{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:13:46Z","timestamp":1788952426671,"version":"build-2803163510"},"reference-count":222,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82322012"],"award-info":[{"award-number":["82322012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170705"],"award-info":[{"award-number":["82170705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2025ZD0547600"],"award-info":[{"award-number":["2025ZD0547600"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502500"],"award-info":[{"award-number":["2022YFC2502500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["eBioMedicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ebiom.2026.106436","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:51:02Z","timestamp":1786798262000},"page":"106436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy"],"prefix":"10.1016","volume":"131","author":[{"given":"Hongtu","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zikang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-1111","authenticated-orcid":false,"given":"Yinghui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ebiom.2026.106436_bib1","doi-asserted-by":"crossref","first-page":"ITC66","DOI":"10.7326\/AITC201711070","article-title":"Acute kidney injury","volume":"167","author":"Levey","year":"2017","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.kint.2020.04.020","article-title":"Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference","volume":"98","author":"Ostermann","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.ebiom.2026.106436_bib3","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2215\/CJN.16541221","article-title":"Postoperative acute kidney injury","volume":"17","author":"Boyer","year":"2022","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0140-6736(24)02385-7","article-title":"Acute kidney injury","volume":"405","author":"Ostermann","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.ebiom.2026.106436_bib5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41581-021-00394-7","article-title":"Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection","volume":"17","author":"Scholz","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib6","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s00134-021-06454-7","article-title":"Acute kidney injury in the critically ill: an updated review on pathophysiology and management","volume":"47","author":"Pickkers","year":"2021","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib7","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/CCM.0000000000006328","article-title":"The road to precision medicine for acute kidney injury","volume":"52","author":"Birkelo","year":"2024","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib8","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1053\/j.ajkd.2017.11.021","article-title":"Management of acute kidney injury: core curriculum 2018","volume":"72","author":"Moore","year":"2018","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.ebiom.2026.106436_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-020518-114605","article-title":"Biomarkers of acute and chronic kidney disease","volume":"81","author":"Zhang","year":"2019","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib10","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.kint.2021.06.028","article-title":"Harmonizing acute and chronic kidney disease definition and classification: report of a Kidney Disease: Improving Global Outcomes (KDIGO) consensus conference","volume":"100","author":"Lameire","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.ebiom.2026.106436_bib11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.ebiom.2026.106436_bib12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ccc.2020.11.013","article-title":"Acute kidney disease to chronic kidney disease","volume":"37","author":"Neyra","year":"2021","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.ebiom.2026.106436_bib13","doi-asserted-by":"crossref","first-page":"F788","DOI":"10.1152\/ajprenal.00184.2024","article-title":"Transition from acute kidney injury to chronic kidney disease: mechanisms, models, and biomarkers","volume":"327","author":"Zhang","year":"2024","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib14","doi-asserted-by":"crossref","first-page":"686","DOI":"10.23876\/j.krcp.23.001","article-title":"Acute kidney disease: an overview of the epidemiology, pathophysiology, and management","volume":"42","author":"Kung","year":"2023","journal-title":"Kidney Res Clin Pract"},{"key":"10.1016\/j.ebiom.2026.106436_bib15","doi-asserted-by":"crossref","first-page":"F452","DOI":"10.1152\/ajprenal.00266.2024","article-title":"Renal macro- and microcirculatory perturbations in acute kidney injury and chronic kidney disease associated with heart failure and cardiac surgery","volume":"328","author":"Trask-Marino","year":"2025","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0286543","article-title":"Impaired microvascular circulation in distant organs following renal ischemia","volume":"18","author":"Dominguez","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2026.106436_bib17","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.jtha.2024.02.006","article-title":"The role of thromboinflammation in acute kidney injury among patients with septic coagulopathy","volume":"22","author":"Iba","year":"2024","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ebiom.2026.106436_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/JCI188358","article-title":"Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury","volume":"135","author":"Baker","year":"2025","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ebiom.2026.106436_bib19","article-title":"Role of the endothelial cell glycocalyx in sepsis-induced acute kidney injury","volume":"12","author":"Wang","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.ebiom.2026.106436_bib20","article-title":"Renal microcirculation injury as the main cause of ischemic acute kidney injury development","volume":"12","author":"Kwiatkowska","year":"2023","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.ebiom.2026.106436_bib21","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.ultrasmedbio.2023.06.002","article-title":"Contrast-enhanced ultrasonography for acute kidney injury: a systematic review and meta-analysis","volume":"49","author":"Li","year":"2023","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.ebiom.2026.106436_bib22","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.7150\/thno.113741","article-title":"Nitric oxide-primed engineered extracellular vesicles restore bioenergetics in acute kidney injury via mitochondrial transfer","volume":"15","author":"Peng","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.ebiom.2026.106436_bib23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41581-021-00489-1","article-title":"Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury","volume":"18","author":"Molema","year":"2022","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib24","doi-asserted-by":"crossref","first-page":"5731","DOI":"10.1007\/s00018-021-03892-w","article-title":"The role of metabolic reprogramming in tubular epithelial cells during the progression of acute kidney injury","volume":"78","author":"Li","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ebiom.2026.106436_bib25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.34067\/KID.0004772020","article-title":"Proximal tubular oxidative metabolism in acute kidney injury and the transition to CKD","volume":"2","author":"Schaub","year":"2021","journal-title":"Kidney360"},{"key":"10.1016\/j.ebiom.2026.106436_bib26","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/CM9.0000000000003142","article-title":"Lactate metabolism and acute kidney injury","volume":"138","author":"Li","year":"2025","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.ebiom.2026.106436_bib27","article-title":"Mitophagy in acute kidney injury and kidney