{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:30:34Z","timestamp":1793284234138,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013050","name":"Guangdong Provincial Applied Science and Technology Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ebiom.2026.106387","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:32:14Z","timestamp":1784205134000},"page":"106387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Autoantibodies against type I interferons in patients with zoonotic H7N9 influenza: an observational case\u2013control study"],"prefix":"10.1016","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7811-476X","authenticated-orcid":false,"given":"Yongkun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1524-9445","authenticated-orcid":false,"given":"Jakob","family":"Ankerhold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2338-1822","authenticated-orcid":false,"given":"Tingting","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1268-5057","authenticated-orcid":false,"given":"Martin","family":"Wolkewitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1974-212X","authenticated-orcid":false,"given":"Jonas","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-2824","authenticated-orcid":false,"given":"Lifang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-1346","authenticated-orcid":false,"given":"Kevin","family":"Groen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Kuratli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3891-9480","authenticated-orcid":false,"given":"Benjamin G.","family":"Hale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Kochs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-6855","authenticated-orcid":false,"given":"Martin","family":"Schwemmle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9279-0916","authenticated-orcid":false,"given":"Yuelong","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5890-4147","authenticated-orcid":false,"given":"Laura","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2026.106387_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/bmb\/ldz036","article-title":"Avian influenza viruses in humans: lessons from past outbreaks","volume":"132","author":"Li","year":"2019","journal-title":"Br Med Bull"},{"key":"10.1016\/j.ebiom.2026.106387_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41579-025-01189-4","article-title":"Evolution, spread and impact of highly pathogenic H5 avian influenza A viruses","volume":"24","author":"Bellido-Mart\u00edn","year":"2026","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ebiom.2026.106387_bib5","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1473-3099(17)30323-7","article-title":"Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013\u201317: an epidemiological study of laboratory-confirmed case series","volume":"17","author":"Wang","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ebiom.2026.106387_bib6","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/irv.12736","article-title":"Seroprevalence of H7N9 infection among humans: a systematic review and meta-analysis","volume":"14","author":"Wang","year":"2020","journal-title":"Influenza Other Respir Viruses"},{"key":"10.1016\/j.ebiom.2026.106387_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/infdis\/jiaa679","article-title":"Serological evidence of human infection with avian influenza A(H7N9) virus: a systematic review and meta-analysis","volume":"226","author":"Wang","year":"2022","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ebiom.2026.106387_bib8","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809528","article-title":"Identification and characterization of GLDC as host susceptibility gene to severe influenza","volume":"11","author":"Zhou","year":"2019","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.ebiom.2026.106387_bib9","doi-asserted-by":"crossref","first-page":"996","DOI":"10.15212\/ZOONOSES-2021-0026","article-title":"Poultry to human passport: cross-species transmission of zoonotic H7N9 Avian influenza virus to humans","volume":"2","author":"Chen","year":"2022","journal-title":"Zoonoses"},{"key":"10.1016\/j.ebiom.2026.106387_bib10","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1126\/science.abg5953","article-title":"Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus","volume":"373","author":"Chen","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2026.106387_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/JCI166283","article-title":"Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs","volume":"133","author":"Casanova","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ebiom.2026.106387_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abl4340","article-title":"Autoantibodies neutralizing type I IFNs are present in \u223c4% of uninfected individuals over 70 years old and account for \u223c20% of COVID-19 deaths","volume":"6","author":"Bastard","year":"2021","journal-title":"Sci Immunol"},{"key":"10.1016\/j.ebiom.2026.106387_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/science.abd4585","article-title":"Autoantibodies against type I IFNs in patients with life-threatening COVID-19","volume":"370","author":"Bastard","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ebiom.2026.106387_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2200413119","article-title":"The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies","volume":"119","author":"Manry","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ebiom.2026.106387_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001709","article-title":"Critically ill COVID-19 patients with neutralizing autoantibodies against type I interferons have increased risk of herpesvirus disease","volume":"20","author":"Busnadiego","year":"2022","journal-title":"PLoS