{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:13:34Z","timestamp":1788952414087,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["QY26496"],"award-info":[{"award-number":["QY26496"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004572","name":"National Health Commission of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2026ZD01909300"],"award-info":[{"award-number":["2026ZD01909300"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ebiom.2026.106425","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:43:05Z","timestamp":1786452185000},"page":"106425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["wbp-encoded LPS O-antigen architecture as a prognostic and therapeutic target in Pseudomonas aeruginosa keratitis"],"prefix":"10.1016","volume":"131","author":[{"given":"Mingda","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingquan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ebiom.2026.106425_bib1","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1007\/s11274-014-1692-2","article-title":"The effects of active efflux pumps on antibiotic resistance in Pseudomonas aeruginosa","volume":"30","author":"Terzi","year":"2014","journal-title":"World J Microbiol Biotechnol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106425_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/nyas.14596","article-title":"How to kill Pseudomonas \u2014emerging therapies for a challenging pathogen","volume":"1496","author":"Yaeger","year":"2021","journal-title":"Ann N Y Acad Sci"},{"issue":"43","key":"10.1016\/j.ebiom.2026.106425_bib3","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000001905","article-title":"Risk factors and microbiological features of patients hospitalized for microbial keratitis: a 10-year study in a referral center in Taiwan","volume":"94","author":"Lin","year":"2015","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106425_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12348-025-00538-x","article-title":"Pseudomonas aeruginosa keratitis in a tertiary referral center: a decade of clinical insights and therapeutic challenges","volume":"15","author":"Soleimani","year":"2025","journal-title":"J Ophthalmic Inflamm Infect"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106425_bib5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1574-6976.2011.00298.x","article-title":"Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology","volume":"36","author":"Croxatto","year":"2012","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.ebiom.2026.106425_bib6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12866-014-0289-0","article-title":"Real-time comparative evaluation of bioMerieux VITEK MS versus Bruker Microflex MS, two matrix-assisted laser desorption-ionization time-of-flight mass spectrometry systems, for identification of clinically significant bacteria","volume":"14","author":"Jamal","year":"2014","journal-title":"BMC Microbiol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106425_bib7","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1016\/j.ygeno.2020.08.032","article-title":"Comparative genomics of ocular Pseudomonas aeruginosa strains from keratitis patients with different clinical outcomes","volume":"112","author":"Kandasamy","year":"2020","journal-title":"Genomics"},{"issue":"24","key":"10.1016\/j.ebiom.2026.106425_bib8","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1042\/BCJ20220527","article-title":"Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity","volume":"479","author":"Foulkes","year":"2022","journal-title":"Biochem J"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106425_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/tcmj.tcmj_47_21","article-title":"The role of Type III secretion system in the pathogenesis of Pseudomonas aeruginosa microbial keratitis","volume":"34","author":"Yang","year":"2022","journal-title":"Tzu Chi Med J"},{"key":"10.1016\/j.ebiom.2026.106425_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66674-z","article-title":"Interplay between T3SS effectors, ExoY activation, and cGMP signaling in Pseudomonas aeruginosa infection","volume":"17","author":"Deruelle","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106425_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1663945","article-title":"Beyond pathogenicity: applications of the type III secretion system (T3SS) of Pseudomonas aeruginosa","volume":"16","author":"Su","year":"2025","journal-title":"Front Microbiol"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106425_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/archophthalmol.2011.315","article-title":"Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT)","volume":"130","author":"Srinivasan","year":"2012","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106425_bib13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ajo.2013.09.025","article-title":"The steroids for corneal ulcers trial (SCUT): secondary 12-month clinical outcomes of a randomized controlled trial","volume":"157","author":"Srinivasan","year":"2014","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106425_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064867","article-title":"Host response and bacterial virulence factor expression in Pseudomonas aeruginosa and Streptococcus pneumoniae corneal ulcers","volume":"8","author":"Karthikeyan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2026.106425_bib15","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s10096-025-05294-3","article-title":"Comparison of virulence factors genes between exoU and exoS Pseudomonas aeruginosa in microbial