{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:17:24Z","timestamp":1793812644198,"version":"4.6.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016036","name":"Health~Holland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007553","name":"Aidsfonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ebiom.2026.106411","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:02:07Z","timestamp":1785700927000},"page":"106411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up study"],"prefix":"10.1016","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-9628","authenticated-orcid":false,"given":"Cynthia","family":"Lungu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4765-6600","authenticated-orcid":false,"given":"Tanvir","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Crespo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1452-7271","authenticated-orcid":false,"given":"Henrieke A.B.","family":"Prins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-2445","authenticated-orcid":false,"given":"Kathryn S.","family":"Hensley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1904-6450","authenticated-orcid":false,"given":"Casper","family":"Rokx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shringar","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen J.A.","family":"van Kampen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.M.C.","family":"van de Vijver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0515-9128","authenticated-orcid":false,"given":"Thibault","family":"Mespl\u00e8de","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7690-5218","authenticated-orcid":false,"given":"Peter D.","family":"Katsikis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8486-5903","authenticated-orcid":false,"given":"Rob A.","family":"Gruters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokameh","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6629","key":"10.1016\/j.ebiom.2026.106411_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/387183a0","article-title":"Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection","volume":"387","author":"Chun","year":"1997","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.ebiom.2026.106411_bib2","doi-asserted-by":"crossref","first-page":"13193","DOI":"10.1073\/pnas.94.24.13193","article-title":"Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy","volume":"94","author":"Chun","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106411_bib3","first-page":"121","article-title":"The latent reservoir for HIV-1 in resting CD4+ T cells: a barrier to cure","volume":"1","author":"Siliciano","year":"2006","journal-title":"Curr Opin HIV AIDS"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106411_bib4","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/8394","article-title":"Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy","volume":"5","author":"Finzi","year":"1999","journal-title":"Nat Med"},{"issue":"43","key":"10.1016\/j.ebiom.2026.106411_bib5","doi-asserted-by":"crossref","first-page":"16725","DOI":"10.1073\/pnas.0804192105","article-title":"HIV rebounds from latently infected cells, rather than from continuing low-level replication","volume":"105","author":"Joos","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106411_bib6","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2217\/fvl-2016-0093","article-title":"HIV-1 latent reservoir: size matters","volume":"11","author":"Hodel","year":"2016","journal-title":"Future Virol"},{"issue":"7742","key":"10.1016\/j.ebiom.2026.106411_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-019-0898-8","article-title":"A quantitative approach for measuring the reservoir of latent HIV-1 proviruses","volume":"566","author":"Bruner","year":"2019","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106411_bib8","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2013.09.020","article-title":"Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure","volume":"155","author":"Ho","year":"2013","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106411_bib9","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/nm.4411","article-title":"Defining total-body AIDS-virus burden with implications for curative strategies","volume":"23","author":"Estes","year":"2017","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106411_bib10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.chom.2020.03.014","article-title":"The biology of the HIV-1 latent reservoir and implications for cure strategies","volume":"27","author":"Cohn","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106411_bib11","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nm.4108","article-title":"International AIDS Society global scientific strategy: towards an HIV cure 2016","volume":"22","author":"Deeks","year":"2016","journal-title":"Nat Med"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106411_bib12","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1038\/s41591-021-01590-5","article-title":"Research priorities for an HIV cure: international AIDS society global scientific strategy 2021","volume":"27","author":"Deeks","year":"2021","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106411_bib13","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/s41467-025-56116-1","article-title":"Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: an individual data-based meta-analysis of 24 prospective studies","volume":"16","author":"Gunst","year":"2025","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106411_bib14","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/jac\/dkaa003","article-title":"Evaluating