{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:11:45Z","timestamp":1778875905352,"version":"3.51.4"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["ACS RSG-22-115-01-DMC"],"award-info":[{"award-number":["ACS RSG-22-115-01-DMC"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["2R35GM138113"],"award-info":[{"award-number":["2R35GM138113"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RR210006"],"award-info":[{"award-number":["RR210006"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["CC2008"],"award-info":[{"award-number":["CC2008"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016042"],"award-info":[{"award-number":["P30CA016042"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA214194"],"award-info":[{"award-number":["U01CA214194"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U2CCA271894"],"award-info":[{"award-number":["U2CCA271894"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMS-1924792"],"award-info":[{"award-number":["DMS-1924792"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMS-2318925"],"award-info":[{"award-number":["DMS-2318925"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010438","name":"Francis Crick Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ebiom.2026.106181","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:49:33Z","timestamp":1771660173000},"page":"106181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Quantifying rate-limiting genetic variation in breast and ovarian tumourigenesis"],"prefix":"10.1016","volume":"125","author":[{"given":"Kathleen E.","family":"Houlahan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahad","family":"Bihie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8006-6078","authenticated-orcid":false,"given":"Yves","family":"Greatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-070X","authenticated-orcid":false,"given":"Juli\u00e1n Grandvallet","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Fulop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Hsiung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Van Loo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C.","family":"Boutros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5537-5817","authenticated-orcid":false,"given":"Kuan-lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6127","key":"10.1016\/j.ebiom.2026.106181_bib1","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cell.2013.03.002","article-title":"Lessons from the cancer genome","volume":"153","author":"Garraway","year":"2013","journal-title":"Cell"},{"issue":"6417","key":"10.1016\/j.ebiom.2026.106181_bib3","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1126\/science.aau3879","article-title":"Somatic mutant clones colonize the human esophagus with age","volume":"362","author":"Martincorena","year":"2018","journal-title":"Science"},{"issue":"7779","key":"10.1016\/j.ebiom.2026.106181_bib4","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/s41586-019-1672-7","article-title":"The landscape of somatic mutation in normal colorectal epithelial cells","volume":"574","author":"Lee-Six","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib5","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1038\/s41467-023-40608-z","article-title":"The mutational landscape of the adult healthy parous and nulliparous human breast","volume":"14","author":"Cereser","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106181_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1745-6150-5-26","article-title":"A new stochastic and state space model of human colon cancer incorporating multiple pathways","volume":"5","author":"Tan","year":"2010","journal-title":"Biol Direct"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106181_bib7","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.2307\/2533259","article-title":"Are two mutations sufficient to cause cancer? Some generalizations of the two-mutation model of carcinogenesis of Moolgavkar, Venzon, and Knudson, and of the multistage model of Armitage and Doll","volume":"51","author":"Little","year":"1995","journal-title":"Biometrics"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib8","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1038\/s41467-018-05467-z","article-title":"Evaluating intrinsic and non-intrinsic cancer risk factors","volume":"9","author":"Wu","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1073\/pnas.1421839112","article-title":"Only three driver gene mutations are required for the development of lung and colorectal cancers","volume":"112","author":"Tomasetti","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106181_bib10","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.cell.2018.07.034","article-title":"Comprehensive characterization of cancer driver genes and mutations","volume":"174","author":"Bailey","year":"2018","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106181_bib11","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.cell.2017.09.042","article-title":"Universal patterns of selection in cancer and somatic tissues","volume":"171","author":"Martincorena","year":"2017","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106181_bib12","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.celrep.2018.09.082","article-title":"Pan-Cancer landscape of aberrant DNA methylation across human tumors","volume":"25","author":"Saghafinia","year":"2018","journal-title":"Cell