{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:18:18Z","timestamp":1783142298548,"version":"3.54.6"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF23SA0087432"],"award-info":[{"award-number":["NNF23SA0087432"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["224600\/Z\/21\/Z"],"award-info":[{"award-number":["224600\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["223187\/Z\/21\/Z"],"award-info":[{"award-number":["223187\/Z\/21\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["219606\/Z\/19\/Z"],"award-info":[{"award-number":["219606\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["19\/0005971"],"award-info":[{"award-number":["19\/0005971"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ebiom.2026.106286","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T15:53:48Z","timestamp":1778342028000},"page":"106286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification of the ACTB p.Ser348Leu de novo variant in individuals with syndromic neonatal diabetes"],"prefix":"10.1016","volume":"128","author":[{"given":"Suhel","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Russ-Silsby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew N.","family":"Wakeling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Thunander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maritza","family":"Vivanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Caswell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Hattersley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashyap","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Flanagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1437-7891","authenticated-orcid":false,"given":"Elisa","family":"De Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2026.106286_bib1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00592-011-0331-8","article-title":"Minimal incidence of neonatal\/infancy onset diabetes in Italy is 1:90,000 live births","volume":"49","author":"Iafusco","year":"2012","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.ebiom.2026.106286_bib2","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s00125-009-1416-6","article-title":"Referral rates for diagnostic testing support an incidence of permanent neonatal diabetes in three European countries of at least 1 in 260,000 live births","volume":"52","author":"Slingerland","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.ebiom.2026.106286_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/pdi.2410","article-title":"An update on the diagnosis and management of monogenic diabetes","volume":"39","author":"Colclough","year":"2022","journal-title":"Pract Diabetes"},{"key":"10.1016\/j.ebiom.2026.106286_bib4","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/jdi.14312","article-title":"Neonatal diabetes mellitus around the world: update 2024","volume":"15","author":"Barbetti","year":"2024","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.ebiom.2026.106286_bib5","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ajhg.2019.03.018","article-title":"A specific CNOT1 mutation results in a novel syndrome of pancreatic agenesis and holoprosencephaly through impaired pancreatic and neurological development","volume":"104","author":"Franco","year":"2019","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2337\/db19-1029","article-title":"De novo mutations in EIF2B1 affecting eIF2 signaling cause neonatal\/early onset diabetes and transient hepatic dysfunction","volume":"69","author":"De Franco","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.ebiom.2026.106286_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ng.1035","article-title":"GATA6 haploinsufficiency causes pancreatic agenesis in humans","volume":"44","author":"Allen","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib8","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.2337\/db16-1296","article-title":"Dominant ER stress\u2013inducing WFS1 mutations underlie a genetic syndrome of Neonatal\/infancy-onset diabetes, congenital sensorineural deafness, and congenital cataracts","volume":"66","author":"De Franco","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.ebiom.2026.106286_bib9","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/ng.3040","article-title":"Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease","volume":"46","author":"Flanagan","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib10","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(15)60098-8","article-title":"The effect of early, comprehensive genomic testing on clinical care in neonatal diabetes: an international cohort study","volume":"386","author":"De Franco","year":"2015","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.ebiom.2026.106286_bib11","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/78085","article-title":"EIF2AK3, encoding translation initiation factor 2-\u03b1 kinase 3, is mutated in patients with Wolcott-Rallison syndrome","volume":"25","author":"Del\u00e9pine","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib12","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1093\/hmg\/ddl101","article-title":"A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes","volume":"15","author":"Proks","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib13","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S2213-8587(18)30106-2","article-title":"Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study","volume":"6","author":"Bowman","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.ebiom.2026.106286_bib14","doi-asserted-by":"crossref","first-page":"15040","DOI":"10.1073\/pnas.0707291104","article-title":"Insulin gene mutations as a cause of permanent neonatal diabetes","volume":"104","author":"St\u00f8y","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ebiom.2026.106286_bib15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ajhg.2020.05.017","article-title":"De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay","volume":"107","author":"Vissers","year":"2020","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib16","article-title":"A homozygous TARS2 variant is a novel cause of syndromic neonatal diabetes","volume":"42","author":"Donis","year":"2024","journal-title":"Diabet Med J Br Diabet Assoc"},{"key":"10.1016\/j.ebiom.2026.106286_bib17","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202216491","article-title":"Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP","volume":"15","author":"Perera","year":"2023","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.ebiom.2026.106286_bib18","first-page":"11.10.1","article-title":"From FastQ data to high confidence variant calls: the genome analysis toolkit best practices pipeline","volume":"11","author":"Van der Auwera","year":"2013","journal-title":"Curr Protoc Bioinforma Ed Board Andreas Baxevanis Al"},{"key":"10.1016\/j.ebiom.2026.106286_bib19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2026.106286_bib20","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1007\/s00125-013-2962-5","article-title":"Improved genetic testing for monogenic diabetes using targeted next-generation sequencing","volume":"56","author":"Ellard","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.ebiom.2026.106286_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009940","article-title":"SavvyCNV: genome-wide CNV calling from off-target reads","volume":"18","author":"Laver","year":"2022","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.ebiom.2026.106286_bib22","first-page":"405","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American college of medical genetics and genomics and the association for molecular pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med Off J Am Coll Med Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib23","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.ajhg.2016.08.016","article-title":"REVEL: an ensemble method for predicting the pathogenicity of rare missense