{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:15:25Z","timestamp":1790198125140,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ebiom.2026.106200","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:48:50Z","timestamp":1772902130000},"page":"106200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Circadian rhythm disruption impairs ovarian follicular development via NAD+ metabolic reprogramming"],"prefix":"10.1016","volume":"126","author":[{"given":"Yan-Yun","family":"Ying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen-Yi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Xue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Qi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cun-Qi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Li","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Qing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1295-4795","authenticated-orcid":false,"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2026.106200_bib1","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1172\/JCI46043","article-title":"Circadian rhythms, sleep, and metabolism","volume":"121","author":"Huang","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ebiom.2026.106200_bib2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1136\/jnnp-2022-330123","article-title":"Insufficient sleep during adolescence and risk of multiple sclerosis: results from a Swedish case-control study","volume":"94","author":"Akerstedt","year":"2023","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.ebiom.2026.106200_bib3","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41586-019-1579-3","article-title":"Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis","volume":"574","author":"Godinho-Silva","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2026.106200_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo1123","article-title":"Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer","volume":"8","author":"Pariollaud","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.ebiom.2026.106200_bib5","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1056\/NEJMra1802337","article-title":"Circadian mechanisms in medicine","volume":"384","author":"Allada","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ebiom.2026.106200_bib6","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.fertnstert.2020.08.1425","article-title":"Association between circadian rhythm disruption and polycystic ovary syndrome","volume":"115","author":"Wang","year":"2021","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ebiom.2026.106200_bib7","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1210\/en.2016-1450","article-title":"The circadian timing system and environmental circadian disruption: from follicles to fertility","volume":"157","author":"Sen","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.ebiom.2026.106200_bib8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41580-018-0096-9","article-title":"Crosstalk between metabolism and circadian clocks","volume":"20","author":"Reinke","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ebiom.2026.106200_bib9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev-physiol-021909-135821","article-title":"The mammalian circadian timing system: organization and coordination of central and peripheral clocks","volume":"72","author":"Dibner","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.ebiom.2026.106200_bib10","doi-asserted-by":"crossref","first-page":"e820","DOI":"10.1016\/S2214-109X(22)00098-5","article-title":"Prevalence of intimate partner violence against infertile women in low-income and middle-income countries: a systematic review and meta-analysis","volume":"10","author":"Wang","year":"2022","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.ebiom.2026.106200_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1083\/jcb.201603076","article-title":"The circadian coordination of cell biology","volume":"215","author":"Chaix","year":"2016","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ebiom.2026.106200_bib12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/s12905-022-01947-z","article-title":"Factors associated with regularity and length of menstrual cycle: Korea Nurses' Health Study","volume":"22","author":"Song","year":"2022","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.ebiom.2026.106200_bib13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/oby.23380","article-title":"Constant light exposure alters gut microbiota and short-\/medium-chain fatty acids and aggravates PCOS-like traits in HFD-fed rats","volume":"30","author":"Yue","year":"2022","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.ebiom.2026.106200_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113290119","article-title":"Light exposure during sleep impairs cardiometabolic function","volume":"119","author":"Mason","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2026.106200_bib15","article-title":"Menstrual cycle regularity and length across the reproductive lifespan and risk of premature mortality: prospective cohort study","volume":"371","author":"Wang","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.ebiom.2026.106200_bib16","first-page":"472","article-title":"Effect of shift work on menopausal age and menstruation span of