2020","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.trecan.2015.07.008","article-title":"Immune response to cancer therapy: mounting an effective antitumor response and mechanisms of resistance","volume":"1","author":"Medler","year":"2015","journal-title":"Trends Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib21","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.1038\/s41467-020-18794-x","article-title":"Concepts of extracellular matrix remodelling in tumour progression and metastasis","volume":"11","author":"Winkler","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106135_bib22","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/s41568-022-00503-z","article-title":"Immunobiology of high-grade serous ovarian cancer: lessons for clinical translation","volume":"22","author":"Kandalaft","year":"2022","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106135_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/cells8050505","article-title":"Current status of patient-derived ovarian cancer models","volume":"8","author":"Maru","year":"2019","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106135_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107762","article-title":"Patient-derived ovarian cancer organoids mimic clinical response and exhibit heterogeneous inter- and intrapatient drug responses","volume":"31","author":"de Witte","year":"2020","journal-title":"Cell Rep"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106135_bib25","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019104013","article-title":"Stable expansion of high-grade serous ovarian cancer organoids requires a low-wnt environment","volume":"39","author":"Hoffmann","year":"2020","journal-title":"EMBO J"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106135_bib26","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/s41591-019-0422-6","article-title":"An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity","volume":"25","author":"Kopper","year":"2019","journal-title":"Nat Med"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106135_bib27","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.devcel.2023.04.012","article-title":"A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids","volume":"58","author":"Senkowski","year":"2023","journal-title":"Dev Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib28","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13048-023-01145-x","article-title":"Insights into high-grade serous carcinoma pathobiology using three-dimensional culture model systems","volume":"16","author":"Tomas","year":"2023","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.ebiom.2026.106135_bib29","article-title":"Omentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment","volume":"19\u201320","author":"Neilson","year":"2023","journal-title":"Matrix Biol Plus"},{"key":"10.1016\/j.ebiom.2026.106135_bib30","first-page":"15","article-title":"Decellularized extracellular matrix scaffolds: recent trends and emerging strategies in tissue engineering","volume":"10","author":"Zhang","year":"2022","journal-title":"Bioact Mater"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106135_bib31","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1089\/ten.tec.2015.0557","article-title":"Mimicking metastases including tumor stroma: a new technique to generate a three-dimensional colorectal cancer model based on a biological decellularized intestinal scaffold","volume":"22","author":"Nietzer","year":"2016","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.ebiom.2026.106135_bib32","doi-asserted-by":"crossref","DOI":"10.1177\/20417314221088514","article-title":"Establishment of the SIS scaffold-based 3D model of human peritoneum for studying the dissemination of ovarian cancer","volume":"13","author":"Herbert","year":"2022","journal-title":"J Tissue Eng"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib33","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1038\/s41467-023-38093-5","article-title":"Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis","volume":"14","author":"Puttock","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106135_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2025.102523","article-title":"Patient-derived extracellular matrix from decellularized high-grade serous ovarian carcinoma tissues as a biocompatible support for organoid growth","volume":"61","author":"Sensi","year":"2025","journal-title":"Transl Oncol"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106135_bib35","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1089\/ten.2006.0388","article-title":"Engineered liver-like tissue on a capillarized matrix for applied research","volume":"13","author":"Linke","year":"2007","journal-title":"Tissue Eng"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106135_bib36","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000880","article-title":"A FIJI macro for quantifying pattern in extracellular matrix","volume":"4","author":"Wershof","year":"2021","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.ebiom.2026.106135_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119766","article-title":"Matrix decoded - a pancreatic extracellular matrix with organ specific cues guiding human iPSC differentiation","volume":"244","author":"Berger","year":"2020","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106135_bib38","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ejpb.2012.07.020","article-title":"Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood\u2013brain barrier penetration models","volume":"82","author":"Hellinger","year":"2012","journal-title":"Eur J Pharm Biopharm"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106135_bib39","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat Biotechnol"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106135_bib40","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.014647","article-title":"The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices","volume":"11","author":"Naba","year":"2012","journal-title":"Mol Cell Proteomics"},{"issue":"D1","key":"10.1016\/j.ebiom.2026.106135_bib41","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106135_bib42","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1089\/hyb.1995.14.461","article-title":"Generation, characterization, and in vivo studies of humanized anticarcinoma antibody CC49","volume":"14","author":"Kashmiri","year":"1995","journal-title":"Hybridoma"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106135_bib43","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008179","article-title":"Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16","volume":"12","author":"Casey","year":"2024","journal-title":"J Immunother Cancer"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106135_bib44","first-page":"56","article-title":"Chimeric antigen receptor preparation from hybridoma to T-cell expression","volume":"2","author":"K\u00f6ksal","year":"2019","journal-title":"Antib Ther"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106135_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027930","article-title":"A practical approach to T-cell receptor cloning and expression","volume":"6","author":"W\u00e4lchli","year":"2011","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106135_bib46","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/j.biomaterials.2011.01.057","article-title":"An overview of tissue and whole organ decellularization processes","volume":"32","author":"Crapo","year":"2011","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106135_bib47","doi-asserted-by":"crossref","first-page":"5937","DOI":"10.1002\/jcp.26403","article-title":"Decellularized colorectal cancer matrix as bioactive microenvironment for in vitro 3D cancer