variants","volume":"99","author":"Ioannidis","year":"2016","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg7492","article-title":"Accurate proteome-wide missense variant effect prediction with AlphaMissense","volume":"381","author":"Cheng","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2026.106286_bib25","doi-asserted-by":"crossref","first-page":"D534","DOI":"10.1093\/nar\/gkab988","article-title":"collaboratively defining the biological context of structural data","volume":"50","author":"PDBe","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ebiom.2026.106286_bib26","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1093\/bioinformatics\/btz184","article-title":"FoldX 5.0: working with RNA, small molecules and a new graphical interface","volume":"35","author":"Delgado","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ebiom.2026.106286_bib27","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.ajhg.2017.11.006","article-title":"ACTB loss-of-function mutations result in a pleiotropic developmental disorder","volume":"101","author":"Cuvertino","year":"2017","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib28","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1002\/ajmg.a.62631","article-title":"A de novo ACTB gene pathogenic variant in identical twins with phenotypic variation for hydrops and jejunal atresia","volume":"188","author":"Sibbin","year":"2022","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.ebiom.2026.106286_bib29","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00439-021-02268-1","article-title":"Exome sequencing reveals predominantly de novo variants in disorders with intellectual disability (ID) in the founder population of Finland","volume":"140","author":"J\u00e4rvel\u00e4","year":"2021","journal-title":"Hum Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib30","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/s41431-022-01087-w","article-title":"Trio-based exome sequencing reveals a high rate of the de novo variants in intellectual disability","volume":"30","author":"Brea-Fern\u00e1ndez","year":"2022","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib31","first-page":"3970","article-title":"Point of care exome sequencing reveals allelic and phenotypic heterogeneity underlying Mendelian disease in Qatar","volume":"28","author":"Fakhro","year":"2019","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib32","article-title":"P192: heterozygous ACTB pathogenic variant causing Baraitser-Winter syndrome presenting with tracheal ring, intestinal atresia, and neonatal diabetes","volume":"1","author":"Hill","year":"2023","journal-title":"Genet Med Open"},{"key":"10.1016\/j.ebiom.2026.106286_bib33","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/hmg\/ddae133","article-title":"Compromised actin dynamics underlie the orofacial cleft in Baraitser-Winter cerebrofrontofacial syndrome with a variant in ACTB","volume":"33","author":"Tsujimoto","year":"2024","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay8793","article-title":"Mechanism of actin N-terminal acetylation","volume":"6","author":"Rebowski","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.ebiom.2026.106286_bib35","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature13127","article-title":"Guidelines for investigating causality of sequence variants in human disease","volume":"508","author":"MacArthur","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2026.106286_bib36","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.93013","article-title":"The non-muscle actinopathy-associated mutation E334Q in cytoskeletal \u03b3-actin perturbs interaction of actin filaments with myosin and ADF\/cofilin family proteins","volume":"12","author":"Greve","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.ebiom.2026.106286_bib37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000492267","article-title":"Could dissimilar phenotypic effects of ACTB missense mutations reflect the actin conformational change? Two novel mutations and literature review","volume":"9","author":"Sandestig","year":"2018","journal-title":"Mol Syndromol"},{"key":"10.1016\/j.ebiom.2026.106286_bib38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/ana.10319","article-title":"Aggregation of actin and cofilin in identical twins with juvenile-onset dystonia","volume":"52","author":"Gearing","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.ebiom.2026.106286_bib39","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1038\/s41467-018-06713-0","article-title":"Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia","volume":"9","author":"Latham","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106286_bib40","first-page":"2487","article-title":"BiP inactivation due to loss of the deAMPylation function of FICD causes a motor neuron disease","volume":"24","author":"Rebelo","year":"2022","journal-title":"Genet Med Off J Am Coll Med Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib41","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1038\/ejhg.2015.161","article-title":"Biallelic RFX6 mutations can cause childhood as well as neonatal onset diabetes mellitus","volume":"23","author":"Sansbury","year":"2015","journal-title":"Eur J Hum Genet EJHG"},{"key":"10.1016\/j.ebiom.2026.106286_bib42","doi-asserted-by":"crossref","DOI":"10.1111\/dme.12122","article-title":"Biallelic PDX1 (insulin promoter factor 1) mutations causing neonatal diabetes without exocrine pancreatic insufficiency","volume":"30","author":"Franco","year":"2013","journal-title":"Diabet Med"},{"key":"10.1016\/j.ebiom.2026.106286_bib43","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1091\/mbc.e11-06-0582","article-title":"\u03b2-Actin specifically controls cell growth, migration, and the G-actin pool","volume":"22","author":"Bunnell","year":"2011","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ebiom.2026.106286_bib44","first-page":"685","article-title":"Cdc42\/N-WASP signaling links actin dynamics to pancreatic \u03b2 cell delamination and differentiation","volume":"141","author":"Kesavan","year":"2014","journal-title":"Dev Camb Engl"},{"key":"10.1016\/j.ebiom.2026.106286_bib45","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41587-020-0430-6","article-title":"Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells","volume":"38","author":"Hogrebe","year":"2020","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ebiom.2026.106286_bib46","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1038\/s41588-023-01565-x","article-title":"Primate-specific ZNF808 is essential for pancreatic development in humans","volume":"55","author":"De Franco","year":"2023","journal-title":"Nat Genet"},{"key":"10.1016\/j.ebiom.2026.106286_bib47","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/s41467-024-45648-7","article-title":"In situ structure of actin remodeling during glucose-stimulated insulin secretion using cryo-electron tomography","volume":"15","author":"Li","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106286_bib48","doi-asserted-by":"crossref","first-page":"E611","DOI":"10.1152\/ajpendo.00268.2015","article-title":"The skeleton in the closet: actin cytoskeletal remodeling in \u03b2-cell function","volume":"309","author":"Arous","year":"2015","journal-title":"Am J Physiol-Endocrinol Metab"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426001684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426001684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:53:22Z","timestamp":1783140802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426001684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":48,"alternative-id":["S2352396426001684"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106286","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of the ACTB p.Ser348Leu de novo variant in individuals with syndromic neonatal diabetes","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106286","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106286"}}