{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:39:01Z","timestamp":1792438741579,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"National Institute of Health and Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001673","name":"Fondation Jerome Lejeune","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000900","name":"European Commission Joint Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"Fundaci\u00f3n la Caixa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023796","name":"MRC-Wellcome Trust Human Developmental Biology Resource","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023796","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ebiom.2026.106370","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T12:18:19Z","timestamp":1783772299000},"page":"106370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["CSF and plasma tau biomarkers in the Down syndrome\u2013Alzheimer\u2019s disease continuum"],"prefix":"10.1016","volume":"130","author":[{"given":"Javier","family":"Arranz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lantero-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Sophie","family":"Braun-Wohlfahrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6776-6559","authenticated-orcid":false,"given":"L\u00eddia","family":"Vaqu\u00e9-Alc\u00e1zar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cd\u00f1igo","family":"Rodr\u00edguez-Baz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemys\u0142aw R.","family":"Kac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-3226","authenticated-orcid":false,"given":"Burak","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Maure-Blesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Pertierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Videla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Carmona-Iragui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bessy","family":"Benejam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Del Hoyo Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Barroeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bejanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Lle\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Fortea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3819-3245","authenticated-orcid":false,"given":"Daniel","family":"Alcolea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7684-6318","authenticated-orcid":false,"given":"Laia","family":"Montoliu-Gaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ebiom.2026.106370_bib1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S1474-4422(16)00063-6","article-title":"Dementia in Down\u2019s syndrome","volume":"15","author":"Ballard","year":"2016","journal-title":"Lancet Neurol"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106370_bib2","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/jir.12390","article-title":"A prospective 20-year longitudinal follow-up of dementia in persons with Down syndrome","volume":"61","author":"McCarron","year":"2017","journal-title":"J Intellect Disabil Res"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106370_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0047-6374(88)90041-3","article-title":"The pathological association between Down syndrome and Alzheimer disease","volume":"43","author":"Mann","year":"1988","journal-title":"Mech Ageing Dev"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106370_bib4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/nbdi.1996.0003","article-title":"Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation","volume":"3","author":"Lemere","year":"1996","journal-title":"Neurobiol Dis"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106370_bib5","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S1474-4422(21)00245-3","article-title":"Alzheimer\u2019s disease associated with Down syndrome: a genetic form of dementia","volume":"20","author":"Fortea","year":"2021","journal-title":"Lancet Neurol"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106370_bib6","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1001\/archneur.60.7.1024","article-title":"Cognitive decline in Down syndrome","volume":"60","author":"Margallo-Lana","year":"2003","journal-title":"Arch Neurol"},{"issue":"10","key":"10.1016\/j.ebiom.2026.106370_bib7","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S1474-4422(18)30285-0","article-title":"Plasma and CSF biomarkers for the diagnosis of Alzheimer\u2019s disease in adults with Down syndrome: a cross-sectional study","volume":"17","author":"Fortea","year":"2018","journal-title":"Lancet Neurol"},{"issue":"10242","key":"10.1016\/j.ebiom.2026.106370_bib8","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/S0140-6736(20)30689-9","article-title":"Clinical and biomarker changes of Alzheimer\u2019s disease in adults with Down syndrome: a cross-sectional study","volume":"395","author":"Fortea","year":"2020","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106370_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1474-4422(21)00129-0","article-title":"Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study","volume":"20","author":"Carmona-Iragui","year":"2021","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ebiom.2026.106370_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104547","article-title":"Plasma and cerebrospinal fluid glial fibrillary acidic protein levels in adults with Down syndrome: a longitudinal cohort study","volume":"90","author":"Montoliu-Gaya","year":"2023","journal-title":"EBioMedicine"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106370_bib11","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s43587-023-00403-3","article-title":"Blood biomarkers for Alzheimer\u2019s disease in clinical practice and trials","volume":"3","author":"Hansson","year":"2023","journal-title":"Nat Aging"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106370_bib12","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41582-022-00665-2","article-title":"Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility","volume":"18","author":"Karikari","year":"2022","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106370_bib13","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s43587-023-00405-1","article-title":"Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies","volume":"3","author":"Montoliu-Gaya","year":"2023","journal-title":"Nat Aging"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106370_bib14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-023-02660-3","article-title":"Optimal blood tau species for the detection of Alzheimer\u2019s disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study","volume":"147","author":"Montoliu-Gaya","year":"2023","journal-title":"Acta Neuropathol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106370_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00401-023-02659-w","article-title":"CSF p-tau205: a biomarker of tau pathology in Alzheimer\u2019s disease","volume":"147","author":"Lantero-Rodriguez","year":"2024","journal-title":"Acta Neuropathol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106370_bib16","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1038\/s41467-024-46876-7","article-title":"Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer\u2019s disease neuropathology","volume":"15","author":"Kac","year":"2024","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106370_bib17","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202115098","article-title":"P-tau235: a novel biomarker for staging preclinical Alzheimer\u2019s disease","volume":"13","author":"Lantero-Rodriguez","year":"2021","journal-title":"EMBO Mol Med"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106370_bib18","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41591-020-0781-z","article-title":"A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer\u2019s disease","volume":"26","author":"Barth\u00e9lemy","year":"2020","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106370_bib19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13024-022-00586-0","article-title":"Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer\u2019s disease continuum","volume":"17","author":"Gobom","year":"2022","journal-title":"Mol Neurodegener"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106370_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-024-00707-x","article-title":"Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer\u2019s Disease","volume":"19","author":"Lantero-Rodriguez","year":"2024","journal-title":"Mol Neurodegener"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106370_bib21","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1038\/s41591-022-02075-9","article-title":"CSF tau microtubule-binding region identifies pathological changes in primary tauopathies","volume":"28","author":"Horie","year":"2022","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106370_bib22","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1038\/s41591-025-03617-7","article-title":"Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer\u2019s disease","volume":"31","author":"Horie","year":"2025","journal-title":"Nat Med"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106370_bib23","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1093\/brain\/awab481","article-title":"N-terminal and mid-region tau fragments as fluid biomarkers in neurological diseases","volume":"145","author":"Snellman","year":"2022","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106370_bib24","first-page":"1797","article-title":"Plasma p-tau231 and p-tau217 as state markers of amyloid-\u03b2 pathology in preclinical Alzheimer\u2019s disease","volume":"28","author":"Mil\u00e0-Alom\u00e0","year":"2022","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106370_bib25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jamaneurol.2023.5319","article-title":"Diagnostic accuracy of a plasma phosphorylated Tau 217 immunoassay for alzheimer disease pathology","volume":"81","author":"Ashton","year":"2024","journal-title":"JAMA Neurol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106370_bib26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3233\/JAD-210677","article-title":"Site-specific cerebrospinal fluid tau hyperphosphorylation in response to Alzheimer\u2019s disease brain pathology: not all tau phospho-sites are hyperphosphorylated","volume":"85","author":"Barth\u00e9lemy","year":"2021","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106370_bib27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41582-024-00942-2","article-title":"Biomarker-based staging of Alzheimer disease: rationale and clinical applications","volume":"20","author":"Therriault","year":"2024","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106370_bib28","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/s41591-024-02988-7","article-title":"Revised criteria for the diagnosis and staging of Alzheimer\u2019s disease","volume":"30","author":"Jack","year":"2024","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106370_bib29","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s43587-024-00599-y","article-title":"Disease staging of Alzheimer\u2019s disease using a CSF-based biomarker model","volume":"4","author":"Salvad\u00f3","year":"2024","journal-title":"Nat Aging"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106370_bib30","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1038\/s43587-025-00951-w","article-title":"Plasma tau biomarkers for biological staging of Alzheimer\u2019s disease","volume":"5","author":"Montoliu-Gaya","year":"2025","journal-title":"Nat Aging"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106370_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00401-025-02863-w","article-title":"Biofluid-based staging of Alzheimer\u2019s disease","volume":"149","author":"Lantero-Rodriguez","year":"2025","journal-title":"Acta Neuropathol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106370_bib32","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1038\/s41467-021-24319-x","article-title":"Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer\u2019s disease in adults with Down syndrome","volume":"12","author":"Lle\u00f3","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106370_bib33","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1038\/s41467-025-65882-x","article-title":"Plasma p-tau217 as a biomarker of Alzheimer\u2019s disease pathology in individuals with Down syndrome","volume":"16","author":"Huber","year":"2025","journal-title":"Nat Commun"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106370_bib34","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1001\/jamaneurol.2022.1740","article-title":"Detection of Brain tau pathology in Down syndrome using plasma biomarkers","volume":"79","author":"Janelidze","year":"2022","journal-title":"JAMA Neurol"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106370_bib35","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1474-4422(25)00158-9","article-title":"Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study","volume":"24","author":"Janelidze","year":"2025","journal-title":"Lancet Neurol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106370_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70259","article-title":"The