{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:42:23Z","timestamp":1788579743657,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["831434"],"award-info":[{"award-number":["831434"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["1.6"],"award-info":[{"award-number":["1.6"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020098","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC TRR241 B03\\u2014Project-ID 375876048"],"award-info":[{"award-number":["CRC TRR241 B03\\u2014Project-ID 375876048"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CH938\/4-1"],"award-info":[{"award-number":["CH938\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020027","name":"Dr Rolf M Schwiete Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ebiom.2026.106326","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:46:05Z","timestamp":1781210765000},"page":"106326","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["IgG4-related disease has a specific intestinal microbiota signature"],"prefix":"10.1016","volume":"129","author":[{"given":"Lisa","family":"Budzinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Elisabeth","family":"Beenken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Sempert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi-Ung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amro","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Lietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8015-6907","authenticated-orcid":false,"given":"Mir-Farzin","family":"Mashreghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7341-4533","authenticated-orcid":false,"given":"Hyun-Dong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ebiom.2026.106326_bib1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41584-020-0500-7","article-title":"IgG4-related disease: an update on pathophysiology and implications for clinical care","volume":"16","author":"Perugino","year":"2020","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106326_bib2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/annrheumdis-2018-214603","article-title":"Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts","volume":"78","author":"Wallace","year":"2019","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106326_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/art.41120","article-title":"The 2019 American College of Rheumatology\/European League against rheumatism classification criteria for IgG4-related disease","volume":"72","author":"Wallace","year":"2020","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106326_bib4","article-title":"Blue-collar work is a risk factor for developing IgG4-related disease of the biliary tract and pancreas","volume":"3","author":"Hubers","year":"2021","journal-title":"JHEP Rep"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106326_bib5","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1093\/rheumatology\/keab172","article-title":"The association of smoking with immunoglobulin G4-related disease: a case-control study","volume":"60","author":"Wallwork","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ebiom.2026.106326_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104821","article-title":"Gut microbiota in the pathogenesis and therapeutic approaches of diabetes","volume":"97","author":"Crudele","year":"2023","journal-title":"eBioMedicine"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106326_bib7","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2452250","article-title":"Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn's disease","volume":"17","author":"Budzinski","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ebiom.2026.106326_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105482","article-title":"Microbiome and metabolomics reveal the effect of gut microbiota on liver regeneration of fatty liver disease","volume":"111","author":"Hu","year":"2025","journal-title":"eBioMedicine"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106326_bib9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/intimm\/dxz050","article-title":"Intestinal dysbiosis mediates experimental autoimmune pancreatitis via activation of plasmacytoid dendritic cells","volume":"31","author":"Kamata","year":"2019","journal-title":"Int Immunol"},{"key":"10.1016\/j.ebiom.2026.106326_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.621532","article-title":"Intestinal dysbiosis and Autoimmune pancreatitis","volume":"12","author":"Yoshikawa","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106326_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13073-021-00853-7","article-title":"Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis","volume":"13","author":"Plichta","year":"2021","journal-title":"Genome Med"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106326_bib12","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/gutjnl-2020-323565","article-title":"Altered faecal microbiome and metabolome in IgG4-related sclerosing cholangitis and primary sclerosing cholangitis","volume":"71","author":"Liu","year":"2022","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106326_bib13","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/eji.201646297","article-title":"High-resolution microbiota flow cytometry reveals dynamic colitis-associated changes in fecal bacterial composition","volume":"46","author":"Zimmermann","year":"2016","journal-title":"Eur J Immunol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106326_bib14","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2081475","article-title":"Flow cytometry can reliably capture gut microbial composition in healthy adults as well as dysbiosis dynamics in patients with aggressive B-cell Non-Hodgkin lymphoma","volume":"14","author":"Schmiester","year":"2022","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106326_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250337","article-title":"Single-cell phenotyping of bacteria combined with deep sequencing for improved contextualization of microbiome analyses","volume":"54","author":"Budzinski","year":"2024","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ebiom.2026.106326_bib16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/bs.mcb.2024.02.023","article-title":"Single-cell multi-parametric