Rep"},{"issue":"7793","key":"10.1016\/j.ebiom.2026.106181_bib13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41586-019-1913-9","article-title":"Patterns of somatic structural variation in human cancer genomes","volume":"578","author":"Li","year":"2020","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ebiom.2026.106181_bib14","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/ng.2762","article-title":"Emerging landscape of oncogenic signatures across human cancers","volume":"45","author":"Ciriello","year":"2013","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/bjc.1953.8","article-title":"A new theory on cancer-inducing mechanism","volume":"7","author":"Nordling","year":"1953","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1954.1","article-title":"The age distribution of cancer and a multi-stage theory of carcinogenesis","volume":"8","author":"Armitage","year":"1954","journal-title":"Br J Cancer"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106181_bib17","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1073\/pnas.68.4.820","article-title":"Mutation and cancer: statistical study of retinoblastoma","volume":"68","author":"Knudson","year":"1971","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106181_bib18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1470-2045(13)70045-7","article-title":"Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies","volume":"14","author":"Rushlow","year":"2013","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.bjc.6603535","article-title":"Cancer risks among BRCA1 and BRCA2 mutation carriers","volume":"96","author":"Levy-Lahad","year":"2007","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrc3181","article-title":"BRCA1 and BRCA2: different roles in a common pathway of genome protection","volume":"12","author":"Roy","year":"2011","journal-title":"Nat Rev Cancer"},{"issue":"7766","key":"10.1016\/j.ebiom.2026.106181_bib21","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41586-019-1382-1","article-title":"Tumour lineage shapes BRCA-mediated phenotypes","volume":"571","author":"Jonsson","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12920-019-0545-0","article-title":"Comprehensive genomic characterization of breast tumors with BRCA1 and BRCA2 mutations","volume":"12","author":"Lal","year":"2019","journal-title":"BMC Med Genomics"},{"issue":"7605","key":"10.1016\/j.ebiom.2026.106181_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature17676","article-title":"Landscape of somatic mutations in 560 breast cancer whole-genome sequences","volume":"534","author":"Nik-Zainal","year":"2016","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106181_bib24","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1038\/bjc.2013.141","article-title":"DNA copy number profiling reveals extensive genomic loss in hereditary BRCA1 and BRCA2 ovarian carcinomas","volume":"108","author":"Kamieniak","year":"2013","journal-title":"Br J Cancer"},{"issue":"14","key":"10.1016\/j.ebiom.2026.106181_bib25","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/jama.2011.1456","article-title":"Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer","volume":"306","author":"Yang","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.ebiom.2026.106181_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13671","article-title":"Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories","volume":"8","author":"Taylor","year":"2017","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.ebiom.2026.106181_bib27","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nrc1457","article-title":"Hallmarks of 'BRCAness' in sporadic cancers","volume":"4","author":"Turner","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1200\/JCO.2003.02.137","article-title":"High prevalence of premalignant lesions in prophylactically removed breasts from women at hereditary risk for breast cancer","volume":"21","author":"Hoogerbrugge","year":"2003","journal-title":"J Clin Oncol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106181_bib30","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/ijc.21988","article-title":"Low prevalence of (pre) malignant lesions in the breast and high prevalence in the ovary and Fallopian tube in women at hereditary high risk of breast and ovarian cancer","volume":"119","author":"Hermsen","year":"2006","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ygyno.2012.06.015","article-title":"Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls","volume":"127","author":"Mingels","year":"2012","journal-title":"Gynecol Oncol"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106181_bib32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2018.03.035","article-title":"Oncogenic signaling pathways in the cancer genome Atlas","volume":"173","author":"Sanchez-Vega","year":"2018","journal-title":"Cell"},{"issue":"7793","key":"10.1016\/j.ebiom.2026.106181_bib33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41586-019-1907-7","article-title":"The evolutionary history of 2,658 cancers","volume":"578","author":"Gerstung","year":"2020","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106181_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cell.2018.03.039","article-title":"Pathogenic germline variants in 10,389 adult