professional women","volume":"39","author":"Xiao","year":"2021","journal-title":"Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi"},{"key":"10.1016\/j.ebiom.2026.106200_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/jwh.2019.8166","article-title":"Night shift work and fecundability in late reproductive-aged African American women","volume":"30","author":"Sponholtz","year":"2021","journal-title":"J Womens Health (Larchmt)"},{"key":"10.1016\/j.ebiom.2026.106200_bib18","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1111\/cas.14890","article-title":"Differentiation of Hodgkin lymphoma cells by reactive oxygen species and regulation by heme oxygenase-1 through HIF-1alpha","volume":"112","author":"Nakashima","year":"2021","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ebiom.2026.106200_bib19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4103\/1673-5374.350194","article-title":"Ataxia-telangiectasia mutated plays an important role in cerebellar integrity and functionality","volume":"18","author":"Mitiagin","year":"2023","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.ebiom.2026.106200_bib20","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.redox.2015.06.001","article-title":"Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster","volume":"5","author":"Abolaji","year":"2015","journal-title":"Redox Biol"},{"key":"10.1016\/j.ebiom.2026.106200_bib21","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1089\/ars.2012.4889","article-title":"Circadian rhythm connections to oxidative stress: implications for human health","volume":"19","author":"Wilking","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.ebiom.2026.106200_bib22","doi-asserted-by":"crossref","first-page":"591-+","DOI":"10.1126\/science.1243417","article-title":"Circadian Clock NAD(+) cycle drives mitochondrial oxidative metabolism in mice","volume":"342","author":"Peek","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2026.106200_bib23","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1038\/s42255-021-00464-x","article-title":"Metabolic remodelling during early mouse embryo development","volume":"3","author":"Zhao","year":"2021","journal-title":"Nat Metab"},{"key":"10.1016\/j.ebiom.2026.106200_bib24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/taap.2001.9156","article-title":"Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells","volume":"172","author":"Lovekamp","year":"2001","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.ebiom.2026.106200_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-09982-5","article-title":"CUT&Tag for efficient epigenomic profiling of small samples and single cells","volume":"10","author":"Kaya-Okur","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106200_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47964-1","article-title":"Efficient derivation of knock-out and knock-in rats using embryos obtained by fertilization","volume":"9","author":"Honda","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2026.106200_bib27","article-title":"BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency","volume":"13","author":"Wang","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106200_bib28","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/cdd.2013.31","article-title":"Rescue of platinum-damaged oocytes from programmed cell death through inactivation of the p53 family signaling network","volume":"20","author":"Kim","year":"2013","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.ebiom.2026.106200_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for -tests and ANOVAs","volume":"4","author":"Lakens","year":"2013","journal-title":"Front Psychol"},{"key":"10.1016\/j.ebiom.2026.106200_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101632","article-title":"Melatonin sensitises shikonin-induced cancer cell death mediated by oxidative stress via inhibition of the SIRT3\/SOD2-AKT pathway","volume":"36","author":"Li","year":"2020","journal-title":"Redox Biol"},{"key":"10.1016\/j.ebiom.2026.106200_bib31","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.7150\/thno.30398","article-title":"SIRT3-dependent mitochondrial dynamics remodeling contributes to oxidative stress-induced melanocyte degeneration in vitiligo","volume":"9","author":"Yi","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.ebiom.2026.106200_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jgg.2021.11.005","article-title":"Mitochondrial sirtuins, metabolism, and aging","volume":"49","author":"Ji","year":"2022","journal-title":"J Genet Genomics"},{"key":"10.1016\/j.ebiom.2026.106200_bib33","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41556-018-0124-1","article-title":"The multifaceted contributions of mitochondria to cellular metabolism","volume":"20","author":"Spinelli","year":"2018","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ebiom.2026.106200_bib34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41392-020-00311-7","article-title":"NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.ebiom.2026.106200_bib35","article-title":"SIRT2 deficiency aggravates diet-induced nonalcoholic fatty liver disease through modulating gut microbiota and