{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:06:18Z","timestamp":1783976778450,"version":"3.55.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ebiom.2026.106201","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:01:32Z","timestamp":1773309692000},"page":"106201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Non-polio enterovirus infection and electrophysiological changes in human iPSC-derived neural networks"],"prefix":"10.1016","volume":"126","author":[{"given":"Feline F.W.","family":"Benavides","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syriam Sooksawasdi","family":"Na Ayudhya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley K.","family":"Pereirinha da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Power","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willemijn F.","family":"Rijnink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auriane","family":"Deguergue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke M.S.","family":"de Vrij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"van Riel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Lanko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-7284","authenticated-orcid":false,"given":"Lisa","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2026.106201_bib1","article-title":"Enterovirus circulation in the WHO European region, 2015-2022: a comparison of data from WHO's three core poliovirus surveillance systems and the European Non-Polio enterovirus Network (ENPEN)","volume":"53","author":"Harvala","year":"2025","journal-title":"Lancet Reg Health Eur"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106201_bib2","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.54909","article-title":"Circulation of rhinoviruses and\/or enteroviruses in pediatric patients with acute respiratory illness before and during the COVID-19 pandemic in the US","volume":"6","author":"Rankin","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106201_bib3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3390\/v17050673","article-title":"Return of the biennial circulation of enterovirus D68 in Colorado children in 2024 following the large 2022 outbreak","volume":"17","author":"Nguyen-Tran","year":"2025","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib4","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1093\/infdis\/jiaf179","article-title":"Epidemiological and clinical insights into enterovirus circulation in Europe, 2018 - 2023: a multi-center retrospective surveillance study","volume":"232","author":"de Schrijver","year":"2025","journal-title":"J Infect Dis"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106201_bib5","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jmii.2019.08.018","article-title":"Enteroviral infection in neonates","volume":"52","author":"Chuang","year":"2019","journal-title":"J Microbiol Immunol Infect"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106201_bib6","first-page":"383","article-title":"Nonpolio enterovirus infection in the neonate and young infant","volume":"10","author":"Hawkes","year":"2005","journal-title":"Paediatr Child Health"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib7","doi-asserted-by":"crossref","first-page":"e02215","DOI":"10.1128\/spectrum.02215-21","article-title":"Enterovirus infections in solid organ transplant recipients: a clinical comparison from a regional university hospital in the Netherlands","volume":"10","author":"Cassidy","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.ebiom.2026.106201_bib8","article-title":"Enterovirus-D68 - a reemerging non-polio enterovirus that causes severe respiratory and neurological disease in children","volume":"4","author":"Grizer","year":"2024","journal-title":"Front Virol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12929-024-01058-x","article-title":"Enteroviruses: epidemic potential, challenges and opportunities with vaccines","volume":"31","author":"Jartti","year":"2024","journal-title":"J Biomed Sci"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106201_bib10","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3390\/v16071165","article-title":"Epidemiology of Enterovirus genotypes in association with human diseases","volume":"16","author":"Xie","year":"2024","journal-title":"Viruses"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106201_bib11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/cid\/cix319","article-title":"Epidemiology of Meningitis and Encephalitis in the United States, 2011-2014","volume":"65","author":"Hasbun","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106201_bib12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.diagmicrobio.2018.10.012","article-title":"Cost of managing meningitis and encephalitis among infants and children in the United States","volume":"93","author":"Balada-Llasat","year":"2019","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib13","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1186\/s12879-017-2572-9","article-title":"Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study","volume":"17","author":"Ai","year":"2017","journal-title":"BMC Infect Dis"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106201_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.15585\/mmwr.mm7304a1","article-title":"Surveillance for acute flaccid myelitis - United States, 2018-2022","volume":"73","author":"Whitehouse","year":"2024","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106201_bib15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S1473-3099(19)30632-2","article-title":"Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: an observational cohort study","volume":"20","author":"Messacar","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/jambio\/lxae311","article-title":"Human enteroviruses and the long road to acute flacid paralysis eradication","volume":"136","author":"Bosch","year":"2025","journal-title":"J