cancers","volume":"173","author":"Huang","year":"2018","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13073-020-00744-3","article-title":"Ancestry-specific predisposing germline variants in cancer","volume":"12","author":"Oak","year":"2020","journal-title":"Genome Med"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106181_bib36","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ccell.2020.04.012","article-title":"Comprehensive analysis of genetic ancestry and its molecular correlates in cancer","volume":"37","author":"Carrot-Zhang","year":"2020","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106181_bib37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cels.2018.03.002","article-title":"Scalable open science approach for mutation calling of tumor exomes using multiple genomic pipelines","volume":"6","author":"Ellrott","year":"2018","journal-title":"Cell Syst"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106181_bib38","article-title":"Diverse immune response of DNA damage repair-deficient tumors","volume":"2","author":"Qing","year":"2021","journal-title":"Cell Rep Med"},{"issue":"18","key":"10.1016\/j.ebiom.2026.106181_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13184572","article-title":"Genomic determinants of homologous recombination deficiency across human cancers","volume":"13","author":"Qing","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106181_bib40","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ccell.2018.03.007","article-title":"Genomic and functional approaches to understanding cancer aneuploidy","volume":"33","author":"Taylor","year":"2018","journal-title":"Cancer Cell"},{"issue":"7403","key":"10.1016\/j.ebiom.2026.106181_bib41","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10983","article-title":"The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups","volume":"486","author":"Curtis","year":"2012","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib42","article-title":"The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes","volume":"7","author":"Pereira","year":"2016","journal-title":"Nat Commun"},{"issue":"23","key":"10.1016\/j.ebiom.2026.106181_bib43","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106181_bib44","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1073\/pnas.1221068110","article-title":"Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation","volume":"110","author":"Tomasetti","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tpb.2009.10.008","article-title":"Evolution of resistance and progression to disease during clonal expansion of cancer","volume":"77","author":"Durrett","year":"2010","journal-title":"Theor Popul Biol"},{"issue":"7624","key":"10.1016\/j.ebiom.2026.106181_bib46","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature19768","article-title":"Tissue-specific mutation accumulation in human adult stem cells during life","volume":"538","author":"Blokzijl","year":"2016","journal-title":"Nature"},{"issue":"7913","key":"10.1016\/j.ebiom.2026.106181_bib47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41586-022-04786-y","article-title":"Clonal dynamics of haematopoiesis across the human lifespan","volume":"606","author":"Mitchell","year":"2022","journal-title":"Nature"},{"issue":"6375","key":"10.1016\/j.ebiom.2026.106181_bib48","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1126\/science.aao4426","article-title":"Aging and neurodegeneration are associated with increased mutations in single human neurons","volume":"359","author":"Lodato","year":"2018","journal-title":"Science"},{"issue":"7938","key":"10.1016\/j.ebiom.2026.106181_bib49","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41586-022-05249-0","article-title":"Single-cell genomic variation induced by mutational processes in cancer","volume":"612","author":"Funnell","year":"2022","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106181_bib50","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1038\/s41588-024-01988-0","article-title":"Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations","volume":"56","author":"Williams","year":"2024","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106181_bib51","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020107333","article-title":"A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast","volume":"40","author":"Pal","year":"2021","journal-title":"EMBO J"},{"key":"10.1016\/j.ebiom.2026.106181_bib52","author":"Timothy"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib53","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12859-019-2610-2","article-title":"BPG: seamless, automated and interactive visualization of scientific data","volume":"20","author":"P'ng","year":"2019","journal-title":"BMC Bioinformatics"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106181_bib54","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ccell.2018.08.019","article-title":"Integrated analysis of genetic ancestry and genomic alterations across cancers","volume":"34","author":"Yuan","year":"2018","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106181_bib55","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ajhg.2011.12.009","article-title":"Age-related somatic structural changes in the nuclear genome of human blood cells","volume":"90","author":"Forsberg","year":"2012","journal-title":"Am J Hum