predictive markers for viral rebound and safety assessment in blood and lumbar fluid during HIV-1 treatment interruption","volume":"75","author":"De Scheerder","year":"2020","journal-title":"J Antimicrob Chemother"},{"issue":"13","key":"10.1016\/j.ebiom.2026.106411_bib15","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1097\/QAD.0000000000001909","article-title":"Analytical antiretroviral therapy interruption does not irreversibly change preinterruption levels of cellular HIV","volume":"32","author":"Papasavvas","year":"2018","journal-title":"AIDS"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106411_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/v13071403","article-title":"Impact of analytical treatment interruption on burden and diversification of HIV peripheral reservoir: a pilot study","volume":"13","author":"Scutari","year":"2021","journal-title":"Viruses"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106411_bib17","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1172\/JCI120194","article-title":"HIV-1 latent reservoir size and diversity are stable following brief treatment interruption","volume":"128","author":"Salantes","year":"2018","journal-title":"J Clin Invest"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106411_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00285-18","article-title":"Effect of short-term antiretroviral therapy interruption on levels of integrated HIV DNA","volume":"92","author":"Strongin","year":"2018","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106411_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006792","article-title":"Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals","volume":"14","author":"Clarridge","year":"2018","journal-title":"PLoS Pathog"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106411_bib20","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.immuni.2023.01.030","article-title":"HIV rapidly targets a diverse pool of CD4(+) T cells to establish productive and latent infections","volume":"56","author":"Gantner","year":"2023","journal-title":"Immunity"},{"issue":"15","key":"10.1016\/j.ebiom.2026.106411_bib21","doi-asserted-by":"crossref","first-page":"8869","DOI":"10.1073\/pnas.95.15.8869","article-title":"Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection","volume":"95","author":"Chun","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106411_bib22","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41591-018-0026-6","article-title":"Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection","volume":"24","author":"Colby","year":"2018","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106411_bib23","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/QAD.0000000000002113","article-title":"Clinical trials of antiretroviral treatment interruption in HIV-infected individuals","volume":"33","author":"Lau","year":"2019","journal-title":"Aids"},{"issue":"22","key":"10.1016\/j.ebiom.2026.106411_bib24","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1056\/NEJMoa062360","article-title":"CD4+ count-guided interruption of antiretroviral treatment","volume":"355","author":"Strategies for Management of Antiretroviral Therapy Study","year":"2006","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106411_bib25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/COH.0000000000000484","article-title":"Lessons learned from HIV antiretroviral treatment interruption trials","volume":"13","author":"Wen","year":"2018","journal-title":"Curr Opin HIV AIDS"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106411_bib26","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s11904-021-00569-8","article-title":"Analytical treatment interruption in HIV trials: statistical and study design considerations","volume":"18","author":"Zheng","year":"2021","journal-title":"Curr HIV\/AIDS Rep"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106411_bib27","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/cid\/ciae235","article-title":"Definition of virological endpoints improving the design of HIV cure strategies using analytical antiretroviral treatment interruption","volume":"79","author":"Alexandre","year":"2024","journal-title":"Clin Infect Dis"},{"issue":"13","key":"10.1016\/j.ebiom.2026.106411_bib28","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1097\/QAD.0000000000001560","article-title":"Impact of long-term antiretroviral therapy interruption and resumption on viral reservoir in HIV-1 infected patients","volume":"31","author":"Montserrat","year":"2017","journal-title":"AIDS"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106411_bib29","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.clim.2011.10.010","article-title":"A phase I\/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption","volume":"142","author":"Allard","year":"2012","journal-title":"Clin Immunol"},{"issue":"25","key":"10.1016\/j.ebiom.2026.106411_bib30","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1016\/j.vaccine.2015.04.047","article-title":"DC immunotherapy in HIV-1 infection induces a major blood transcriptome shift","volume":"33","author":"de Goede","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.ebiom.2026.106411_bib31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ymeth.2021.05.006","article-title":"Triplex digital PCR assays for the quantification of intact proviral HIV-1 DNA","volume":"201","author":"van