metabolites","volume":"24","author":"Li","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2026.106200_bib36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.apsb.2022.07.016","article-title":"Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators","volume":"13","author":"Tang","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.ebiom.2026.106200_bib37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41583-018-0088-y","article-title":"Rhythms of life: circadian disruption and brain disorders across the lifespan","volume":"20","author":"Logan","year":"2019","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ebiom.2026.106200_bib38","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1126\/science.1171641","article-title":"Circadian clock feedback cycle through NAMPT-mediated NAD(+) biosynthesis","volume":"324","author":"Ramsey","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2026.106200_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101161","article-title":"Time-restricted eating: benefits, mechanisms, and challenges in translation","volume":"23","author":"Regmi","year":"2020","journal-title":"Iscience"},{"key":"10.1016\/j.ebiom.2026.106200_bib40","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.aninu.2022.06.009","article-title":"NAD(+) and its possible role in gut microbiota: insights on the mechanisms by which gut microbes influence host metabolism","volume":"10","author":"Ren","year":"2022","journal-title":"Anim Nutr"},{"key":"10.1016\/j.ebiom.2026.106200_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12510","article-title":"Improvement of oocyte quality through the SIRT signaling pathway","volume":"22","author":"Vo","year":"2023","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.ebiom.2026.106200_bib42","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.freeradbiomed.2022.10.267","article-title":"NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7","volume":"193","author":"Zhao","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ebiom.2026.106200_bib43","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.gendis.2020.11.010","article-title":"NADPH debt drives redox bankruptcy: SLC7A11\/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation","volume":"8","author":"Liu","year":"2021","journal-title":"Genes Dis"},{"key":"10.1016\/j.ebiom.2026.106200_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098972","article-title":"Nicotinamide mononucleotide, an Intermediate of NAD(+) synthesis, protects the heart from ischemia and reperfusion","volume":"9","author":"Yamamoto","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2026.106200_bib45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuroscience.2019.09.037","article-title":"Nicotinamide mononucleotide and melatonin alleviate aging-induced cognitive impairment via modulation of mitochondrial function and apoptosis in the prefrontal cortex and Hippocampus","volume":"423","author":"Hosseini","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.ebiom.2026.106200_bib46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/jpi.12075","article-title":"The role of melatonin in the cells of the innate immunity: a review","volume":"55","author":"Calvo","year":"2013","journal-title":"J Pineal Res"},{"key":"10.1016\/j.ebiom.2026.106200_bib47","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12905-016-0301-y","article-title":"Rotating shift work and menstrual characteristics in a cohort of Chinese nurses","volume":"16","author":"Wang","year":"2016","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.ebiom.2026.106200_bib48","article-title":"Shift work and menstruation: a meta-analysis study","volume":"24","author":"Hu","year":"2023","journal-title":"SSM Popul Health"},{"key":"10.1016\/j.ebiom.2026.106200_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600960","article-title":"Differential roles of AVP and VIP signaling in the postnatal changes of neural networks for coherent circadian rhythms in the SCN","volume":"2","author":"Ono","year":"2016","journal-title":"Sci Adv"},{"key":"10.1016\/j.ebiom.2026.106200_bib50","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/CM9.0000000000000702","article-title":"Gut microbiota: closely tied to the regulation of circadian clock in the development of type 2 diabetes mellitus","volume":"133","author":"Ding","year":"2020","journal-title":"Chin Med J"},{"key":"10.1016\/j.ebiom.2026.106200_bib51","article-title":"Association between Fat Mass-and Obesity-Associated (FTO) gene polymorphism and polycystic ovary syndrome: a meta-analysis","volume":"9","author":"Cai","year":"2014","journal-title":"Plos One"},{"issue":"Suppl 6","key":"10.1016\/j.ebiom.2026.106200_bib52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/rda.12003","article-title":"Chemical composition of lipids present in cat and dog oocyte by matrix-assisted desorption ionization mass spectrometry (MALDI- MS)","volume":"47","author":"Apparicio","year":"2012","journal-title":"Reprod Domest Anim"},{"key":"10.1016\/j.ebiom.2026.106200_bib53","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1177\/1933719116673197","article-title":"MicroRNA-145 negatively regulates cell proliferation through targeting IRS1 in isolated ovarian granulosa cells from patients with polycystic ovary syndrome","volume":"24","author":"Cai","year":"2017","journal-title":"Reprod