{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:21:12Z","timestamp":1783084872245,"version":"3.54.6"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR 5705"],"award-info":[{"award-number":["FOR 5705"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["516868494"],"award-info":[{"award-number":["516868494"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["518551069"],"award-info":[{"award-number":["518551069"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["247354600"],"award-info":[{"award-number":["247354600"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["247377969"],"award-info":[{"award-number":["247377969"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["426788273"],"award-info":[{"award-number":["426788273"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["523862973"],"award-info":[{"award-number":["523862973"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["865026"],"award-info":[{"award-number":["865026"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030B_201271"],"award-info":[{"award-number":["310030B_201271"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_215050"],"award-info":[{"award-number":["310030_215050"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung Technologie und Raumfahrt Informationstechnikzentrum Bund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003493","name":"Hertie Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003493","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007458","name":"German Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kroner-Fresenius Foundation","doi-asserted-by":"publisher","award":["2023_EKMS.03"],"award-info":[{"award-number":["2023_EKMS.03"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ebiom.2026.106282","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:14:33Z","timestamp":1778138073000},"page":"106282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The presynaptic protein bassoon is a biofluid biomarker of synaptic pathology in multiple sclerosis"],"prefix":"10.1016","volume":"128","author":[{"given":"Marcel S.","family":"Woo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Rothammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-2311","authenticated-orcid":false,"given":"Lukas C.","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Krisp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Kreutzfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-1517","authenticated-orcid":false,"given":"Susanne","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Maleska Maceski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9183-0381","authenticated-orcid":false,"given":"Bente","family":"Siebels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Raich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-7070","authenticated-orcid":false,"given":"Ingo","family":"Winschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Willing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-9073","authenticated-orcid":false,"given":"Benjamin","family":"Schattling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Schl\u00fcter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina C.","family":"Rosenkranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Kuhle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Patrick","family":"Stellmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3169-2076","authenticated-orcid":false,"given":"Jan Broder","family":"Engler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Merkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-2420","authenticated-orcid":false,"given":"Manuel A.","family":"Friese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2026.106282_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(23)01473-3","article-title":"Multiple sclerosis","volume":"403","author":"Jakimovski","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2026.106282_bib2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41583-024-00823-z","article-title":"The neuropathobiology of multiple sclerosis","volume":"25","author":"Woo","year":"2024","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ebiom.2026.106282_bib3","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1093\/brain\/awac111","article-title":"Progression is independent of relapse activity in early multiple sclerosis: a real-life cohort study","volume":"145","author":"Portaccio","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.ebiom.2026.106282_bib4","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jamaneurol.2020.1568","article-title":"Contribution of relapse-independent progression vs relapse-associated worsening to overall confirmed disability accumulation in typical relapsing multiple sclerosis in a pooled analysis of 2 randomized clinical trials","volume":"77","author":"Kappos","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.ebiom.2026.106282_bib5","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1001\/jamaneurol.2022.1025","article-title":"Association of brain atrophy with disease progression independent of relapse activity in patients with relapsing multiple sclerosis","volume":"79","author":"Cagol","year":"2022","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.ebiom.2026.106282_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-022-00718-z","article-title":"The immunology of multiple sclerosis","author":"Attfield","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ebiom.2026.106282_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/brain\/awv353","article-title":"Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis","volume":"139","author":"J\u00fcrgens","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.ebiom.2026.106282_bib8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41593-020-00780-7","article-title":"Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation","volume":"24","author":"Jafari","year":"2021","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ebiom.2026.106282_bib9","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201290","article-title":"Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation","volume":"218","author":"Woo","year":"2021","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2026.106282_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.104970","article-title":"Guidance for use of neurofilament light chain as a cerebrospinal fluid and blood biomarker in multiple sclerosis management","volume":"101","author":"Freedman","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2026.106282_bib11","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200335","article-title":"Temporal dynamics of plasma neurofilament light in blood donors with preclinical multiple sclerosis","volume":"12","author":"Britze","year":"2025","journal-title":"Neurol Neuroimmunol Neuroinflammation"},{"key":"10.1016\/j.ebiom.2026.106282_bib12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2026.106282_bib13","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200052","article-title":"Serum GFAP and NfL levels differentiate subsequent progression and disease activity in patients with progressive multiple sclerosis","volume":"10","author":"Barro","year":"2023","journal-title":"Neurol Neuroimmunol Neuroinflammation"},{"key":"10.1016\/j.ebiom.2026.106282_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1001\/jamaneurol.2022.5250","article-title":"Serum glial fibrillary acidic protein compared with neurofilament light chain as a biomarker for disease progression in multiple sclerosis","volume":"80","author":"Meier","year":"2023","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.ebiom.2026.106282_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67934-2","article-title":"Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity","volume":"10","author":"Ayrignac","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2026.106282_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-75290-8","article-title":"The combination of CSF neurofilament light chain and glial fibrillary acidic protein improves the prediction of long-term confirmed disability worsening in multiple sclerosis","volume":"14","author":"Thebault","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2026.106282_bib17","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200435","article-title":"Synaptic density in multiple sclerosis","volume":"12","author":"Luoma","year":"2025","journal-title":"Neurol Neuroimmunol Neuroinflammation"},{"key":"10.1016\/j.ebiom.2026.106282_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adt5585","article-title":"SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis","volume":"17","author":"Ullrich Gavilanes","year":"2025","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ebiom.2026.106282_bib19","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/s41591-025-03565-2","article-title":"A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease","volume":"31","author":"Oh","year":"2025","journal-title":"Nat Med"},{"key":"10.1016\/j.ebiom.2026.106282_bib20","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/s41593-019-0385-4","article-title":"Bassoon proteinopathy drives neurodegeneration in multiple sclerosis","volume":"22","author":"Schattling","year":"2019","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ebiom.2026.106282_bib21","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1016\/j.cell.2025.05.029","article-title":"The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis","volume":"188","author":"Woo","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2026.106282_bib22","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1016\/j.cell.2024.05.031","article-title":"STING orchestrates the neuronal inflammatory stress response in multiple sclerosis","volume":"187","author":"Woo","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.ebiom.2026.106282_bib23","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.3390\/cancers11111690","article-title":"Successful targeting of the warburg effect in prostate cancer by glucose-conjugated 1,4-Naphthoquinones","volume":"11","author":"Dyshlovoy","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ebiom.2026.106282_bib24","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S1474-4422(22)00009-6","article-title":"Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study","volume":"21","author":"Benkert","year":"2022","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ebiom.2026.106282_bib25","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/jnnp-2023-331183","article-title":"Visual function resists early neurodegeneration in the visual system in primary progressive multiple sclerosis","volume":"94","author":"Rosenkranz","year":"2023","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.ebiom.2026.106282_bib26","series-title":"Distinct molecular trajectories precede amyloid-\u03b2 and tau pathology in Alzheimer's disease","author":"Woo","year":"2026"},{"key":"10.1016\/j.ebiom.2026.106282_bib27","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J Stat Softw"},{"key":"10.1016\/j.ebiom.2026.106282_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.70018","article-title":"Tidyplots empowers life scientists with easy code-based data visualization","author":"Engler","year":"2025","journal-title":"IMeta"},{"key":"10.1016\/j.ebiom.2026.106282_bib29","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omi A J Integr Biol"},{"key":"10.1016\/j.ebiom.2026.106282_bib30","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000010131","article-title":"Dissection of synaptic pathways through the CSF biomarkers for predicting Alzheimer disease","volume":"95","author":"Tible","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.ebiom.2026.106282_bib31","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/s41380-023-02376-6","article-title":"Monitoring synaptic pathology in Alzheimer's disease through fluid and PET imaging biomarkers: a comprehensive review and future perspectives","volume":"29","author":"Lista","year":"2024","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.ebiom.2026.106282_bib32","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nn835","article-title":"Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways","volume":"5","author":"Hardingham","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ebiom.2026.106282_bib33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bbi.2024.03.039","article-title":"Instability of excitatory synapses in experimental autoimmune encephalomyelitis and the outcome for excitatory circuit inputs to individual cortical neurons","volume":"119","author":"Gillani","year":"2024","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.ebiom.2026.106282_bib34","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00401-020-02258-z","article-title":"Selective vulnerability of inhibitory networks in multiple sclerosis","volume":"141","author":"Zoupi","year":"2021","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.ebiom.2026.106282_bib35","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/s41593-018-0193-2","article-title":"Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis","volume":"21","author":"Ellwardt","year":"2018","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ebiom.2026.106282_bib36","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.4161\/auto.21561","article-title":"Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke","volume":"8","author":"He","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.ebiom.2026.106282_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgae457","article-title":"Neuron-specific deficiency of autophagy increases neuronal loss in traumatic brain