keratitis","volume":"45","author":"Akter","year":"2026","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106425_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1001\/jamaophthalmol.2013.778","article-title":"Association between cytotoxic and invasive Pseudomonas aeruginosa and clinical outcomes in bacterial keratitis","volume":"131","author":"Borkar","year":"2013","journal-title":"JAMA Ophthalmol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106425_bib17","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1074\/jbc.M708894200","article-title":"Flagellin glycosylation in Pseudomonas aeruginosa PAK requires the O-antigen biosynthesis enzyme WbpO","volume":"283","author":"Miller","year":"2008","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106425_bib18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1186\/s12864-017-3842-z","article-title":"Comparative genome and transcriptome analysis reveals distinctive surface characteristics and unique physiological potentials of Pseudomonas aeruginosa ATCC 27853","volume":"18","author":"Cao","year":"2017","journal-title":"BMC Genomics"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106425_bib19","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1006\/exer.2002.2072","article-title":"Pseudomonas aeruginosa strains with lipopolysaccharide defects exhibit reduced intracellular viability after invasion of corneal epithelial cells","volume":"75","author":"Evans","year":"2002","journal-title":"Exp Eye Res"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106425_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00860-21","article-title":"O-specific antigen-dependent surface hydrophobicity mediates aggregate assembly type in Pseudomonas aeruginosa","volume":"12","author":"Azimi","year":"2021","journal-title":"mBio"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106425_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1099\/jmm.0.001110","article-title":"Pseudomonas aeruginosa and microbial keratitis","volume":"69","author":"Hilliam","year":"2020","journal-title":"J Med Microbiol"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106425_bib22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/pathogens9010006","article-title":"The role of Pseudomonas aeruginosa lipopolysaccharide in bacterial pathogenesis and physiology","volume":"9","author":"Huszczynski","year":"2019","journal-title":"Pathogens"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106425_bib23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1753425909106436","article-title":"Review: lipopolysaccharide biosynthesis in Pseudomonas aeruginosa","volume":"15","author":"King","year":"2009","journal-title":"Innate Immun"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106425_bib24","doi-asserted-by":"crossref","first-page":"P87","DOI":"10.1016\/j.ophtha.2023.12.035","article-title":"Bacterial keratitis preferred practice pattern\u00ae","volume":"131","author":"Rhee","year":"2024","journal-title":"Ophthalmology"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106425_bib49","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/archopht.1990.01070070051034","article-title":"Wound healing after excimer laser keratomileusis (Photorefractive keratectomy) in monkeys","volume":"108","author":"Fantes","year":"1990","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ebiom.2026.106425_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1250257","article-title":"Staphylococcus aureus and Pseudomonas aeruginosa infectious keratitis: key bacterial mechanisms that mediate pathogenesis and emerging therapeutics","volume":"13","author":"Shah","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106425_bib26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/jamaophthalmol.2015.4776","article-title":"Global survey of corneal transplantation and eye banking","volume":"134","author":"Gain","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.ebiom.2026.106425_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10096-025-05295-2","article-title":"Structural and functional insights into Pseudomonas aeruginosa's secretion systems 1-6: regulation, role in microbial keratitis and drug targets","volume":"45","author":"Akter","year":"2026","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106425_bib28","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.3390\/pathogens13121030","article-title":"The exoS, exoT, exoU and exoY virulotypes of the type 3 secretion system in multidrug resistant Pseudomonas aeruginosa as a death risk factor in pediatric patients","volume":"13","author":"Nolasco-Romero","year":"2024","journal-title":"Pathogens"},{"key":"10.1016\/j.ebiom.2026.106425_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47303-4","article-title":"High frequency of the exoU+\/exoS+ genotype associated with multidrug-resistant \"high-risk clones\" of Pseudomonas aeruginosa clinical isolates from Peruvian hospitals","volume":"9","author":"Horna","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2026.106425_bib31","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jconrel.2019.01.028","article-title":"Liposomal dexamethasone inhibits tumor growth in an advanced human-mouse hybrid model of multiple myeloma","volume":"296","author":"Deshantri","year":"2019","journal-title":"J Control Release"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106425_bib32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/02713680701229638","article-title":"Multifocal electroretinography, color discrimination and ocular toxicity in tamoxifen use","volume":"32","author":"Salomao","year":"2007","journal-title":"Curr Eye Res"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106425_bib33","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s10792-025-03744-7","article-title":"Metaheuristic-optimized