Sci"},{"key":"10.1016\/j.ebiom.2026.106200_bib54","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1095\/biolreprod.110.090365","article-title":"Nongenomic steroid- and ceramide-induced maturation in amphibian oocytes involves functional caveolae-like microdomains associated with a cytoskeletal environment","volume":"85","author":"Buschiazzo","year":"2011","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ebiom.2026.106200_bib55","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.fertnstert.2006.12.055","article-title":"Role of insulin in the hyperandrogenemia of lean women with polycystic ovary syndrome and normal insulin sensitivity","volume":"88","author":"Baillargeon","year":"2007","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ebiom.2026.106200_bib56","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12846","article-title":"Continuous light exposure influences luteinization and luteal function of ovary in ICR mice","volume":"74","author":"Li","year":"2023","journal-title":"J Pineal Res"},{"key":"10.1016\/j.ebiom.2026.106200_bib57","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/humupd\/dmg038","article-title":"Menstrual disorders in adolescence: investigation and management","volume":"9","author":"Hickey","year":"2003","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ebiom.2026.106200_bib58","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.mayocp.2023.05.027","article-title":"Functional hypothalamic amenorrhea: Recognition and management of a challenging diagnosis","volume":"98","author":"Saadedine","year":"2023","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ebiom.2026.106200_bib59","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.bpobgyn.2004.05.004","article-title":"The pathophysiology of polycystic ovary syndrome: trying to understand PCOS and its endocrinology","volume":"18","author":"Balen","year":"2004","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ebiom.2026.106200_bib60","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12961","article-title":"The value of prolactin in predicting prolactinma in hyperprolactinaemic polycystic ovarian syndrome","volume":"48","author":"Kyritsi","year":"2018","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.ebiom.2026.106200_bib61","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1095\/biolreprod.111.093252","article-title":"Cell-secreted vesicles in equine ovarian follicular fluid contain miRNAs and proteins: a possible new form of cell communication within the ovarian follicle","volume":"86","author":"da Silveira","year":"2012","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ebiom.2026.106200_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/cells9041002","article-title":"A comparative analysis of oocyte development in mammals","volume":"9","author":"Dalbies-Tran","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ebiom.2026.106200_bib63","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/jms.4301","article-title":"Comprehensive lipid profiling of early stage oocytes and embryos by MRM profiling","volume":"53","author":"de Lima","year":"2018","journal-title":"J Mass Spectrom"},{"key":"10.1016\/j.ebiom.2026.106200_bib64","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1071\/RD14452","article-title":"Effects of age on follicular fluid exosomal microRNAs and granulosa cell transforming growth factor-beta signalling during follicle development in the mare","volume":"27","author":"da Silveira","year":"2015","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.ebiom.2026.106200_bib65","article-title":"Importance of lipid metabolism on oocyte maturation and early embryo development: can we apply what we know to buffalo?","volume":"211","author":"Marin","year":"2019","journal-title":"Anim Reprod Sci"},{"key":"10.1016\/j.ebiom.2026.106200_bib66","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.semcdb.2008.12.013","article-title":"Mitochondrial function and redox state in mammalian embryos","volume":"20","author":"Dumollard","year":"2009","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.ebiom.2026.106200_bib67","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1126\/science.1170803","article-title":"Circadian control of the NAD(+) salvage pathway by CLOCK-SIRT1","volume":"324","author":"Nakahata","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2026.106200_bib68","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1042\/BST20210508","article-title":"Circadian rhythm of lipid metabolism","volume":"50","author":"Sinturel","year":"2022","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.ebiom.2026.106200_bib69","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/07420528.2018.1527773","article-title":"Systematic review of light exposure impact on human circadian rhythm","volume":"36","author":"Tahkamo","year":"2019","journal-title":"Chronobiol Int"},{"key":"10.1016\/j.ebiom.2026.106200_bib70","doi-asserted-by":"crossref","first-page":"re6","DOI":"10.1126\/scisignal.2005685","article-title":"Sirtuins and the circadian clock: bridging chromatin and metabolism","volume":"7","author":"Masri","year":"2014","journal-title":"Sci Signal"},{"key":"10.1016\/j.ebiom.2026.106200_bib71","doi-asserted-by":"crossref","DOI":"10.1186\/s12979-023-00398-w","article-title":"Impact of NAD plus metabolism on ovarian aging","volume":"20","author":"Liang","year":"2023","journal-title":"Immun