injury","volume":"3","author":"Pei","year":"2024","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.ebiom.2026.106282_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/cns.13229","article-title":"Regulation of hippocampal neuronal apoptosis and autophagy in mice with sepsis-associated encephalopathy by immunity-related GTPase M1","volume":"26","author":"Zhou","year":"2020","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.ebiom.2026.106282_bib39","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.neuron.2025.01.019","article-title":"Neuronal autophagy in the control of synapse function","volume":"113","author":"Karpova","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.ebiom.2026.106282_bib40","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.ebiom.2026.106282_bib41","doi-asserted-by":"crossref","first-page":"10256","DOI":"10.1523\/JNEUROSCI.0189-14.2014","article-title":"STAT1 regulates the homeostatic component of visual cortical plasticity via an AMPA receptor-mediated mechanism","volume":"34","author":"Nagakura","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.ebiom.2026.106282_bib42","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201847202","article-title":"Tau accumulation triggers STAT 1-dependent memory deficits by suppressing NMDA receptor expression","volume":"20","author":"Li","year":"2019","journal-title":"EMBO Rep"},{"key":"10.1016\/j.ebiom.2026.106282_bib43","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/npp.2013.263","article-title":"STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of A\u03b2","volume":"39","author":"Hsu","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ebiom.2026.106282_bib44","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/s41593-022-01191-6","article-title":"Bassoon contributes to tau-seed propagation and neurotoxicity","volume":"25","author":"Martinez","year":"2022","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ebiom.2026.106282_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/ejn.70066","article-title":"Bassoon, presynaptic scaffolding protein: narrative review in health and disease","volume":"61","author":"Kaladiyil","year":"2025","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.ebiom.2026.106282_bib46","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/neup.13009","article-title":"Pathological study of progressive supranuclear palsy the cases with mutations in Bassoon","volume":"45","author":"Wakita","year":"2025","journal-title":"Neuropathology"},{"key":"10.1016\/j.ebiom.2026.106282_bib47","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41598-018-19198-0","article-title":"Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome","volume":"8","author":"Yabe","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2026.106282_bib48","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/mds.29676","article-title":"The genetic drivers of juvenile, young, and early-onset parkinson\u2019s disease in India","volume":"39","author":"Andrews","year":"2024","journal-title":"Mov Disord"},{"key":"10.1016\/j.ebiom.2026.106282_bib49","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0896-6273(03)00088-6","article-title":"Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon","volume":"37","author":"Altrock","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.ebiom.2026.106282_bib50","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1136\/jmg-2022-108865","article-title":"Variants in BSN gene associated with epilepsy with favourable outcome","volume":"60","author":"Ye","year":"2023","journal-title":"J Med Genet"},{"key":"10.1016\/j.ebiom.2026.106282_bib51","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.neuroimage.2014.06.009","article-title":"Axonal transport rate decreased at the onset of optic neuritis in EAE mice","volume":"100","author":"Lin","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.ebiom.2026.106282_bib52","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.neuron.2014.11.006","article-title":"Pervasive axonal transport deficits in multiple sclerosis models","volume":"84","author":"Sorbara","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.ebiom.2026.106282_bib53","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/nan.12305","article-title":"Axonal motor protein KIF5A and associated cargo deficits in multiple sclerosis lesional and normal-appearing white matter","volume":"43","author":"Hares","year":"2017","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.ebiom.2026.106282_bib54","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s43587-025-00823-3","article-title":"Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease","volume":"5","author":"Cai","year":"2025","journal-title":"Nat Aging"},{"key":"10.1016\/j.ebiom.2026.106282_bib55","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/s41467-018-03509-0","article-title":"A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers","volume":"9","author":"Thibaudeau","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106282_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2024.105644","article-title":"Evaluating the utility of serum NfL, GFAP, UCHL1 and tTAU as estimates of CSF levels and diagnostic instrument in neuroinflammation and multiple sclerosis","volume":"87","author":"Koerbel","year":"2024","journal-title":"Mult Scler Relat Disord"},{"key":"10.1016\/j.ebiom.2026.106282_bib57","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1001\/jamaneurol.2021.3671","article-title":"Differences between plasma and cerebrospinal fluid glial fibrillary acidic protein levels across the alzheimer disease continuum","volume":"78","author":"Benedet","year":"2021","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.ebiom.2026.106282_bib58","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1038\/s41467-023-42834-x","article-title":"NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing","volume":"14","author":"Feng","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106282_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103590","article-title":"NfL predicts relapse-free progression in a longitudinal multiple sclerosis cohort study","volume":"72","author":"Uphaus","year":"2021","journal-title":"EBioMedicine"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426001647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426001647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:46:59Z","timestamp":1783082819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426001647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":59,"alternative-id":["S2352396426001647"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106282","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The presynaptic protein bassoon is a biofluid biomarker of synaptic pathology in multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106282","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106282"}}