repair","volume":"9","author":"Wang","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ebiom.2026.106436_bib28","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2393262","article-title":"Mitochondrial dysfunction in acute kidney injury","volume":"46","author":"Yao","year":"2024","journal-title":"Ren Fail"},{"key":"10.1016\/j.ebiom.2026.106436_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.170521","article-title":"Calponin 2 regulates ketogenesis to mitigate acute kidney injury","volume":"8","author":"Gui","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.ebiom.2026.106436_bib30","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1681\/ASN.0000001014","article-title":"Renal ketogenesis protects against ischemic kidney injury","volume":"37","author":"Feola","year":"2026","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib31","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1681\/ASN.0000000967","article-title":"Matrix stiffness directs early injury and ketogenesis programs to prime kidney repair","volume":"37","author":"Gui","year":"2026","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib32","doi-asserted-by":"crossref","first-page":"8915","DOI":"10.1007\/s11033-023-08713-w","article-title":"\u03b2-hydroxybutyrate ameliorates sepsis-induced acute kidney injury","volume":"50","author":"Kim","year":"2023","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.ebiom.2026.106436_bib33","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2354918","article-title":"\u03b2-Hydroxybutyrate protects against cisplatin-induced renal damage via regulating ferroptosis","volume":"46","author":"Tian","year":"2024","journal-title":"Ren Fail"},{"key":"10.1016\/j.ebiom.2026.106436_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149482","article-title":"Pre-treatment with \u03b2-hydroxybutyrate mitigates cisplatin-induced acute kidney injury","volume":"695","author":"Kim","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ebiom.2026.106436_bib35","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.celrep.2019.09.050","article-title":"Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury","volume":"29","author":"Maekawa","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.ebiom.2026.106436_bib36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.molmed.2024.12.004","article-title":"NAD(+) metabolism in acute kidney injury and chronic kidney disease transition","volume":"31","author":"Alhumaidi","year":"2025","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102984","article-title":"Dimethyl malonate preserves renal and mitochondrial functions following ischemia-reperfusion via inhibition of succinate dehydrogenase","volume":"69","author":"Carlstr\u00f6m","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.ebiom.2026.106436_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jointm.2024.08.001","article-title":"New drugs for acute kidney injury","volume":"5","author":"Hariri","year":"2025","journal-title":"J Intensive Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s43188-024-00272-x","article-title":"Oxidative stress and NRF2 signaling in kidney injury","volume":"41","author":"Ng","year":"2025","journal-title":"Toxicol Res"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106436_bib40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/ijms25010003","article-title":"Molecular mechanisms of oxidative stress in acute kidney injury: targeting the loci by resveratrol","volume":"25","author":"Rashid","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2026.106436_bib41","article-title":"The role of oxidative stress as a mechanism in the pathogenesis of acute heart failure in acute kidney injury","volume":"14","author":"Tasi\u0107","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.ebiom.2026.106436_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052948","article-title":"Neutrophils and NADPH oxidases are major contributors to mild but not severe ischemic acute kidney injury in mice","volume":"25","author":"R\u00e9v\u00e9sz","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2026.106436_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1193734","article-title":"Inhibition of the NADPH oxidase pathway reduces ferroptosis during septic renal injury in diabetic mice","volume":"2022","author":"Yao","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ebiom.2026.106436_bib44","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1080\/10715762.2021.2024529","article-title":"SIRT2 tyrosine nitration by peroxynitrite in response to renal ischemia\/reperfusion injury","volume":"55","author":"Wang","year":"2021","journal-title":"Free Radic Res"},{"key":"10.1016\/j.ebiom.2026.106436_bib45","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41419-022-04628-9","article-title":"Targeting ferroptosis in acute kidney injury","volume":"13","author":"Ni","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ebiom.2026.106436_bib46","article-title":"The role of oxidative stress in kidney injury","volume":"12","author":"Piko","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.ebiom.2026.106436_bib47","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6193694","article-title":"Oxidative stress and acute kidney injury in critical illness: Pathophysiologic mechanisms-biomarkers-interventions, and future perspectives","volume":"2017","author":"Pavlakou","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.ebiom.2026.106436_bib48","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41392-022-01036-5","article-title":"Signaling pathways of chronic kidney diseases, implications for therapeutics","volume":"7","author":"Yuan","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.ebiom.2026.106436_bib49","article-title":"Redox regulation of Nrf2 in cisplatin-induced kidney injury","volume":"12","author":"Mapuskar","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.ebiom.2026.106436_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105294","article-title":"Renal tubular epithelial cells response to injury in acute kidney injury","volume":"107","author":"Li","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ebiom.2026.106436_bib51","article-title":"Research progress on damage-associated molecular patterns in acute kidney injury","volume":"16","author":"Li","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2026.106436_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2025.02.003","article-title":"Macrophage-driven inflammation in acute kidney injury: therapeutic opportunities and challenges","volume":"278","author":"Mu","year":"2025","journal-title":"Transl Res"},{"key":"10.1016\/j.ebiom.2026.106436_bib53","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41420-024-01979-4","article-title":"The emerging role of regulated cell death in ischemia and reperfusion-induced acute kidney injury: current evidence and future perspectives","volume":"10","author":"Li","year":"2024","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.ebiom.2026.106436_bib54","doi-asserted-by":"crossref","first-page":"F269","DOI":"10.1152\/ajprenal.00338.2024","article-title":"Renal ischemia-reperfusion injury triggers proximal tubular apoptosis and NHE3 dysfunction via p38MAPK\/ezrin signaling pathway","volume":"329","author":"Costa-Pessoa","year":"2025","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib55","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1038\/s41467-023-40037-y","article-title":"Longitudinal tracking of acute kidney injury reveals injury propagation along the nephron","volume":"14","author":"Bordoni","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106436_bib56","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s43556-025-00293-4","article-title":"Acute kidney injury: pathogenesis and therapeutic interventions","volume":"6","author":"Xu","year":"2025","journal-title":"Mol Biomed"},{"key":"10.1016\/j.ebiom.2026.106436_bib57","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2504565122","article-title":"Rac1 promotes proximal