Ageing"},{"key":"10.1016\/j.ebiom.2026.106200_bib72","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s43587-023-00532-9","article-title":"NADase CD38 is a key determinant of ovarian aging","volume":"4","author":"Yang","year":"2024","journal-title":"Nat Aging"},{"key":"10.1016\/j.ebiom.2026.106200_bib73","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/jcp.31156","article-title":"NAMPT regulates mitochondria function and lipid metabolism during porcine oocyte maturation","volume":"239","author":"Guo","year":"2024","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ebiom.2026.106200_bib74","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.cmet.2010.11.015","article-title":"Calorie restriction reduces oxidative stress by SIRT3-Mediated SOD2 activation","volume":"12","author":"Qiu","year":"2010","journal-title":"Cell Metab"},{"key":"10.1016\/j.ebiom.2026.106200_bib75","first-page":"2758","article-title":"Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice","volume":"119","author":"Sundaresan","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ebiom.2026.106200_bib76","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1080\/15384101.2017.1320004","article-title":"Sirt3-dependent deacetylation of SOD2 plays a protective role against oxidative stress in oocytes from diabetic mice","volume":"16","author":"Liu","year":"2017","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ebiom.2026.106200_bib77","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1096\/fj.202000153R","article-title":"Sirt3 is dispensable for oocyte quality and female fertility in lean and obese mice","volume":"34","author":"Iljas","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.ebiom.2026.106200_bib78","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12431","article-title":"Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway","volume":"63","author":"Han","year":"2017","journal-title":"J Pineal Res"},{"key":"10.1016\/j.ebiom.2026.106200_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2025.107797","article-title":"Nicotinamide mononucleotide enhances porcine sperm quality by activating the SIRT3-SOD2\/ROS pathway and promoting oxidative phosphorylation","volume":"275","author":"Zhang","year":"2025","journal-title":"Anim Reprod Sci"},{"key":"10.1016\/j.ebiom.2026.106200_bib80","doi-asserted-by":"crossref","DOI":"10.1186\/s13048-024-01534-w","article-title":"Nicotinamide mononucleotide improves the ovarian reserve of POI by inhibiting NLRP3-mediated pyroptosis of ovarian granulosa cells","volume":"17","author":"Ma","year":"2024","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.ebiom.2026.106200_bib81","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cmet.2016.09.013","article-title":"Long-Term administration of Nicotinamide mononucleotide mitigates age-associated physiological decline in mice","volume":"24","author":"Mills","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.ebiom.2026.106200_bib82","doi-asserted-by":"crossref","DOI":"10.1186\/s12970-021-00442-4","article-title":"Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study","volume":"18","author":"Liao","year":"2021","journal-title":"J Int Soc Sport Nutr"},{"key":"10.1016\/j.ebiom.2026.106200_bib83","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.abe9985","article-title":"Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women","volume":"372","author":"Yoshino","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2026.106200_bib84","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s42255-019-0161-5","article-title":"NAD+ homeostasis in health and disease","volume":"2","author":"Katsyuba","year":"2020","journal-title":"Nat Metab"},{"key":"10.1016\/j.ebiom.2026.106200_bib85","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat Rev Mol Cell Bio"},{"key":"10.1016\/j.ebiom.2026.106200_bib86","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1507\/endocrj.EJ19-0313","article-title":"Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men","volume":"67","author":"Irie","year":"2020","journal-title":"Endocr J"},{"key":"10.1016\/j.ebiom.2026.106200_bib87","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.868640","article-title":"Oral administration of nicotinamide mononucleotide is safe and efficiently increases blood nicotinamide adenine dinucleotide levels in healthy subjects","volume":"9","author":"Okabe","year":"2022","journal-title":"Front Nutr"},{"key":"10.1016\/j.ebiom.2026.106200_bib88","article-title":"Citation-classic - quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man","volume":"18","author":"Freireich","year":"1986","journal-title":"Cancer Chemother Rep"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426000824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426000824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:01:30Z","timestamp":1783972890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426000824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":88,"alternative-id":["S2352396426000824"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106200","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circadian rhythm disruption impairs ovarian follicular development via NAD+ metabolic reprogramming","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106200"}}