research","volume":"233","author":"Piccoli","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ebiom.2026.106135_bib48","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.biomaterials.2015.10.005","article-title":"Improvement of diaphragmatic performance through orthotopic application of decellularized extracellular matrix patch","volume":"74","author":"Piccoli","year":"2016","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106135_bib50","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3390\/bios10110152","article-title":"Biocompatibility of blank, post-processed and coated 3D printed resin structures with electrogenic cells","volume":"10","author":"Hart","year":"2020","journal-title":"Biosensors"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nphoton.an.2010.2","article-title":"Multiphoton microscopy","volume":"5","author":"Larson","year":"2011","journal-title":"Nat Photonics"},{"issue":"7822","key":"10.1016\/j.ebiom.2026.106135_bib52","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41586-020-2612-2","article-title":"Effects of extracellular matrix viscoelasticity on cellular behaviour","volume":"584","author":"Chaudhuri","year":"2020","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106135_bib53","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1002\/jbm.a.36444","article-title":"Comparative proteomic analyses of human adipose extracellular matrices decellularized using alternative procedures","volume":"106","author":"Thomas-Porch","year":"2018","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.ebiom.2026.106135_bib54","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1038\/ncomms3126","article-title":"Evaluating cell lines as tumour models by comparison of genomic profiles","volume":"4","author":"Domcke","year":"2013","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106135_bib55","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1084\/jem.20180765","article-title":"Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer","volume":"216","author":"Gao","year":"2019","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib56","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/1878-0261.13556","article-title":"Ovarian cancer relies on the PDGFR\u03b2-fibronectin axis for tumorsphere formation and metastatic spread","volume":"18","author":"Gendrau-Sanclemente","year":"2024","journal-title":"Mol Oncol"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106135_bib57","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1158\/1541-7786.MCR-23-0347","article-title":"Stromal DDR2 promotes ovarian cancer metastasis through regulation of metabolism and secretion of extracellular matrix proteins","volume":"21","author":"Schab","year":"2023","journal-title":"Mol Cancer Res"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106135_bib58","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1158\/1541-7786.MCR-12-0307","article-title":"Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue","volume":"10","author":"Karagiannis","year":"2012","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.ebiom.2026.106135_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.837233","article-title":"Novel Ex vivo models of epithelial ovarian cancer: the future of biomarker and therapeutic research","volume":"12","author":"Clark","year":"2022","journal-title":"Front Oncol"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106135_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15072059","article-title":"Patient derived organoids (PDOs), extracellular matrix (ECM), tumor microenvironment (TME) and drug screening: state of the art and clinical implications of ovarian cancer organoids in the era of precision medicine","volume":"15","author":"Spagnol","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106135_bib61","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00429-004-0446-6","article-title":"A comparative study of the structure of human and murine greater omentum","volume":"209","author":"Wilkosz","year":"2005","journal-title":"Anat Embryol"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106135_bib62","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF00235068","article-title":"Mesothelial stomata overlying omental milky spots: scanning electron microscopic study","volume":"201","author":"Mironov","year":"1979","journal-title":"Cell Tissue Res"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib63","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1038\/s41598-018-25589-0","article-title":"The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation","volume":"8","author":"McKenzie","year":"2018","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106135_bib64","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix crosslinking forces tumor progression by enhancing integrin signaling","volume":"139","author":"Levental","year":"2009","journal-title":"Cell"},{"issue":"47","key":"10.1016\/j.ebiom.2026.106135_bib65","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1038\/s41388-023-02844-x","article-title":"Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine","volume":"42","author":"Xin","year":"2023","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-72559-6","article-title":"Inspired by the human placenta: a novel 3D bioprinted membrane system to create barrier models","volume":"10","author":"Kreuder","year":"2020","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106135_bib67","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41580-019-0134-2","article-title":"Integrins as biomechanical sensors of the microenvironment","volume":"20","author":"Kechagia","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106135_bib68","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41568-020-00329-7","article-title":"The matrix in cancer","volume":"21","author":"Cox","year":"2021","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106135_bib69","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/s41467-022-29279-4","article-title":"Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids","volume":"13","author":"Kim","year":"2022","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106135_bib70","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1002\/jbm.b.35300","article-title":"Comparative proteomic analysis of regenerative acellular matrices: the effects of tissue source and processing method","volume":"111","author":"Wang","year":"2023","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"621","key":"10.1016\/j.ebiom.2026.106135_bib71","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd5758","article-title":"Importance of the pig as a human biomedical model","volume":"13","author":"Lunney","year":"2021","journal-title":"Sci Transl Med"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106135_bib72","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrc1877","article-title":"Fibroblasts in cancer","volume":"6","author":"Kalluri","year":"2006","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106135_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102676","article-title":"A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion","volume":"24","author":"Malacrida","year":"2021","journal-title":"iScience"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426000162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426000162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:39:11Z","timestamp":1778873951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426000162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":72,"alternative-id":["S2352396426000162"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106135","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A 3D ovarian cancer metastasis model using a decellularised peritoneal matrix to study therapy response","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106135"}}