characterization of microbiota by flow cytometry","volume":"186","author":"Budzinski","year":"2024","journal-title":"Methods Cell Biol"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106326_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v087.i07","article-title":"Flexible Self-Organizing Maps in kohonen 3.0","volume":"87","author":"Wehrens","year":"2018","journal-title":"J Stat Softw"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106326_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v021.i05","article-title":"Self- and Super-organizing Maps in R: the kohonen package","volume":"21","author":"Wehrens","year":"2007","journal-title":"J Stat Softw"},{"key":"10.1016\/j.ebiom.2026.106326_bib19","series-title":"vegan: Community Ecology Package (Version 2.0-7) [Computer software]","author":"Oksanen","year":"2013"},{"key":"10.1016\/j.ebiom.2026.106326_bib20","series-title":"caret: Classification and Regression Training. R package version 6.0-68 (or later 6.0-71\/6.0-73 releases in 2016)","author":"Kuhn","year":"2016"},{"key":"10.1016\/j.ebiom.2026.106326_bib21","series-title":"MLeval: Machine Learning Model Evaluation. R package version 0.3","author":"John","year":"2020"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106326_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gks808","article-title":"Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies","volume":"41","author":"Klindworth","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"15","key":"10.1016\/j.ebiom.2026.106326_bib23","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106326_bib24","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"10.1016\/j.ebiom.2026.106326_bib25","first-page":"V1","article-title":"138.1 prokaryotic SSU taxonomic training data formatted for DADA2","author":"McLaren","year":"2021","journal-title":"Zenodo"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106326_bib26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.32614\/RJ-2016-025","article-title":"Using DECIPHER v2.0 to analyze big biological sequence data in R","volume":"8","author":"Es","year":"2016","journal-title":"R J"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106326_bib27","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/molbev\/msp077","article-title":"FastTree: computing large minimum evolution trees with profiles instead of a distance matrix","volume":"26","author":"Price","year":"2009","journal-title":"Mol Biol Evol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106326_bib28","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for prediction of metagenome functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat Biotechnol"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106326_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061217","article-title":"Phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLoS ONE"},{"issue":"16","key":"10.1016\/j.ebiom.2026.106326_bib30","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1093\/bioinformatics\/btac438","article-title":"microbiomeMarker: an R\/Bioconductor package for microbiome marker identification and visualization","volume":"38","author":"Cao","year":"2022","journal-title":"Bioinformatics"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106326_bib31","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol"},{"key":"10.1016\/j.ebiom.2026.106326_bib32","series-title":"Data Analysis","first-page":"189","author":"Wickham","year":"2016"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106326_bib33","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40348-024-00186-6","article-title":"Age-stratification reveals age-specific intestinal microbiota signatures in juvenile idiopathic arthritis","volume":"11","author":"Budzinski","year":"2024","journal-title":"Mol Cell Pediatr"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106326_bib34","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ismej.2009.46","article-title":"Isolation and characterization of low nucleic acid (LNA)-content bacteria","volume":"3","author":"Wang","year":"2009","journal-title":"ISME J"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106326_bib35","first-page":"41","article-title":"Activity and diversity of bacterial cells with high and low nucleic acid content","volume":"33","author":"Pierre","year":"2003","journal-title":"Aquatic Microbial Ecology"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106326_bib36","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41396-020-00762-4","article-title":"Cytometric fingerprints of gut microbiota predict Crohn's disease state","volume":"15","author":"Rubbens","year":"2021","journal-title":"ISME J"},{"issue":"7402","key":"10.1016\/j.ebiom.2026.106326_bib37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","year":"2012","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106326_bib38","article-title":"Immunological mechanism of IgG4-related disease","author":"Liu","year":"2020","journal-title":"J Transl Autoimmun"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106326_bib39","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41579-020-0367-2","article-title":"Host-microbiota interactions in immune-mediated diseases","volume":"18","author":"Ruff","year":"2020","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106326_bib40","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1186\/s12866-025-04350-4","article-title":"Gut microbiome alterations in IgG4-related ophthalmic disease","volume":"25","author":"Ren","year":"2025","journal-title":"BMC Microbiol"},{"issue":"13","key":"10.1016\/j.ebiom.2026.106326_bib41","article-title":"Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results","author":"Koshida","year":"2023","journal-title":"Front Cell Infect Microbiol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:05:14Z","timestamp":1785891914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426002082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":41,"alternative-id":["S2352396426002082"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106326","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IgG4-related disease has a specific intestinal microbiota signature","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106326","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106326"}}