tubule kidney repair by coupling the actin cytoskeleton to mitochondrial function","volume":"122","author":"M Viquez","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2026.106436_bib58","article-title":"Modeling hypoxia\/reoxygenation injury in proximal tubular epithelial cells","volume":"225","author":"Marin-Blazquez","year":"2025","journal-title":"J Vis Exp"},{"key":"10.1016\/j.ebiom.2026.106436_bib59","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.kint.2025.08.010","article-title":"Metabolic heavyweight: thick ascending limb or proximal tubule? Next round","volume":"108","author":"Hurtado","year":"2025","journal-title":"Kidney Int"},{"key":"10.1016\/j.ebiom.2026.106436_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/biom15060794","article-title":"Mechanisms of acute kidney injury-chronic kidney disease transition: unraveling maladaptive repair and therapeutic opportunities","volume":"15","author":"Xu","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.ebiom.2026.106436_bib61","doi-asserted-by":"crossref","first-page":"724","DOI":"10.23876\/j.krcp.23.344","article-title":"The crosstalk of Wnt\/\u03b2-catenin signaling and p53 in acute kidney injury and chronic kidney disease","volume":"43","author":"Ming","year":"2024","journal-title":"Kidney Res Clin Pract"},{"key":"10.1016\/j.ebiom.2026.106436_bib62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13613-024-01360-9","article-title":"Biomarkers in acute kidney injury","volume":"14","author":"Ostermann","year":"2024","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.ebiom.2026.106436_bib63","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12882-025-04040-3","article-title":"Advances in the diagnosis of early biomarkers for acute kidney injury: a literature review","volume":"26","author":"Yang","year":"2025","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib64","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/s12882-025-04222-z","article-title":"Inhibition of Axl attenuates acute kidney injury by alleviating inflammation via SOCS3 downregulation in tubular epithelial cells","volume":"26","author":"Kang","year":"2025","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib65","article-title":"Mechanisms and therapeutic prospects of hypoxia-inducible factor 1-alpha in acute kidney injury: a systematic review","volume":"13","author":"Kang","year":"2025","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.ebiom.2026.106436_bib66","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkac059","article-title":"Autophagy in acute kidney injury and maladaptive kidney repair","volume":"11","author":"Xiang","year":"2023","journal-title":"Burns Trauma"},{"key":"10.1016\/j.ebiom.2026.106436_bib67","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/ndt\/gfaf132","article-title":"SGLT2 inhibitors and acute kidney injury","volume":"41","author":"Nakao","year":"2026","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ebiom.2026.106436_bib68","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1111\/bph.16152","article-title":"Compound-42 alleviates acute kidney injury by targeting RIPK3-mediated necroptosis","volume":"180","author":"He","year":"2023","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ebiom.2026.106436_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.crphys.2025.100152","article-title":"From acute tubular injury to tubular repair and chronic kidney diseases - KIM-1 as a promising biomarker for predicting renal tubular pathology","volume":"8","author":"Zhang","year":"2025","journal-title":"Curr Res Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib70","doi-asserted-by":"crossref","first-page":"F4","DOI":"10.1152\/ajprenal.00275.2023","article-title":"Cell death induced by acute renal injury: a perspective on the contributions of accidental and programmed cell death","volume":"327","author":"Noh","year":"2024","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib71","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41581-023-00694-0","article-title":"Regulated cell death pathways in kidney disease","volume":"19","author":"Sanz","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010412","article-title":"TUNEL assay: a powerful tool for kidney injury evaluation","volume":"22","author":"Moore","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2026.106436_bib73","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13054-025-05329-3","article-title":"Pyroptosis in sepsis-associated acute kidney injury: mechanisms and therapeutic perspectives","volume":"29","author":"Wu","year":"2025","journal-title":"Crit Care"},{"key":"10.1016\/j.ebiom.2026.106436_bib74","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.kint.2019.07.002","article-title":"Gasdermin D and pyroptosis in acute kidney injury","volume":"96","author":"Tonnus","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.ebiom.2026.106436_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-21248-7","article-title":"Extracellular DNA concentrations in various aetiologies of acute kidney injury","volume":"12","author":"Ga\u00e1l Koval\u010d\u00edkov\u00e1","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2026.106436_bib76","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/00041552-200205000-00006","article-title":"Role of apoptosis in the pathogenesis of acute renal failure","volume":"11","author":"Bonegio","year":"2002","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.ebiom.2026.106436_bib77","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/sj.ki.5000315","article-title":"Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure","volume":"69","author":"Homsi","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.ebiom.2026.106436_bib78","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41419-018-0936-8","article-title":"RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ebiom.2026.106436_bib79","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1042\/BCJ20240569","article-title":"Inhibition of RIPK1 or RIPK3 kinase activity post ischemia-reperfusion reduces the development of chronic kidney injury","volume":"482","author":"Pefanis","year":"2025","journal-title":"Biochem J"},{"key":"10.1016\/j.ebiom.2026.106436_bib80","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41581-024-00875-5","article-title":"Lymphocytes and innate immune cells in acute kidney injury and repair","volume":"20","author":"Lee","year":"2024","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1688207","article-title":"Neutrophil and neutrophil extracellular traps in acute kidney injury: from mechanisms to treatments","volume":"16","author":"Fu","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2026.106436_bib82","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1294807","article-title":"Advances in understanding of dendritic cell in the pathogenesis of acute kidney injury","volume":"15","author":"Lv","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2026.106436_bib83","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1111\/jcmm.17771","article-title":"The role of regulatory T cells in the pathogenesis of acute kidney injury","volume":"27","author":"Liu","year":"2023","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib84","first-page":"738","article-title":"Mechanisms underlying the impact of interleukin family on acute kidney injury: pathogenesis, progression, and therapy","volume":"8","author":"Ji","year":"2025","journal-title":"Research (Wash D C)"},{"key":"10.1016\/j.ebiom.2026.106436_bib85","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25073763","article-title":"Monocytes and macrophages in kidney disease and homeostasis","volume":"25","author":"Nachiappa Ganesh","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2026.106436_bib86","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/s41467-024-45752-8","article-title":"High resolution spatial profiling of kidney injury and repair using RNA hybridization-based in situ sequencing","volume":"15","author":"Wu","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106436_bib87","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1681\/ASN.0000000000000191","article-title":"Divergent actions of renal tubular and endothelial type 1 IL-1 receptor signaling in toxin-induced AKI","volume":"34","author":"Ren","year":"2023","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib88","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s13577-024-01072-z","article-title":"Crosstalk among proximal tubular cells, macrophages, and fibroblasts in acute kidney injury: single-cell profiling from the perspective of ferroptosis","volume":"37","author":"Wang","year":"2024","journal-title":"Hum Cell"},{"key":"10.1016\/j.ebiom.2026.106436_bib89","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1681\/ASN.0000000000000215","article-title":"Targeting IL-1 receptor signaling in AKI","volume":"34","author":"Steiger","year":"2023","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib90","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2478482","article-title":"Crosstalk between macrophages and adjacent cells in AKI to CKD transition","volume":"47","author":"Lin","year":"2025","journal-title":"Ren Fail"},{"key":"10.1016\/j.ebiom.2026.106436_bib91","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1097\/CM9.0000000000003698","article-title":"Cellular senescence in renal ischemia-reperfusion injury","volume":"138","author":"Chen","year":"2025","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.ebiom.2026.106436_bib92","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.175416","article-title":"Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism","volume":"9","author":"Noonan","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.ebiom.2026.106436_bib93","doi-asserted-by":"crossref","first-page":"12576","DOI":"10.1096\/fj.201900651RR","article-title":"Early activation of fibroblasts is required for kidney repair and regeneration after injury","volume":"33","author":"Zhou","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.ebiom.2026.106436_bib94","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1089\/end.2023.0705","article-title":"Local renal treatments for acute kidney injury: a review of current progress and future translational opportunities","volume":"38","author":"Chen","year":"2024","journal-title":"J Endourol"},{"key":"10.1016\/j.ebiom.2026.106436_bib95","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13287-024-03736-x","article-title":"Subcutaneous injection of adipose stromal cell-secretome improves renal function and reduces inflammation in established acute kidney injury","volume":"15","author":"Ullah","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.ebiom.2026.106436_bib96","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adt5553","article-title":"Human iPSC-derived nephron progenitor cells treat acute kidney injury and chronic kidney disease in mouse models","volume":"17","author":"Araoka","year":"2025","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib97","article-title":"The multifaceted role of macrophages in kidney physiology and diseases","volume":"16","author":"Ma","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.ebiom.2026.106436_bib98","doi-asserted-by":"crossref","DOI":"10.1093\/ckj\/sfaf190","article-title":"Understanding and targeting senescence in kidney disease","volume":"18","author":"Chanvillard","year":"2025","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.ebiom.2026.106436_bib99","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41420-024-01831-9","article-title":"Cellular senescence of renal tubular epithelial cells in acute kidney injury","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.ebiom.2026.106436_bib100","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1097\/CM9.0000000000003746","article-title":"Cellular senescence in kidney diseases","volume":"138","author":"Wang","year":"2025","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.ebiom.2026.106436_bib101","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.166643","article-title":"Tubular cell senescence promotes maladaptive kidney repair and chronic kidney disease after cisplatin nephrotoxicity","volume":"8","author":"Li","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.ebiom.2026.106436_bib102","doi-asserted-by":"crossref","first-page":"142","DOI":"10.34067\/KID.0000000000000316","article-title":"Targeting senescent cells as therapy for CKD","volume":"5","author":"Mylonas","year":"2024","journal-title":"Kidney360"},{"key":"10.1016\/j.ebiom.2026.106436_bib103","doi-asserted-by":"crossref","first-page":"7699","DOI":"10.1038\/s41467-025-63152-4","article-title":"Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury","volume":"16","author":"Huang","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106436_bib104","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41419-025-07386-6","article-title":"Human proximal tubular epithelial cell interleukin-1 receptor signalling triggers G2\/M arrest and cellular senescence during hypoxic kidney injury","volume":"16","author":"Giuliani","year":"2025","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ebiom.2026.106436_bib105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41419-025-08268-7","article-title":"Inhibition of MCL-1 to eliminate senescent cells and mitigate renal fibrosis in aristolochic acid nephropathy","volume":"17","author":"Gao","year":"2026","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ebiom.2026.106436_bib106","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1186\/s12964-024-01968-1","article-title":"Targeting cellular senescence in kidney diseases and aging: a focus on mesenchymal stem cells and their paracrine factors","volume":"22","author":"Hejazian","year":"2024","journal-title":"Cell Commun Signal"},{"issue":"21","key":"10.1016\/j.ebiom.2026.106436_bib107","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3390\/cells14211662","article-title":"Erythropoiesis-stimulating agent protects against kidney fibrosis by inhibiting G2\/M cell cycle arrest","volume":"14","author":"Oh","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.ebiom.2026.106436_bib108","article-title":"The deleterious effects of CDK4\/6 inhibition on renal recovery post-acute kidney injury","volume":"14","author":"Zhou","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2026.106436_bib109","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/ndt\/gfad199","article-title":"Single-cell RNA sequencing identifies senescence as therapeutic target in rhabdomyolysis-induced acute kidney injury","volume":"39","author":"Rao","year":"2024","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ebiom.2026.106436_bib110","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3390\/ph18060822","article-title":"Dasatinib and quercetin combination increased kidney damage in acute folic acid-induced experimental nephropathy","volume":"18","author":"Battaglia-Vieni","year":"2025","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.ebiom.2026.106436_bib111","article-title":"Postischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis","volume":"135","author":"Tiwari","year":"2024","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ebiom.2026.106436_bib112","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.kint.2023.08.005","article-title":"A comprehensive description of kidney disease progression after acute kidney injury from a prospective, parallel-group cohort study","volume":"104","author":"Horne","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.ebiom.2026.106436_bib113","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1042\/CS20241851","article-title":"Persistent subclinical renal injury in female rats following renal ischemia-reperfusion injury","volume":"139","author":"Moronge","year":"2025","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.ebiom.2026.106436_bib114","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167731","article-title":"Longitudinal biomarkers and