{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:28:00Z","timestamp":1790886480775,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01-MH125103"],"award-info":[{"award-number":["R01-MH125103"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TR002000"],"award-info":[{"award-number":["TR002000"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011125","name":"School of Medicine and Dentistry, University of Rochester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"National Institutes of Health Office of the Director","doi-asserted-by":"publisher","award":["5UH3OD023349"],"award-info":[{"award-number":["5UH3OD023349"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ebiom.2026.106360","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:41:27Z","timestamp":1782816087000},"page":"106360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Early-life gut microbiome composition and rotavirus vaccine-induced IgA responses in U.S. infants: a longitudinal cohort study"],"prefix":"10.1016","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-9475","authenticated-orcid":false,"given":"Janiret","family":"Narv\u00e1ez-Miranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6520-5777","authenticated-orcid":false,"given":"Daniel","family":"Velasquez-Portocarrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3885-4725","authenticated-orcid":false,"given":"Ann L.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Beblavy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darline","family":"Castro-Melendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelechi","family":"Ejiofor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Laniewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Groff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Ras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3838-3149","authenticated-orcid":false,"given":"Alena","family":"Leger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Macomber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Caddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7879-8222","authenticated-orcid":false,"given":"Kristin","family":"Scheible","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2026.106360_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2025.103122","article-title":"Global estimates of rotavirus vaccine efficacy and effectiveness: a rapid review and meta-regression analysis","volume":"81","author":"Prunas","year":"2025","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.ebiom.2026.106360_bib2","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/infdis\/jiaa081","article-title":"Global impact of rotavirus vaccination on diarrhea hospitalizations and deaths among children <5 years old: 2006-2019","volume":"222","author":"Burnett","year":"2020","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ebiom.2026.106360_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/INF.0000000000000481","article-title":"Rotavirus-specific IgG antibodies from mothers' serum may inhibit infant immune responses to the pentavalent rotavirus vaccine","volume":"34","author":"Becker-Dreps","year":"2015","journal-title":"Pediatr Infect J"},{"key":"10.1016\/j.ebiom.2026.106360_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003005","article-title":"Antirotavirus IgA seroconversion rates in children who receive concomitant oral poliovirus vaccine: a secondary, pooled analysis of Phase II and III trial data from 33 countries","volume":"16","author":"Baker","year":"2019","journal-title":"PLoS Med"},{"key":"10.1016\/j.ebiom.2026.106360_bib5","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1097\/INF.0000000000002485","article-title":"Enteropathogens and rotavirus vaccine immunogenicity in a cluster randomized trial of improved water, sanitation and hygiene in rural Zimbabwe","volume":"38","author":"Church","year":"2019","journal-title":"Pediatr Infect J"},{"key":"10.1016\/j.ebiom.2026.106360_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009010","article-title":"Maternal antibody interference contributes to reduced rotavirus vaccine efficacy in developing countries","volume":"16","author":"Otero","year":"2020","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ebiom.2026.106360_bib7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/INF.0b013e318290646d","article-title":"Differential profiles and inhibitory effect on rotavirus vaccines of nonantibody components in breast milk from mothers in developing and developed countries","volume":"32","author":"Moon","year":"2013","journal-title":"Pediatr Infect J"},{"key":"10.1016\/j.ebiom.2026.106360_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104007","article-title":"Aberrant newborn T cell and microbiota developmental trajectories predict respiratory compromise during infancy","volume":"25","author":"McDavid","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.ebiom.2026.106360_bib9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-018-0617-x","article-title":"Temporal development of the gut microbiome in early childhood from the TEDDY study","volume":"562","author":"Stewart","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2026.106360_bib10","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/mi.2016.114","article-title":"Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43","volume":"10","author":"Wu","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.ebiom.2026.106360_bib11","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1084\/jem.20062008","article-title":"A bacterial carbohydrate links innate and adaptive responses through toll-like receptor 2","volume":"203","author":"Wang","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2026.106360_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/19490976.2017.1376162","article-title":"Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan","volume":"9","author":"Harris","year":"2018","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ebiom.2026.106360_bib13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/infdis\/jiw518","article-title":"Significant correlation between the infant gut microbiome and Rotavirus vaccine response in rural Ghana","volume":"215","author":"Harris","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ebiom.2026.106360_bib14","doi-asserted-by":"crossref","first-page":"7288","DOI":"10.1038\/s41467-021-27074-1","article-title":"Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants","volume":"12","author":"Parker","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106360_bib15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.vaccine.2017.11.031","article-title":"Influence of the intestinal microbiota on the immunogenicity of oral rotavirus vaccine given to infants in South India","volume":"36","author":"Parker","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.ebiom.2026.106360_bib16","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s12866-023-03098-z","article-title":"Increased bacterial taxonomic and functional diversity is associated with impaired rotavirus vaccine immunogenicity in infants from India and Malawi","volume":"23","author":"Cunningham-Oakes","year":"2023","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.ebiom.2026.106360_bib17","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1038\/s41467-025-58632-6","article-title":"Early-life gut microbiome associates with positive vaccine take and shedding in neonatal schedule of the human neonatal rotavirus vaccine RV3-BB","volume":"16","author":"Wagner","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106360_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4269\/ajtmh.19-0355","article-title":"Association between gut microbiome composition and Rotavirus vaccine response among Nicaraguan infants","volume":"102","author":"Fix","year":"2020","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ebiom.2026.106360_bib19","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1016\/j.vaccine.2021.07.076","article-title":"The