{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:19:33Z","timestamp":1788985173925,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018703","name":"European Innovation Council","doi-asserted-by":"publisher","award":["681032"],"award-info":[{"award-number":["681032"]}],"id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-10-INBS-05-02"],"award-info":[{"award-number":["ANR-10-INBS-05-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-10-LABX-77"],"award-info":[{"award-number":["ANR-10-LABX-77"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-17-EURE-0003"],"award-info":[{"award-number":["ANR-17-EURE-0003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005626","name":"Universit\u00e4t Regensburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005626","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006489","name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012948","name":"Minist\u00e8re de l'Enseignement sup\u00e9rieur, de la Recherche et de l'Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["12964"],"award-info":[{"award-number":["12964"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["gp120 10\\u20131074 mAb"],"award-info":[{"award-number":["gp120 10\\u20131074 mAb"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["ARP-2426"],"award-info":[{"award-number":["ARP-2426"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["ARP-8662"],"award-info":[{"award-number":["ARP-8662"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["ARP-12477"],"award-info":[{"award-number":["ARP-12477"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["93MW965.26"],"award-info":[{"award-number":["93MW965.26"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["96ZM651"],"award-info":[{"award-number":["96ZM651"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HRP-10463"],"award-info":[{"award-number":["HRP-10463"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["HRP-8129"],"award-info":[{"award-number":["HRP-8129"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011658","name":"French Infrastructure for Integrated Structural Biology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011045","name":"Minist\u00e8re de l'Enseignement sup\u00e9rieur et de la Recherche","doi-asserted-by":"publisher","award":["ED SVS 402"],"award-info":[{"award-number":["ED SVS 402"]}],"id":[{"id":"10.13039\/501100011045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ebiom.2026.106269","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:06:31Z","timestamp":1777935991000},"page":"106269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Antibody-mediated targeting of SOSIP HIV-1 Env to skin Langerhans cells potentiates humoral responses"],"prefix":"10.1016","volume":"127","author":[{"given":"Adele","family":"Hammoudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Surenaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Legros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Hypolite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Manso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba","family":"Agyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Kembou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Sicherre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Flor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borys","family":"Pedenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Guilligay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahar","family":"Bouceba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Fenwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Moog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Zurawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Zurawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pantaleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5532-4959","authenticated-orcid":false,"given":"Winfried","family":"Weissenhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Centlivre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Godot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"L\u00e9vy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2650-1108","authenticated-orcid":false,"given":"Sylvain","family":"Cardinaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2026.106269_bib1","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa0908492","article-title":"Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand","volume":"361","author":"Rerks-Ngarm","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ebiom.2026.106269_bib2","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3390\/vaccines13070690","article-title":"Progress and recent developments in HIV vaccine research","volume":"13","author":"Shim","year":"2025","journal-title":"Vaccines"},{"key":"10.1016\/j.ebiom.2026.106269_bib3","doi-asserted-by":"crossref","DOI":"10.2174\/011570162X358302250206074255","article-title":"The germline targeting vaccine concept: overview and updates from HIV pre-clinical and clinical trials","volume":"23","author":"Stamatatos","year":"2025","journal-title":"CHR"},{"key":"10.1016\/j.ebiom.2026.106269_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/science.add6502","article-title":"Vaccination induces HIV broadly neutralizing antibody precursors in humans","volume":"378","author":"Leggat","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2026.106269_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/science.adr8382","article-title":"Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans","volume":"389","author":"Willis","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2026.106269_bib6","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1016\/j.cell.2024.04.033","article-title":"Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans","volume":"187","author":"Williams","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2026.106269_bib7","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20240604","article-title":"Use of 3M-052-AF with alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies","volume":"221","author":"Hahn","year":"2024","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2026.106269_bib8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41541-025-01168-z","article-title":"Optimizing human B cell repertoire analyses to interpret clinical data and design sequential HIV