Snippenberg","year":"2022","journal-title":"Methods"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106411_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01297-20","article-title":"The intact non-inducible latent HIV-1 reservoir is established in an in vitro primary T(CM) cell model of latency","volume":"95","author":"Sarabia","year":"2021","journal-title":"J Virol"},{"issue":"10","key":"10.1016\/j.ebiom.2026.106411_bib33","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/nprot.2017.079","article-title":"Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique","volume":"12","author":"Baxter","year":"2017","journal-title":"Nat Protoc"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106411_bib34","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1038\/s41467-021-22608-z","article-title":"Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir","volume":"12","author":"Rao","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106411_bib35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s43856-024-00553-4","article-title":"Specific quantification of inducible HIV-1 reservoir by RT-LAMP","volume":"4","author":"Hossain","year":"2024","journal-title":"Commun Med"},{"key":"10.1016\/j.ebiom.2026.106411_bib36","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/978-1-0716-1871-4_24","article-title":"TILDA: Tat\/Rev induced limiting dilution assay","volume":"2407","author":"Lungu","year":"2022","journal-title":"Methods Mol Biol"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106411_bib37","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/cyto.a.24900","article-title":"OMIP-109: 45-color full spectrum flow cytometry panel for deep immunophenotyping of the major lineages present in human peripheral blood mononuclear cells with emphasis on the T cell memory compartment","volume":"105","author":"Park","year":"2024","journal-title":"Cytometry A"},{"issue":"10","key":"10.1016\/j.ebiom.2026.106411_bib38","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nbt.1991","article-title":"Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE","volume":"29","author":"Qiu","year":"2011","journal-title":"Nat Biotechnol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106411_bib39","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s43586-024-00363-x","article-title":"Uniform manifold approximation and projection","volume":"4","author":"Healy","year":"2024","journal-title":"Nat Rev Methods Primers"},{"issue":"9","key":"10.1016\/j.ebiom.2026.106411_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109643","article-title":"Combined single-cell transcriptional, translational, and genomic profiling reveals HIV-1 reservoir diversity","volume":"36","author":"Sannier","year":"2021","journal-title":"Cell Rep"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106411_bib41","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1172\/JCI124291","article-title":"Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy","volume":"129","author":"Einkauf","year":"2019","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106411_bib42","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.cell.2021.12.011","article-title":"Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses","volume":"185","author":"Einkauf","year":"2022","journal-title":"Cell"},{"issue":"12 Suppl 2","key":"10.1016\/j.ebiom.2026.106411_bib43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/infdis\/jiaa649","article-title":"Low inducibility of latent human immunodeficiency virus type 1 proviruses as a major barrier to cure","volume":"223","author":"Siliciano","year":"2021","journal-title":"J Infect Dis"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106411_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007991","article-title":"Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations","volume":"15","author":"Grau-Exp\u00f3sito","year":"2019","journal-title":"PLoS Pathog"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106411_bib45","article-title":"The efficacy and tolerability of latency-reversing agents in reactivating the HIV-1 reservoir in clinical studies: a systematic review","volume":"9","author":"Debrabander","year":"2023","journal-title":"J Virus Erad"},{"issue":"24","key":"10.1016\/j.ebiom.2026.106411_bib46","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01605-22","article-title":"New assay reveals vast excess of defective over intact HIV-1 transcripts in antiretroviral therapy-suppressed individuals","volume":"96","author":"Martin","year":"2022","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106411_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089444","article-title":"Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging","volume":"9","author":"Lee","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106411_bib48","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/QAD.0b013e32835b8cb3","article-title":"CD3+CD8+CD161high Tc17 cells are depleted in HIV-infection","volume":"27","author":"Gaardbo","year":"2013","journal-title":"AIDS"},{"key":"10.1016\/j.ebiom.2026.106411_bib49","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fimmu.2018.00144","article-title":"Blood CXCR3(+) CD4 T cells are enriched in inducible replication competent HIV in aviremic antiretroviral therapy-treated individuals","volume":"9","author":"Banga","year":"2018","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106411_bib50","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/hiv.12986","article-title":"Long-term clinical, virological and immunological outcomes following planned treatment interruption in HIV-infected