fecal microbiome and rotavirus vaccine immunogenicity in rural Zimbabwean infants","volume":"39","author":"Robertson","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/j.ebiom.2026.106360_bib20","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-044798","article-title":"Cohort profile: understanding Pregnancy Signals and Infant Development (UPSIDE): a pregnancy cohort study on prenatal exposure mechanisms for child health","volume":"11","author":"O'Connor","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.ebiom.2026.106360_bib21","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ebiom.2026.106360_bib22","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/AEM.03006-05","article-title":"Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB","volume":"72","author":"DeSantis","year":"2006","journal-title":"Appl Env Microbiol"},{"key":"10.1016\/j.ebiom.2026.106360_bib23","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ebiom.2026.106360_bib24","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S1473-3099(22)00368-1","article-title":"Head-to-head comparison of the immunogenicity of RotaTeq and Rotarix rotavirus vaccines and factors associated with seroresponse in infants in Bangladesh: a randomised, controlled, open-label, parallel, phase 4 trial","volume":"22","author":"Velasquez-Portocarrero","year":"2022","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106360_bib25","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/infdis\/jiae055","article-title":"Correlates of Rotavirus vaccine shedding and seroconversion in a US cohort of healthy infants","volume":"230","author":"Burke","year":"2024","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ebiom.2026.106360_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.cct.2020.106237","article-title":"Race and ethnicity reporting for clinical trials in ClinicalTrials.gov and publications","volume":"101","author":"Fain","year":"2021","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.ebiom.2026.106360_bib27","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.31316","article-title":"Reporting and representation of participant race and ethnicity in national Institutes of health\u2013funded pediatric clinical trials","volume":"6","author":"Lee","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ebiom.2026.106360_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J Stat Softw"},{"key":"10.1016\/j.ebiom.2026.106360_bib29","series-title":"Emmeans: estimated marginal means, aka least-squares means","author":"Lenth","year":"2025"},{"key":"10.1016\/j.ebiom.2026.106360_bib30","series-title":"Rstatix: Pipe-Friendly framework for basic statistical tests","author":"Kassambara","year":"2023"},{"key":"10.1016\/j.ebiom.2026.106360_bib31","series-title":"Vegan: community ecology package","author":"Oksanen","year":"2025"},{"key":"10.1016\/j.ebiom.2026.106360_bib32","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1093\/bioinformatics\/btaa951","article-title":"MiRKAT: Kernel machine regression-based global association tests for the microbiome","volume":"37","author":"Wilson","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ebiom.2026.106360_bib33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s40168-018-0566-5","article-title":"Neonatal gut and respiratory microbiota: coordinated development through time and space","volume":"6","author":"Grier","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.ebiom.2026.106360_bib34","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1046\/j.1365-2249.1996.d01-620.x","article-title":"Subclasses of IgA antibodies in serum and saliva samples of newborns and infants immunized against rotavirus","volume":"103","author":"Friedman","year":"1996","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ebiom.2026.106360_bib35","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1080\/21645515.2016.1274474","article-title":"Rotavirus specific maternal antibodies and immune response to RV3-BB neonatal rotavirus vaccine in New Zealand","volume":"13","author":"Chen","year":"2017","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.ebiom.2026.106360_bib36","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1038\/s41467-025-58768-5","article-title":"Cord blood IgA\/M reveals in utero response to SARS-CoV-2 with fluctuations in relation to circulating variants","volume":"16","author":"Pernet","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106360_bib37","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41541-024-01000-0","article-title":"Systematic review of the impact of intestinal microbiota on vaccine responses","volume":"9","author":"Ardura-Garcia","year":"2024","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.ebiom.2026.106360_bib38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/infdis\/jiaa068","article-title":"Postvaccination serum Antirotavirus Immunoglobulin A as a correlate of protection against rotavirus gastroenteritis across settings","volume":"222","author":"Baker","year":"2020","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ebiom.2026.106360_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2023.111135","article-title":"Survival at older ages: are greater influenza antibody titers protective?","volume":"178","author":"Metcalf","year":"2023","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.ebiom.2026.106360_bib40","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1086\/317619","article-title":"Serum antibody as a marker of protection against natural rotavirus infection and disease","volume":"182","author":"Vel\u00e1zquez","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ebiom.2026.106360_bib41","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41390-022-02154-0","article-title":"A prospective study of the infant gut microbiome in relation to vaccine response","volume":"93","author":"Moroishi","year":"2023","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ebiom.2026.106360_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13099-016-0136-y","article-title":"Modeling human enteric dysbiosis and rotavirus immunity in gnotobiotic pigs","volume":"8","author":"Twitchell","year":"2016","journal-title":"Gut Pathog"},{"key":"10.1016\/j.ebiom.2026.106360_bib43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13073-016-0299-7","article-title":"An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis","volume":"8","author":"Chen","year":"2016","journal-title":"Genome Med"},{"key":"10.1016\/j.ebiom.2026.106360_bib44","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.4049\/jimmunol.1200955","article-title":"Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis","volume":"189","author":"Cao","year":"1950","journal-title":"J Immunol"},{"key":"10.1016\/j.ebiom.2026.106360_bib45","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41586-025-08796-4","article-title":"Bifidobacteria support optimal infant vaccine responses","volume":"641","author":"Ryan","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ebiom.2026.106360_bib46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41577-021-00554-7","article-title":"Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms","volume":"22","author":"Lynn","year":"2022","journal-title":"Nat Rev Immunol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T08:12:41Z","timestamp":1783498361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426002434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":46,"alternative-id":["S2352396426002434"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106360","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early-life gut microbiome composition and rotavirus vaccine-induced IgA responses in U.S. infants: a longitudinal cohort study","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106360","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106360"}}