kidney disease progression after acute kidney injury","volume":"8","author":"Wen","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.ebiom.2026.106436_bib115","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10051106","article-title":"Urinary KIM-1 correlates with the subclinical sequelae of tubular damage persisting after the apparent functional recovery from intrinsic acute kidney injury","volume":"10","author":"Cuesta","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.ebiom.2026.106436_bib116","article-title":"Advancements in the non-invasive diagnosis of renal fibrosis","volume":"12","author":"Yuan","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.ebiom.2026.106436_bib117","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3349\/ymj.2023.0306","article-title":"Recent update on acute kidney injury-to-chronic kidney disease transition","volume":"65","author":"Koh","year":"2024","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.ebiom.2026.106436_bib118","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.kint.2023.03.025","article-title":"Acute kidney injury and distant organ dysfunction-network system analysis","volume":"103","author":"Matsuura","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.ebiom.2026.106436_bib119","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13092455","article-title":"Treatment of acute kidney injury: a review of current approaches and emerging innovations","volume":"13","author":"Tamargo","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib120","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1097\/CCM.0000000000005849","article-title":"Predicting the development of renal replacement therapy indications by combining the furosemide stress test and chemokine (C-C motif) ligand 14 in a cohort of postsurgical patients","volume":"51","author":"Meersch","year":"2023","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib121","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24044103","article-title":"Norepinephrine and vasopressin in hemorrhagic shock: a focus on renal hemodynamics","volume":"24","author":"Fage","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2026.106436_bib122","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1016\/j.ekir.2023.08.006","article-title":"Assessing GFR with proenkephalin","volume":"8","author":"Beunders","year":"2023","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.ebiom.2026.106436_bib123","doi-asserted-by":"crossref","first-page":"C243","DOI":"10.1152\/ajpcell.00147.2023","article-title":"Renoprotective effects of GLP-1 receptor agonists and SGLT-2 inhibitors-is hemodynamics the key point?","volume":"325","author":"Lee","year":"2023","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib124","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/10408363.2023.2242481","article-title":"New biomarkers in acute kidney injury","volume":"61","author":"Rossiter","year":"2024","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"Suppl 1","key":"10.1016\/j.ebiom.2026.106436_bib125","first-page":"S25","article-title":"Early biomarkers of renal injury","volume":"16","author":"Cruz","year":"2010","journal-title":"Congest Heart Fail"},{"key":"10.1016\/j.ebiom.2026.106436_bib126","doi-asserted-by":"crossref","first-page":"e731","DOI":"10.34067\/KID.0002502022","article-title":"Fractional excretion of sodium and urea are useful tools in the evaluation of AKI: COMMENTARY","volume":"4","author":"Brown","year":"2023","journal-title":"Kidney360"},{"key":"10.1016\/j.ebiom.2026.106436_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2024.154926","article-title":"Clinician assessment of kidney function from plasma creatinine values during critical illness: a scenario-based international multi-professional survey","volume":"85","author":"Azzopardi","year":"2025","journal-title":"J Crit Care"},{"key":"10.1016\/j.ebiom.2026.106436_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2024.154809","article-title":"How a positive fluid balance develops in acute kidney injury: a binational, observational study","volume":"82","author":"White","year":"2024","journal-title":"J Crit Care"},{"key":"10.1016\/j.ebiom.2026.106436_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2024.111458","article-title":"Biomarkers of acute kidney injury: from discovery to the future of clinical practice","volume":"95","author":"Strau\u00df","year":"2024","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.ebiom.2026.106436_bib130","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/phar.2893","article-title":"Urinary biomarkers as indicators of acute kidney injury in critically ill children exposed to vancomycin","volume":"44","author":"Spyhalsky","year":"2024","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.ebiom.2026.106436_bib131","doi-asserted-by":"crossref","DOI":"10.3390\/jcm14082595","article-title":"The furosemide stress test: a dynamic tool for predicting acute kidney injury progression in critical care medicine","volume":"14","author":"La Via","year":"2025","journal-title":"J Clin Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib132","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1159\/000522341","article-title":"The proximal tubule as the pathogenic and therapeutic target in acute kidney injury","volume":"146","author":"Ho","year":"2022","journal-title":"Nephron"},{"key":"10.1016\/j.ebiom.2026.106436_bib133","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s00467-023-06264-7","article-title":"Adverse effects of acute tubular injury on the glomerulus: contributing factors and mechanisms","volume":"39","author":"Babickova","year":"2024","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib134","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000490007","article-title":"Tubular recovery after acute kidney injury","volume":"140","author":"Fattah","year":"2018","journal-title":"Nephron"},{"key":"10.1016\/j.ebiom.2026.106436_bib135","doi-asserted-by":"crossref","first-page":"e728","DOI":"10.34067\/KID.0002512022","article-title":"Fractional excretion of sodium and urea are useful tools in the evaluation of AKI: CON","volume":"4","author":"Aron","year":"2023","journal-title":"Kidney360"},{"key":"10.1016\/j.ebiom.2026.106436_bib136","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/jalm\/jfab020","article-title":"AACC guidance document on laboratory investigation of acute kidney injury","volume":"6","author":"El-Khoury","year":"2021","journal-title":"J Appl Lab Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib137","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11606-025-09704-2","article-title":"Imaging of medical patients with acute kidney injury: patterns of ultrasound use and the role of point-of-care ultrasound at a tertiary care center","volume":"41","author":"Gaudreau-Simard","year":"2026","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib138","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1410764","article-title":"Modeling the interaction between tubuloglomerular feedback and myogenic mechanisms in the control of glomerular mechanics","volume":"15","author":"Richfield","year":"2024","journal-title":"Front Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1684\/ndt.2026.182","article-title":"Analysis of the predictive value of serum Cys-C and IL-6 levels for acute kidney injury in patients with acute respiratory distress syndrome","volume":"22","author":"Cui","year":"2026","journal-title":"Nephrol Ther"},{"issue":"1","key":"10.1016\/j.ebiom.2026.106436_bib140","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1186\/s12872-026-06040-z","article-title":"Association between intrarenal venous flow and postoperative acute kidney injury in cardiac surgery patients following cardiopulmonary bypass: a prospective cohort study","volume":"26","author":"Zhao","year":"2026","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.ebiom.2026.106436_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2026.102752","article-title":"Venous excess