vaccines","volume":"10","author":"Maciel","year":"2025","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.ebiom.2026.106269_bib9","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.cell.2019.04.012","article-title":"Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance","volume":"177","author":"Cirelli","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2026.106269_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/JCI185292","article-title":"The saponin monophosphoryl lipid A nanoparticle adjuvant induces dose-dependent HIV vaccine responses in nonhuman Primates","volume":"135","author":"Ramezani-Rad","year":"2025","journal-title":"J Clin Investig"},{"key":"10.1016\/j.ebiom.2026.106269_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature06175","article-title":"Taking dendritic cells into medicine","volume":"449","author":"Steinman","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2026.106269_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104062","article-title":"Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine","volume":"80","author":"Col\u00e9on","year":"2022","journal-title":"eBioMedicine"},{"key":"10.1016\/j.ebiom.2026.106269_bib13","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1172\/JCI99005","article-title":"TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs","volume":"128","author":"Cheng","year":"2018","journal-title":"J Clin Investig"},{"key":"10.1016\/j.ebiom.2026.106269_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-25382-0","article-title":"Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques","author":"Marlin","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106269_bib15","article-title":"A vaccine targeting antigen-presenting cells through CD40 induces protective immunity against Nipah disease","volume":"5","author":"Pastor","year":"2024","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.ebiom.2026.106269_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102845","article-title":"Safety and immunogenicity of CD40.HIVRI.Env, a dendritic cell-based HIV vaccine, in healthy HIV-uninfected adults: a first-in-human randomized, placebo-controlled, dose-escalation study (ANRS VRI06)","volume":"77","author":"L\u00e9vy","year":"2024","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.ebiom.2026.106269_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.humimm.2009.02.004","article-title":"Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines","volume":"70","author":"Klechevsky","year":"2009","journal-title":"Hum Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.949779","article-title":"Refining the DC-targeting vaccination for preventing emerging infectious diseases","volume":"13","author":"Pastor","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/vaccines4020008","article-title":"Direct delivery of antigens to dendritic cells via antibodies specific for endocytic receptors as a promising strategy for future therapies","volume":"4","author":"Lehmann","year":"2016","journal-title":"Vaccines"},{"key":"10.1016\/j.ebiom.2026.106269_bib20","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.4049\/jimmunol.1102390","article-title":"Noncovalent assembly of anti-dendritic cell antibodies and antigens for evoking immune responses in vitro and in vivo","volume":"189","author":"Flamar","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib21","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.jid.2017.04.016","article-title":"Critical role for skin-derived migratory DCs and langerhans cells in TFH and GC responses after intradermal immunization","volume":"137","author":"Levin","year":"2017","journal-title":"J Investig Dermatol"},{"key":"10.1016\/j.ebiom.2026.106269_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2019.01134","article-title":"DC subsets regulate humoral immune responses by supporting the differentiation of distinct TFH cells","volume":"10","author":"Bouteau","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib23","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.jaci.2015.04.001","article-title":"Skin dendritic cells induce follicular helper T cells and protective humoral immune responses","volume":"136","author":"Yao","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib24","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.4049\/jimmunol.1303339","article-title":"Macrophage- and neutrophil-derived TNF- instructs skin langerhans cells to prime antiviral immune responses","volume":"193","author":"Epaulard","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib25","first-page":"1","article-title":"Intradermal injection of an anti-Langerin-HIVGag fusion vaccine targets epidermal Langerhans cells in non-human primates and can be tracked in vivo","volume":"17","author":"Salabert","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009749","article-title":"Targeting human langerin promotes HIV-1 specific humoral immune responses","volume":"17","author":"Kervevan","year":"2021","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ebiom.2026.106269_bib27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41541-025-01214-w","article-title":"Targeting Langerhans cells via skin delivery of HIV Envelope enhances the antibody response to vaccination","volume":"10","author":"Lanza","year":"2025","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.ebiom.2026.106269_bib28","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1128\/JVI.03451-14","article-title":"Single-chain soluble BG505.SOSIP gp140 trimers as structural and antigenic mimics of mature closed HIV-1 env","volume":"89","author":"Georgiev","year":"2015","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2026.106269_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003618","article-title":"A next-generation cleaved, soluble HIV-1 env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies","volume":"9","author":"Sanders","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ebiom.2026.106269_bib30","doi-asserted-by":"crossref","first-page":"9503","DOI":"10.1038\/s41467-024-53120-9","article-title":"Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies","volume":"15","author":"Henderson","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106269_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41401-025-01535-5","article-title":"The conformational epitope of a gp41-specific mucosal protective IgA binds to the HIV-1 envelope and