Genet"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106181_bib56","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nm.4292","article-title":"HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures","volume":"23","author":"Davies","year":"2017","journal-title":"Nat Med"},{"issue":"50","key":"10.1016\/j.ebiom.2026.106181_bib57","doi-asserted-by":"crossref","first-page":"14330","DOI":"10.1073\/pnas.1616440113","article-title":"Evaluating the evaluation of cancer driver genes","volume":"113","author":"Tokheim","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7353","key":"10.1016\/j.ebiom.2026.106181_bib58","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"Bell","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib59","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41597-022-01236-2","article-title":"R code and downstream analysis objects for the scRNA-seq atlas of normal and tumorigenic human breast tissue","volume":"9","author":"Chen","year":"2022","journal-title":"Sci Data"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106181_bib60","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ccell.2016.04.001","article-title":"Comprehensive characterization of molecular differences in cancer between male and female patients","volume":"29","author":"Yuan","year":"2016","journal-title":"Cancer Cell"},{"issue":"19","key":"10.1016\/j.ebiom.2026.106181_bib61","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1158\/0008-5472.CAN-18-0362","article-title":"Sex differences in cancer driver genes and biomarkers","volume":"78","author":"Li","year":"2018","journal-title":"Cancer Res"},{"issue":"7974","key":"10.1016\/j.ebiom.2026.106181_bib62","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41586-023-06333-9","article-title":"Evolutionary histories of breast cancer and related clones","volume":"620","author":"Nishimura","year":"2023","journal-title":"Nature"},{"issue":"7549","key":"10.1016\/j.ebiom.2026.106181_bib63","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nature14418","article-title":"TP53 loss creates therapeutic vulnerability in colorectal cancer","volume":"520","author":"Liu","year":"2015","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106181_bib64","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s12307-012-0103-1","article-title":"Signification of hypermethylated in cancer 1 (HIC1) as tumor suppressor gene in tumor progression","volume":"5","author":"Zheng","year":"2012","journal-title":"Cancer Microenviron"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106181_bib65","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/cdd.2017.99","article-title":"The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway","volume":"24","author":"Furth","year":"2017","journal-title":"Cell Death Differ"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106181_bib66","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.celrep.2014.04.004","article-title":"CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer","volume":"7","author":"Kemp","year":"2014","journal-title":"Cell Rep"},{"issue":"7793","key":"10.1016\/j.ebiom.2026.106181_bib67","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41586-020-1943-3","article-title":"The repertoire of mutational signatures in human cancer","volume":"578","author":"Alexandrov","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib68","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1038\/s41467-020-17374-3","article-title":"Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions","volume":"11","author":"Fahed","year":"2020","journal-title":"Nat Commun"},{"issue":"14","key":"10.1016\/j.ebiom.2026.106181_bib69","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1158\/1078-0432.CCR-18-0468","article-title":"Genomic signatures predict the immunogenicity of BRCA-Deficient breast cancer","volume":"25","author":"Kraya","year":"2019","journal-title":"Clin Cancer Res"},{"issue":"8050","key":"10.1016\/j.ebiom.2026.106181_bib70","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s41586-024-08377-x","article-title":"Complex rearrangements fuel ER+ and HER2+ breast tumours","volume":"638","author":"Houlahan","year":"2025","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib71","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/s12864-021-07686-z","article-title":"Evaluation of tools for identifying large copy number variations from ultra-low-coverage whole-genome sequencing data","volume":"22","author":"Smolander","year":"2021","journal-title":"BMC Genomics"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106181_bib72","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/s41467-017-00965-y","article-title":"Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors","volume":"8","author":"Adalsteinsson","year":"2017","journal-title":"Nat Commun"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426000629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426000629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:39:50Z","timestamp":1778873990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426000629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":71,"alternative-id":["S2352396426000629"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106181","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantifying rate-limiting genetic variation in breast and ovarian tumourigenesis","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106181"}}