children","volume":"22","author":"Freguja","year":"2021","journal-title":"HIV Med"},{"key":"10.1016\/j.ebiom.2026.106411_bib51","article-title":"Multiple treatment interruptions and protecting HIV-specific CD4 T cells enable durable CD8 T cell response and viral control","volume":"11","author":"Jain","year":"2024","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106411_bib52","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1128\/CMR.00015-16","article-title":"Total HIV-1 DNA, a marker of viral reservoir dynamics with clinical implications","volume":"29","author":"Avettand-Fenoel","year":"2016","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106411_bib53","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/COH.0000000000000849","article-title":"Persistent HIV-1 transcription during ART: time to reassess its significance?","volume":"19","author":"Fombellida-Lopez","year":"2024","journal-title":"Curr Opin HIV AIDS"},{"key":"10.1016\/j.ebiom.2026.106411_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.coviro.2023.101301","article-title":"HIV persistence: silence or resistance?","volume":"59","author":"Pasternak","year":"2023","journal-title":"Curr Opin Virol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106411_bib55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/pathogens14010015","article-title":"The proviral reservoirs of Human Immunodeficiency Virus (HIV) infection","volume":"14","author":"Murzin","year":"2024","journal-title":"Pathogens"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106411_bib56","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1086\/425983","article-title":"Cellular viral rebound after cessation of potent antiretroviral therapy predicted by levels of multiply spliced HIV-1 RNA encoding nef","volume":"190","author":"Fischer","year":"2004","journal-title":"J Infect Dis"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106411_bib57","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41392-022-01058-z","article-title":"Natural killer cell homing and trafficking in tissues and tumors: from biology to application","volume":"7","author":"Ran","year":"2022","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106411_bib58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41541-023-00631-z","article-title":"Autologous dendritic cell vaccination against HIV-1 induces changes in natural killer cell phenotype and functionality","volume":"8","author":"Laeremans","year":"2023","journal-title":"NPJ Vaccines"},{"issue":"16","key":"10.1016\/j.ebiom.2026.106411_bib59","doi-asserted-by":"crossref","first-page":"8439","DOI":"10.1128\/JVI.00199-07","article-title":"Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction","volume":"81","author":"Brainard","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.ebiom.2026.106411_bib60","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.3389\/fimmu.2019.01896","article-title":"CD8(+) T-Cell response to HIV infection in the era of antiretroviral therapy","volume":"10","author":"Perdomo-Celis","year":"2019","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106411_bib61","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.yexcr.2010.12.017","article-title":"CXCR3 in T cell function","volume":"317","author":"Groom","year":"2011","journal-title":"Exp Cell Res"},{"issue":"8","key":"10.1016\/j.ebiom.2026.106411_bib62","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/eji.202048943","article-title":"CXCR3 and CXCR5 are highly expressed in HIV-1-specific CD8 central memory T cells from infected patients","volume":"51","author":"Olivo","year":"2021","journal-title":"Eur J Immunol"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106411_bib63","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/infdis\/jiz123","article-title":"Increased CXCR3+ T cells impairs recruitment of T-Helper type 17 cells via interferon \u03b3 and interleukin 18 in the small intestine mucosa during treated HIV-1 infection","volume":"220","author":"Loiseau","year":"2019","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106411_bib64","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/COH.0000000000000281","article-title":"Diversity of HIV-1 reservoirs in CD4+ T-cell subpopulations","volume":"11","author":"Lee","year":"2016","journal-title":"Curr Opin HIV AIDS"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106411_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192278","article-title":"Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment","volume":"13","author":"van den Ham","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106411_bib66","doi-asserted-by":"crossref","first-page":"e271","DOI":"10.1016\/S2352-3018(25)00373-X","article-title":"Recommendations from the 2nd consensus workshop on analytical treatment interruption in HIV research trials","volume":"13","author":"Ndung'u","year":"2026","journal-title":"Lancet HIV"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426002951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:28:21Z","timestamp":1788949701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426002951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":66,"alternative-id":["S2352396426002951"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106411","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HIV-1 reservoir inducibility and immune phenotypes after prolonged analytical treatment interruption: a long-term follow-up study","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106411","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106411"}}