Biol"},{"key":"10.1016\/j.ebiom.2026.106387_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/irv.13116","article-title":"Type I interferon autoantibodies in hospitalized patients with Middle East respiratory syndrome and association with outcomes and treatment effect of interferon beta-1b in MIRACLE clinical trial","volume":"17","author":"Alotaibi","year":"2023","journal-title":"Influenza Other Respir Viruses"},{"key":"10.1016\/j.ebiom.2026.106387_bib17","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20202486","article-title":"Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine","volume":"218","author":"Bastard","year":"2021","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2026.106387_bib18","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20230661","article-title":"Autoantibodies neutralizing type I IFNs underlie west Nile virus encephalitis in \u223c40% of patients","volume":"220","author":"Gervais","year":"2023","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2026.106387_bib19","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20240637","article-title":"Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in \u223c10% of patients","volume":"221","author":"Gervais","year":"2024","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2026.106387_bib20","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20240942","article-title":"Auto-abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease","volume":"221","author":"Gervais","year":"2024","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2026.106387_bib21","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20220514","article-title":"Autoantibodies against type I IFNs in patients with critical influenza pneumonia","volume":"219","author":"Zhang","year":"2022","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2026.106387_bib22","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20251962","article-title":"Autoantibodies neutralizing type I IFNs in a fatal case of H5N1 avian influenza","volume":"223","author":"Zhang","year":"2026","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2026.106387_bib23","doi-asserted-by":"crossref","first-page":"6936","DOI":"10.1038\/s41467-022-34500-5","article-title":"H7N9 avian influenza virus infection in men is associated with testosterone depletion","volume":"13","author":"Bai","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106387_bib24","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1002\/sim.1047","article-title":"A solution to the problem of separation in logistic regression","volume":"21","author":"Heinze","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.ebiom.2026.106387_bib25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.7326\/M16-2607","article-title":"Sensitivity analysis in observational research: introducing the E-Value","volume":"167","author":"VanderWeele","year":"2017","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ebiom.2026.106387_bib26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/1471-2164-9-488","article-title":"BioVenn \u2013 a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams","volume":"9","author":"Hulsen","year":"2008","journal-title":"BMC Genom"},{"key":"10.1016\/j.ebiom.2026.106387_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1327784","article-title":"Interferon autoantibodies as signals of a sick thymus","volume":"15","author":"Oftedal","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2026.106387_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250164","article-title":"Autoantibodies targeting type I interferons: prevalence, mechanisms of induction, and association with viral disease susceptibility","volume":"53","author":"Hale","year":"2023","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ebiom.2026.106387_bib29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/imr.13304","article-title":"Human autoantibodies neutralizing type I IFNs: from 1981 to 2023","volume":"322","author":"Bastard","year":"2024","journal-title":"Immunol Rev"},{"key":"10.1016\/j.ebiom.2026.106387_bib30","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20240365","article-title":"Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies","volume":"221","author":"Fernbach","year":"2024","journal-title":"J Exp Med"},{"key":"10.1016\/j.ebiom.2026.106387_bib31","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1093\/infdis\/jit440","article-title":"Cytokine and chemokine levels in patients infected with the novel Avian influenza A (H7N9) virus in China","volume":"208","author":"Chi","year":"2013","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ebiom.2026.106387_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00601-13","article-title":"The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue","volume":"4","author":"Knepper","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.ebiom.2026.106387_bib33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3201\/eid3101.241236","article-title":"Replication restriction of influenza A(H5N1) clade 2.3.4.4b viruses by human immune factor, 2023-2024","volume":"31","author":"Ankerhold","year":"2025","journal-title":"Emerg Infect Dis"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:17:23Z","timestamp":1786522643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426002719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":31,"alternative-id":["S2352396426002719"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106387","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autoantibodies against type I interferons in patients with zoonotic H7N9 influenza: an observational case\u2013control study","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106387","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106387"}}