ultrasound score and acute kidney injury in patients with acute heart failure","volume":"5","author":"Araiza-Garaygordobil","year":"2026","journal-title":"JACC Adv"},{"key":"10.1016\/j.ebiom.2026.106436_bib142","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13054-025-05785-x","article-title":"Microvascular phenotypes in pediatric sepsis identified by machine learning: prognostic implications for organ dysfunction and mortality","volume":"30","author":"Beltr\u00e1n","year":"2026","journal-title":"Crit Care"},{"key":"10.1016\/j.ebiom.2026.106436_bib143","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12944-026-02888-4","article-title":"Metabolic phenotyping of sepsis in large multicenter cohorts: identification of a reproducible high-risk subgroup","volume":"25","author":"Zhang","year":"2026","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.ebiom.2026.106436_bib144","series-title":"Clinical practice guideline for the diagnosis and treatment of cardiorenal syndrome","first-page":"3705","volume":"103","year":"2023"},{"key":"10.1016\/j.ebiom.2026.106436_bib145","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1163\/18762891-bja00032","article-title":"Association of gut microbiota with acute kidney injury: a two-sample Mendelian randomisation and case-control study","volume":"15","author":"Liu","year":"2024","journal-title":"Benef Microbes"},{"key":"10.1016\/j.ebiom.2026.106436_bib146","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2556295","article-title":"Beyond creatinine: diagnostic accuracy of emerging biomarkers for AKI in the ICU - a systematic review","volume":"47","author":"Matarneh","year":"2025","journal-title":"Ren Fail"},{"key":"10.1016\/j.ebiom.2026.106436_bib147","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.19209","article-title":"Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference: a consensus statement","volume":"3","author":"Ostermann","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ebiom.2026.106436_bib148","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1164\/rccm.202006-2239ED","article-title":"Subclinical acute kidney injury is acute kidney injury and should not be ignored","volume":"202","author":"Koyner","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib149","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0330280","article-title":"The efficacy of novel biomarkers for the early detection and management of acute kidney injury: a systematic review","volume":"20","author":"Almulhim","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.ebiom.2026.106436_bib150","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1164\/rccm.201401-0077OC","article-title":"Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication","volume":"189","author":"Bihorac","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib151","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1038\/s41598-023-33233-9","article-title":"Predictive value of urinary cell cycle arrest biomarkers for all cause-acute kidney injury: a meta-analysis","volume":"13","author":"Huang","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.ebiom.2026.106436_bib152","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1681\/ASN.2014060535","article-title":"Furosemide stress test and biomarkers for the prediction of AKI severity","volume":"26","author":"Koyner","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib153","doi-asserted-by":"crossref","DOI":"10.1186\/cc13015","article-title":"Development and standardization of a furosemide stress test to predict the severity of acute kidney injury","volume":"17","author":"Chawla","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.ebiom.2026.106436_bib154","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13054-019-2504-8","article-title":"Clinical use of [TIMP-2]\u2022[IGFBP7] biomarker testing to assess risk of acute kidney injury in critical care: guidance from an expert panel","volume":"23","author":"Guzzi","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.ebiom.2026.106436_bib155","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-070240","article-title":"Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial","volume":"13","author":"von Groote","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.ebiom.2026.106436_bib156","first-page":"555","article-title":"Acute kidney injury subphenotyping and personalized medicine","volume":"30","author":"Meersch","year":"2024","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.ebiom.2026.106436_bib157","article-title":"Sepsis-associated acute kidney injury: what's new regarding its diagnostics and therapeutics?","volume":"14","author":"Kounatidis","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.ebiom.2026.106436_bib158","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1016\/j.ekir.2024.09.001","article-title":"Exploring Angiopoietin-2: clinical insights and experimental perspectives in kidney diseases","volume":"9","author":"Luo","year":"2024","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.ebiom.2026.106436_bib159","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2215\/CJN.04840513","article-title":"Renal relevant radiology: use of ultrasonography in patients with AKI","volume":"9","author":"Faubel","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib160","first-page":"777","article-title":"Role of resistive index to differentiate between prerenal acute kidney injury and acute tubular necrosis","volume":"34","author":"Mahjabin","year":"2025","journal-title":"Mymensingh Med J"},{"key":"10.1016\/j.ebiom.2026.106436_bib161","doi-asserted-by":"crossref","DOI":"10.1177\/20503121241228446","article-title":"Review of the limitations of current biomarkers in acute kidney injury clinical practices","volume":"12","author":"Bufkin","year":"2024","journal-title":"SAGE Open Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib162","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12050931","article-title":"The role of biomarkers in diagnosis of sepsis and acute kidney injury","volume":"12","author":"Ferreira","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.ebiom.2026.106436_bib163","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2026.2620162","article-title":"Biochemical phenotypes of acute kidney injury and their association with major adverse kidney events","volume":"48","author":"Maggiani-Aguilera","year":"2026","journal-title":"Ren Fail"},{"key":"10.1016\/j.ebiom.2026.106436_bib164","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.ekir.2022.03.026","article-title":"Considerations in controlling for urine concentration for biomarkers of kidney disease progression after acute kidney injury","volume":"7","author":"Wen","year":"2022","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.ebiom.2026.106436_bib165","doi-asserted-by":"crossref","DOI":"10.3390\/cells13191613","article-title":"Senescence biomarkers CKAP4 and PTX3 stratify severe kidney disease patients","volume":"13","author":"McCallion","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.ebiom.2026.106436_bib166","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1093\/ckj\/sfad129","article-title":"Epidemiology and outcomes of post-AKI proteinuria","volume":"16","author":"Su","year":"2023","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.ebiom.2026.106436_bib167","article-title":"Kidney injury molecule 1 in the early detection of acute kidney injury-a systematic review and meta-analysis","volume":"12","author":"Su","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.ebiom.2026.106436_bib168","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/MNH.0000000000001098","article-title":"Moving beyond the syndrome: how can acute kidney injury phenotypes help?","volume":"34","author":"Scott","year":"2025","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.ebiom.2026.106436_bib169","doi-asserted-by":"crossref","first-page":"F563","DOI":"10.1152\/ajprenal.00402.2023","article-title":"Rodent models of AKI and AKI-CKD transition: an update in 2024","volume":"326","author":"Fu","year":"2024","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib170","doi-asserted-by":"crossref","first-page":"F304","DOI":"10.1152\/ajprenal.00017.2020","article-title":"A two-stage bilateral ischemia-reperfusion injury-induced AKI to CKD transition model in mice","volume":"319","author":"Zhang","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib171","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.7150\/thno.84308","article-title":"Tubular Elabela-APJ axis attenuates ischemia-reperfusion induced acute kidney injury and the following AKI-CKD transition by protecting renal microcirculation","volume":"13","author":"Xiong","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.ebiom.2026.106436_bib172","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/s41419-024-07231-2","article-title":"Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis","volume":"15","author":"Su","year":"2024","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ebiom.2026.106436_bib173","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41419-022-05492-3","article-title":"Tubular aryl hydratocarbon receptor upregulates EZH2 to promote cellular senescence in cisplatin-induced acute kidney injury","volume":"14","author":"Wen","year":"2023","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ebiom.2026.106436_bib174","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41581-023-00683-3","article-title":"Sepsis-associated acute kidney injury: consensus report of the 28th acute disease quality initiative workgroup","volume":"19","author":"Zarbock","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib175","doi-asserted-by":"crossref","first-page":"12299","DOI":"10.1007\/s00210-025-04071-5","article-title":"Effect of dexpanthenol on glycerol-induced acute kidney injury by targeting the PGC-1\u03b1\/SIRT3 pathway","volume":"398","author":"Koyuncu","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.ebiom.2026.106436_bib176","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12882-024-03570-6","article-title":"Contrast-induced acute kidney injury: a review of definition, pathogenesis, risk factors, prevention and treatment","volume":"25","author":"Li","year":"2024","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib177","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1097\/ALN.0000000000005452","article-title":"Persistent renal hypoxia and histologic changes at 4 weeks after cardiopulmonary bypass in sheep","volume":"142","author":"Furukawa","year":"2025","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ebiom.2026.106436_bib178","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13054-024-04877-4","article-title":"Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials","volume":"28","author":"Legrand","year":"2024","journal-title":"Crit Care"},{"key":"10.1016\/j.ebiom.2026.106436_bib179","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2025.1603392","article-title":"Review of research progress in sepsis-associated acute kidney injury","volume":"12","author":"Nian","year":"2025","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.ebiom.2026.106436_bib180","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1681\/ASN.2021050693","article-title":"Tissue culture models of AKI: from tubule cells to human kidney organoids","volume":"33","author":"Bejoy","year":"2022","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ebiom.2026.106436_bib181","doi-asserted-by":"crossref","first-page":"F702","DOI":"10.1152\/ajprenal.00044.2017","article-title":"Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells","volume":"314","author":"Adedoyin","year":"2018","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib182","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137211","article-title":"Human stem cell and organoid models to advance acute kidney injury diagnostics and therapeutics","volume":"23","author":"Pode-Shakked","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2026.106436_bib183","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ajpath.2022.01.009","article-title":"Human kidney organoids and tubuloids as models of complex kidney disease","volume":"192","author":"Nunez-Nescolarde","year":"2022","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ebiom.2026.106436_bib184","doi-asserted-by":"crossref","first-page":"F971","DOI":"10.1152\/ajprenal.00597.2019","article-title":"Evaluation of cisplatin-induced injury in human kidney organoids","volume":"318","author":"Digby","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib185","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.reth.2024.06.006","article-title":"Revolutionizing renal research: the future of kidney-on-a-chip in biotechnology","volume":"26","author":"Nishimura","year":"2024","journal-title":"Regen Ther"},{"key":"10.1016\/j.ebiom.2026.106436_bib186","doi-asserted-by":"crossref","first-page":"F41","DOI":"10.1152\/ajprenal.00069.2020","article-title":"Open microfluidic coculture reveals paracrine signaling from human kidney epithelial cells promotes kidney specificity of endothelial cells","volume":"319","author":"Zhang","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib187","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj4772","article-title":"Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair","volume":"14","author":"Gupta","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib188","doi-asserted-by":"crossref","first-page":"7567","DOI":"10.1038\/s41467-025-62599-9","article-title":"Multimodal spatial transcriptomic characterization of mouse kidney injury and repair","volume":"16","author":"Xuanyuan","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106436_bib189","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.827280","article-title":"Intravital multiphoton microscopy as a tool for studying renal physiology, pathophysiology and therapeutics","volume":"13","author":"Molitoris","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.ebiom.2026.106436_bib190","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74211","article-title":"Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia","volume":"11","author":"Freitas","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.ebiom.2026.106436_bib191","first-page":"149","article-title":"Advances in molecular imaging of kidney diseases","volume":"149","author":"Klinkhammer","year":"2025","journal-title":"Nephron"},{"key":"10.1016\/j.ebiom.2026.106436_bib192","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1038\/s41467-025-59997-4","article-title":"Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype","volume":"16","author":"Reck","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106436_bib193","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2026684118","article-title":"Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury","volume":"118","author":"Gerhardt","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2026.106436_bib194","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109255","article-title":"Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury","volume":"27","author":"Buse","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.ebiom.2026.106436_bib195","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41420-025-02557-y","article-title":"Roles of ACSL4\/GPX4 and FSP1 in oxalate-induced acute kidney injury","volume":"11","author":"Ye","year":"2025","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.ebiom.2026.106436_bib196","doi-asserted-by":"crossref","first-page":"15874","DOI":"10.1073\/pnas.2005477117","article-title":"Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury","volume":"117","author":"Kirita","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ebiom.2026.106436_bib197","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbi.2023.104393","article-title":"Identifying acute kidney injury subphenotypes using an outcome-driven deep-learning