swin transformer with SHAP explainability for keratoconus classification from corneal topography maps","volume":"45","author":"Sujitha","year":"2025","journal-title":"Int Ophthalmol"},{"issue":"6","key":"10.1016\/j.ebiom.2026.106425_bib34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1167\/iovs.66.6.58","article-title":"Whole genome analysis of ocular Pseudomonas aeruginosa isolates reveals genetic diversity","volume":"66","author":"Miranda","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"10.1016\/j.ebiom.2026.106425_bib35","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3390\/antibiotics12050866","article-title":"Comparative genomics of Pseudomonas aeruginosa strains isolated from different ecological niches","volume":"12","author":"G\u00f3mez-Mart\u00ednez","year":"2023","journal-title":"Antibiotics (Basel)"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106425_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007740","article-title":"Pseudomonas aeruginosa population structure revisited","volume":"4","author":"Pirnay","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2026.106425_bib37","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1099\/mic.0.029082-0","article-title":"Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis","volume":"155","author":"Lesic","year":"2009","journal-title":"Microbiology"},{"issue":"2","key":"10.1016\/j.ebiom.2026.106425_bib38","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3390\/microorganisms8020260","article-title":"Characterization of ocular clinical isolates of Pseudomonas aeruginosa from non-contact lens related keratitis patients from South India","volume":"8","author":"Dave","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.ebiom.2026.106425_bib39","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jtos.2025.10.011","article-title":"Phenotypic and genotypic profiling of antimicrobial resistance genes and virulence factors in Pseudomonas aeruginosa isolates from keratitis patients","volume":"38","author":"Tigabu","year":"2025","journal-title":"Ocul Surf"},{"issue":"3","key":"10.1016\/j.ebiom.2026.106425_bib30","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1128\/MMBR.63.3.523-553.1999","article-title":"Genetics of O-antigen biosynthesis in Pseudomonas aeruginosa","volume":"63","author":"Rocchetta","year":"1999","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.ebiom.2026.106425_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2011.00118","article-title":"Genetic and functional diversity of Pseudomonas aeruginosa lipopolysaccharide","volume":"2","author":"Lam","year":"2011","journal-title":"Front Microbiol"},{"issue":"31","key":"10.1016\/j.ebiom.2026.106425_bib42","doi-asserted-by":"crossref","first-page":"10593","DOI":"10.1074\/jbc.REV120.009402","article-title":"Lipopolysaccharide O-antigens-bacterial glycans made to measure","volume":"295","author":"Whitfield","year":"2020","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.ebiom.2026.106425_bib43","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/femsre\/fuw007","article-title":"Lipopolysaccharide modification in Gram-negative bacteria during chronic infection","volume":"40","author":"Maldonado","year":"2016","journal-title":"FEMS Microbiol Rev"},{"issue":"7","key":"10.1016\/j.ebiom.2026.106425_bib44","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.4049\/jimmunol.1000874","article-title":"TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways","volume":"185","author":"Sun","year":"2010","journal-title":"J Immunol"},{"issue":"12","key":"10.1016\/j.ebiom.2026.106425_bib45","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3390\/microorganisms7120707","article-title":"Pseudomonas aeruginosa toxin ExoU as a therapeutic target in the treatment of bacterial infections","volume":"7","author":"Foulkes","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.ebiom.2026.106425_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2017.00130","article-title":"Signaling mediated by toll-like receptor 5 sensing of Pseudomonas aeruginosa Flagellin influences IL-1\u03b2 and IL-18 production by primary fibroblasts derived from the human cornea","volume":"7","author":"Cendra","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"issue":"11","key":"10.1016\/j.ebiom.2026.106425_bib47","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3390\/pathogens13110975","article-title":"Multidrug resistant P seudomonas aeruginosa in clinical settings: a review of resistance mechanisms and treatment strategies","volume":"13","author":"Schwartz","year":"2024","journal-title":"Pathogens"},{"key":"10.1016\/j.ebiom.2026.106425_bib48","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jgar.2019.04.012","article-title":"Colistin plus meropenem combination is synergistic in vitro against extensively drug-resistant Pseudomonas aeruginosa, including high-risk clones","volume":"18","author":"Montero","year":"2019","journal-title":"J Glob Antimicrob Resist"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426003099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426003099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:31:09Z","timestamp":1788949869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426003099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":48,"alternative-id":["S2352396426003099"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106425","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"wbp-encoded LPS O-antigen architecture as a prognostic and therapeutic target in Pseudomonas aeruginosa keratitis","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106425","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106425"}}