Appl Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12929-019-0573-2","article-title":"The history of enterovirus A71 outbreaks and molecular epidemiology in the Asia-Pacific Region","volume":"26","author":"Puenpa","year":"2019","journal-title":"J Biomed Sci"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106201_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.70372","article-title":"Outbreak of enterovirus D68 in young children, Brescia, Italy, August to November 2024","volume":"97","author":"Messali","year":"2025","journal-title":"J Med Virol"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106201_bib19","doi-asserted-by":"crossref","first-page":"e0046925","DOI":"10.1128\/jcm.00469-25","article-title":"Enhanced genomic surveillance of enteroviruses reveals a surge in enterovirus D68 cases, the Johns Hopkins health system, Maryland, 2024","volume":"63","author":"Fall","year":"2025","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ebiom.2026.106201_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2025.105785","article-title":"Sustained circulation of enterovirus D68 in Europe in 2023 and the continued evolution of enterovirus D68 B3-lineages associated with distinct amino acid substitutions in VP1 protein","volume":"178","author":"Hirvonen","year":"2025","journal-title":"J Clin Virol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib21","doi-asserted-by":"crossref","DOI":"10.1093\/jpids\/piae069","article-title":"Enterovirus and parechovirus neurologic infections in children: clinical presentations and neuropathogenesis","volume":"14","author":"Freeman","year":"2025","journal-title":"J Pediatric Infect Dis Soc"},{"issue":"Pt 7","key":"10.1016\/j.ebiom.2026.106201_bib22","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1099\/vir.0.000103","article-title":"Differential permissivity of human cerebrovascular endothelial cells to enterovirus infection and specificities of serotype EV-A71 in crossing an in vitro model of the human blood\u2013brain barrier","volume":"96","author":"Volle","year":"2015","journal-title":"J Gen Virol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106201_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00690-24","article-title":"Enterovirus A71 crosses a human blood-brain barrier model through infected immune cells","volume":"12","author":"Gaume","year":"2024","journal-title":"Microbiol Spectr"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106201_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00526-23","article-title":"Human B cells and dendritic cells are susceptible and permissive to enterovirus D68 infection","volume":"9","author":"Laksono","year":"2024","journal-title":"mSphere"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106201_bib25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3174\/ajnr.A4188","article-title":"MRI findings in children with acute flaccid paralysis and cranial nerve dysfunction occurring during the 2014 enterovirus D68 outbreak","volume":"36","author":"Maloney","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106201_bib26","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3109\/00207454.2012.657379","article-title":"MRI findings of neurological complications in hand-foot-mouth disease by enterovirus 71 infection","volume":"122","author":"Li","year":"2012","journal-title":"Int J Neurosci"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106201_bib27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/nen.0b013e318163a990","article-title":"The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways","volume":"67","author":"Wong","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.ebiom.2026.106201_bib28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fcimb.2016.00192","article-title":"The preferential infection of astrocytes by Enterovirus 71 plays a key role in the viral neurogenic pathogenesis","volume":"6","author":"Feng","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"issue":"21","key":"10.1016\/j.ebiom.2026.106201_bib29","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMc2118155","article-title":"Enterovirus D68 in the anterior horn cells of a child with acute flaccid myelitis","volume":"386","author":"Vogt","year":"2022","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106201_bib30","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.humpath.2009.01.015","article-title":"Neuropathology in 2 cases of fatal enterovirus type 71 infection from a recent epidemic in the People's Republic of China: a histopathologic, immunohistochemical, and reverse transcription polymerase chain reaction study","volume":"40","author":"Yang","year":"2009","journal-title":"Hum Pathol"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106201_bib31","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1056\/NEJMoa065954","article-title":"Neurodevelopment and cognition in children after enterovirus 71 infection","volume":"356","author":"Chang","year":"2007","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106201_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0013039","article-title":"Clinical characteristics and severity of hand, foot, and mouth disease by virus serotype: a prospective hospital-based cohort study","volume":"19","author":"Li","year":"2025","journal-title":"PLoS Negl Trop Dis"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106201_bib33","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1523\/JNEUROSCI.1740-17.2018","article-title":"Long-Term neuroinflammation induced by influenza A virus infection and the impact on Hippocampal Neuron morphology and function","volume":"38","author":"Hosseini","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.ebiom.2026.106201_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbrc.2020.12.092","article-title":"Spatial learning and memory impaired after infection of non-neurotropic influenza virus in BALB\/c male mice","volume":"540","author":"Gu","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ebiom.2026.106201_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.115020","article-title":"SARS-CoV-2 