down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer\u2019s disease in Down syndrome: a decade of discovery","volume":"21","author":"Videla","year":"2025","journal-title":"Alzheimers Dement"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106370_bib37","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/wps.20050","article-title":"The DSM-5: classification and criteria changes","volume":"12","author":"Regier","year":"2013","journal-title":"World Psychiatry"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106370_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70307","article-title":"Discrepancies in assessing intellectual disability levels in adults with Down syndrome: implications for dementia diagnosis","volume":"21","author":"Soriano","year":"2025","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ebiom.2026.106370_bib39","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.trci.2019.09.005","article-title":"The sant pau initiative on neurodegeneration (SPIN) cohort: a data set for biomarker discovery and validation in neurodegenerative disorders","volume":"5","author":"Alcolea","year":"2019","journal-title":"Alzheimers Dement (N Y)"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106370_bib40","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/acn3.50873","article-title":"Agreement of amyloid PET and CSF biomarkers for Alzheimer\u2019s disease on Lumipulse","volume":"6","author":"Alcolea","year":"2019","journal-title":"Ann Clin Transl Neurol"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106370_bib41","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00401-021-02275-6","article-title":"Plasma p-tau231: a new biomarker for incipient Alzheimer\u2019s disease pathology","volume":"141","author":"Ashton","year":"2021","journal-title":"Acta Neuropathol"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106370_bib42","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1038\/s41591-022-02074-w","article-title":"Differential roles of A\u03b242\/40, p-tau231 and p-tau217 for Alzheimer\u2019s trial selection and disease monitoring","volume":"28","author":"Ashton","year":"2022","journal-title":"Nat Med"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106370_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70562","article-title":"Plasma tau biomarkers are distinctly associated with tau tangles and decreased with Lewy body pathology","volume":"21","author":"Montoliu-Gaya","year":"2025","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106370_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70208","article-title":"A comparison of p-tau assays for the specificity to detect tau changes in Alzheimer\u2019s disease","volume":"21","author":"Janelidze","year":"2025","journal-title":"Alzheimers Dement"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106370_bib45","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.cell.2020.10.029","article-title":"Tau PTM profiles identify patient heterogeneity and stages of Alzheimer\u2019s disease","volume":"183","author":"Wesseling","year":"2020","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106370_bib46","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s Association Workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106370_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70357","article-title":"PET-measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations","volume":"21","author":"McVea","year":"2025","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ebiom.2026.106370_bib48","article-title":"The tau biomarker cascade is condensed in Down syndrome compared to sporadic Alzheimer\u2019s disease","author":"Zammit","year":"2025","journal-title":"Brain"},{"key":"10.1016\/j.ebiom.2026.106370_bib49","article-title":"Differential roles of plasma p-tau217, p-tau231 and A\u03b242\/40 for trial selection and longitudinal disease monitoring in early Alzheimer\u2019s disease","author":"Nicholas","year":"2022","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106370_bib50","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1001\/jama.2025.7817","article-title":"Frequency and clinical outcomes associated with Tau positron emission tomography positivity","volume":"334","author":"Moscoso","year":"2025","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106370_bib51","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41593-025-02000-6","article-title":"Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-\u03b2 status, APOE genotype and sex","volume":"28","author":"Ossenkoppele","year":"2025","journal-title":"Nat Neurosci"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106370_bib52","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1038\/s41467-025-61054-z","article-title":"Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer\u2019s disease","volume":"16","author":"Montoliu-Gaya","year":"2025","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106370_bib53","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1093\/brain\/awaa326","article-title":"Evolution of neuroinflammation across the lifespan of individuals with Down syndrome","volume":"143","author":"Flores-Aguilar","year":"2020","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106370_bib54","doi-asserted-by":"crossref","first-page":"6527","DOI":"10.1002\/alz.14146","article-title":"Characterization of white matter hyperintensities in Down syndrome","volume":"20","author":"Morcillo-Nieto","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ebiom.2026.106370_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103836","article-title":"Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer\u2019s disease","volume":"76","author":"Ashton","year":"2022","journal-title":"EBioMedicine"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106370_bib56","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/jamaneurol.2025.5670","article-title":"Sex differences in P-Tau217, tau aggregation, and cognitive decline","volume":"83","author":"Coughlan","year":"2026","journal-title":"JAMA Neurol"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:20:29Z","timestamp":1786522829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426002537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":56,"alternative-id":["S2352396426002537"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106370","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CSF and plasma tau biomarkers in the Down syndrome\u2013Alzheimer\u2019s disease continuum","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106370","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106393","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106370"}}