neutralizes infection","author":"Sahnoune","year":"2025","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.ebiom.2026.106269_bib32","first-page":"1","article-title":"Changes in SARS-CoV-2 spike versus nucleoprotein antibody responses impact the estimates of infections in population-based seroprevalence studies","volume":"95","author":"Fenwick","year":"2020","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2026.106269_bib33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.ebiom.2026.106269_bib34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/pro.3235","article-title":"UCSF ChimeraX: meeting modern challenges in visualization and analysis","volume":"27","author":"Goddard","year":"2018","journal-title":"Protein Sci"},{"key":"10.1016\/j.ebiom.2026.106269_bib35","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1128\/JVI.76.9.4634-4642.2002","article-title":"Highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of T4 bacteriophage fibritin","volume":"76","author":"Yang","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2026.106269_bib36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.virol.2009.07.041","article-title":"Cross-reactive monoclonal antibodies to multiple HIV-1 subtype and SIVcpz envelope glycoproteinsHIS","volume":"394","author":"Gao","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.ebiom.2026.106269_bib37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.smim.2007.12.001","article-title":"Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function","volume":"20","author":"Allen","year":"2008","journal-title":"Semin Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101477","article-title":"Safety and immunogenicity of an HIV-1 prefusion-stabilized envelope trimer (trimer 4571) vaccine in healthy adults: a first-in-human open-label, randomized, dose-escalation, phase 1 clinical trial","volume":"48","author":"Houser","year":"2022","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.ebiom.2026.106269_bib39","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1073\/pnas.1019547108","article-title":"Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A","volume":"108","author":"Idoyaga","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ebiom.2026.106269_bib40","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/cmi.2015.87","article-title":"Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells","volume":"14","author":"Fehres","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib41","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.jid.2017.06.014","article-title":"Langerhans cells orchestrate TFH-dependent humoral immunity","volume":"137","author":"Vardam","year":"2017","journal-title":"J Investig Dermatol"},{"key":"10.1016\/j.ebiom.2026.106269_bib42","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1002\/eji.201344263","article-title":"Langerhans cells promote early germinal center formation in response to Leishmania-derived cutaneous antigens","volume":"44","author":"Zimara","year":"2014","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2016.00225","article-title":"How follicular dendritic cells shape the B-Cell antigenome","volume":"7","author":"Kranich","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib44","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1084\/jem.20111449","article-title":"Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers","volume":"208","author":"Wang","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2026.106269_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1611812","article-title":"Langerhans cells drive Tfh and B cell responses independent of canonical cytokine signals","volume":"16","author":"Bouteau","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2026.106269_bib46","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jim.2008.11.012","article-title":"A method for identification of HIV gp140 binding memory B cells in human blood","volume":"343","author":"Scheid","year":"2009","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.ebiom.2026.106269_bib47","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1128\/JVI.02252-09","article-title":"Breadth of neutralizing antibodies elicited by stable, homogeneous clade A and clade C HIV-1 gp140 envelope trimers in Guinea pigs","volume":"84","author":"Nkolola","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2026.106269_bib48","doi-asserted-by":"crossref","first-page":"7436","DOI":"10.1074\/jbc.M114.620534","article-title":"Immunosilencing a highly immunogenic protein trimerization domain","volume":"290","author":"Sliepen","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ebiom.2026.106269_bib49","article-title":"Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens","volume":"3","author":"Kraft","year":"2022","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.ebiom.2026.106269_bib50","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/j.celrep.2016.07.074","article-title":"Holes in the glycan shield of the native HIV envelope are a target of trimer-elicited neutralizing antibodies","volume":"16","author":"McCoy","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.ebiom.2026.106269_bib51","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1038\/s41467-019-12080-1","article-title":"Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle","volume":"10","author":"Brouwer","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106269_bib52","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adm7097","article-title":"Immunization with germ line\u2013targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques","volume":"9","author":"Nelson","year":"2024","journal-title":"Sci Immunol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426001519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426001519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:40:27Z","timestamp":1783168827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426001519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":52,"alternative-id":["S2352396426001519"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106269","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibody-mediated targeting of SOSIP HIV-1 Env to skin Langerhans cells potentiates humoral responses","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106269","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106269"}}