spike S1 protein induces microglial NLRP3-dependent neuroinflammation and cognitive impairment in mice","volume":"383","author":"Jiang","year":"2025","journal-title":"Exp Neurol"},{"key":"10.1016\/j.ebiom.2026.106201_bib36","article-title":"Decreased Na(+) influx lowers hippocampal neuronal excitability in a mouse model of neonatal influenza infection","volume":"5","author":"Park","year":"2015","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106201_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00245-23","article-title":"Enterovirus D-68 infection of primary rat cortical neurons: entry, replication, and functional consequences","volume":"14","author":"Poelaert","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.ebiom.2026.106201_bib38","first-page":"119","article-title":"Rapid neuronal differentiation of induced pluripotent stem cells for measuring network activity on micro-electrode arrays","volume":"8","author":"Frega","year":"2017","journal-title":"J Vis Exp"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106201_bib39","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.neuron.2013.05.029","article-title":"Rapid single-step induction of functional neurons from human pluripotent stem cells","volume":"78","author":"Zhang","year":"2013","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106201_bib40","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0148-24.2024","article-title":"Human pluripotent stem cell-derived Astrocyte functionality compares favorably with primary rat astrocytes","volume":"11","author":"Lendemeijer","year":"2024","journal-title":"eNeuro"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106201_bib41","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/mp.2017.56","article-title":"A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells","volume":"23","author":"Gunhanlar","year":"2018","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.ebiom.2026.106201_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2021.102386","article-title":"Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies","volume":"54","author":"Shih","year":"2021","journal-title":"Stem Cell Res"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106201_bib43","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00270-21","article-title":"Replication kinetics, cell tropism, and associated immune responses in SARS-CoV-2- and H5N1 virus-infected human induced pluripotent stem cell-derived neural models","volume":"6","author":"Bauer","year":"2021","journal-title":"mSphere"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106201_bib44","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty per cent ENDPOINTS12","volume":"27","author":"Reed","year":"1938","journal-title":"Am J Epidemiol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106201_bib46","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.stemcr.2022.07.012","article-title":"Development of a platform to investigate long-term potentiation in human iPSC-derived neuronal networks","volume":"17","author":"Pr\u00e9","year":"2022","journal-title":"Stem Cell Reports"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106201_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000904","article-title":"Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C","volume":"18","author":"Bauer","year":"2020","journal-title":"PLoS Biol"},{"key":"10.1016\/j.ebiom.2026.106201_bib48","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00521-009-0307-6","article-title":"A comparison of binless spike train measures","volume":"19","author":"Paiva","year":"2010","journal-title":"Neural Comput Appl"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib49","doi-asserted-by":"crossref","first-page":"9110","DOI":"10.1038\/s41598-021-88675-w","article-title":"Development of an objective index, neural activity score (NAS), reveals neural network ontogeny and treatment effects on microelectrode arrays","volume":"11","author":"Passaro","year":"2021","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41597-022-01242-4","article-title":"Comparative microelectrode array data of the functional development of hPSC-derived and rat neuronal networks","volume":"9","author":"Kapucu","year":"2022","journal-title":"Sci Data"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106201_bib51","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1021\/acsinfecdis.5c00063","article-title":"Sialic acid-containing glycolipids extend the receptor repertoire of Enterovirus-D68","volume":"11","author":"Pereirinha da Silva","year":"2025","journal-title":"ACS Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib52","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.1038\/s41467-025-60727-z","article-title":"Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells","volume":"16","author":"Wang","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106201_bib53","series-title":"Viral and Fungal Infections of the Central Nervous System: a Microbiological Perspective","first-page":"97","article-title":"Enterovirus-associated meningoencephalitis and enteroviruses in patients with acute encephalitis","author":"Halawani","year":"2023"},{"key":"10.1016\/j.ebiom.2026.106201_bib54","article-title":"Human assembloid model of emergent neurotropic enteroviruses","author":"Peters","year":"2025","journal-title":"bioRxiv"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106201_bib55","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00425-23","article-title":"Enterovirus D68 infection induces TDP-43 cleavage, aggregation, and neurotoxicity","volume":"97","author":"Zhang","year":"2023","journal-title":"J Virol"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106201_bib56","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02370-19","article-title":"Neurotropism of enterovirus D68 isolates is independent of sialic acid and is not a recently