approach","volume":"143","author":"Tan","year":"2023","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.ebiom.2026.106436_bib198","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ade7287","article-title":"Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury","volume":"15","author":"Wen","year":"2023","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib199","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.24272\/j.issn.2095-8137.2024.072","article-title":"Experimental models for preclinical research in kidney disease","volume":"45","author":"Miao","year":"2024","journal-title":"Zool Res"},{"key":"10.1016\/j.ebiom.2026.106436_bib200","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.34067\/KID.0000000000000227","article-title":"Animal models of kidney disease: challenges and perspectives","volume":"4","author":"Liang","year":"2023","journal-title":"Kidney360"},{"key":"10.1016\/j.ebiom.2026.106436_bib201","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076636","article-title":"The reduction of uromodulin, complement factor H, and their interaction is associated with acute kidney injury to chronic kidney disease transition in a four-time cisplatin-injected rat model","volume":"24","author":"Xing","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2026.106436_bib202","doi-asserted-by":"crossref","first-page":"E302","DOI":"10.1152\/ajpendo.00237.2023","article-title":"Renal ischemia\/reperfusion induces prominent progressive kidney disease in diabetic mice","volume":"327","author":"de Ponte","year":"2024","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ebiom.2026.106436_bib203","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev-bioeng-072623-044010","article-title":"Kidney disease modeling with organoids and organs-on-chips","volume":"26","author":"Musah","year":"2024","journal-title":"Annu Rev Biomed Eng"},{"key":"10.1016\/j.ebiom.2026.106436_bib204","first-page":"369","article-title":"Give them vasculature and immune cells: how to fill the gap of organoids","volume":"212","author":"Yip","year":"2023","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.ebiom.2026.106436_bib205","article-title":"The gut-organ-axis concept: advances the application of gut-on-chip technology","volume":"24","author":"Guo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ebiom.2026.106436_bib206","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1161\/CIRCRESAHA.125.325497","article-title":"In vitro modeling of interorgan crosstalk: multi-organ-On-A-chip for studying cardiovascular-kidney-metabolic syndrome","volume":"136","author":"Juguilon","year":"2025","journal-title":"Circ Res"},{"key":"10.1016\/j.ebiom.2026.106436_bib207","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwaf034","article-title":"An initiative on digital nephrology: the kidney imageomics project","volume":"12","author":"Zhou","year":"2025","journal-title":"Natl Sci Rev"},{"key":"10.1016\/j.ebiom.2026.106436_bib208","doi-asserted-by":"crossref","DOI":"10.3390\/s25164909","article-title":"Future designs of clinical trials in nephrology: integrating methodological innovation and computational power","volume":"25","author":"Strizzi","year":"2025","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.ebiom.2026.106436_bib209","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ae0dba","article-title":"From organ to system: multiorgan-on-a-chip platforms as next-generation biomedical simulators","volume":"17","author":"Chen","year":"2025","journal-title":"Biofabrication"},{"key":"10.1016\/j.ebiom.2026.106436_bib210","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.ebiom.2026.106436_bib211","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.5005\/jp-journals-10071-24109","article-title":"ISCCM guidelines on acute kidney injury and renal replacement therapy","volume":"26","author":"Mishra","year":"2022","journal-title":"Indian J Crit Care Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib212","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jointm.2024.12.004","article-title":"Timing of initiating renal replacement therapy in acute kidney injury","volume":"5","author":"Barbar","year":"2025","journal-title":"J Intensive Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib213","first-page":"577","article-title":"New drugs on the horizon for acute kidney injury","volume":"30","author":"Mourisse","year":"2024","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.ebiom.2026.106436_bib214","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1007\/s00134-022-06859-y","article-title":"New drugs for acute kidney injury","volume":"48","author":"Pickkers","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib215","doi-asserted-by":"crossref","first-page":"11365","DOI":"10.1021\/acs.jmedchem.3c00837","article-title":"Design, synthesis, and biological evaluation of novel P2X7 receptor antagonists for the treatment of septic acute kidney injury","volume":"66","author":"Zhang","year":"2023","journal-title":"J Med Chem"},{"key":"10.1016\/j.ebiom.2026.106436_bib216","doi-asserted-by":"crossref","first-page":"11517","DOI":"10.1021\/acs.jmedchem.3c01031","article-title":"Structure-activity relationship studies of 2,4,5-Trisubstituted pyrimidine derivatives leading to the identification of a novel and potent sirtuin 5 inhibitor against sepsis-associated acute kidney injury","volume":"66","author":"Mou","year":"2023","journal-title":"J Med Chem"},{"key":"10.1016\/j.ebiom.2026.106436_bib217","doi-asserted-by":"crossref","first-page":"11926","DOI":"10.1021\/acs.jmedchem.5c03440","article-title":"X-ray crystallography-guided discovery of a potent dual-pocket competitive SIRT5 inhibitor against sepsis-associated AKI","volume":"69","author":"Jiang","year":"2026","journal-title":"J Med Chem"},{"key":"10.1016\/j.ebiom.2026.106436_bib218","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1007\/s00134-024-07560-y","article-title":"Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement","volume":"50","author":"Zarbock","year":"2024","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ebiom.2026.106436_bib219","first-page":"6046","article-title":"Early strategy vs. late initiation of renal replacement therapy in adult patients with acute kidney injury: an updated systematic review and meta-analysis of randomized controlled trials","volume":"27","author":"Li","year":"2023","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.ebiom.2026.106436_bib220","doi-asserted-by":"crossref","first-page":"393","DOI":"10.23876\/j.krcp.23.284","article-title":"Biomarkers in pursuit of precision medicine for acute kidney injury: hard to get rid of customs","volume":"43","author":"Lin","year":"2024","journal-title":"Kidney Res Clin Pract"},{"key":"10.1016\/j.ebiom.2026.106436_bib221","doi-asserted-by":"crossref","first-page":"7497","DOI":"10.1038\/s41467-022-35306-1","article-title":"Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease","volume":"13","author":"Widjaja","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.ebiom.2026.106436_bib222","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1016\/S0140-6736(25)01717-9","article-title":"A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial","volume":"406","author":"Zarbock","year":"2025","journal-title":"Lancet"}],"container-title":["eBioMedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426003208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352396426003208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:30:15Z","timestamp":1788949815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352396426003208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":222,"alternative-id":["S2352396426003208"],"URL":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106436","relation":{},"ISSN":["2352-3964"],"issn-type":[{"value":"2352-3964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy","name":"articletitle","label":"Article Title"},{"value":"eBioMedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ebiom.2026.106436","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106436"}}