{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:12:09Z","timestamp":1790478729455,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2021-00178"],"award-info":[{"award-number":["2021-00178"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005348","name":"Socialdepartementet","doi-asserted-by":"publisher","award":["2021-03324"],"award-info":[{"award-number":["2021-03324"]}],"id":[{"id":"10.13039\/501100005348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004318","name":"Microsoft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ebiom.2026.106399","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:33:13Z","timestamp":1784295193000},"page":"106399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Association between GDF-15 and sarcopenia progression in older adults: results from a population-based study"],"prefix":"10.1016","volume":"130","author":[{"given":"Yuh-Shiou","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7927-793X","authenticated-orcid":false,"given":"Alice Margherita","family":"Ornago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Gregorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5064-1672","authenticated-orcid":false,"given":"Chiara","family":"Ceolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7032-3487","authenticated-orcid":false,"given":"Anna","family":"Picca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5472-2365","authenticated-orcid":false,"given":"Riccardo","family":"Calvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Marzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birger C.","family":"Forsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3099-4830","authenticated-orcid":false,"given":"Davide Liborio","family":"Vetrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2026.106399_bib1","article-title":"Epidemiology of sarcopenia: prevalence, risk factors, and consequences","volume":"144","author":"Yuan","year":"2023","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106399_bib2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41572-024-00550-w","article-title":"Sarcopenia","volume":"10","author":"Sayer","year":"2024","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106399_bib3","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1007\/s00198-015-3194-y","article-title":"Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older","volume":"26","author":"Bischoff-Ferrari","year":"2015","journal-title":"Osteoporos Int"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106399_bib4","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/gerona\/glx245","article-title":"Associations of sarcopenia definitions, and their components, with the incidence of recurrent falling and fractures: the longitudinal aging study Amsterdam","volume":"73","author":"Schaap","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106399_bib5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/jcsm.12048","article-title":"SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes","volume":"7","author":"Malmstrom","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106399_bib6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/jcsm.12149","article-title":"Validation of the SarQoL\u00ae, a specific health-related quality of life questionnaire for Sarcopenia","volume":"8","author":"Beaudart","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106399_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106399_bib8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/biof.5","article-title":"Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction","volume":"35","author":"Marzetti","year":"2009","journal-title":"Biofactors"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106399_bib9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12877-024-04764-1","article-title":"Low physical activity is a risk factor for sarcopenia: a cross-sectional analysis of two exercise trials on community-dwelling older adults","volume":"24","author":"H\u00e4m\u00e4l\u00e4inen","year":"2024","journal-title":"BMC Geriatr"},{"issue":"20","key":"10.1016\/j.ebiom.2026.106399_bib10","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1161\/CIRCULATIONAHA.123.064071","article-title":"Sarcopenia and cardiovascular diseases","volume":"147","author":"Damluji","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.ebiom.2026.106399_bib11","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.2147\/DMSO.S410834","article-title":"The Association between sarcopenia and diabetes: from pathophysiology mechanism to therapeutic strategy","volume":"16","author":"Chen","year":"2023","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.ebiom.2026.106399_bib12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tipsro.2020.10.001","article-title":"Sarcopenia in cancer: risking more than muscle loss","volume":"16","author":"Anjanappa","year":"2020","journal-title":"Tech Innov Patient Support Radiat Oncol"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106399_bib13","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1002\/jcsm.13485","article-title":"Meta-analysis on the interrelationship between sarcopenia and mild cognitive impairment, Alzheimer's disease and other forms of dementia","volume":"15","author":"Amini","year":"2024","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ebiom.2026.106399_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.598035","article-title":"Sarcopenia in patients with Parkinson's disease: a systematic review and meta-analysis","volume":"12","author":"Cai","year":"2021","journal-title":"Front Neurol"},{"key":"10.1016\/j.ebiom.2026.106399_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.103471","article-title":"Sarcopenia in patients with multiple sclerosis","volume":"58","author":"Yuksel","year":"2022","journal-title":"Mult Scler Relat Disord"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106399_bib16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s42978-020-00065-2","article-title":"Molecular