acquired phenotype","volume":"10","author":"Rosenfeld","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.ebiom.2026.106201_bib57","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.virol.2014.09.017","article-title":"Enterovirus 71 infects brain-derived neural progenitor cells","volume":"468\u2013470","author":"Huang","year":"2014","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib58","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12974-024-03275-5","article-title":"Antiviral immunity within neural stem cells distinguishes Enterovirus-D68 strain differences in forebrain organoids","volume":"21","author":"Vazquez","year":"2024","journal-title":"J Neuroinflammation"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106201_bib59","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01694-22","article-title":"Enterovirus D68 infection in human primary airway and brain organoids: no additional role for heparan sulfate binding for neurotropism","volume":"10","author":"Sridhar","year":"2022","journal-title":"Microbiol Spectr"},{"issue":"16","key":"10.1016\/j.ebiom.2026.106201_bib60","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00578-19","article-title":"Contemporary circulating enterovirus D68 strains infect and undergo retrograde axonal transport in spinal motor neurons independent of sialic acid","volume":"93","author":"Hixon","year":"2019","journal-title":"J Virol"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106201_bib61","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01954-18","article-title":"Contemporary circulating enterovirus D68 strains have acquired the capacity for viral entry and replication in human neuronal cells","volume":"9","author":"Brown","year":"2018","journal-title":"mBio"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106201_bib62","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/v10030139","article-title":"Enterovirus transmission by secretory autophagy","volume":"10","author":"Mutsafi","year":"2018","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib63","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1080\/21505594.2020.1766790","article-title":"Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation","volume":"11","author":"You","year":"2020","journal-title":"Virulence"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106201_bib64","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1111\/j.1462-5822.2007.00988.x","article-title":"Enterovirus 71 triggering of neuronal apoptosis through activation of Abl-Cdk5 signalling","volume":"9","author":"Chen","year":"2007","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.ebiom.2026.106201_bib65","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.virol.2018.05.025","article-title":"Pyroptosis induced by enterovirus A71 infection in cultured human neuroblastoma cells","volume":"521","author":"Zhu","year":"2018","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib66","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2024.2382235","article-title":"Enterovirus-A71 preferentially infects and replicates in human motor neurons, inducing neurodegeneration by ferroptosis","volume":"13","author":"Chooi","year":"2024","journal-title":"Emerg Microbes Infect"},{"issue":"10","key":"10.1016\/j.ebiom.2026.106201_bib67","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/iub.1434","article-title":"Enterovirus 71 infection caused neuronal cell death and cytokine expression in cultured rat neural cells","volume":"67","author":"Chang","year":"2015","journal-title":"IUBMB Life"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106201_bib68","article-title":"Calcium-Dependent hyperexcitability in Human stem cell-derived rett syndrome neuronal networks","volume":"4","author":"Pradeepan","year":"2024","journal-title":"Biol Psychiatry Glob Open Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib69","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1038\/s41467-019-12947-3","article-title":"Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling","volume":"10","author":"Frega","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106201_bib70","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1038\/s41467-024-46634-9","article-title":"Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease","volume":"15","author":"Capendale","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106201_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2024.105664","article-title":"Enterovirus and parechovirus meningoencephalitis in infants: a ten-year prospective observational study in a neonatal intensive care unit","volume":"173","author":"Pietrasanta","year":"2024","journal-title":"J Clin Virol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106201_bib73","doi-asserted-by":"crossref","first-page":"793","DOI":"10.5858\/2010-0174-CR.1","article-title":"A fatal central nervous system enterovirus 68 infection","volume":"135","author":"Kreuter","year":"2011","journal-title":"Arch Pathol Lab Med"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106201_bib74","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0022-3476(98)70155-6","article-title":"Fatal enterovirus 71 encephalomyelitis","volume":"133","author":"Lum","year":"1998","journal-title":"J Pediatr"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426000836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426000836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:04:13Z","timestamp":1783973053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426000836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":73,"alternative-id":["S2352396426000836"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106201","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-polio enterovirus infection and electrophysiological changes in human iPSC-derived neural networks","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106201","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106201"}}