and cellular aspects of Sarcopenia, muscle healthy aging and physical conditioning in the elderly","volume":"2","author":"Di Filippo","year":"2020","journal-title":"J Sci Sport Exerc"},{"issue":"22","key":"10.1016\/j.ebiom.2026.106399_bib17","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1042\/CS20230319","article-title":"Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men","volume":"137","author":"Granic","year":"2023","journal-title":"Clin Sci"},{"key":"10.1016\/j.ebiom.2026.106399_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/490842","article-title":"GDF-15 as a target and biomarker for diabetes and cardiovascular diseases: a translational prospective","volume":"2015","author":"Adela","year":"2015","journal-title":"J Diabetes Res"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106399_bib19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.tem.2024.09.002","article-title":"GDF15 is still a mystery hormone","volume":"36","author":"Sigvardsen","year":"2025","journal-title":"Trends Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106399_bib20","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.2174\/0115665240327723241018073535","article-title":"The hormetic potential of GDF15 in skeletal muscle health and regeneration: a comprehensive systematic review","volume":"25","author":"Tarchi","year":"2025","journal-title":"Curr Mol Med"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106399_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4093\/dmj.2023.0115","article-title":"Mitochondrial stress and mitokines: therapeutic perspectives for the treatment of metabolic diseases","volume":"48","author":"Zhang","year":"2024","journal-title":"Diabetes Metab J"},{"key":"10.1016\/j.ebiom.2026.106399_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2025.112117","article-title":"The stress-responsive cytokine GDF-15 and Sarcopenia: a systematic review and meta-analysis on aging muscle decline","volume":"228","author":"Papa","year":"2025","journal-title":"Mech Ageing Dev"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106399_bib23","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/jcsm.13513","article-title":"GDF-15 is associated with sarcopenia and frailty in acutely admitted older medical patients","volume":"15","author":"Kamper","year":"2024","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106399_bib24","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1159\/000513600","article-title":"Serum GDF15 level is independent of Sarcopenia in older Asian adults","volume":"67","author":"Nga","year":"2021","journal-title":"Gerontology"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106399_bib25","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s12603-022-1800-1","article-title":"Circulating levels of Apelin, GDF-15 and sarcopenia: lack of association in the MAPT study","volume":"26","author":"Sanchez-Sanchez","year":"2022","journal-title":"J Nutr Health Aging"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106399_bib26","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1093\/gerona\/glab201","article-title":"Associations between elevated growth differentiation factor-15 and sarcopenia among community-dwelling older adults","volume":"77","author":"Kim","year":"2022","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106399_bib27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF03324546","article-title":"A longitudinal study integrating population, care and social services data. The Swedish National study on Aging and Care (SNAC)","volume":"16","author":"Lagergren","year":"2004","journal-title":"Aging Clin Exp Res"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106399_bib28","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/jcsm.12875","article-title":"Twelve-year sarcopenia trajectories in older adults: results from a population-based study","volume":"13","author":"Trevisan","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106399_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.13835","article-title":"Association of Alzheimer's disease blood biomarkers with sarcopenia incidence and progression: a 12-year population-based study","volume":"16","author":"Ceolin","year":"2025","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"10","key":"10.1016\/j.ebiom.2026.106399_bib30","first-page":"1417","article-title":"Assessing and measuring chronic multimorbidity in the older population: a proposal for its operationalization","volume":"72","author":"Calder\u00f3n-Larra\u00f1aga","year":"2017","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106399_bib31","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12943","article-title":"mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism","volume":"18","author":"Tang","year":"2019","journal-title":"Aging Cell"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106399_bib32","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.3390\/biomedicines13081931","article-title":"The multifaceted role of Growth Differentiation Factor 15 (GDF15): a narrative review from cancer cachexia to target therapy","volume":"13","author":"Filippini","year":"2025","journal-title":"Biomedicines"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106399_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0309394","article-title":"Neutralizing antibody against GDF15 for treatment of cancer-associated cachexia","volume":"19","author":"Xiong","year":"2024","journal-title":"PLoS One"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:17:49Z","timestamp":1786522669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426002835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":33,"alternative-id":["S2352396426002835"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106399","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between GDF-15 and sarcopenia progression in older adults: results from a population-based study","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106399"}}